TDR Targets

Basic information

Technical information

TDR Targets ID: 227161
Name: ethyl (1S,6R)-4-[(5-chloropyridin-2-yl)amino] -6-methyl-2-oxocyclohex-3-ene-1-carboxylate
MW: 308.76 | Formula: C15H17ClN2O3
H donors: 1 H acceptors: 3 LogP: 2.97 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)[C@H]1[C@H](C)CC(=CC1=O)Nc1ccc(cn1)Cl
InChi: 1S/C15H17ClN2O3/c1-3-21-15(20)14-9(2)6-11(7-12(14)19)18-13-5-4-10(16)8-17-13/h4-5,7-9,14H,3,6H2,1-2H3,(H,17,18)/t9-,14+/m1/s1
InChiKey: MBSGLTDLXRVGJU-OTYXRUKQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl (1S,6R)-4-[(5-chloro-2-pyridyl)amino]-6-methyl-2-oxo-cyclohex-3-ene-1-carboxylate
(1S,6R)-4-[(5-chloro-2-pyridyl)amino]-6-methyl-2-oxo-1-cyclohex-3-enecarboxylic acid ethyl ester
ethyl (1S,6R)-4-[(5-chloropyridin-2-yl)amino]-6-methyl-2-oxo-cyclohex-3-ene-1-carboxylate
(1S,6R)-4-[(5-chloro-2-pyridyl)amino]-2-keto-6-methyl-cyclohex-3-ene-1-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear hormone receptor	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Onchocerca volvulus	Protein ultraspiracle homolog	0.0079	0.0181	0.0124
Trichomonas vaginalis	adenosine deaminase, putative	0.3418	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0079	0.0181	0.0181
Brugia malayi	hypothetical protein	0.0037	0.0058	0.0058
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0181	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0079	0.0181	0.0181
Echinococcus multilocularis	adenosine deaminase	0.3418	1	1
Echinococcus granulosus	adenosine deaminase	0.3418	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0079	0.0181	0.0181
Schistosoma mansoni	alkaline phosphatase	0.0322	0.0894	0.0894
Schistosoma mansoni	retinoic acid receptor RXR	0.05	0.1417	0.1417
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0071	0.0071
Echinococcus granulosus	nuclear receptor nhr 48	0.0037	0.0058	0.0058
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Plasmodium vivax	adenosine deaminase, putative	0.3418	1	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0058	0.0058
Loa Loa (eye worm)	AMP deaminase	0.1546	0.4495	0.4495
Mycobacterium ulcerans	adenosine deaminase	0.3418	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.2187	0.638	0.638
Brugia malayi	nuclear receptor RXR	0.0037	0.0058	0.0058
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0079	0.0181	0.0181
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0058	0.0058
Brugia malayi	WD domain containing protein	0.0036	0.0054	0.0054
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Brugia malayi	nuclear receptor NHR-88	0.0079	0.0181	0.0181
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0042	0.0071	0.0071
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.05	0.1417	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Trypanosoma cruzi	PAB1-binding protein , putative	0.0022	0.0014	0.0031
Echinococcus granulosus	FTZ F1 alpha	0.0079	0.0181	0.0181
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0181	0.0181
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0079	0.0181	0.0181
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.0181	0.0181
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0037	0.0058	0.0058
Schistosoma mansoni	nuclear receptor	0.0037	0.0058	0.0058
Brugia malayi	hypothetical protein	0.0037	0.0058	0.0058
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0004	0.0004
Echinococcus multilocularis	phospholipase A 2 activating protein	0.0036	0.0054	0.0054
Schistosoma mansoni	adenosine deaminase	0.3418	1	1
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.3418	1	0.5
Schistosoma mansoni	alkaline phosphatase	0.0322	0.0894	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Trichomonas vaginalis	adenosine deaminase, putative	0.3418	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0058	0.0058
Schistosoma mansoni	zinc finger protein	0.0037	0.0058	0.0058
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0079	0.0181	0.0181
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0058	0.0058
Entamoeba histolytica	hypothetical protein	0.0023	0.0017	0.0017
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0079	0.0181	0.0181
Loa Loa (eye worm)	WD domain-containing protein	0.0024	0.0019	0.0019
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.1546	0.4495	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0042	0.0071	0.0071
Plasmodium falciparum	ataxin-2 like protein, putative	0.0022	0.0014	0.001
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0079	0.0181	0.0181
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.1546	0.4495	1
Brugia malayi	hypothetical protein	0.0042	0.0071	0.0071
Schistosoma mansoni	ap endonuclease	0.0019	0.0004	0.0004
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0058	0.0058
Toxoplasma gondii	PUL domain-containing protein	0.0036	0.0054	0.005
Leishmania major	hypothetical protein, conserved	0.0036	0.0054	0.0054
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0079	0.0181	0.0181
Brugia malayi	steroid hormone receptor	0.0079	0.0181	0.0181
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0079	0.0181	0.0181
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0004	0.0008
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.1546	0.4495	0.4495
Schistosoma mansoni	nuclear receptor nhr-48	0.0037	0.0058	0.0058
Trypanosoma cruzi	WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative	0.0036	0.0054	0.012
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0058	0.0058
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0181	0.0181
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0079	0.0181	0.0181
Onchocerca volvulus	Adenosine deaminase homolog	0.3418	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0079	0.0181	0.0181
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0079	0.0181	0.0181
