Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0132 | 0.0191 | 0.0431 |
Plasmodium falciparum | plasmepsin X | 0.0132 | 0.0191 | 0.5 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0132 | 0.0191 | 0.0431 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0132 | 0.0191 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.015 | 0.0246 | 0.0555 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.091 | 0.2599 | 0.2599 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.083 | 0.2353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1429 | 0.4209 | 0.9504 |
Plasmodium vivax | plasmepsin IV, putative | 0.0132 | 0.0191 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.015 | 0.0246 | 0.0555 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0079 | 0.0026 | 0.0112 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.015 | 0.0246 | 0.1044 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0132 | 0.0191 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0132 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0191 | 0.0431 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.015 | 0.0246 | 0.0246 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0079 | 0.0026 | 0.0101 |
Schistosoma mansoni | coup transcription factor | 0.015 | 0.0246 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.015 | 0.0246 | 0.0555 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.015 | 0.0246 | 0.0246 |
Plasmodium falciparum | plasmepsin VII | 0.0132 | 0.0191 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.015 | 0.0246 | 0.0555 |
Plasmodium vivax | aspartyl protease, putative | 0.0132 | 0.0191 | 0.5 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0132 | 0.0191 | 0.0431 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0026 | 0.0059 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.015 | 0.0246 | 0.1044 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.015 | 0.0246 | 0.0526 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.015 | 0.0246 | 0.0246 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0132 | 0.0191 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.015 | 0.0246 | 0.0946 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Brugia malayi | nuclear hormone receptor | 0.15 | 0.4428 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.015 | 0.0246 | 0.0246 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Plasmodium falciparum | plasmepsin V | 0.0132 | 0.0191 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0246 | 0.0555 |
Plasmodium vivax | plasmepsin V, putative | 0.0132 | 0.0191 | 0.5 |
Onchocerca volvulus | 0.015 | 0.0246 | 0.0526 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.015 | 0.0246 | 0.1044 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.015 | 0.0246 | 0.0555 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.015 | 0.0246 | 0.0555 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.091 | 0.2599 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0246 | 0.0555 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0132 | 0.0191 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.015 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0152 | 0.0343 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.015 | 0.0246 | 0.0555 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.015 | 0.0246 | 0.0946 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.015 | 0.0246 | 0.0246 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | steroid hormone receptor | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0132 | 0.0191 | 0.0431 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.015 | 0.0246 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0246 | 0.0555 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Brugia malayi | ecdysteroid receptor | 0.015 | 0.0246 | 0.0555 |
Onchocerca volvulus | 0.0132 | 0.0191 | 0.0409 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.015 | 0.0246 | 0.0946 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0079 | 0.0026 | 0.0059 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | nuclear hormone receptor | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0191 | 0.0431 |
Brugia malayi | Pepsin A precursor | 0.0132 | 0.0191 | 0.0431 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0132 | 0.0191 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0026 | 0.0059 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.0246 | 0.0246 |
Plasmodium falciparum | plasmepsin IV | 0.0132 | 0.0191 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0079 | 0.0026 | 0.0059 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.015 | 0.0246 | 0.1044 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0612 | 0.1676 | 0.1676 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0152 | 0.0343 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.015 | 0.0246 | 0.0946 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Plasmodium falciparum | plasmepsin I | 0.0132 | 0.0191 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0132 | 0.0191 | 0.0735 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0132 | 0.0191 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0132 | 0.0191 | 0.0431 |
Plasmodium falciparum | plasmepsin IX | 0.0132 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0026 | 0.0059 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0132 | 0.0191 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0079 | 0.0026 | 0.0026 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.015 | 0.0246 | 0.0946 |
Brugia malayi | nuclear receptor NHR-88 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0026 | 0.0059 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1579 | 0.4674 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.0152 | 0.0325 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.015 | 0.0246 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0191 | 0.0431 |
Loa Loa (eye worm) | steroid hormone receptor | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | hypothetical protein | 0.0132 | 0.0191 | 0.0431 |
Echinococcus granulosus | FTZ F1 alpha | 0.015 | 0.0246 | 0.0946 |
Brugia malayi | hypothetical protein | 0.0132 | 0.0191 | 0.0431 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0026 | 0.0059 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.015 | 0.0246 | 0.0946 |
Onchocerca volvulus | 0.0132 | 0.0191 | 0.0409 | |
Plasmodium falciparum | plasmepsin VI | 0.0132 | 0.0191 | 0.5 |
Brugia malayi | hypothetical protein | 0.012 | 0.0152 | 0.0343 |
Onchocerca volvulus | Bile acid receptor homolog | 0.015 | 0.0246 | 0.0526 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.15 | 0.4428 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0132 | 0.0191 | 0.5 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0132 | 0.0191 | 0.0431 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0132 | 0.0191 | 0.0812 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.015 | 0.0246 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0246 | 0.0555 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0026 | 0.0059 |
Plasmodium vivax | aspartyl protease, putative | 0.0132 | 0.0191 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0079 | 0.0026 | 0.0059 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.015 | 0.0246 | 0.0246 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.015 | 0.0246 | 0.0246 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0079 | 0.0026 | 0.0026 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.015 | 0.0246 | 0.1044 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.015 | 0.0246 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0026 | 0.0059 |
Plasmodium falciparum | plasmepsin III | 0.0132 | 0.0191 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.0152 | 0.0325 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0079 | 0.0026 | 0.0059 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0246 | 0.0555 |
Plasmodium vivax | aspartyl protease, putative | 0.0132 | 0.0191 | 0.5 |
Toxoplasma gondii | aspartyl protease | 0.0132 | 0.0191 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.015 | 0.0246 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.015 | 0.0246 | 0.0555 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.015 | 0.0246 | 0.0946 |
Echinococcus multilocularis | FTZ F1 alpha | 0.015 | 0.0246 | 0.1044 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 49 % | In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration | ChEMBL. | 9406595 |
Inhibition (binding) | = 49 % | In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration | ChEMBL. | 9406595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.