Detailed information for compound 227639

Basic information

Technical information
  • TDR Targets ID: 227639
  • Name: 3-[4-[5-[di(propan-2-yl)amino]pentyl]-3-oxo-1 ,4-benzoxazin-2-yl]benzenecarboximidamide
  • MW: 436.59 | Formula: C26H36N4O2
  • H donors: 1 H acceptors: 1 LogP: 4.43 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(N(C(C)C)CCCCCN1c2ccccc2OC(C1=O)c1cccc(c1)C(=N)N)C
  • InChi: 1S/C26H36N4O2/c1-18(2)29(19(3)4)15-8-5-9-16-30-22-13-6-7-14-23(22)32-24(26(30)31)20-11-10-12-21(17-20)25(27)28/h6-7,10-14,17-19,24H,5,8-9,15-16H2,1-4H3,(H3,27,28)
  • InChiKey: IMYQMGQWJNWTLF-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[4-[5-(diisopropylamino)pentyl]-3-oxo-1,4-benzoxazin-2-yl]benzamidine
  • 3-[4-[5-(diisopropylamino)pentyl]-3-keto-1,4-benzoxazin-2-yl]benzamidine
  • 3-[4-[5-(di(propan-2-yl)amino)pentyl]-3-oxo-1,4-benzoxazin-2-yl]benzenecarboximidamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protease, serine, 1 (trypsin 1) Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.001 0.004 0.0224
Brugia malayi Cadherin domain containing protein 0.0007 0.0015 0.0103
Schistosoma mansoni notch 0.0007 0.0015 0.0013
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Brugia malayi hypothetical protein 0.0013 0.0076 0.051
Schistosoma mansoni roundabout 0.0032 0.0258 0.0256
Brugia malayi Immunoglobulin I-set domain containing protein 0.0148 0.1403 0.9398
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0556 0.0554
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0308 0.1228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0356 0.2377
Echinococcus granulosus protein jagged 1 0.0007 0.0015 0.0043
Entamoeba histolytica cysteine proteinase, putative 0.001 0.004 0.0309
Brugia malayi Serotonin receptor 0.0037 0.0308 0.2063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Trypanosoma cruzi protein farnesyltransferase, putative 0.001 0.004 0.0363
Brugia malayi Phospholipase A2 family protein 0.0092 0.0851 0.5701
Echinococcus granulosus Immunoglobulin 0.0114 0.107 0.4315
Leishmania major cathepsin L-like protease 0.001 0.004 0.0366
Brugia malayi beta-lactamase family protein 0.001 0.0042 0.0279
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0556 0.2233
Trypanosoma brucei protein farnesyltransferase beta subunit 0.001 0.004 0.0363
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0034 0.0276 0.11
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Mycobacterium tuberculosis Conserved protein 0.001 0.0042 0.0121
Brugia malayi Protein kinase domain containing protein 0.001 0.0038 0.0251
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0232 0.023
Trichomonas vaginalis 2-nitropropane dioxygenase precursor, putative 0.0035 0.029 0.1957
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0556 0.2233
Echinococcus granulosus protein jagged 2 0.0007 0.0015 0.0043
Schistosoma mansoni hypothetical protein 0.0205 0.1967 0.1965
Onchocerca volvulus Cathepsin L homolog 0.001 0.004 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0025 0.0187 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.001 0.004 0.0226
Plasmodium falciparum cysteine proteinase falcipain 2a 0.001 0.004 0.0309
Loa Loa (eye worm) choline O-acetyltransferase 0.0006 0.0005 0.0023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.001 0.0042 0.0121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0556 0.2233
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0308 0.0306
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.1781
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0232 0.1556
Schistosoma mansoni 3-dehydroquinate synthase 0.0291 0.2808 0.2807
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0133 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.027
Onchocerca volvulus 0.0037 0.0308 0.2093
Brugia malayi Cathepsin L-like precursor 0.0007 0.0008 0.0055
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0037 0.0306 0.0417
Schistosoma mansoni hypothetical protein 0.0032 0.0259 0.0257
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0025 0.0187 0.1238
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0291 0.2808 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0308 0.1228
Onchocerca volvulus 0.0026 0.0201 0.1353
Schistosoma mansoni peroxidasin 0.0032 0.0258 0.0256
Onchocerca volvulus 0.001 0.004 0.0245
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0308 0.0306
Schistosoma mansoni netrin receptor unc5 0.0032 0.0258 0.0256
Trichomonas vaginalis penicillin-binding protein, putative 0.001 0.0042 0.0235
Echinococcus multilocularis roundabout 2 0.0034 0.0276 0.11
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0556 0.3725
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0005 0.0032
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0006 0.0005 0.0023
Brugia malayi Inositol-1 0.0025 0.0187 0.125
Onchocerca volvulus 0.0021 0.0153 0.1022
Onchocerca volvulus 0.0007 0.0015 0.0073
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.001 0.0042 0.0235
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.001 0.004 0.0224
Echinococcus multilocularis GPCR, family 2 0.0013 0.0074 0.028
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.1781
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus granulosus neuropeptide receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.0038 0.0242
Echinococcus multilocularis microtubule associated protein 2 0.0257 0.2473 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0007 0.0015 0.0043
Echinococcus granulosus peroxidasin 0.0032 0.0258 0.1024
Plasmodium falciparum protein farnesyltransferase subunit beta 0.001 0.004 0.0306
Plasmodium vivax vivapain-2 0.001 0.004 0.0309
Brugia malayi Protein kinase domain containing protein 0.0008 0.0026 0.0176
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0308 0.1228
Onchocerca volvulus 0.0013 0.0076 0.0493
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.001 0.0042 0.004
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0747 0.7303 1
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0114 0.1066 0.7142
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0007 0.0008 0.0065
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0153 0.1372
Mycobacterium ulcerans hypothetical protein 0.0013 0.0072 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.1015
Brugia malayi Cathepsin L-like precursor 0.001 0.004 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Brugia malayi Cathepsin L-like precursor 0.001 0.004 0.027
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Echinococcus granulosus g protein coupled receptor 0.0037 0.0308 0.1228
Schistosoma mansoni transketolase 0.0007 0.0008 0.0006
Plasmodium falciparum cysteine proteinase falcipain 2b 0.001 0.004 0.0309
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0009 0.0034 0.0181
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0064 0.0392
Loa Loa (eye worm) cysteine protease 0.001 0.004 0.0261
Onchocerca volvulus Arrow homolog 0.0017 0.011 0.0724
Mycobacterium ulcerans hypothetical protein 0.0013 0.0072 0.0097
Echinococcus granulosus neuroglian 0.0034 0.0276 0.11
Schistosoma mansoni ankyrin 23/unc44 0.001 0.0038 0.0036
Echinococcus granulosus pyruvate dehydrogenase 0.0007 0.0008 0.0011
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0099 0.0916 0.6139
Schistosoma mansoni notch 0.0007 0.0015 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Mycobacterium ulcerans hypothetical protein 0.001 0.0042 0.0055
Echinococcus granulosus somatostatin receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0114 0.1066 0.1064
Schistosoma mansoni amine GPCR 0.0037 0.0308 0.0306
Brugia malayi Peroxidasin 0.0032 0.0258 0.1726
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.001 0.004 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0032 0.0258 0.1718
Schistosoma mansoni slit 0.0007 0.0015 0.0013
Brugia malayi beta-lactamase 0.001 0.0042 0.0279
Trypanosoma cruzi lanosterol synthase, putative 0.0011 0.0049 0.0451
Brugia malayi Fibroblast growth factor family protein 0.0061 0.0545 0.365
Schistosoma mansoni hypothetical protein 0.0013 0.0074 0.0072
Schistosoma mansoni netrin receptor unc5 0.0041 0.0352 0.035
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0076 0.0074
Brugia malayi Pre-SET motif family protein 0.0019 0.0133 0.0894
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0232 0.023
Leishmania major enoyl-[acyl-carrier-protein] reductase, putative 0.0035 0.029 0.2714
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0308 0.1228
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0232 0.0922
Mycobacterium ulcerans 1-deoxy-D-xylulose-5-phosphate synthase 0.0007 0.0008 0.0009
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0232 0.023
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0006 0.0005 0.0032
Brugia malayi Papain family cysteine protease containing protein 0.001 0.004 0.027
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0009 0.0034 0.0036
Trypanosoma cruzi lanosterol synthase, putative 0.0011 0.0049 0.0451
