TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.45 | Formula: C19H28N4O4
H donors: 3 H acceptors: 5 LogP: 1.72 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)C(=O)C(NC(=O)C(NC(=O)c1cccnc1)CC(C)C)CC
InChi: 1S/C19H28N4O4/c1-5-14(16(24)19(27)21-6-2)22-18(26)15(10-12(3)4)23-17(25)13-8-7-9-20-11-13/h7-9,11-12,14-15H,5-6,10H2,1-4H3,(H,21,27)(H,22,26)(H,23,25)
InChiKey: IBEAJSQPIKDSAN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calpain 1, (mu/I) large subunit	Starlite/ChEMBL	References
Homo sapiens	calpain 2, (m/II) large subunit	Starlite/ChEMBL	References
Bos taurus	Cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	312 aa	23.7 %
Cryptosporidium hominis	preprocathepsin c precursor	Cathepsin B	335 aa	280 aa	25.7 %
Echinococcus granulosus	calpain A	calpain 1, (mu/I) large subunit	714 aa	753 aa	31.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	25.1 %
Onchocerca volvulus	Cathepsin L homolog	Cathepsin B	335 aa	316 aa	25.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.6 %
Plasmodium berghei	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	311 aa	22.5 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	286 aa	26.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	25.1 %
Toxoplasma gondii	preprocathepsin c precursor, putative	Cathepsin B	335 aa	272 aa	24.3 %
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	313 aa	25.6 %
Plasmodium knowlesi	knowpain-3	Cathepsin B	335 aa	301 aa	22.6 %
Neospora caninum	hypothetical protein	Cathepsin B	335 aa	303 aa	28.4 %
Dictyostelium discoideum	cysteine proteinase 3	Cathepsin B	335 aa	275 aa	28.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	272 aa	24.6 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	297 aa	24.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	289 aa	22.8 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	272 aa	25.0 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	24.4 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Cathepsin B	335 aa	287 aa	25.1 %
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Cathepsin B	335 aa	288 aa	26.4 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Cathepsin B	335 aa	351 aa	28.5 %
Brugia malayi	Cathepsin L-like precursor	Cathepsin B	335 aa	312 aa	25.0 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Cathepsin B	335 aa	275 aa	32.7 %
Dictyostelium discoideum	cysteine proteinase 5 precursor	Cathepsin B	335 aa	271 aa	24.4 %
Onchocerca volvulus		Cathepsin B	335 aa	275 aa	24.7 %
Schistosoma japonicum	Cathepsin C precursor, putative	Cathepsin B	335 aa	289 aa	28.4 %
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin B	335 aa	322 aa	26.4 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin B	335 aa	296 aa	28.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.6 %
Echinococcus granulosus	calpain A	calpain 2, (m/II) large subunit	622 aa	663 aa	31.2 %
Onchocerca volvulus	Cathepsin B-like cysteine proteinase 6 homolog	Cathepsin B	335 aa	315 aa	49.2 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin B	335 aa	313 aa	25.2 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	335 aa	280 aa	25.0 %
Onchocerca volvulus		Cathepsin B	335 aa	326 aa	34.7 %
Plasmodium knowlesi	knowpain-4	Cathepsin B	335 aa	304 aa	25.3 %
Babesia bovis	cathepsin C precursor, putative	Cathepsin B	335 aa	305 aa	25.9 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	276 aa	26.1 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	276 aa	25.7 %
Plasmodium knowlesi	knowpain-2	Cathepsin B	335 aa	308 aa	23.1 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	25.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0035	0.0504	0.8642
Brugia malayi	Bromodomain containing protein	0.0026	0.0337	0.0313
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.4359	1
Plasmodium falciparum	calpain	0.0015	0.0133	0.1975
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.2539	0.2843
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0144	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0072	0.1194	0.4031
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0053	0.0851	0.0945
Trypanosoma brucei	kinesin, putative	0.0035	0.0504	0.5634
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0015	0.0133	0.0383
Loa Loa (eye worm)	calpain	0.005	0.0784	0.0868
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.001	0.004	0.0134
Trypanosoma brucei	Calpain-like protein 2	0.0015	0.0133	0.1312
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.0784	0.2596
Brugia malayi	intermediate filament protein	0.0028	0.0382	0.0364
Brugia malayi	beta-lactamase	0.0038	0.0559	0.0568
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0661	0.0535
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0015	0.0133	0.0383
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.2962	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0108	0.0365
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0559	0.1249
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0073	0.1228	0.4146
