Detailed information for compound 22707

Basic information

Technical information
  • TDR Targets ID: 22707
  • Name: 2,2,2-trifluoroethyl pyrazine-2-carboxylate
  • MW: 206.122 | Formula: C7H5F3N2O2
  • H donors: 0 H acceptors: 3 LogP: 1.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nccnc1)OCC(F)(F)F
  • InChi: 1S/C7H5F3N2O2/c8-7(9,10)4-14-6(13)5-3-11-1-2-12-5/h1-3H,4H2
  • InChiKey: ULSGTKAIZYJJHM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-pyrazinecarboxylic acid 2,2,2-trifluoroethyl ester
  • pyrazin 2,2,2-trifluoroethyl ester
  • pyrazinic acid 2,2,2-trifluoroethyl ester
  • 139244-46-5
  • AIDS010181
  • BRN 5334238
  • Pyrazinecarboxylic acid, 2,2,2-trifluoroethyl ester
  • 2,2,2-Trifluoroethyl Pyrazinoate
  • AIDS-010181

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0236 0.0419
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0066 0.0066
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Echinococcus multilocularis snurportin 1 0.0302 0.3769 0.3769
Trichomonas vaginalis aldo-keto reductase, putative 0.013 0.1605 0.2811
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0023
Echinococcus multilocularis aldo keto reductase 0.045 0.5647 0.5647
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0313 0.0555
Onchocerca volvulus 0.045 0.5647 1
Giardia lamblia Aldose reductase 0.045 0.5647 0.5
Loa Loa (eye worm) oxidoreductase 0.045 0.5647 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Brugia malayi kap beta 3 protein 0.0005 0.0024 0.0042
Toxoplasma gondii aldo-keto reductase 0.013 0.1605 0.2841
Echinococcus granulosus aldo keto reductase 0.045 0.5647 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.045 0.5647 1
Echinococcus granulosus translational activator gcn1 0.0005 0.0024 0.0042
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Trichomonas vaginalis aldo/keto reductase, putative 0.045 0.5647 1
Trypanosoma cruzi aldo/keto reductase, putative 0.045 0.5647 1
Plasmodium falciparum aldehyde reductase, putative 0.013 0.1605 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0045 0.0045
Entamoeba histolytica aldose reductase, putative 0.045 0.5647 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.063 0.1116
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0005 0.0024 0.0042
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0024 0.0042
Echinococcus granulosus aldo keto reductase family 1, member B4 0.013 0.1605 0.2841
Mycobacterium ulcerans oxidoreductase 0.045 0.5647 1
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0037 0.0023
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Onchocerca volvulus 0.045 0.5647 1
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0024 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0037 0.0023
Plasmodium vivax importin-beta 2, putative 0.0028 0.0313 0.1832
Trichomonas vaginalis conserved hypothetical protein 0.013 0.1605 0.2811
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.045 0.5647 1
Schistosoma mansoni aldo-keto reductase 0.045 0.5647 1
Echinococcus granulosus aldo keto reductase 0.045 0.5647 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0023
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Brugia malayi RNA, U transporter 1 0.008 0.0972 0.1721
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Echinococcus granulosus hypothetical protein 0.045 0.5647 1
Echinococcus granulosus cpg binding protein 0.003 0.0332 0.0588
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.045 0.5647 1
Schistosoma mansoni cpg binding protein 0.003 0.0332 0.0588
Giardia lamblia Aldose reductase 0.045 0.5647 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Mycobacterium tuberculosis Probable oxidoreductase 0.045 0.5647 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.3769 0.6674
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.013 0.1605 0.2841
Schistosoma mansoni potassium channel beta 0.013 0.1605 0.2841
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Trypanosoma cruzi aldo/keto reductase, putative 0.013 0.1605 0.2841
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0313 0.0313
Trichomonas vaginalis alcohol dehydrogenase, putative 0.013 0.1605 0.2811
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Schistosoma mansoni hypothetical protein 0.0401 0.5022 0.8894
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0555
Echinococcus granulosus voltage gated potassium channel subunit 0.013 0.1605 0.2841
Trypanosoma brucei prostaglandin f synthase 0.045 0.5647 1
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5022 0.8894
Schistosoma mansoni pol-related 0.045 0.5647 1
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0045 0.0079
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.045 0.5647 1
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0023
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Echinococcus granulosus importin 5 0.0005 0.0024 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0246 0.0395
Entamoeba histolytica alcohol dehydrogenase, putative 0.013 0.1605 0.2811
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0024 0.0042
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.013 0.1605 0.2841
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.045 0.5647 1
Loa Loa (eye worm) hypothetical protein 0.045 0.5647 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0045 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0246 0.0395
Schistosoma mansoni importin-beta 2 0.0005 0.0024 0.0042
Loa Loa (eye worm) oxidoreductase 0.045 0.5647 1
Schistosoma mansoni importin beta-1 0.0028 0.0313 0.0555
Leishmania major importin beta-1 subunit, putative 0.0023 0.0246 0.0435