Mycobacterium leprae Probable lipase LipE 0.001 0.0042 0.0047
Leishmania major protein kinase, putative 0.0009 0.0034 0.0304
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0.0064 0.043
Onchocerca volvulus 0.0037 0.0308 0.2093
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0232 0.1556
Brugia malayi EGF-like domain containing protein 0.0007 0.0015 0.0103
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0456 0.4438 1
Brugia malayi hypothetical protein 0.0033 0.0267 0.1789
Echinococcus multilocularis musashi 0.001 0.0042 0.0151
Brugia malayi bHLH-PAS transcription factor 0.0026 0.0201 0.1345
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0146 0.1384 0.9272
Loa Loa (eye worm) intermediate filament protein 0.001 0.0042 0.0274
Plasmodium falciparum ataxin-2 like protein, putative 0.0009 0.0031 0.0222
Echinococcus multilocularis irregular chiasm roughest protein immunoglobulin set domain containing protein 0.0114 0.107 0.4315
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0308 0.2055
Echinococcus granulosus tumor protein p63 0.0126 0.1182 0.4769
Echinococcus multilocularis roundabout 2 0.0034 0.0276 0.11
Brugia malayi Dopamine receptor protein 2 0.0037 0.0308 0.2063
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0456 0.4438 0.6077
Echinococcus granulosus intermediate filament protein 0.001 0.0042 0.0151
Onchocerca volvulus 0.0007 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.012 0.1124 0.7525
Brugia malayi Kringle domain containing protein 0.0021 0.0153 0.1024
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0556 0.2233
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0308 0.1228
Brugia malayi GCC2 and GCC3 family protein 0.0009 0.0031 0.0209
Echinococcus granulosus fmrfamide receptor 0.0037 0.0308 0.1228
Echinococcus multilocularis neurogenic locus notch protein 0.0007 0.0015 0.0043
Brugia malayi RE15519p 0.0037 0.0308 0.2063
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0007 0.0014 0.0058
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0308 0.1228
Plasmodium vivax vivapain-2 0.001 0.004 0.0309
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0308 0.1228
Brugia malayi nuclear receptor NHR-88 0.0029 0.0232 0.1556
Echinococcus multilocularis tumor protein p63 0.0126 0.1182 0.4769
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0133 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0008 0.0004
Brugia malayi hypothetical protein 0.0033 0.0267 0.1789
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0009 0.0034 0.0181
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus granulosus Tolloid protein 1 0.0017 0.011 0.0425
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0308 0.1228
Brugia malayi Dopamine receptor 0.0037 0.0308 0.2063
Echinococcus multilocularis Immunoglobulin subtype 0.0032 0.0258 0.1024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Entamoeba histolytica cysteine protease, putative 0.001 0.004 0.0309
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0074 0.0495
Brugia malayi Heparan sulfate 0.0032 0.0258 0.1726
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0556 0.3725
Mycobacterium tuberculosis Probable esterase LipL 0.001 0.0042 0.0121
Toxoplasma gondii cathepsin CPL 0.001 0.004 0.0045
Brugia malayi Trypsin family protein 0.0013 0.0076 0.051
Schistosoma mansoni septate junction protein 0.0032 0.0258 0.0256
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Schistosoma mansoni myosin xvIII 0.0037 0.0308 0.0306
Echinococcus granulosus neuropeptide receptor 0.0037 0.0308 0.1228
Toxoplasma gondii calcium binding egf domain-containing protein 0.0017 0.011 0.014
Echinococcus granulosus fibropellin Ia 0.0007 0.0015 0.0043
Trichomonas vaginalis adenylate cyclase, putative 0.0009 0.0034 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0556 0.3719
Schistosoma mansoni hypothetical protein 0.0032 0.0258 0.0256
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0232 0.0922
Wolbachia endosymbiont of Brugia malayi 2-nitropropane dioxygenase 0.0013 0.0072 0.0145
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0009 0.0034 0.0117
Onchocerca volvulus 0.0037 0.0308 0.2093
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0232 0.1571
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0153 0.1372
Mycobacterium ulcerans lipase LipD 0.001 0.0042 0.0055
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0308 0.1228
Onchocerca volvulus 0.0013 0.0076 0.0493
Brugia malayi hypothetical protein 0.0119 0.111 0.7438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0008 0.0004
Brugia malayi EGF-like domain containing protein 0.0007 0.0015 0.0103
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0267 0.1062
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0034 0.0279 0.1109
Echinococcus granulosus neural cadherin 0.0007 0.0015 0.0043
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0747 0.7303 1
Schistosoma mansoni amine GPCR 0.0037 0.0308 0.0306
Trypanosoma cruzi 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative 0.0007 0.0008 0.0059
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0308 0.1228
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Brugia malayi ORL1-like opioid receptor 0.0037 0.0308 0.2063
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Brugia malayi hypothetical protein 0.0009 0.0031 0.0209
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0006 0.0005 0.0032
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0556 0.2233
Echinococcus multilocularis serotonin receptor 0.0037 0.0308 0.1228
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0556 0.2233
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0556 0.0554
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0308 0.2055
Echinococcus granulosus aryl hydrocarbon receptor 0.0009 0.0034 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Loa Loa (eye worm) hypothetical protein 0.0092 0.0851 0.5697
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Echinococcus multilocularis roundabout 2 0.0034 0.0276 0.11
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0308 0.1228
Schistosoma mansoni hypothetical protein 0.0013 0.0076 0.0074
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0308 0.1228
Brugia malayi Melatonin receptor type 1A 0.0037 0.0308 0.2063
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0556 0.0554
Echinococcus granulosus allatostatin A receptor 0.0037 0.0308 0.1228
Brugia malayi Cadherin domain containing protein 0.0007 0.0015 0.0103
Toxoplasma gondii exonuclease III APE 0.0012 0.0064 0.0078
Brugia malayi hypothetical protein 0.0029 0.0232 0.1556
Brugia malayi Immunoglobulin domain containing protein 0.0032 0.0258 0.1726
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0267 0.1789
Brugia malayi Dopamine receptor protein 1 0.0037 0.0308 0.2063
Schistosoma mansoni hypothetical protein 0.0032 0.0258 0.0256
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus multilocularis lachesin 0.0032 0.0258 0.1024
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.001 0.004 0.0224
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0032 0.0258 0.0256
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0114 0.1066 1
Schistosoma mansoni cellular tumor antigen P53 0.0018 0.0125 0.0123
Echinococcus multilocularis protein jagged 1 0.0007 0.0015 0.0043
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0308 0.2093
Trypanosoma cruzi PAB1-binding protein , putative 0.0009 0.0031 0.028
Echinococcus granulosus neuropeptide receptor A26 0.0208 0.1995 0.8061
Brugia malayi conserved hypotetical protein 0.0029 0.0232 0.1556
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0009 0.0034 0.0304
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0274
Loa Loa (eye worm) notch protein 0.0007 0.0015 0.0094
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0308 0.1228
Echinococcus multilocularis neurogenic locus protein delta 0.0007 0.0015 0.0043
Leishmania major protein kinase, putative 0.0009 0.0034 0.0304
Mycobacterium tuberculosis Probable lipase LipD 0.001 0.0042 0.0121
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0306
Schistosoma mansoni amine GPCR 0.0037 0.0308 0.0306
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0034 0.0276 0.0274
Mycobacterium tuberculosis Probable hydrolase 0.001 0.0042 0.0121
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.001 0.0038 0.0036
Onchocerca volvulus 0.0037 0.0308 0.2093
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0232 0.0922
Onchocerca volvulus 0.0037 0.0308 0.2093
Schistosoma mansoni neuropeptide receptor 0.0037 0.0308 0.0306
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0.0064 0.0421
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0007 0.0015 0.0103
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0308 0.0306
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0556 0.3725
Brugia malayi G protein-coupled receptor 0.0037 0.0308 0.2063
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.001 0.004 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0556 0.3719