Brugia malayi	hypothetical protein	0.0037	0.0058	0.0058
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0071	0.0071
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0004	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0874	0.0874
Onchocerca volvulus		0.0079	0.0181	0.0124
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0058	0.0058
Entamoeba histolytica	AMP deaminase, putative	0.1546	0.4495	0.4495
Leishmania major	hypothetical protein, conserved	0.1231	0.3569	0.3569
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.1546	0.4495	0.4495
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0004	0.5
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0004	0.0004
Brugia malayi	adenosine monophosphate deaminase	0.1546	0.4495	0.4495
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.0299	0.0299
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.3418	1	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0037	0.0058	0.0058
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0042	0.0071	0.0071
Trypanosoma brucei	WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative	0.0024	0.0019	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Plasmodium falciparum	AMP deaminase, putative	0.1546	0.4495	0.4493
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0181	0.0181
Trypanosoma brucei	AMP deaminase, putative	0.1546	0.4495	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0042	0.0071	0.0071
Schistosoma mansoni	adenosine deaminase-related	0.3418	1	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0322	0.0894	0.0894
Brugia malayi	hypothetical protein	0.0042	0.0071	0.0071
Trypanosoma cruzi	AMP deaminase, putative	0.1546	0.4495	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0058	0.0058
Loa Loa (eye worm)	DR-78	0.0037	0.0058	0.0058
Echinococcus granulosus	alkaline phosphatase	0.0322	0.0894	0.0894
Echinococcus multilocularis	AMP deaminase 2	0.1546	0.4495	0.4495
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0079	0.0181	0.0181
Trypanosoma cruzi	AMP deaminase, putative	0.1546	0.4495	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0079	0.0181	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0181	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0079	0.0181	0.0181
Trypanosoma brucei	AMP deaminase, putative	0.1546	0.4495	1
Trypanosoma cruzi	AMP deaminase 2, putative	0.1231	0.3569	0.794
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0058	0.0058
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0181	0.0181
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0004	0.0004
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0004	0.0004
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0079	0.0181	0.0181
Trypanosoma brucei	PAB1-binding protein , putative	0.0022	0.0014	0.0031
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.3418	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Brugia malayi	nuclear hormone receptor	0.0778	0.2237	0.2237
Leishmania major	AMP deaminase, putative	0.1546	0.4495	0.4495
Trichomonas vaginalis	phospholipase A-2-activating protein, putative	0.0024	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Loa Loa (eye worm)	nuclear hormone receptor	0.0037	0.0058	0.0058
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0079	0.0181	0.0181
Onchocerca volvulus	Bile acid receptor homolog	0.0079	0.0181	0.0124
Entamoeba histolytica	hypothetical protein	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0004	0.0004
Schistosoma mansoni	nuclear hormone receptor	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.2187	0.638	0.638
Schistosoma mansoni	phospholipase A-2-activating protein	0.0024	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0778	0.2237	0.2237
Brugia malayi	ecdysone receptor	0.0037	0.0058	0.0058
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.1546	0.4495	0.4495
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0071	0.0071
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0058	0.0058
Entamoeba histolytica	hypothetical protein	0.0037	0.0058	0.0058
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0079	0.0181	0.0181
Toxoplasma gondii	AMP deaminase	0.1546	0.4495	0.4493
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0322	0.0894	0.0894
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0058	0.0058
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0004	0.0004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.2187	0.638	0.638
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0079	0.0181	0.0181
Echinococcus multilocularis	nuclear receptor nhr 48	0.0037	0.0058	0.0058
Trypanosoma cruzi	PAB1-binding protein , putative	0.0022	0.0014	0.0031
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0058	0.0058
Schistosoma mansoni	RAR-like nuclear receptor	0.0079	0.0181	0.0181
Loa Loa (eye worm)	steroid hormone receptor	0.0079	0.0181	0.0181
Plasmodium falciparum	adenosine deaminase	0.3418	1	1
Brugia malayi	conserved hypotetical protein	0.0037	0.0058	0.0058
Brugia malayi	tailless protein	0.0037	0.0058	0.0058
Schistosoma mansoni	coup transcription factor	0.0079	0.0181	0.0181
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0079	0.0181	0.0181
Brugia malayi	photoreceptor-specific nuclear receptor	0.0079	0.0181	0.0181
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0322	0.0894	0.0894
Onchocerca volvulus	AMP deaminase 2 homolog	0.1546	0.4495	0.4463
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0322	0.0894	0.0894
Trypanosoma cruzi	AMP deaminase, putative	0.1546	0.4495	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0004	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0014	0.0014
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0022	0.0014	0.0014