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.045 0.5647 1
Onchocerca volvulus 0.045 0.5647 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0023
Echinococcus granulosus transportin 1 0.0005 0.0024 0.0042
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Trypanosoma brucei aldo/keto reductase, putative 0.013 0.1605 0.2841
Brugia malayi NADH-dependent xylose reductase 0.013 0.1605 0.2841
Leishmania major aldo-keto reductase-like protein 0.045 0.5647 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0312 0.0552
Loa Loa (eye worm) oxidoreductase 0.045 0.5647 1
Echinococcus multilocularis aldo keto reductase 0.045 0.5647 0.5647
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Entamoeba histolytica aldose reductase, putative 0.045 0.5647 1
Trypanosoma cruzi aldo-keto reductase 0.045 0.5647 1
Trichomonas vaginalis aldo/keto reductase, putative 0.045 0.5647 1
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Mycobacterium leprae Conserved hypothetical protein 0.032 0.3999 0.7081
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.013 0.1605 0.2841
Plasmodium falciparum aldo-keto reductase, putative 0.013 0.1605 1
Echinococcus granulosus aldehyde reductase 0.032 0.3999 0.7081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0045 0.0079
Mycobacterium tuberculosis Conserved protein 0.013 0.1605 0.2841
Trichomonas vaginalis aldo-keto reductase, putative 0.013 0.1605 0.2811
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0312 0.0552
Schistosoma mansoni cpg binding protein 0.003 0.0332 0.0588
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Leishmania major hypothetical protein, conserved 0.0005 0.0024 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Echinococcus multilocularis voltage gated potassium channel subunit 0.013 0.1605 0.1605
Onchocerca volvulus 0.013 0.1605 0.2423
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0007 0.0013
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0005 0.0024 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0023
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0066 0.0117
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0024 0.0042
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.045 0.5647 1
Echinococcus granulosus importin subunit beta 1 0.0028 0.0313 0.0555
Trichomonas vaginalis aldo/keto reductase, putative 0.045 0.5647 1
Echinococcus multilocularis aldehyde reductase 0.032 0.3999 0.3999
Echinococcus multilocularis cpg binding protein 0.003 0.0332 0.0332
Entamoeba histolytica hypothetical protein 0.0023 0.0246 0.0395
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.045 0.5647 1
Echinococcus granulosus aldo keto reductase 0.045 0.5647 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.045 0.5647 1
Schistosoma mansoni hypothetical protein 0.0302 0.3769 0.6674
Echinococcus multilocularis transportin 1 0.0005 0.0024 0.0024
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0045 0.0079
Echinococcus multilocularis importin 5 0.0005 0.0024 0.0024
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0065 0.0115
Trypanosoma brucei aldo-keto reductase, putative 0.045 0.5647 1
Onchocerca volvulus 0.045 0.5647 1
Echinococcus multilocularis translational activator gcn1 0.0005 0.0024 0.0024
Plasmodium falciparum importin beta, putative 0.0028 0.0313 0.1832
Brugia malayi Cytochrome P450 family protein 0.0022 0.0236 0.0419
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0246 0.0435
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0023
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0313 0.0555
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.013 0.1605 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0246 0.0395
Echinococcus multilocularis aldo keto reductase 0.045 0.5647 0.5647
Trichomonas vaginalis aldo-keto reductase, putative 0.013 0.1605 0.2811
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647
Echinococcus granulosus snurportin 1 0.0302 0.3769 0.6674
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.013 0.1605 0.2841
Echinococcus multilocularis aldo keto reductase 0.045 0.5647 0.5647
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0711 0.1259
Brugia malayi Importin beta-1 subunit 0.0028 0.0313 0.0555
Onchocerca volvulus 0.045 0.5647 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.013 0.1605 0.2811
Toxoplasma gondii aldose reductase, putative 0.045 0.5647 1
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5022 0.5022
Mycobacterium ulcerans hypothetical protein 0.013 0.1605 0.2841
Loa Loa (eye worm) oxidoreductase 0.045 0.5647 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.045 0.5647 1
Trichomonas vaginalis aldo-keto reductase, putative 0.045 0.5647 1
Schistosoma mansoni aldo-keto reductase 0.045 0.5647 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.045 0.5647 1
Loa Loa (eye worm) oxidoreductase 0.045 0.5647 1
Mycobacterium leprae Possible oxidoreductase 0.013 0.1605 0.2841
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.013 0.1605 0.2841
Trichomonas vaginalis helicase, putative 0.0006 0.0037 0.0023
Entamoeba histolytica aldose reductase, putative 0.045 0.5647 1
Leishmania major prostaglandin f synthase, putative 0.045 0.5647 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0313 0.0555
Onchocerca volvulus 0.045 0.5647 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0023
Schistosoma mansoni cpg binding protein 0.0028 0.0312 0.0552
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0066 0.0117
Plasmodium vivax aldehyde reductase, putative 0.013 0.1605 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.045 0.5647 0.5647