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.001 0.004 0.0226
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0556 0.2233
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.3719
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0034 0.0279 0.2603
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0308 0.1228
Mycobacterium tuberculosis Conserved protein 0.001 0.0042 0.0121
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0308 0.2063
Schistosoma mansoni amine GPCR 0.0037 0.0308 0.0306
Echinococcus granulosus Immunoglobulin 0.0032 0.0258 0.1024
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0042 0.0378
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Brugia malayi Serotonin receptor 0.0037 0.0308 0.2063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0076 0.0502
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0153 0.1015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0019 0.0133 0.0132
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Brugia malayi pyruvate dehydrogenase E1 component beta subunit, putative 0.0007 0.0008 0.0051
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0308 0.1228
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0456 0.4438 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0009 0.0031 0.0222
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0009 0.0034 0.0304
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Brugia malayi GnHR receptor homolog 0.0037 0.0308 0.2063
Schistosoma mansoni aryl hydrocarbon receptor 0.0035 0.0291 0.0289
Schistosoma mansoni pyruvate dehydrogenase (lipoamide) 0.0007 0.0008 0.0006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0187 0.1739
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0556 0.3725
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0018 0.0117 0.015
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0556 0.0554
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0187 0.1739
Echinococcus multilocularis transketolase 0.0007 0.0008 0.0011
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0032 0.0258 0.1024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Echinococcus granulosus tyrosine protein kinase otk 0.0032 0.0258 0.1024
Schistosoma mansoni adenoreceptor 0.0037 0.0308 0.0306
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.001 0.004 0.0259
Brugia malayi Protein kinase domain containing protein 0.0021 0.0153 0.1024
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0308 0.1228
Echinococcus granulosus contactin 0.0034 0.0276 0.11
Onchocerca volvulus 0.0007 0.0015 0.0073
Onchocerca volvulus Phospholipase A2 homolog 0.0092 0.0851 0.5842
Onchocerca volvulus 0.0037 0.0308 0.2093
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0187 0.1739
Onchocerca volvulus Slit protein homolog 0.0007 0.0015 0.0073
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0153 0.0199
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0747 0.7303 1
Leishmania major hypothetical protein, conserved 0.0009 0.0031 0.028
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0017 0.011 0.0108
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0009 0.0034 0.0304
Echinococcus multilocularis cathepsin L cysteine protease 0.001 0.004 0.0144
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0012 0.0064 0.0923
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0032 0.0258 0.1024
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0114 0.1066 0.7142
Brugia malayi neuropeptide F receptor 0.0037 0.0308 0.2063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0019 0.0133 0.0521
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0308 0.2055
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0114 0.1066 0.1451
Echinococcus granulosus inositol monophosphatase 1 0.0025 0.0187 0.0736
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0308 0.0306
Echinococcus granulosus basement membrane specific heparan sulfate 0.0032 0.0258 0.1024
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0556 0.3725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0009 0.0034 0.0304
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0556 0.3806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0232 0.0922
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) LAD-2 short isoform 0.0032 0.0258 0.1718
Trichomonas vaginalis D-aminoacylase, putative 0.001 0.0042 0.0235
Leishmania major 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative 0.0007 0.0008 0.0059
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0308 0.0306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0322 0.032
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Brugia malayi Immunoglobulin domain containing protein 0.0032 0.0258 0.1726
Mycobacterium tuberculosis Conserved hypothetical protein 0.0013 0.0072 0.0229
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0308 0.1228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.1781
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0064 0.0241
Leishmania major hypothetical protein, conserved 0.0021 0.0153 0.1422
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0187 0.1739
Brugia malayi larval opioid receptor 0.0037 0.0308 0.2063
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0032 0.0258 0.1746
Echinococcus multilocularis transfer RNA-Lys 0.0026 0.0201 0.0794
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0308 0.1228
Echinococcus granulosus Ankyrin 0.001 0.0038 0.0136
Echinococcus multilocularis neuroglian 0.0034 0.0276 0.11
Onchocerca volvulus 0.0007 0.0015 0.0073
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0064 0.0571 0.2013
Onchocerca volvulus 0.001 0.0042 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0276 0.1844
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Schistosoma mansoni notch 0.0007 0.0015 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0556 0.3719
Schistosoma mansoni biogenic amine receptor 0.0037 0.0308 0.0306
Schistosoma mansoni notch 0.0007 0.0015 0.0013
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0556 0.3806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0046
Onchocerca volvulus Putative cubilin 0.0007 0.0015 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0232 0.1571
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.027
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0114 0.1066 1
Schistosoma mansoni egf-like domain protein 0.0017 0.011 0.0108
Echinococcus multilocularis cathepsin L cysteine protease 0.001 0.004 0.0144
Onchocerca volvulus 0.0032 0.0259 0.1757
Onchocerca volvulus 0.0037 0.0308 0.2093
Brugia malayi Cathepsin L-like precursor 0.001 0.004 0.027
Schistosoma mansoni hypothetical protein 0.0032 0.0258 0.0256
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0261
Onchocerca volvulus 0.0037 0.0308 0.2093
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.001 0.004 0.0261
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Brugia malayi steroid hormone receptor 0.0062 0.0556 0.3725
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0556 0.3725
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0556 0.3719
Brugia malayi G-protein coupled receptor 0.0037 0.0308 0.2063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0038 0.0322 0.1284
Schistosoma mansoni laminin gamma-3 chain 0.0007 0.0015 0.0013
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0034 0.0276 0.11
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.001 0.004 0.0224
Leishmania major cathepsin L-like protease 0.001 0.004 0.0366
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0114 0.1066 0.43
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0006 0.0005 0.0032
Loa Loa (eye worm) ctsf protein 0.001 0.004 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Brugia malayi PAS domain containing protein 0.0035 0.0291 0.195
Toxoplasma gondii calcium binding egf domain-containing protein 0.0017 0.011 0.014
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Schistosoma mansoni intermediate filament proteins 0.001 0.0042 0.004
Trypanosoma cruzi protein farnesyltransferase, putative 0.001 0.004 0.0363
Loa Loa (eye worm) inositol-1 0.0025 0.0187 0.1242
Brugia malayi Intermediate filament tail domain containing protein 0.001 0.0042 0.0282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.001 0.0042 0.027
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0007 0.0015 0.0073
Echinococcus multilocularis serotonin receptor 0.0037 0.0308 0.1228
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0006 0.0005 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.011 0.0735
Echinococcus granulosus protein jagged 2 0.0007 0.0015 0.0043
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Schistosoma mansoni neuropeptide receptor 0.0037 0.0308 0.0306
Echinococcus multilocularis Mastin 0.0013 0.0076 0.0289
Schistosoma mansoni hypothetical protein 0.0013 0.0074 0.0072
Echinococcus granulosus glycoprotein Antigen 5 0.0013 0.0076 0.0289
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0114 0.1066 1
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0232 0.0922