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0851	0.2825
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0851	0.0728
Brugia malayi	PHD-finger family protein	0.0018	0.0191	0.0145
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0012	0.0084	0.1093
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0078	0.1318	0.4451
Brugia malayi	cathepsin B-like cysteine proteinase	0.0166	0.2962	0.3329
Trypanosoma cruzi	kinesin, putative	0.0035	0.0504	0.1645
Echinococcus multilocularis	calpain	0.005	0.0784	0.2647
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0559	0.1886
Echinococcus granulosus	calpain	0.005	0.0784	0.2647
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0382	0.1288
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0022	0.0262	0.1294
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0851	0.0728
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0053	0.0851	0.9676
Loa Loa (eye worm)	hypothetical protein	0.0017	0.018	0.0177
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0851	0.2874
Echinococcus multilocularis	calpain 7 (C02 family)	0.005	0.0784	0.2647
Trypanosoma brucei	calpain, putative	0.0015	0.0133	0.1312
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0072	0.1194	0.1298
Leishmania major	calpain protease-like protein	0.0015	0.0133	0.1312
Echinococcus granulosus	cathepsin b	0.0166	0.2962	1
Schistosoma mansoni	calpain-2 (C02 family)	0.0015	0.0133	0.0449
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0275	0.0928
Trichomonas vaginalis	esterase, putative	0.0038	0.0559	0.0431
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0015	0.0143	0.1422
Echinococcus multilocularis	lamin dm0	0.0028	0.0382	0.1288
Plasmodium vivax	SET domain protein, putative	0.0068	0.1132	1
Leishmania major	hypothetical protein, unknown function	0.0015	0.0133	0.1312
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0879	0.2968
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0015	0.0133	0.0383
Toxoplasma gondii	cathepsin B	0.0055	0.0879	0.7469
Brugia malayi	AMP-binding enzyme family protein	0.0012	0.0084	0.0022
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0291
Brugia malayi	hypothetical protein	0.0164	0.2921	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0372	0.0396
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0067
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Brugia malayi	latrophilin 2 splice variant baaae	0.0027	0.0356	0.0336
Leishmania major	4-coumarate:coa ligase-like protein	0.0012	0.0084	0.0738
Trypanosoma brucei	unspecified product	0.0016	0.0144	0.1439
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0015	0.0133	0.0383
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0013	0.01	0.0336
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0879	0.0756
Echinococcus granulosus	GPCR family 2	0.0012	0.0086	0.0291
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0012	0.0086	0.0291
Echinococcus multilocularis	dna polymerase eta	0.0037	0.0553	0.1867
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0851	0.2874
Schistosoma mansoni	hypothetical protein	0.0015	0.0133	0.0449
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0559	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0012	0.0084	0.1093
Onchocerca volvulus		0.0028	0.0382	0.03
Brugia malayi	calpain 7	0.005	0.0784	0.0827
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0012	0.0084	0.0156
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.1339	0.4519
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0851	0.0728
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0009	0.0026	0.5
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0012	0.0084	0.0156
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.057	0.1926
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0055	0.0879	1
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0275	0.0928
Echinococcus multilocularis	cathepsin b	0.0166	0.2962	1
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Onchocerca volvulus		0.0038	0.0559	0.0479
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0559	0.0568
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.005	0.0784	0.8891
Schistosoma mansoni	lamin	0.0028	0.0382	0.1288
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0012	0.0084	0.1093
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.2438	0.8232
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0053	0.0851	0.2825
Leishmania major	DNA polymerase eta, putative	0.0037	0.0553	0.6202
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0559	0.1886
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0275	0.0285
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0851	0.0728
Loa Loa (eye worm)	acetyltransferase	0.0143	0.2539	0.2875
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.0383
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0033	0.0479	0.0476
Trypanosoma cruzi	conserved protein	0.0015	0.0133	0.0383
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0559	0.1249
