Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.5554 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5554 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5554 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.5554 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5554 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.4218 | 0.6484 | 0.5675 |
Trypanosoma brucei | AMP deaminase, putative | 0.4218 | 0.6484 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5554 | 1 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.4218 | 0.6484 | 0.5675 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5554 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.4218 | 0.6484 | 0.5675 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.4218 | 0.6484 | 0.5675 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.4218 | 0.6484 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.5554 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.5554 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.4218 | 0.6484 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5554 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.4218 | 0.6484 | 0.5675 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.4218 | 0.6484 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.4218 | 0.6484 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 0.3516 | 0.3516 |
Trypanosoma brucei | AMP deaminase, putative | 0.4218 | 0.6484 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5554 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.5554 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.5554 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 0.3516 | 0.3516 |
Treponema pallidum | adenosine deaminase | 0.5554 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.5554 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.5554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 0.3516 | 0.3516 |
Plasmodium falciparum | adenosine deaminase | 0.5554 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.5554 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.5554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2464 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | AMP deaminase | 0.4218 | 0.6484 | 0.6484 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 0.3516 | 0.3516 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.4 mg kg-1 | Effect on the antagonism of nicotine-induced tonic-extensor convulsions (TE) in mice | ChEMBL. | 6103959 |
ED50 (functional) | = 1.4 mg kg-1 | Effect on the antagonism of nicotine-induced death (D) | ChEMBL. | 6103959 |
ED50 (functional) | = 1.4 mg kg-1 | Effect on the antagonism of nicotine-induced tonic-extensor convulsions (TE) in mice | ChEMBL. | 6103959 |
ED50 (functional) | = 1.4 mg kg-1 | Effect on the antagonism of nicotine-induced death (D) | ChEMBL. | 6103959 |
ED50 (functional) | = 9 mg kg-1 | Effect on the prolongation of hypoxic survival time (HS) | ChEMBL. | 6103959 |
ED50 (functional) | = 9 mg kg-1 | Effect on the prolongation of hypoxic survival time (HS) | ChEMBL. | 6103959 |
ED50 (functional) | = 14.9 mg kg-1 | Effect on the antagonism of pentylenetetrazole-induced clonic convulsions (P) | ChEMBL. | 6103959 |
ED50 (functional) | = 14.9 mg kg-1 | Effect on the antagonism of pentylenetetrazole-induced clonic convulsions (P) | ChEMBL. | 6103959 |
ED50 (functional) | = 25 mg kg-1 | Effect on the potentiation of gamma-butyrolactone-induced sleep (gamma-B) | ChEMBL. | 6103959 |
ED50 (functional) | = 25 mg kg-1 | Effect on the potentiation of gamma-butyrolactone-induced sleep (gamma-B) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the antagonism of bicuculline-induced tonic-extensor convulsions (B) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the potentiation of yohimbine-induced toxicity (Y) in aggregated mice | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the antagonism of oxotremorine-induced hypothermia (OX) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect of test compound on the potentiation of apomorphine-induced gnawing (AG) in aggregated mice | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the antagonism of bicuculline-induced tonic-extensor convulsions (B) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the potentiation of yohimbine-induced toxicity (Y) in aggregated mice | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the antagonism of oxotremorine-induced hypothermia (OX) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect of test compound on the potentiation of apomorphine-induced gnawing (AG) in aggregated mice | ChEMBL. | 6103959 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.