Detailed information for compound 227084

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 476.523 | Formula: C30H24N2O4
  • H donors: 2 H acceptors: 4 LogP: 5.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccc2c(c1)ccc(c2)OCc1ccc2c(n1)cccc2)C(=O)Nc1ccc(cc1)C(=O)O
  • InChi: 1S/C30H24N2O4/c1-19(29(33)32-25-12-9-21(10-13-25)30(34)35)22-6-7-24-17-27(15-11-23(24)16-22)36-18-26-14-8-20-4-2-3-5-28(20)31-26/h2-17,19H,18H2,1H3,(H,32,33)(H,34,35)
  • InChiKey: LJGACYHHXPUHQJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Cysteinyl leukotriene receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis neuropeptide receptor Cysteinyl leukotriene receptor 1   340 aa 300 aa 24.7 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 304 aa 22.0 %
Echinococcus granulosus tachykinin peptides receptor 99D Cysteinyl leukotriene receptor 1   340 aa 309 aa 22.3 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 303 aa 21.1 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Cysteinyl leukotriene receptor 1   340 aa 313 aa 21.4 %
Echinococcus multilocularis allatostatin A receptor Cysteinyl leukotriene receptor 1   340 aa 318 aa 23.6 %
Brugia malayi GnHR receptor homolog Cysteinyl leukotriene receptor 1   340 aa 317 aa 19.2 %
Schistosoma mansoni neuropeptide receptor Cysteinyl leukotriene receptor 1   340 aa 302 aa 23.8 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Cysteinyl leukotriene receptor 1   340 aa 307 aa 25.1 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 298 aa 21.5 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 280 aa 26.8 %
Schistosoma mansoni opsin-like receptor Cysteinyl leukotriene receptor 1   340 aa 324 aa 23.8 %
Echinococcus granulosus neuropeptide receptor Cysteinyl leukotriene receptor 1   340 aa 299 aa 24.1 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 311 aa 19.3 %
Schistosoma mansoni neuropeptide F-like receptor Cysteinyl leukotriene receptor 1   340 aa 279 aa 21.1 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 317 aa 19.9 %
Loa Loa (eye worm) neuropeptide F receptor Cysteinyl leukotriene receptor 1   340 aa 309 aa 23.0 %
Schistosoma mansoni peptide (allatostatin)-like receptor Cysteinyl leukotriene receptor 1   340 aa 309 aa 26.5 %
Echinococcus granulosus allatostatin A receptor Cysteinyl leukotriene receptor 1   340 aa 330 aa 23.6 %
Onchocerca volvulus Programmed cell death protein 5 homolog Cysteinyl leukotriene receptor 1   340 aa 286 aa 23.8 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 317 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Schistosoma mansoni biogenic amine receptor 0.0025 0.0085 0.0085
Plasmodium falciparum esterase, putative 0.0021 0.0044 0.0119
Plasmodium vivax alpha/beta hydrolase, putative 0.0021 0.0044 0.0119
Onchocerca volvulus 0.0089 0.0778 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0044 0.0119
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0019 0.0019
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0021 0.0044 0.6021
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.052 0.1404
Schistosoma mansoni tyrosinase precursor 0.0089 0.0778 0.0778
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0778 0.0778
Toxoplasma gondii phospholipase 0.0021 0.0044 0.6021
Schistosoma mansoni biogenic amine receptor 0.0025 0.0085 0.0085
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0113 0.1043 0.1043
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0025 0.0085 0.0085
Plasmodium vivax lysophospholipase, putative 0.0021 0.0044 0.0119
Entamoeba histolytica hypothetical protein 0.0021 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus neuropeptide receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0019 0.0019
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0359 0.3704 1
Onchocerca volvulus 0.0025 0.0085 0.109
Schistosoma mansoni amine GPCR 0.0025 0.0085 0.0085
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0085 0.0085
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0085 0.0085
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0113 0.1043 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0085 0.0085
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0021 0.0044 0.0119
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0085 0.0085
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0085 0.0085
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Plasmodium falciparum prodrug activation and resistance esterase 0.0021 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.094 1 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0073 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0113 0.1043 0.2672
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus multilocularis fatty acid amide hydrolase 1 0.094 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0085 0.0085
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0085 0.0085
Leishmania major hypothetical protein, conserved 0.0021 0.0044 0.0119
Toxoplasma gondii phospholipase/carboxylesterase 0.0021 0.0044 0.6021
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0085 0.0085
Schistosoma mansoni opsin-like receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0019 0.0019
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0073 0.0137
Brugia malayi ShTK domain containing protein 0.0089 0.0778 0.0778
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0019 0.0019
Plasmodium vivax PST-A protein 0.0021 0.0044 0.0119
Mycobacterium ulcerans amidase 0.0113 0.1043 0.2773
Echinococcus granulosus serotonin receptor 0.0025 0.0085 0.0085
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Toxoplasma gondii hypothetical protein 0.0021 0.0044 0.6021
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.052 0.1404
