Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 40.3 uM | In vitro inhibition of murine Lck kinase. | ChEMBL. | 14592495 |
IC50 (binding) | = 40.3 uM | Inhibition of murine Lck in presence of ATP | ChEMBL. | 17154512 |
IC50 (binding) | = 40.3 uM | In vitro inhibition of murine Lck kinase. | ChEMBL. | 14592495 |
IC50 (binding) | = 40.3 uM | Inhibition of murine Lck in presence of ATP | ChEMBL. | 17154512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.