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.3418	1	1
Loa Loa (eye worm)	hypothetical protein	0.1231	0.3569	0.3569
Echinococcus granulosus	phospholipase A 2 activating protein	0.0036	0.0054	0.0054
Echinococcus multilocularis	FTZ F1 alpha	0.0079	0.0181	0.0181
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0079	0.0181	0.0181
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Schistosoma mansoni	hypothetical protein	0.0037	0.0058	0.0058
Trypanosoma brucei	AMP deaminase, putative	0.1546	0.4495	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0458	0.1295	0.1295
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Toxoplasma gondii	LsmAD domain-containing protein	0.0022	0.0014	0.001
Entamoeba histolytica	adenosine deaminase, putative	0.3418	1	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0004	0.0004
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0181	0.0181
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0037	0.0058	0.0058
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0004	0.0004
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0004	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0004	0.0008
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0071	0.0071
Trypanosoma cruzi	AMP deaminase, putative	0.1546	0.4495	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0079	0.0181	0.0181
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0181	0.0181
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.1546	0.4495	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0079	0.0181	0.0181
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0058	0.0058
Leishmania major	hypothetical protein, conserved	0.0022	0.0014	0.0014
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0037	0.0058	0.0058
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.082	0.236	0.2315
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0004	0.0004
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0181	0.0181
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0058	0.0058
Echinococcus granulosus	AMP deaminase 2	0.1546	0.4495	0.4495
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.3418	1	1
Brugia malayi	nuclear receptor NHR-67	0.0037	0.0058	0.0058
Plasmodium vivax	adenosine/AMP deaminase, putative	0.1546	0.4495	0.4493
Plasmodium falciparum	ataxin-2 like protein, putative	0.0022	0.0014	0.001
Entamoeba histolytica	adenosine deaminase, putative	0.3418	1	1
Brugia malayi	ecdysteroid receptor	0.0079	0.0181	0.0181
Echinococcus multilocularis	alkaline phosphatase	0.0322	0.0894	0.0894
Echinococcus granulosus	ecdysone induced protein 78C	0.0079	0.0181	0.0181
Brugia malayi	MH2 domain containing protein	0.0119	0.0299	0.0299
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0071	0.0071
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0037	0.0058	0.0058
Treponema pallidum	adenosine deaminase	0.3418	1	1
Schistosoma mansoni	hypothetical protein	0.0167	0.044	0.044
Schistosoma mansoni	nuclear receptor	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.2187	0.638	0.638
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.0299	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Schistosoma mansoni	AMP deaminase	0.1546	0.4495	0.4495
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0058	0.0058
Trichomonas vaginalis	phospholipase A-2-activating protein, putative	0.0036	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0741	0.2127	0.2127
Trypanosoma cruzi	AMP deaminase, putative	0.1546	0.4495	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0022	0.0014	0.001
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0079	0.0181	0.0181
Plasmodium falciparum	polyubiquitin binding protein, putative	0.0036	0.0054	0.005
Entamoeba histolytica	AMP deaminase, putative	0.1546	0.4495	0.4495
Brugia malayi	nuclear receptor RXR	0.0042	0.0071	0.0071
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0079	0.0181	0.0181
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0322	0.0894	0.0894
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0181	0.0181
Brugia malayi	orphan nuclear receptor NR2E1	0.0037	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0079	0.0181	0.0181
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0322	0.0894	0.0894
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0037	0.0058	0.0058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0079	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0071	0.0071
Echinococcus multilocularis	ecdysone induced protein 78C	0.0079	0.0181	0.0181
Onchocerca volvulus		0.1231	0.3569	0.3531
Trypanosoma cruzi	WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative	0.0036	0.0054	0.012
Leishmania major	adenine aminohydrolase	0.3418	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Anticonvulsant activity (functional)	= 1	Anticonvulsant activity was determined in mice; 1 indicates 100 mg/kg or less	ChEMBL.	7562939
Anticonvulsant activity (functional)	= 1	Anticonvulsant activity was determined in mice; 1 indicates 100 mg/kg or less	ChEMBL.	7562939
Anticonvulsant activity (functional)	= 1	Anticonvulsant activity was determined in rat; 1 indicates 100 mg/kg or less	ChEMBL.	7562939
ED50 (functional)	= 12.1 mg kg-1	Effective dose for anticonvulsant activity determined in rats using MES test procedure.(Phase VIA,parentheses value indicate 95% confidence limits)	ChEMBL.	7562939
PI (functional)	= 28.4	Protective index measured as the ratio of ED50 to that of TD50.	ChEMBL.	7562939
TD50 (ADMET)	> 344 mg kg-1	Toxic dose determined in rats using MES test procedure.(Phase VIA, parentheses value indicate 95% confidence limits)	ChEMBL.	7562939

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL130445
PubChem: 10244796

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 227161