Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor III (thromboplastin, tissue factor) | References | |
Homo sapiens | Coagulation factor VII/tissue factor | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | References | |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1502 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1323 | 0.8192 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1502 | 1 | 0.5 |
Onchocerca volvulus | 0.1323 | 0.8192 | 1 | |
Brugia malayi | thymidylate synthase | 0.1067 | 0.5625 | 0.6866 |
Echinococcus granulosus | thymidylate synthase | 0.1067 | 0.5625 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1502 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0819 | 0.3132 | 0.3132 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1502 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0508 | 0 | 0.5 |
Onchocerca volvulus | 0.1067 | 0.5625 | 0.4927 | |
Brugia malayi | Protein kinase domain containing protein | 0.0819 | 0.3132 | 0.3823 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1067 | 0.5625 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1067 | 0.5625 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0819 | 0.3132 | 0.3823 |
Loa Loa (eye worm) | hypothetical protein | 0.1323 | 0.8192 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1502 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.1323 | 0.8192 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1323 | 0.8192 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.1067 | 0.5625 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.1067 | 0.5625 | 0.4927 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1067 | 0.5625 | 0.4927 |
Onchocerca volvulus | 0.0875 | 0.3692 | 0.1108 | |
Loa Loa (eye worm) | hypothetical protein | 0.1323 | 0.8192 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1067 | 0.5625 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.05 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 0.05 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 3.21 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 3.21 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.