Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0733 | 0.8885 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0733 | 0.8885 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0396 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0438 | 0.1115 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0438 | 0.1115 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 18 ug ml-1 | MIC of the compound at which cleaved DNA (linear) is observed at an intensity relative to oxolinic acid at 10 microg/mL by using Gyrase Induced DNA-Cleavage assay | ChEMBL. | 3005575 |
MIC (functional) | = 18 ug ml-1 | MIC of the compound at which cleaved DNA (linear) is observed at an intensity relative to oxolinic acid at 10 microg/mL by using Gyrase Induced DNA-Cleavage assay | ChEMBL. | 3005575 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity of the compound against Staphylococcus aureus (H228) | ChEMBL. | 3005575 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity of the compound against Staphylococcus aureus (H228) | ChEMBL. | 3005575 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity of the compound against Escherichia coli (H560) | ChEMBL. | 3005575 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity of the compound against Escherichia coli (vogel) | ChEMBL. | 3005575 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity of the compound against Escherichia coli (H560) | ChEMBL. | 3005575 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity of the compound against Escherichia coli (vogel) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Klebsiella pneumonia (MGH-2) | ChEMBL. | 3005575 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity of the compound against Pseudomonas aeruginosa (UI-18) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity of the compound against Streptococcus pneumoniae (SV-1) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Klebsiella pneumonia (MGH-2) | ChEMBL. | 3005575 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity of the compound against Pseudomonas aeruginosa (UI-18) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity of the compound against Streptococcus pneumoniae (SV-1) | ChEMBL. | 3005575 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.