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.052 0.1404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Loa Loa (eye worm) tyrosinase 1 0.0089 0.0778 0.0778
Onchocerca volvulus 0.0025 0.0085 0.109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0021 0.0044 0.6021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0019 0.0019
Echinococcus multilocularis serotonin receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0019 0.0019 0.005
Brugia malayi Dopamine receptor protein 1 0.0025 0.0085 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0085 0.0085
Brugia malayi larval opioid receptor 0.0025 0.0085 0.0085
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0085 0.0085
Echinococcus granulosus allatostatin A receptor 0.0025 0.0085 0.0085
Mycobacterium ulcerans hypothetical protein 0.0021 0.0044 0.0058
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0023 0.0062
Schistosoma mansoni neuropeptide receptor 0.0025 0.0085 0.0085
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0085 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.052 0.1404
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0085 0.0085
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis somatostatin receptor 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0021 0.0044 0.0119
Echinococcus granulosus hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0085 0.0085
Brugia malayi MGC83647 protein 0.0021 0.0044 0.0044
Echinococcus granulosus Phospholipase carboxylesterase 0.0021 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Echinococcus granulosus orexin receptor type 2 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0085 0.0085
Brugia malayi Serotonin receptor 0.0025 0.0085 0.0085
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0021 0.0044 0.0119
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Loa Loa (eye worm) amidase 0.0113 0.1043 0.1043
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0021 0.0044 0.0119
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0062
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0073 0.0198
Plasmodium vivax PST-A protein 0.0021 0.0044 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0019 0.0019
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0019 0.005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Plasmodium vivax PST-A protein 0.0021 0.0044 0.0119
Brugia malayi putative amidase 0.0113 0.1043 0.1043
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0085 0.0085
Mycobacterium ulcerans lysophospholipase 0.0359 0.3704 1
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0113 0.1043 0.2773
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0044 0.0119
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0085 0.0085
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0062
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0113 0.1043 0.2672
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0044 0.0119
Mycobacterium ulcerans hypothetical protein 0.0359 0.3704 1
Plasmodium falciparum exported lipase 1 0.0021 0.0044 0.0119
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0085 0.0085
Brugia malayi AKH receptor 0.0025 0.0085 0.0085
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0085 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0044
Entamoeba histolytica ;Alias 0.0021 0.0044 0.0119
Brugia malayi G-protein coupled receptor 0.0025 0.0085 0.0085
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0019
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0085 0.0085
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0044 0.0119
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0085 0.0085
Brugia malayi hypothetical protein 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0085 0.0085
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.0778 0.0778
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0113 0.1043 1
Schistosoma mansoni amine GPCR 0.0025 0.0085 0.0085
Mycobacterium ulcerans peptide amidase, GatA 0.0113 0.1043 0.2773
Echinococcus granulosus fatty acid amide hydrolase 1 0.0113 0.1043 0.1043
Plasmodium falciparum exported lipase 2 0.0021 0.0044 0.0119
Onchocerca volvulus 0.0025 0.0085 0.109
Plasmodium falciparum lysophospholipase, putative 0.0021 0.0044 0.0119
Plasmodium vivax PST-A protein 0.0359 0.3704 1
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0085 0.0085
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0085 0.0085
Brugia malayi Dopamine receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Leishmania major cathepsin L-like protease 0.0065 0.052 0.1404
Brugia malayi hypothetical protein 0.0019 0.0019 0.0019
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0019 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Leishmania major hypothetical protein, conserved 0.0021 0.0044 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0778 0.0778
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0113 0.1043 0.2773
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0085 0.0085
Plasmodium falciparum esterase, putative 0.0359 0.3704 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0073 0.0496
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0085 0.0085
Onchocerca volvulus 0.0025 0.0085 0.109
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0085 0.109
Toxoplasma gondii exonuclease III APE 0.0019 0.0023 0.3107
Schistosoma mansoni biogenic amine receptor 0.0025 0.0085 0.0085
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0021 0.0044 0.0044
Echinococcus granulosus neuropeptide receptor 0.0025 0.0085 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0085 0.0085
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0025 0.0085 0.0085
Plasmodium vivax unspecified product 0.0021 0.0044 0.0119
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.0021 0.0044 0.6021