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.027
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0232 0.0922
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0025 0.0187 0.0254
Trypanosoma brucei PAB1-binding protein , putative 0.0009 0.0031 0.028
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0006 0.0005 0.0032
Mycobacterium ulcerans beta-lactamase 0.001 0.0042 0.0055
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0308 0.1228
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0556 0.3806
Loa Loa (eye worm) hypothetical protein 0.0013 0.0076 0.0502
Schistosoma mansoni amine GPCR 0.0037 0.0308 0.0306
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0006 0.0005 0.0032
Mycobacterium ulcerans 2-nitropropane dioxygenase 0.0035 0.029 0.0396
Onchocerca volvulus 0.0013 0.0076 0.0493
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0267 0.1789
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0232 0.1556
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0076 0.0074
Chlamydia trachomatis oxoisovalerate dehydrogenase subunits alpha/beta 0.0007 0.0015 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.3719
Echinococcus multilocularis aryl hydrocarbon receptor 0.0009 0.0034 0.0117
Loa Loa (eye worm) fibroinase 0.001 0.004 0.0261
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0005 0.0032
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Entamoeba histolytica cysteine proteinase, putative 0.001 0.004 0.0309
Brugia malayi EGF-like domain containing protein 0.0007 0.0015 0.0103
Brugia malayi Trypsin family protein 0.012 0.1124 0.7528
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0306
Brugia malayi beta-lactamase family protein 0.001 0.0042 0.0279
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0032 0.0258 0.0256
Onchocerca volvulus 0.0037 0.0308 0.2093
Brugia malayi hypothetical protein 0.0029 0.0232 0.1556
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.001 0.0042 0.0055
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0006 0.0005 0.0032
Schistosoma mansoni inositol monophosphatase 0.0025 0.0187 0.0185
Brugia malayi EGF-like domain containing protein 0.0007 0.0015 0.0103
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0291 0.2808 0.3844
Brugia malayi nuclear hormone receptor 0.0062 0.0556 0.3725
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0556 0.3725
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.1781
Echinococcus multilocularis fibrillin 1 0.0017 0.011 0.0425
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0013 0.0076 0.0289
Echinococcus multilocularis bloom syndrome protein 0.0008 0.0018 0.0052
Echinococcus granulosus g protein coupled receptor 0.0037 0.0308 0.1228
Echinococcus multilocularis fat cadherin tumor suppressor 0.0007 0.0015 0.0043
Echinococcus granulosus nephrin 0.0116 0.1089 0.439
Echinococcus multilocularis sex peptide receptor 0.0037 0.0308 0.1228
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0013
Brugia malayi nuclear receptor RXR 0.0029 0.0232 0.1556
Trichomonas vaginalis D-aminoacylase, putative 0.001 0.0042 0.0235
Brugia malayi nuclear receptor RXR 0.0033 0.0267 0.1789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Echinococcus granulosus laminin 0.0017 0.011 0.0425
Echinococcus granulosus roundabout 2 0.0034 0.0276 0.11
Onchocerca volvulus 0.0037 0.0308 0.2093
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0114 0.1066 0.7326
Echinococcus granulosus roundabout 2 0.0034 0.0276 0.11
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0038 0.0322 0.1284
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.001 0.004 0.0224
Onchocerca volvulus 0.001 0.0042 0.0254
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0556 0.3719
Trichomonas vaginalis DNA helicase recq, putative 0.0008 0.0018 0.0069
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0232 0.1556
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Echinococcus granulosus cathepsin l cysteine peptidase 0.001 0.004 0.0144
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0308 0.2063
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0006 0.0005 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0267 0.0265
Schistosoma mansoni neuropeptide receptor 0.0037 0.0308 0.0306
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0232 0.1549
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0034 0.0276 0.11
Loa Loa (eye worm) hypothetical protein 0.0013 0.0076 0.0502
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0308 0.1228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0308 0.1228
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0006 0.0005 0.0032
Onchocerca volvulus 0.0037 0.0308 0.2093
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0114 0.1066 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0258 0.1718
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Trypanosoma cruzi pyruvate dehydrogenase E1 beta subunit, putative 0.0007 0.0008 0.0059
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0308 0.0306
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0308 0.2063
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0005 0.0032
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0114 0.1066 1
Trypanosoma cruzi 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative 0.0007 0.0008 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Echinococcus granulosus hypothetical protein 0.0037 0.0308 0.1228
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0308 0.0306
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0006 0.0005 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0556 0.0554
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Echinococcus multilocularis neuropeptide s receptor 0.0208 0.1995 0.8061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0291 0.2808 0.3839
Leishmania major carnitine palmitoyltransferase-like protein 0.0006 0.0005 0.0032
Onchocerca volvulus 0.001 0.0042 0.0254
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Mycobacterium tuberculosis Possible alanine rich oxidoreductase 0.0035 0.029 0.101
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0308 0.2055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0074 0.028
Echinococcus granulosus nephrin 0.0114 0.107 0.4315
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0308 0.2055
Schistosoma mansoni lamin 0.001 0.0042 0.004
Brugia malayi Cytochrome P450 family protein 0.0006 0.0001 0.0009
Schistosoma mansoni hypothetical protein 0.0029 0.0225 0.0223
Echinococcus multilocularis peroxidasin 0.0032 0.0258 0.1024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0038 0.0322 0.1284
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0276 0.1851
Onchocerca volvulus 0.0013 0.0076 0.0493
Mycobacterium ulcerans hypothetical protein 0.0035 0.029 0.0396
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0308 0.1228
Mycobacterium tuberculosis Probable lipase LipE 0.001 0.0042 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0133 0.0132
Echinococcus multilocularis neuropeptide receptor A26 0.0208 0.1995 0.8061
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Leishmania major cathepsin L-like protease 0.001 0.004 0.0366
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0013
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0013
Echinococcus granulosus bloom syndrome protein 0.0008 0.0018 0.0052
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0007 0.0015 0.0013
Echinococcus granulosus orexin receptor type 2 0.0037 0.0308 0.1228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0038 0.0322 0.1284
Brugia malayi pyruvate dehydrogenase E1 component beta subunit, mitochondrial 0.0007 0.0008 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Echinococcus granulosus microtubule associated protein 2 0.0257 0.2473 1
Brugia malayi Cathepsin L-like precursor 0.001 0.004 0.027
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0025 0.0187 0.169
Toxoplasma gondii LsmAD domain-containing protein 0.0009 0.0031 0.0032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0074 0.0486
Echinococcus granulosus low density lipoprotein receptor ldl 0.0032 0.0258 0.1024
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0556 0.3719
Echinococcus granulosus serotonin receptor 0.0037 0.0308 0.1228
Echinococcus multilocularis slit 2 protein 0.0007 0.0015 0.0043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0556 0.2233
Onchocerca volvulus 0.001 0.004 0.0245
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0012 0.0064 0.0535
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.001 0.0042 0.0121
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0009 0.0034 0.0181
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0034 0.0276 0.11
Echinococcus granulosus neurogenic locus notch protein 4 0.0007 0.0015 0.0043
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Schistosoma mansoni cell adhesion molecule 0.0032 0.0258 0.0256
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.3719
