Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | adenosine deaminase-related growth factor | Adenosine deaminase | 363 aa | 299 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adenosine deaminase | 0.0104 | 0.0372 | 0.0726 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 0.0372 | 0.0372 |
Schistosoma mansoni | adenosine deaminase | 0.0104 | 0.0372 | 0.0656 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.0372 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0104 | 0.0372 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0104 | 0.0372 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0104 | 0.0372 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 0.0372 | 0.0656 |
Plasmodium falciparum | adenosine deaminase | 0.0104 | 0.0372 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.8969 | 0.9485 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0.0372 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0104 | 0.0372 | 0.0656 |
Leishmania major | adenine aminohydrolase | 0.0104 | 0.0372 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0496 | 0.5675 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0104 | 0.0372 | 0.5 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0104 | 0.0372 | 0.0394 |
Plasmodium vivax | adenosine deaminase, putative | 0.0104 | 0.0372 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0.0372 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0775 | 0.9455 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0496 | 0.5675 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.0372 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0455 | 0.513 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.0372 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.0372 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0372 | 0.0394 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0775 | 0.9455 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 50 uM | In vitro evaluation of anti-HIV-1 activity in C8166 cells infected with HIV-1 IIIB. | ChEMBL. | 7562937 |
Ki (binding) | = 2.2 uM | Inhibition calf intestine adenosine deaminase | ChEMBL. | 7562937 |
Ki (binding) | = 2.2 uM | Inhibition calf intestine adenosine deaminase | ChEMBL. | 7562937 |
TC50 (ADMET) | = 100 uM | In vitro evaluation of cytotoxicity in C8166 cells infected with HIV-1 IIIB. | ChEMBL. | 7562937 |
TC50 (ADMET) | = 100 uM | In vitro evaluation of cytotoxicity in C8166 cells infected with HIV-1 IIIB. | ChEMBL. | 7562937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.