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0068	0.1132	0.3822
Loa Loa (eye worm)	calpain D	0.0015	0.0133	0.0123
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0275	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0097	0.167	0.1881
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0559	0.061
Plasmodium falciparum	ataxin-2 like protein, putative	0.0017	0.018	0.2841
Mycobacterium ulcerans	lipase LipD	0.0038	0.0559	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0144	0.1439
Loa Loa (eye worm)	bromodomain containing protein	0.0014	0.0111	0.0098
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0039	0.0589	0.0603
Giardia lamblia	Cathepsin B precursor	0.0055	0.0879	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0039	0.0589	0.0645
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.057	0.4889
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0132	0.2321	0.7834
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0275	0.0596
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0013	0.01	0.0336
Schistosoma mansoni	methyl-cpg binding protein mbd	0.001	0.004	0.0134
Mycobacterium ulcerans	acyl-CoA synthetase	0.0012	0.0084	0.1093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0291
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0559	0.1249
Leishmania major	hypothetical protein, conserved	0.0017	0.018	0.1862
Schistosoma mansoni	hypothetical protein	0.0012	0.0079	0.0266
Brugia malayi	Latrophilin receptor protein 2	0.0012	0.0086	0.0025
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0661	0.5288
Schistosoma mansoni	hypothetical protein	0.0073	0.1228	0.4146
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0382	0.0407
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0015	0.0133	0.0383
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1132	0.3822
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0073	0.1228	0.4146
Trypanosoma cruzi	kinesin, putative	0.0035	0.0504	0.1645
Schistosoma mansoni	calpain-7 (C02 family)	0.005	0.0784	0.2647
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0851	0.2874
Leishmania major	hypothetical protein, conserved	0.0038	0.0559	0.6266
Plasmodium vivax	ataxin-2 like protein, putative	0.0017	0.018	0.1399
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0262	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0559	0.061
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0275	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0553	0.0603
Echinococcus multilocularis	zinc finger protein	0.0015	0.0132	0.0447
Echinococcus granulosus	dna polymerase eta	0.0037	0.0553	0.1867
Echinococcus granulosus	survival motor neuron protein 1	0.0164	0.2921	0.9862
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0012	0.0084	0.1093
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0067
Entamoeba histolytica	calpain family cysteine protease, putative	0.0015	0.0133	0.1014
Schistosoma mansoni	hypothetical protein	0.0009	0.002	0.0069
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0078	0.1318	0.4451
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0559	0.1829
Brugia malayi	calpain 5	0.0035	0.0504	0.0505
Echinococcus multilocularis	survival motor neuron protein 1	0.0164	0.2921	0.9862
Echinococcus granulosus	calpain 5	0.005	0.0784	0.2647
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0275	0.2963
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0015	0.0133	0.0383
Schistosoma mansoni	lamin	0.0028	0.0382	0.1288
Leishmania major	4-coumarate:coa ligase-like protein	0.0012	0.0084	0.0738
Schistosoma mansoni	hypothetical protein	0.0027	0.0356	0.1203
Loa Loa (eye worm)	calpain 5	0.0035	0.0504	0.0548
Mycobacterium ulcerans	acyl-CoA synthetase	0.0012	0.0084	0.1093
Loa Loa (eye worm)	cathepsin B	0.0055	0.0879	0.0976
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0055	0.0879	1
Schistosoma mansoni	calpain C (C02 family)	0.005	0.0784	0.2647
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0067
Trichomonas vaginalis	set domain proteins, putative	0.0541	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0382	0.0407
Loa Loa (eye worm)	calpain family protein 1	0.0132	0.2321	0.2625
Loa Loa (eye worm)	hypothetical protein	0.0166	0.2962	0.3359
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.005	0.0784	0.2596
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0275	0.2963
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0559	0.0431
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Brugia malayi	ImpB/MucB/SamB family protein	0.0037	0.0553	0.0561
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.057	1
Brugia malayi	calpain family protein 1	0.0132	0.2321	0.2592
Brugia malayi	calpain family protein 1	0.0132	0.2321	0.2592
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.0383
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0068	0.1132	0.3822
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.0784	0.2596
Schistosoma mansoni	hypothetical protein	0.0033	0.0479	0.1617