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0113 0.1043 0.2818
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0019 0.0019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0734 0.0734
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0085 0.0085
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0019
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0073 0.0198
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0369 0.0997
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0734 0.0734
Schistosoma mansoni fatty-acid amide hydrolase 0.094 1 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0089 0.0778 0.0778
Schistosoma mansoni neuropeptide receptor 0.0025 0.0085 0.0085
Toxoplasma gondii hypothetical protein 0.0021 0.0044 0.6021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Plasmodium vivax lysophospholipase, putative 0.0021 0.0044 0.0119
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0459 0.1239
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0085 0.0085
Echinococcus granulosus g protein coupled receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis abhydrolase domain containing 3 0.0021 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0021 0.0044 0.0058
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0073 0.0292
Onchocerca volvulus 0.0025 0.0085 0.109
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0019 0.0019
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0019 0.0019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0085 0.0085
Trypanosoma brucei monoglyceride lipase, putative 0.0359 0.3704 1
Brugia malayi G-protein coupled receptor 0.0025 0.0085 0.0085
Brugia malayi Serotonin receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis serotonin receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0021 0.0044 0.0044
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0044 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0021 0.0044 0.6021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus g protein coupled receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0019 0.0019
Echinococcus granulosus somatostatin receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0085 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0085 0.0734 0.0734
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0073 0.0137
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus fatty acid amide hydrolase 1 0.094 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.0062
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.0062
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0359 0.3704 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0085 0.0085
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0085 0.0085
Plasmodium vivax lysophospholipase, putative 0.0021 0.0044 0.0119
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0025 0.0085 0.0085
Mycobacterium tuberculosis Possible lysophospholipase 0.0359 0.3704 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Brugia malayi putative neuropeptide receptor 0.0025 0.0085 0.0085
Mycobacterium ulcerans hydrolase 0.0021 0.0044 0.0058
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0085 0.0085
Loa Loa (eye worm) amidase 0.0113 0.1043 0.1043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0085 0.0085
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0778 0.0778
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0085 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0019 0.0019
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0019
Echinococcus granulosus abhydrolase domain containing 3 0.0021 0.0044 0.0044
Plasmodium vivax PST-A protein 0.0021 0.0044 0.0119
Onchocerca volvulus 0.0025 0.0085 0.109
Mycobacterium ulcerans amidase 0.0113 0.1043 0.2773
Toxoplasma gondii hypothetical protein 0.0021 0.0044 0.6021
Brugia malayi neuropeptide F receptor 0.0025 0.0085 0.0085
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0085 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus multilocularis fatty acid amide hydrolase 1 0.094 1 1
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0044 0.0119
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0085 0.0085
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0021 0.0044 0.0044
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0021 0.0044 0.0119
Plasmodium falciparum epoxide hydrolase 2 0.0021 0.0044 0.0119
Onchocerca volvulus 0.0025 0.0085 0.109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0085 0.0085
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0085 0.0085
Schistosoma mansoni opsin-like receptor 0.0025 0.0085 0.0085
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni neuropeptide receptor 0.0025 0.0085 0.0085
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0044 0.0119
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0021 0.0044 0.0119
Onchocerca volvulus 0.0025 0.0085 0.109
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0085 0.0085
Brugia malayi G protein-coupled receptor 0.0025 0.0085 0.0085
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0021 0.0044 0.0119
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0085 0.0085
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0019 0.0019
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0019 0.0019
Brugia malayi Amidase family protein 0.0113 0.1043 0.1043
Entamoeba histolytica hypothetical protein 0.0019 0.0019 0.005
Echinococcus granulosus sex peptide receptor 0.0025 0.0085 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0021 0.0044 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Brugia malayi RE15519p 0.0025 0.0085 0.0085
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.0198
Plasmodium vivax alpha/beta hydrolase, putative 0.0021 0.0044 0.0119
Plasmodium falciparum lysophospholipase, putative 0.0021 0.0044 0.0119