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 12.5 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain CES (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 12.5 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain GLA (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 12.5 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain CES (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 12.5 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain GLA (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-H37Rv) at pH 5.8 ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-BUR)at pH 5.8 ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-ATCC 35828)at pH 5.8 ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-ATCC 27289).at pH 5.8 ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain BUR (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain DOL (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain SMA (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain DUB (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain ING (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain MCQ (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain WOO (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain BAK (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain ATCC35828 (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain SCH (Mycobacterium kansasii) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-H37Rv) at pH 5.8 ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-BUR)at pH 5.8 ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-ATCC 35828)at pH 5.8 ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain BUR (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain DOL (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain SMA (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain DUB (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain ING (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain MCQ (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain WOO (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain BAK (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 25 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain ATCC35828 (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 50 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain LEL (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 50 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain LEL (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 100 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-H37Rv) at pH 6.6 ChEMBL. 1560435
MIC (functional) = 100 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. kansasii (strain type-SWK)at pH 5.8 ChEMBL. 1560435
MIC (functional) = 100 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain DOU (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) = 100 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-H37Rv) at pH 6.6 ChEMBL. 1560435
MIC (functional) = 100 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain DOU (Mycobacterium tuberculosis) ChEMBL. 1560435
MIC (functional) > 200 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-ATCC 35828) at pH 6.6 ChEMBL. 1560435
MIC (functional) > 200 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-ATCC 27289). at pH 6.6 ChEMBL. 1560435
MIC (functional) > 200 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. kansasii (strain type-SWK) pH 6.6 ChEMBL. 1560435
MIC (functional) = 200 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium strain SWK (Mycobacterium kansasii) ChEMBL. 1560435
MIC (functional) > 200 ug ml-1 Compound was evaluated in vitro for its activity against Mycobacterium. tuberculosis (strain type-ATCC 35828) at pH 6.6 ChEMBL. 1560435

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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