Schistosoma mansoni microtubule-associated protein tau 0.0257 0.2473 0.2472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.3719
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0308 0.2063
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0886
Echinococcus multilocularis laminin 0.0017 0.011 0.0425
Loa Loa (eye worm) beta-lactamase 0.001 0.0042 0.027
Echinococcus multilocularis Immunoglobulin 0.0032 0.0258 0.1024
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0064 0.0392
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0008 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0006 0.0005 0.0023
Schistosoma mansoni cell adhesion molecule 0.0032 0.0258 0.0256
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0308 0.0306
Leishmania major pyruvate dehydrogenase E1 beta subunit, putative 0.0007 0.0008 0.0059
Loa Loa (eye worm) DR-78 0.0029 0.0232 0.1549
Echinococcus multilocularis conserved hypothetical protein 0.0114 0.107 0.4315
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0308 0.1228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0034 0.0276 0.1844
Echinococcus multilocularis inositol monophosphatase 1 0.0025 0.0187 0.0736
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0032 0.0258 0.1024
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0049 0.0426 0.1706
Brugia malayi transketolase 0.0007 0.0008 0.0051
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0153 0.06
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0032 0.0258 0.1718
Echinococcus granulosus single minded 2 0.0026 0.0201 0.0794
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.1124 0.1122
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0232 0.1549
Echinococcus multilocularis glycoprotein Antigen 5 0.0013 0.0076 0.0289
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0114 0.1066 0.7139
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0308 0.1228
Brugia malayi Muscle positioning protein 4 0.0007 0.0015 0.0103
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0008
Mycobacterium tuberculosis Conserved protein 0.0013 0.0072 0.0229
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.001 0.0042 0.0274
Echinococcus granulosus roundabout 2 0.0034 0.0276 0.11
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0114 0.1066 0.7139
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Schistosoma mansoni hypothetical protein 0.0021 0.0153 0.0151
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0114 0.1066 0.43
Plasmodium vivax farnesyltransferase beta subunit, putative 0.001 0.004 0.0306
Brugia malayi Trypsin-like protease protein 5 0.0013 0.0076 0.051
Echinococcus multilocularis hemicentin 1 0.0032 0.0258 0.1024
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0308 0.1228
Onchocerca volvulus Neurogenic locus notch homolog 0.0007 0.0016 0.0078
Echinococcus granulosus sex peptide receptor 0.0037 0.0308 0.1228
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0556 0.2233
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0308 0.2063
Echinococcus multilocularis neurogenic locus protein delta 0.0007 0.0015 0.0043
Echinococcus granulosus cathepsin L cysteine proteinase 0.001 0.004 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0556 0.3725
Onchocerca volvulus 0.0009 0.0034 0.02
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0556 0.2233
Onchocerca volvulus Netrin receptor homolog 0.001 0.0038 0.0226
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.001 0.0042 0.0121
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0556 0.2233
Schistosoma mansoni nephrin related 0.0032 0.0258 0.0256
Brugia malayi hypothetical protein 0.0157 0.1493 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0034 0.0276 0.1844
Schistosoma mansoni neuroglian 0.0034 0.0276 0.0274
Schistosoma mansoni nuclear receptor 0.0029 0.0232 0.023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Chlamydia trachomatis dehyroquinate synthase 0.0291 0.2808 0.3839
Schistosoma mansoni opsin-like receptor 0.0037 0.0308 0.0306
Onchocerca volvulus 0.0037 0.0308 0.2093
Loa Loa (eye worm) RecQ helicase 0.0008 0.0018 0.0109
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0248
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0267 0.1781
Leishmania major cathepsin L-like protease 0.001 0.004 0.0366
Brugia malayi Trypsin family protein 0.0013 0.0076 0.051
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.3719
Loa Loa (eye worm) Notch2 0.0007 0.0015 0.0094
Brugia malayi tailless protein 0.0029 0.0232 0.1556
Trypanosoma brucei transketolase, putative 0.0007 0.0008 0.0059
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0308 0.1228
Echinococcus granulosus survival motor neuron protein 1 0.0157 0.1493 0.6028
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0308 0.0306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0456 0.4438 0.6073
Brugia malayi EGF-like domain containing protein 0.0007 0.0015 0.0103
Loa Loa (eye worm) hypothetical protein 0.0099 0.0916 0.6135
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0322 0.032
Brugia malayi hypoxia-induced factor 1 0.0109 0.102 0.6833
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Treponema pallidum exodeoxyribonuclease (exoA) 0.0012 0.0064 0.0128
Schistosoma mansoni single-minded 0.0035 0.0291 0.0289
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0012 0.0064 0.0086
Brugia malayi Death domain containing protein 0.001 0.0038 0.0251
Brugia malayi putative neuropeptide receptor 0.0037 0.0308 0.2063
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0013 0.0076 0.0289
Onchocerca volvulus 0.001 0.004 0.0245
Onchocerca volvulus 0.001 0.0042 0.0258
Trichomonas vaginalis guanylate cyclase, putative 0.0009 0.0034 0.0181
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0556 0.0554
Echinococcus multilocularis survival motor neuron protein 1 0.0157 0.1493 0.6028
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0556 0.0554
Trypanosoma cruzi pyruvate dehydrogenase E1 beta subunit, putative 0.0007 0.0008 0.0059
Onchocerca volvulus 0.0037 0.0308 0.2093
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0074 0.028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0032 0.0258 0.1024
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0308 0.2055
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0308 0.1228
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0308 0.1228
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0032 0.0258 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Schistosoma mansoni tyrosine kinase 0.0032 0.0258 0.0256
Schistosoma mansoni biogenic amine receptor 0.0037 0.0308 0.0306
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0352 0.2357
Schistosoma mansoni hypothetical protein 0.0114 0.107 0.1068
Onchocerca volvulus 0.001 0.004 0.0245
Leishmania major cathepsin L-like protease 0.001 0.004 0.0366
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0006 0.0005 0.0032
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Schistosoma mansoni choline o-acyltransferase 0.0006 0.0005 0.0003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.001 0.004 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0826
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Schistosoma mansoni septate junction protein 0.0007 0.0015 0.0013
Brugia malayi 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor 0.0007 0.0008 0.0051
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0232 0.1549
Echinococcus granulosus neurogenic locus notch protein 0.0007 0.0015 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.004 0.0366
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0308 0.1228
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0308 0.1228
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0005 0.0032
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0308 0.0306
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0308 0.0306
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0034 0.0279 0.2603
Echinococcus granulosus protein farnesyltransferase subunit beta 0.001 0.004 0.0143
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0022 0.0161 0.0548
Schistosoma mansoni hypothetical protein 0.001 0.0038 0.0036
Echinococcus multilocularis Immunoglobulin 0.0114 0.107 0.4315
Echinococcus granulosus cathepsin l1 0.0007 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Schistosoma mansoni choline o-acyltransferase 0.0006 0.0005 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0308 0.1228
Leishmania major transketolase 0.0007 0.0008 0.0059
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0308 0.0306
Schistosoma mansoni opsin-like receptor 0.0037 0.0308 0.0306
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0013 0.0076 0.051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0076 0.0502
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.027
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0308 0.1228
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0556 0.3725
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0157 0.1493 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0232 0.0922