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0019 0.0019
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.0778 0.0778
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0085 0.0085
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0021 0.0044 0.0119
Brugia malayi Amidase family protein 0.0113 0.1043 0.1043
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0085 0.0085
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0085 0.0085
Plasmodium falciparum BEM46-like protein, putative 0.0021 0.0044 0.0119
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0025 0.0085 0.0085
Trypanosoma cruzi amidase, putative 0.0113 0.1043 0.2818
Onchocerca volvulus 0.0089 0.0778 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0113 0.1043 0.2818
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0085 0.0085
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0359 0.3704 1
Schistosoma mansoni myosin xvIII 0.0025 0.0085 0.0085
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Plasmodium vivax PST-A protein 0.0021 0.0044 0.0119
Mycobacterium ulcerans amidase 0.0113 0.1043 0.2773
Schistosoma mansoni fatty-acid amide hydrolase 0.0113 0.1043 0.1043
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0085 0.0085
Schistosoma mansoni opsin-like receptor 0.0025 0.0085 0.0085
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.005
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0113 0.1043 0.1043
Trypanosoma cruzi amidase, putative 0.0113 0.1043 0.2818
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0113 0.1043 0.2773
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0085 0.0085
Plasmodium vivax unspecified product 0.0021 0.0044 0.0119
Onchocerca volvulus 0.0025 0.0085 0.109
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0021 0.0044 0.0058
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0085 0.0085
Onchocerca volvulus 0.0025 0.0085 0.109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0073 0.0198
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0085 0.0085
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0019 0.0019
Mycobacterium ulcerans hypothetical protein 0.0021 0.0044 0.0058
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0085 0.0085
Echinococcus granulosus g protein coupled receptor 0.0025 0.0085 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Toxoplasma gondii protein c14orf29, putative 0.0021 0.0044 0.6021
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Onchocerca volvulus 0.0089 0.0778 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0085 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0019 0.0019
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Brugia malayi neuropeptide F receptor 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.005
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0044 0.0119
Plasmodium falciparum lysophospholipase, putative 0.0359 0.3704 1
Brugia malayi GnHR receptor homolog 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni adenoreceptor 0.0025 0.0085 0.0085
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0085 0.0085
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0073 1
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0113 0.1043 0.2773
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0085 0.0085
Toxoplasma gondii peptidase S15, putative 0.0021 0.0044 0.6021
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0085 0.0085
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0073 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0023
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0085 0.0085
Mycobacterium ulcerans amidase 0.0113 0.1043 0.2773
Plasmodium falciparum lysophospholipase, putative 0.0359 0.3704 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0085 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0023 0.0062
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0734 0.0734
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0073 0.0496
Echinococcus multilocularis Phospholipase carboxylesterase 0.0021 0.0044 0.0044
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0044 0.0058
Echinococcus granulosus fatty acid amide hydrolase 1 0.094 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Onchocerca volvulus 0.0025 0.0085 0.109
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0085 0.0085
Onchocerca volvulus 0.0025 0.0085 0.109
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0085 0.0085
Brugia malayi PXA domain containing protein 0.0019 0.0019 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0085 0.0085
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0085 0.109
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0359 0.3704 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Leishmania major cathepsin L-like protease 0.0065 0.052 0.1404
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0021 0.0044 1
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0021 0.0044 0.0119
Echinococcus multilocularis expressed protein 0.0366 0.3782 0.3782
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0023
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0778 0.0778
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Entamoeba histolytica hypothetical protein 0.0019 0.0019 0.005
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Leishmania major monoglyceride lipase, putative 0.0359 0.3704 1
Mycobacterium ulcerans amidase 0.0113 0.1043 0.2773
Brugia malayi PXA domain containing protein 0.0019 0.0019 0.0019
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0113 0.1043 0.2773
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0085 0.0085
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0085 0.0085
Onchocerca volvulus 0.0085 0.0734 0.9434
