Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor III (thromboplastin, tissue factor) | References | |
Homo sapiens | Coagulation factor VII/tissue factor | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosine deaminase | 0.1826 | 1 | 1 |
Onchocerca volvulus | 0.0748 | 0.3553 | 0.3553 | |
Trypanosoma cruzi | AMP deaminase, putative | 0.1158 | 0.6004 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1158 | 0.6004 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.1826 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.1826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1078 | 0.5527 | 0.4718 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1158 | 0.6004 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1158 | 0.6004 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1158 | 0.6004 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1158 | 0.6004 | 0.5 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.1158 | 0.6004 | 0.3803 |
Loa Loa (eye worm) | hypothetical protein | 0.1078 | 0.5527 | 0.4718 |
Loa Loa (eye worm) | AMP deaminase | 0.1158 | 0.6004 | 0.5282 |
Loa Loa (eye worm) | hypothetical protein | 0.0748 | 0.3553 | 0.2387 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.1826 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1158 | 0.6004 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.1826 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.1826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1078 | 0.5527 | 0.4718 |
Mycobacterium ulcerans | adenosine deaminase | 0.1826 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.1826 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.1826 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1078 | 0.5527 | 0.4718 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.1158 | 0.6004 | 0.3803 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.1158 | 0.6004 | 0.3803 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.1826 | 1 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.1158 | 0.6004 | 0.6004 |
Leishmania major | AMP deaminase, putative | 0.1158 | 0.6004 | 0.3803 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.1826 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.1158 | 0.6004 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.1826 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.1826 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.1826 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.1826 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.1826 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1158 | 0.6004 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.1826 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1158 | 0.6004 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.1826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1826 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1158 | 0.6004 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.1 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 9.1 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 19.9 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 19.9 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.