Onchocerca volvulus		0.0033	0.0479	0.0399
Brugia malayi	MAP kinase sur-1	0.0053	0.0851	0.0904
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0661	0.0535
Trypanosoma brucei	cysteine peptidase, putative	0.0015	0.0133	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0384	0.041
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0068	0.1132	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0275	0.0865
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0275	0.0144
Trypanosoma brucei	calpain, putative	0.0015	0.0133	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0133	0.0123
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0559	0.1829
Onchocerca volvulus		0.0038	0.0559	0.0479
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0015	0.0133	0.0383
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.057	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.0784	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0363	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0626	0.0686
Leishmania major	DNA polymerase eta, putative	0.0022	0.0262	0.2817
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0851	0.2874
Echinococcus multilocularis	calpain A	0.0138	0.2432	0.8211
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0275	0.0928
Plasmodium falciparum	ataxin-2 like protein, putative	0.0017	0.018	0.2841
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0072	0.1194	0.4031
Giardia lamblia	Kinase, CMGC MAPK	0.0053	0.0851	0.9539
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0086	0.0069
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0275	0.4677
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0559	0.061
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0851	0.9676
Toxoplasma gondii	ABC1 family protein	0.0038	0.0559	0.4259
Echinococcus multilocularis	calpain family protein 1, d	0.0097	0.167	0.5637
Trypanosoma brucei	antigen, putative	0.005	0.0784	0.8891
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0015	0.0133	0.1312
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0559	0.0431
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0559	0.1249
Echinococcus granulosus	fetal alzheimer antigen falz	0.0013	0.01	0.0336
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0072	0.1194	0.4031
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0661	0.2233
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0559	1
Schistosoma mansoni	survival motor neuron protein	0.0033	0.0479	0.1617
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.005	0.0784	0.8891
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.005	0.0784	0.2596
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0559	0.061
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.005	0.0784	0.8891
Schistosoma mansoni	methyl-cpg binding protein mbd	0.001	0.004	0.0134
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0275	0.4677
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.2962	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0275	0.0596
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0559	0.0431
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0275	0.2963
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0138	0.2432	0.8211
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0021	0.0246	0.083
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0476	0.8768	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0559	0.1886
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0166	0.2962	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0382	0.0364
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0275	0.0928
Echinococcus multilocularis	GPCR, family 2	0.0012	0.0086	0.0291
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0012	0.0086	0.0025
Trypanosoma brucei	unspecified product	0.0016	0.0144	0.1439
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0382	0.0407
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0559	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0082	0.139	0.1561
Leishmania major	kinesin, putative	0.0035	0.0504	0.5634
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0072	0.1194	0.4031
Brugia malayi	Bromodomain containing protein	0.0047	0.0738	0.0773
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0072	0.1194	0.4031
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0559	0.1249
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0291
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.005	0.0784	0.8891
Onchocerca volvulus		0.0038	0.0559	0.0479
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0559	0.6266
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0559	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0589	0.0645
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.005	0.0784	0.8891
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0079	0.1339	0.4519
Loa Loa (eye worm)	hypothetical protein	0.0164	0.2921	0.3312
Plasmodium vivax	calpain, putative	0.005	0.0784	0.6855