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Trypanosoma cruzi transketolase, putative 0.0007 0.0008 0.0059
Loa Loa (eye worm) hypothetical protein 0.0061 0.0545 0.3645
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0126 0.0493
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0009 0.0034 0.0181
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0017 0.011 0.0735
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0556 0.2233
Brugia malayi ecdysone receptor 0.0029 0.0232 0.1556
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0038 0.0322 0.2149
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0006 0.0005 0.0032
Onchocerca volvulus 0.0007 0.0015 0.0073
Schistosoma mansoni biogenic amine receptor 0.0037 0.0308 0.0306
Loa Loa (eye worm) hypoxia-induced factor 1 0.0109 0.102 0.683
Loa Loa (eye worm) hypothetical protein 0.0019 0.0127 0.0844
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0133 0.0521
Plasmodium falciparum cysteine proteinase falcipain 3 0.001 0.004 0.0309
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0267 0.1062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0308 0.1228
Echinococcus multilocularis enteropeptidase 0.0013 0.0076 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Echinococcus multilocularis notch 0.0007 0.0015 0.0043
Schistosoma mansoni hypothetical protein 0.0013 0.0074 0.0072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.02
Brugia malayi hypothetical protein 0.0146 0.1384 0.9272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Schistosoma mansoni basigin related 0.0032 0.0258 0.0256
Schistosoma mansoni cathepsin F (C01 family) 0.0007 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0556 0.3725
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0032 0.0258 0.1024
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0232 0.0922
Onchocerca volvulus 0.0106 0.0991 0.6807
Schistosoma mansoni protein farnesyltransferase subunit beta 0.001 0.004 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0032 0.0258 0.1024
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0726
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0133 0.0521
Schistosoma mansoni cell adhesion molecule 0.0034 0.0276 0.0274
Brugia malayi Immunoglobulin domain containing protein 0.0032 0.0258 0.1726
Schistosoma mansoni septate junction protein 0.0032 0.0258 0.0256
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Mycobacterium ulcerans pyruvate dehydrogenase E1 component subunit PdhB 0.0007 0.0008 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0012 0.0064 0.059
Echinococcus multilocularis neural cadherin 0.0007 0.0015 0.0043
Onchocerca volvulus 0.012 0.1124 0.7725
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0017 0.011 0.0726
Onchocerca volvulus 0.0153 0.1453 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0308 0.0306
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0556 0.3719
Echinococcus granulosus lamin 0.001 0.0042 0.0151
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0114 0.1066 1
Brugia malayi EGF-like domain containing protein 0.0007 0.0015 0.0103
Brugia malayi nuclear receptor NHR-88 0.0062 0.0556 0.3725
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0012 0.0064 0.0128
Schistosoma mansoni lamin 0.001 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.3719
Echinococcus multilocularis tyrosine protein kinase otk 0.0032 0.0258 0.1024
Leishmania major farnesyltransferase beta subunit 0.001 0.004 0.0363
Echinococcus granulosus cathepsin l1 0.001 0.004 0.0144
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0009 0.0034 0.0117
Schistosoma mansoni ap endonuclease 0.0012 0.0064 0.0062
Trichomonas vaginalis DNA helicase recq1, putative 0.0008 0.0018 0.0069
Echinococcus multilocularis protein jagged 1 0.0007 0.0015 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0009 0.0031 0.028
Toxoplasma gondii ABC1 family protein 0.001 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0013 0.0074 0.0486
Brugia malayi Fibroblast growth factor family protein 0.0061 0.0545 0.365
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.004 0.0366
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0009 0.0034 0.0304
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0064 0.0535
Trichomonas vaginalis guanylate cyclase, putative 0.0009 0.0034 0.0181
Echinococcus multilocularis nephrin 0.0114 0.107 0.4315
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0148 0.1403 0.9397
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Brugia malayi Uncoordinated protein 44 0.001 0.0038 0.0251
Trichomonas vaginalis penicillin-binding protein, putative 0.001 0.0042 0.0235
Schistosoma mansoni notch 0.0007 0.0016 0.0014
Giardia lamblia Hypothetical protein 0.0061 0.0545 1
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0556 0.3725
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0308 0.1228
Brugia malayi Calcium binding EGF domain containing protein 0.0007 0.0015 0.0103
Onchocerca volvulus 0.0037 0.0308 0.2093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.001 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0076 0.0502
Mycobacterium ulcerans esterase/lipase LipP 0.001 0.0042 0.0055
Schistosoma mansoni ap endonuclease 0.0012 0.0064 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0034 0.0181
Schistosoma mansoni cell adhesion molecule 0.0034 0.0276 0.0274
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0013 0.0076 0.0289
Echinococcus granulosus death domain containing protein 0.001 0.0038 0.0133
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0308 0.0306
Loa Loa (eye worm) trypsin family protein 0.0013 0.0076 0.0502
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0232 0.0922
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Schistosoma mansoni neuropeptide receptor 0.0037 0.0308 0.0306
Echinococcus granulosus g protein coupled receptor 0.0037 0.0308 0.1228
Brugia malayi Prion-like- 0.0032 0.0258 0.1726
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0308 0.1228
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0114 0.1066 0.7326
Schistosoma mansoni zinc finger protein 0.0029 0.0232 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0034 0.0181
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0232 0.0922
Schistosoma mansoni hypothetical protein 0.0032 0.0258 0.0256
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0025 0.0187 0.1238
Echinococcus multilocularis Immunoglobulin 0.0032 0.0258 0.1024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0545 0.3645
Wolbachia endosymbiont of Brugia malayi trans-2-enoyl-ACP reductase, FabK 0.0035 0.029 0.0638
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0034 0.0279 0.1109
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0556 0.0554
Schistosoma mansoni septate junction protein 0.0032 0.0258 0.0256
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0276 0.1851
Echinococcus granulosus lamin dm0 0.001 0.0042 0.0151
Echinococcus granulosus neurogenic locus notch protein 0.0007 0.0015 0.0043
Brugia malayi Cathepsin L-like cysteine proteinase 0.0007 0.0008 0.0055
Echinococcus multilocularis neurogenic locus notch protein 0.0007 0.0015 0.0043
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus multilocularis pyruvate dehydrogenase 0.0007 0.0008 0.0011
Trypanosoma brucei 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative 0.0007 0.0008 0.0059
Echinococcus multilocularis Ankyrin 0.001 0.0038 0.0136
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0042 0.0378
Leishmania major cysteine peptidase A (CPA) 0.001 0.004 0.0366
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.02
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.004 0.0261
Mycobacterium tuberculosis Conserved protein 0.001 0.0042 0.0121
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0034 0.0276 0.11
Brugia malayi nuclear receptor NHR-67 0.0029 0.0232 0.1556
Brugia malayi Delta serrate ligand family protein 0.0007 0.0015 0.0103
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Brugia malayi Trypsin family protein 0.0013 0.0076 0.051
Loa Loa (eye worm) 2-oxoisovalerate dehydrogenase subunit beta 0.0007 0.0008 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.1384 0.9272
Brugia malayi Cytochrome P450 family protein 0.0006 0.0001 0.0009
Echinococcus multilocularis geminin 0.0205 0.1967 0.7948
Plasmodium vivax ataxin-2 like protein, putative 0.0009 0.0031 0.0222
Leishmania major cathepsin L-like protease 0.001 0.004 0.0366
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0008 0.0059
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0037 0.0306 0.1064
Brugia malayi Choline O-acetyltransferase 0.0006 0.0005 0.0032
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0308 0.1228
Brugia malayi G-protein coupled receptor 0.0037 0.0308 0.2063
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0009 0.0034 0.0181
Onchocerca volvulus 0.0019 0.0133 0.0889
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0074 0.0495