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0359 0.3704 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0359 0.3704 1
Brugia malayi ORL1-like opioid receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0085 0.0085
Plasmodium falciparum lysophospholipase, putative 0.0359 0.3704 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Schistosoma mansoni peptidase 0.0021 0.0044 0.0044
Schistosoma mansoni amidase 0.094 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.005
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0019
Trypanosoma cruzi serine peptidase, putative 0.0021 0.0044 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0113 0.1043 1
Trypanosoma cruzi serine peptidase, putative 0.0021 0.0044 0.0119
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0025 0.0085 0.0085
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0044
Plasmodium falciparum esterase, putative 0.0021 0.0044 0.0119
Echinococcus granulosus expressed protein 0.0366 0.3782 0.3782
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0085 0.0085
Schistosoma mansoni amine GPCR 0.0025 0.0085 0.0085
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0021 0.0044 0.0119
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0085 0.0085
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0044
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0085 0.0085
Trypanosoma cruzi monoglyceride lipase, putative 0.0359 0.3704 1
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0021 0.0044 0.0119
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.005
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0085 0.0085
Schistosoma mansoni amine GPCR 0.0025 0.0085 0.0085
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0019 0.0019
Brugia malayi MGC79044 protein 0.0021 0.0044 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0025 0.0085 0.0085
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0019 0.0019
Onchocerca volvulus 0.0089 0.0778 1
Brugia malayi Melatonin receptor type 1A 0.0025 0.0085 0.0085
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0359 0.3704 1
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0085 0.0085
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0778 0.0778
Trypanosoma brucei monoglyceride lipase, putative 0.0359 0.3704 1
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0021 0.0044 0.0044
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0021 0.0044 0.0119
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.0023
Onchocerca volvulus 0.0025 0.0085 0.109
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0359 0.3704 1
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0021 0.0044 0.0058
Onchocerca volvulus 0.0025 0.0085 0.109
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0085 0.0085
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0021 0.0044 0.0119
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0113 0.1043 0.2773
Brugia malayi sulfakinin receptor protein 0.0025 0.0085 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0085 0.0085
Brugia malayi Dopamine receptor protein 2 0.0025 0.0085 0.0085
Schistosoma mansoni histamine h1 receptor 0.0025 0.0085 0.0085
Entamoeba histolytica hypothetical protein 0.0021 0.0044 0.0119
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0085 0.0085
Leishmania major cathepsin L-like protease 0.0065 0.052 0.1404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0062
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0085 0.0085
Brugia malayi Protein C20orf22 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0085 0.0085
Echinococcus granulosus abhydrolase domain containing protein 13 0.0021 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.052 0.1351
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0359 0.3704 1
Onchocerca volvulus 0.0025 0.0085 0.109
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0019 0.0019
Onchocerca volvulus 0.0025 0.0085 0.109
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Schistosoma mansoni tyrosinase precursor 0.0089 0.0778 0.0778
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0359 0.3704 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0113 0.1043 0.1043
Echinococcus granulosus fmrfamide receptor 0.0025 0.0085 0.0085
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0019
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0359 0.3704 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0085 0.0085
Echinococcus multilocularis sex peptide receptor 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0044
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0113 0.1043 0.1043
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0113 0.1043 0.2773
Onchocerca volvulus 0.0025 0.0085 0.109
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0021 0.0044 0.0119
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0089 0.0778 0.0778
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0073 1
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0019 0.0019
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0085 0.0085
Leishmania major hypothetical protein, conserved 0.0113 0.1043 0.2818
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0044 0.0119
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0085 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0085 0.0085
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0019 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0085 0.0085

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 118 nM In vitro binding affinity towards Cysteinyl leukotriene D4 receptor ChEMBL. 10669566
Ki (binding) = 118 nM In vitro binding affinity towards Cysteinyl leukotriene D4 receptor ChEMBL. 10669566

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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