Brugia malayi	hypothetical protein	0.0017	0.018	0.0133
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.1339	0.4519
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0559	0.1249
Echinococcus granulosus	cathepsin b	0.0166	0.2962	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0017	0.018	0.0544
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0012	0.0084	0.1093
Brugia malayi	AMP-binding enzyme family protein	0.0012	0.0084	0.0022
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0012	0.0086	0.0291
Brugia malayi	AMP-binding enzyme family protein	0.0012	0.0084	0.0022
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0559	0.1249
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0559	0.4817
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0275	0.0865
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0356	0.0379
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0559	0.1249
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0559	0.1249
Echinococcus granulosus	zinc finger protein	0.0015	0.0132	0.0447
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0559	0.1249
Trypanosoma brucei	DNA polymerase eta, putative	0.0037	0.0553	0.6202
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0559	0.061
Echinococcus granulosus	intermediate filament protein	0.0028	0.0382	0.1288
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0275	0.3927
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0275	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0099	0.0084
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.0383
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0072	0.1194	0.4031
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.057	0.1926
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0291
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0661	0.5288
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0072	0.1194	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2041	0.2305
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0661	0.5746
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0144	0.1439
Echinococcus granulosus	methyl CpG binding domain protein 2	0.001	0.004	0.0134
Leishmania major	calpain family cysteine protease-like protein	0.0015	0.0133	0.1312
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.005	0.0784	0.2596
Echinococcus granulosus	lamin	0.0028	0.0382	0.1288
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0012	0.0086	0.0291
Trypanosoma cruzi	PAB1-binding protein , putative	0.0017	0.018	0.0544
Echinococcus multilocularis	calpain 5	0.005	0.0784	0.2647
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0559	1
Echinococcus granulosus	lamin dm0	0.0028	0.0382	0.1288
Toxoplasma gondii	LsmAD domain-containing protein	0.0017	0.018	0.0473
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.0383
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0136	0.0127
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.2539	0.8571
Leishmania major	hypothetical protein, conserved	0.0015	0.0133	0.1312
Trypanosoma brucei	PAB1-binding protein , putative	0.0017	0.018	0.1862
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0851	0.2874
Mycobacterium ulcerans	hypothetical protein	0.0012	0.0084	0.1093
Trypanosoma brucei	Calpain-like protein 1.1	0.0015	0.0133	0.1312
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.2539	0.8571
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0136	0.0083
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.0383
Trypanosoma brucei	Calpain-like protein 1.2	0.0015	0.0133	0.1312
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0138	0.2432	0.8211
Trypanosoma cruzi	DNA polymerase eta, putative	0.0037	0.0553	0.1811
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0055	0.0879	0.2919
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.0383
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0015	0.0133	0.1312
Schistosoma mansoni	DNA polymerase eta	0.0037	0.0553	0.1867
Brugia malayi	calpain D	0.0015	0.0133	0.0079
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0009	0.0026	0.0022
Trypanosoma brucei	hypothetical protein	0.0015	0.0133	0.1312
Trypanosoma brucei	unspecified product	0.0022	0.0275	0.2963
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0015	0.0133	0.0383
Trypanosoma brucei	calpain-like protein, putative	0.005	0.0784	0.8891
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0559	0.061
Echinococcus multilocularis	hypothetical protein	0.005	0.0784	0.2647
Loa Loa (eye worm)	calpain family protein 1	0.0097	0.167	0.1881
Loa Loa (eye worm)	PHD-finger family protein	0.0012	0.0079	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1318	0.1479
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0559	0.1886
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Trypanosoma brucei	calpain-like protein, putative	0.005	0.0784	0.8891
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0108	0.0095
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Trypanosoma brucei	protein kinase, putative	0.0053	0.0851	0.9676