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0308 0.1228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0074 0.028
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0308 0.1228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0076 0.0289
Onchocerca volvulus 0.0062 0.0556 0.3806
Plasmodium vivax SET domain protein, putative 0.0019 0.0133 0.1189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0032 0.0259 0.1737
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0556 0.0554
Schistosoma mansoni opsin-like receptor 0.0037 0.0308 0.0306
Brugia malayi ecdysteroid receptor 0.0062 0.0556 0.3725
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.004 0.0366
Mycobacterium tuberculosis Conserved hypothetical protein 0.0013 0.0072 0.0229
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.004 0.0366
Schistosoma mansoni survival motor neuron protein 0.0032 0.0259 0.0257
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.3719
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0726
Brugia malayi Choline O-acetyltransferase 0.0006 0.0005 0.0032
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0308 0.0306
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.001 0.0038 0.0133
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus granulosus beta LACTamase domain containing family member 0.001 0.0042 0.0149
Echinococcus granulosus lachesin 0.0032 0.0258 0.1024
Schistosoma mansoni basigin related 0.0032 0.0258 0.0256
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0308 0.1228
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0009 0.0034 0.0304
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0019 0.0133 0.0173
Echinococcus granulosus transketolase 0.0007 0.0008 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0018 0.0117 0.0391
Brugia malayi Calcium binding EGF domain containing protein 0.0007 0.0015 0.0103
Echinococcus granulosus slit 2 protein 0.0007 0.0015 0.0043
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0726
Schistosoma mansoni hypothetical protein 0.0013 0.0076 0.0074
Brugia malayi basement membrane proteoglycan precursor 0.0032 0.0258 0.1726
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0005 0.0032
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Brugia malayi basement membrane proteoglycan 0.0032 0.0258 0.1726
Schistosoma mansoni inositol monophosphatase 0.0025 0.0187 0.0185
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0032 0.0258 0.1024
Mycobacterium leprae conserved hypothetical protein 0.001 0.0042 0.0047
Trypanosoma brucei 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative 0.0007 0.0008 0.0059
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0308 0.1228
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.1124 0.1122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0852
Echinococcus granulosus geminin 0.0205 0.1967 0.7948
Onchocerca volvulus 0.001 0.004 0.0245
Loa Loa (eye worm) hypothetical protein 0.0092 0.0851 0.5697
Schistosoma mansoni nuclear receptor 0.0029 0.0232 0.023
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0556 0.2233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Echinococcus granulosus Immunoglobulin 0.0032 0.0258 0.1024
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0032 0.0258 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0034 0.0181
Echinococcus multilocularis lamin 0.001 0.0042 0.0151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.001 0.0042 0.0279
Echinococcus multilocularis Tolloid protein 1 0.0017 0.011 0.0425
Echinococcus multilocularis transmembrane protease serine 3 0.0013 0.0076 0.0289
Schistosoma mansoni coup transcription factor 0.0062 0.0556 0.0554
Echinococcus granulosus nuclear factor of activated T cells 5 0.0049 0.0426 0.1706
Onchocerca volvulus 0.0007 0.0015 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0232 0.1556
Echinococcus granulosus delta-like protein 1 0.0007 0.0015 0.0043
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0308 0.1228
Echinococcus granulosus irregular chiasm roughest protein 0.0114 0.107 0.4315
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.1781
Brugia malayi intermediate filament protein 0.001 0.0042 0.0282
Echinococcus multilocularis cysteine protease 0.001 0.004 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus multilocularis transketolase 0.0007 0.0008 0.0011
Echinococcus granulosus enteropeptidase 0.0013 0.0076 0.0289
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0232 0.0922
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0064 0.059
Echinococcus multilocularis cathepsin l cysteine peptidase 0.001 0.004 0.0144
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0291 0.2808 1
Trypanosoma brucei pyruvate dehydrogenase E1 beta subunit, putative 0.0007 0.0008 0.0059
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0308 0.1228
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0308 0.0306
Mycobacterium tuberculosis Possible oxidoreductase 0.0035 0.029 0.101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Schistosoma mansoni histamine h1 receptor 0.0037 0.0308 0.0306
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Schistosoma mansoni hypothetical protein 0.0114 0.107 0.1068
Onchocerca volvulus Phospholipase A2 homolog 0.0092 0.0851 0.5842
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0556 0.3725
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0022 0.0161 0.021
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0308 0.2055
Brugia malayi neuropeptide F receptor 0.0037 0.0308 0.2063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0012 0.0064 0.0202
Schistosoma mansoni hypothetical protein 0.0013 0.0074 0.0072
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus granulosus neurogenic locus protein delta 0.0007 0.0015 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.027
Onchocerca volvulus 0.0037 0.0308 0.2093
Echinococcus granulosus neuropeptide s receptor 0.0208 0.1995 0.8061
Onchocerca volvulus Cathepsin L homolog 0.001 0.004 0.0245
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Schistosoma mansoni basigin related 0.0032 0.0258 0.0256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Giardia lamblia Prenyltransferase 0.001 0.004 0.0465
Brugia malayi notch-like transmembrane receptor 0.0007 0.0015 0.0103
Onchocerca volvulus 0.001 0.0042 0.0254
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.001 0.004 0.0224
Loa Loa (eye worm) hypothetical protein 0.0119 0.111 0.7436
Schistosoma mansoni cell polarity protein 0.0007 0.0015 0.0013
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.004 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0232 0.1556
Brugia malayi Cathepsin L-like precursor 0.001 0.004 0.027
Onchocerca volvulus 0.0029 0.0232 0.1571
Echinococcus multilocularis netrin receptor unc 5 0.0041 0.0352 0.1406
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Trypanosoma cruzi transketolase, putative 0.0007 0.0008 0.0059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0074 0.028
Echinococcus multilocularis cysteine protease 0.001 0.004 0.0144
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0009 0.0034 0.0217
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0308 0.2063
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus granulosus netrin receptor unc 5 0.0041 0.0352 0.1406
Onchocerca volvulus 0.0013 0.0076 0.0493
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus granulosus Mastin 0.0013 0.0076 0.0289
Mycobacterium ulcerans transketolase 0.0007 0.0008 0.0009
Mycobacterium ulcerans putative regulatory protein 0.0026 0.0201 0.0273
Echinococcus multilocularis fibropellin Ia 0.0007 0.0015 0.0043
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.001 0.0038 0.0133
Onchocerca volvulus 0.0037 0.0308 0.2093
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0032 0.0258 0.0256
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0064 0.0241
Echinococcus multilocularis beta LACTamase domain containing family member 0.001 0.0042 0.0149
Schistosoma mansoni hypothetical protein 0.0032 0.0258 0.0256
Echinococcus granulosus notch 0.0007 0.0015 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0153 0.1422
Echinococcus granulosus transketolase 0.0007 0.0008 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0556 0.3719
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0225 0.1509
Echinococcus multilocularis somatostatin receptor 0.0037 0.0308 0.1228
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0556 0.2233
Schistosoma mansoni hypothetical protein 0.0032 0.0258 0.0256
Brugia malayi Calcium binding EGF domain containing protein 0.0007 0.0015 0.0103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0556 0.3725
Echinococcus multilocularis protein jagged 2 0.0007 0.0015 0.0043
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0094
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0308 0.0306
Plasmodium vivax hypothetical protein, conserved 0.001 0.0042 0.0321
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0308 0.1228
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0556 0.2233
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0046
Echinococcus granulosus GPCR family 2 0.0013 0.0074 0.028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Trichomonas vaginalis inositol monophosphatase, putative 0.0025 0.0187 0.1238
Onchocerca volvulus 0.0018 0.0125 0.0827
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0013
Toxoplasma gondii EGF family domain-containing protein 0.0007 0.0015 0.0011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0356 0.2384
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0306
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Leishmania major cathepsin L-like protease 0.001 0.004 0.0366
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0276 0.1851
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Trypanosoma brucei lanosterol synthase 0.0011 0.0049 0.0451
Trypanosoma cruzi cruzipain precursor, putative 0.001 0.004 0.0366
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0153 0.06
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0012 0.0064 0.059
Loa Loa (eye worm) hypothetical protein 0.0029 0.0225 0.1501
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0038 0.0322 0.2156
Leishmania major hypothetical protein, conserved 0.001 0.0042 0.0378
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0267 0.0265
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0308 0.2055
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0556 0.0554
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0012 0.0064 0.059
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0356 0.2384
Brugia malayi Cathepsin L-like precursor 0.001 0.004 0.027
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0556 0.3725
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0135 0.1269 0.8501
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0556 0.0554
Brugia malayi AKH receptor 0.0037 0.0308 0.2063
Schistosoma mansoni nephrin 0.0034 0.0276 0.0274
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0009 0.0034 0.0304
Schistosoma mansoni cell adhesion molecule 0.0032 0.0258 0.0256
Loa Loa (eye worm) hypothetical protein 0.012 0.1124 0.7525
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0308 0.2055
Mycobacterium leprae Possible regulatory protein 0.0009 0.0034 0.0036
Brugia malayi Pre-SET motif family protein 0.0135 0.1269 0.8503
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0007 0.0009 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0308 0.2063
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0017 0.011 0.0726
Mycobacterium ulcerans lipoprotein LpqF 0.0018 0.0117 0.0159
Echinococcus multilocularis hemicentin 1 0.0032 0.0258 0.1024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0042
Schistosoma mansoni cell adhesion molecule 0.0034 0.0276 0.0274
Echinococcus granulosus Immunoglobulin subtype 0.0032 0.0258 0.1024
Onchocerca volvulus 0.001 0.004 0.0245
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0308 0.2063
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0032 0.0258 0.0256
Trypanosoma brucei beta lactamase 0.0018 0.0117 0.1088
Onchocerca volvulus 0.0037 0.0308 0.2093
Brugia malayi sulfakinin receptor protein 0.0037 0.0308 0.2063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0308 0.1228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0308 0.0306
Schistosoma mansoni notch 0.0007 0.0015 0.0013
Echinococcus granulosus transmembrane protease serine 3 0.0013 0.0076 0.0289
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0064 0.0535
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Schistosoma mansoni titin 0.0032 0.0258 0.0256
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0034 0.0276 0.11
Brugia malayi nuclear hormone receptor 0.0029 0.0232 0.1556
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0556 0.2233
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0308 0.1228
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0076 0.0074
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0032 0.0258 0.1024
Schistosoma mansoni transketolase 0.0007 0.0008 0.0006
Echinococcus granulosus hemicentin 1 0.0032 0.0258 0.1024
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0747 0.7303 1
Brugia malayi EGF-like domain containing protein 0.0007 0.0015 0.0103
Echinococcus multilocularis lamin dm0 0.001 0.0042 0.0151
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Brugia malayi Cathepsin L-like precursor 0.0007 0.0008 0.0055
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0232 0.0922
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.001 0.004 0.0306
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0308 0.0306
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0308 0.2055
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.001 0.004 0.0268
Onchocerca volvulus 0.0029 0.0232 0.1571
Schistosoma mansoni hypothetical protein 0.0205 0.1967 0.1965
Mycobacterium ulcerans hypothetical protein 0.0013 0.0076 0.0102
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1549
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0013 0.0076 0.0074
Brugia malayi hypothetical protein 0.0037 0.0308 0.2063
Brugia malayi Fibulin-1 precursor 0.0017 0.011 0.0735
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0034 0.0276 0.11
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0556 0.2233
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0556 0.3725
Leishmania major carnitine/choline acetyltransferase, putative 0.0006 0.0005 0.0032
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0027 0.0213 0.0211
Echinococcus granulosus protein jagged 1 0.0007 0.0015 0.0043
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0232 0.023
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0556 0.0554
Onchocerca volvulus 0.001 0.004 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Leishmania major lanosterol synthase, putative 0.0008 0.0023 0.0205
Brugia malayi cathepsin L-like precursor 0.0007 0.0008 0.0055
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0017 0.011 0.0726
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0076 0.0074
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0011 0.0049 0.0149
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.3719
Schistosoma mansoni septate junction protein 0.0032 0.0258 0.0256
Loa Loa (eye worm) hypothetical protein 0.0042 0.0356 0.2377
Leishmania major cathepsin L-like protease 0.001 0.004 0.0366
Brugia malayi Bloom's syndrome protein homolog 0.0008 0.0018 0.0118
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0308 0.2055
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0308 0.1228
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0556 0.3725
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0308 0.2093
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0032 0.0258 0.1024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.1718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.004 0.0226
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0308 0.1228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.004 0.0226
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0042 0.0378
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0005 0.0032
Trichomonas vaginalis set domain proteins, putative 0.0153 0.1453 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0258 0.1726
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0308 0.0306
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0025 0.0187 0.0404
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0034 0.0279 0.2603
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0556 0.2233
Trichomonas vaginalis esterase, putative 0.001 0.0042 0.0235
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0114 0.1066 1
Onchocerca volvulus Cathepsin F homolog 0.001 0.004 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.004 0.0366
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0308 0.2063
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0261
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.2055
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0308 0.1228
Loa Loa (eye worm) hypothetical protein 0.0008 0.0026 0.0167
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0308 0.0306

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.12 uM In vitro inhibition of coagulation factor Xa. ChEMBL. 11063603
IC50 (binding) = 0.12 uM In vitro inhibition of coagulation factor Xa. ChEMBL. 11063603
IC50 (binding) = 1.2 uM Inhibition of thrombin ChEMBL. 11063603
IC50 (binding) = 1.2 uM In vitro inhibitory activity against trypsin ChEMBL. 11063603
IC50 (binding) = 1.2 uM Inhibition of thrombin ChEMBL. 11063603
IC50 (binding) = 1.2 uM In vitro inhibitory activity against trypsin ChEMBL. 11063603
Inhibition (binding) = 72 % Compound was tested for in vitro inhibitory activity against plasmin at 100 microM ChEMBL. 11063603
Inhibition (binding) = 72 % Compound was tested for in vitro inhibitory activity against plasmin at 100 microM ChEMBL. 11063603

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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