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0851	0.2825
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0559	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0012	0.0086	0.0069
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0166	0.2962	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Schistosoma mansoni	calpain-7 (C02 family)	0.005	0.0784	0.2647
Entamoeba histolytica	protein kinase, putative	0.0035	0.0513	0.8827
Giardia lamblia	Cathepsin B precursor	0.0055	0.0879	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0021	0.0246	0.083
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0108	0.0365
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0072	0.1194	0.4031
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.0383
Schistosoma mansoni	bromodomain containing protein	0.004	0.061	0.2058
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0138	0.2432	0.8211
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0012	0.0086	0.0291
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0066	0.1085	0.3663
Schistosoma mansoni	calpain (C02 family)	0.005	0.0784	0.2647
Brugia malayi	beta-lactamase family protein	0.0038	0.0559	0.0568
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.0784	0.2596
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0138	0.2432	0.8211
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.2962	1
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0559	0.061
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0099	0.0084
Echinococcus granulosus	calpain A	0.0138	0.2432	0.8211
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0275	0.0928
Brugia malayi	calpain 5	0.0015	0.0133	0.0079
Brugia malayi	Pre-SET motif family protein	0.0476	0.8768	1
Onchocerca volvulus		0.0082	0.139	0.1317
Trypanosoma brucei	calpain-like protein, putative	0.005	0.0784	0.8891
Onchocerca volvulus		0.0068	0.1132	0.1057
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0559	1
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0015	0.0133	0.1312
Schistosoma mansoni	zinc finger protein	0.0015	0.0132	0.0447
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0275	0.0928
Onchocerca volvulus		0.0028	0.0382	0.03
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.0784	0.2596
Leishmania major	4-coumarate:coa ligase-like protein	0.0012	0.0084	0.0738
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0275	0.2963
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0078	0.1318	0.4451
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0272	0.0282
Giardia lamblia	Cathepsin B precursor	0.0055	0.0879	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0053	0.0851	0.719
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0275	0.0144
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.005	0.0784	0.2596
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0015	0.0133	0.1312
Schistosoma mansoni	Mername-AA248 (C02 family)	0.005	0.0784	0.2647
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0053	0.0851	0.9676
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0053	0.0851	0.2825
Echinococcus multilocularis	cathepsin b	0.0166	0.2962	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.005	0.0784	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0132	0.2321	0.2625
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0559	0.0431
Brugia malayi	Pre-SET motif family protein	0.0068	0.1132	0.1227
Schistosoma mansoni	zinc finger protein	0.0009	0.002	0.0069
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0015	0.0133	0.0383
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0275	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0559	0.061
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0015	0.0133	0.0383
Echinococcus granulosus	histone lysine methyltransferase setb	0.0078	0.1318	0.4451
Echinococcus multilocularis	musashi	0.0028	0.0382	0.1288
Echinococcus granulosus	calpain A	0.005	0.0784	0.2647
Brugia malayi	beta-lactamase family protein	0.0038	0.0559	0.0568
Echinococcus granulosus	calpain 7 C02 family	0.005	0.0784	0.2647
Echinococcus multilocularis	lamin	0.0028	0.0382	0.1288
Trypanosoma brucei	calpain-like protein, putative	0.005	0.0784	0.8891
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0039	0.0589	0.0603

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.83 nM	Compound was evaluated for the inhibition of Cysteine protease Calpain 2	ChEMBL.	8831774
Ki (binding)	= 0.88 nM	Inhibition of bovine cathepsin B	ChEMBL.	8831774
Ki (binding)	= 1.3 nM	Inhibition of the cysteine protease human Calpain 1	ChEMBL.	8831774
Ki (binding)	= 0.83 uM	Compound was evaluated for the inhibition of Cysteine protease Calpain 2	ChEMBL.	8831774
Ki (binding)	= 0.88 uM	Inhibition of bovine cathepsin B	ChEMBL.	8831774
Ki (binding)	= 1.3 uM	Inhibition of the cysteine protease human Calpain 1	ChEMBL.	8831774

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL130722

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 227623