Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.6434 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.0774 | 0.1592 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0105 | 0.0216 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0126 | 0.1436 | 0.2953 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.199 | 0.6374 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0755 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.0755 | 0.0755 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.0678 | 0.1395 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.01 | 1 |
Onchocerca volvulus | 0.0297 | 0.3561 | 0.5534 | |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0015 | 0.0057 | 0.01 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0402 | 0.4864 | 0.4864 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.0105 | 0.0105 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0018 | 0.0102 | 0.0102 |
Echinococcus granulosus | tumor protein p63 | 0.0369 | 0.4458 | 0.7868 |
Echinococcus granulosus | dnaJ subfamily B | 0.0402 | 0.4864 | 0.8585 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0247 | 0.2948 | 0.4582 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0521 | 0.081 |
Onchocerca volvulus | Huntingtin homolog | 0.0528 | 0.6434 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0015 | 0.0057 | 0.0057 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0521 | 0.081 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.0755 | 0.1552 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.199 | 0.6374 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0209 | 0.2469 | 0.2469 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.061 | 0.1255 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0755 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.3099 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.002 | 0.0121 | 0.0249 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1055 | 0.2169 |
Schistosoma mansoni | cpg binding protein | 0.0059 | 0.061 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.061 | 0.0949 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0521 | 0.081 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.0678 | 0.1395 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.199 | 0.6374 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.2948 | 0.4582 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.01 | 0.5 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.061 | 0.061 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0521 | 0.0919 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0057 | 0.01 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.1365 | 0.2121 |
Echinococcus multilocularis | tumor protein p63 | 0.0369 | 0.4458 | 0.4458 |
Onchocerca volvulus | 0.0095 | 0.1055 | 0.164 | |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0521 | 0.0919 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.061 | 0.0949 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0154 | 0.0316 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.026 | 0.3099 | 0.4816 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0154 | 0.0239 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.01 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0466 | 0.5666 | 0.8806 |
Brugia malayi | hypothetical protein | 0.0466 | 0.5666 | 0.8806 |
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.6434 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0466 | 0.5666 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0521 | 0.1071 |
Onchocerca volvulus | 0.0054 | 0.0545 | 0.0847 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0361 | 0.0361 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.061 | 0.0949 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.061 | 0.061 |
Schistosoma mansoni | hypothetical protein | 0.0402 | 0.4864 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0015 | 0.0057 | 0.0117 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0726 | 0.1281 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.3099 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.01 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.002 | 0.0121 | 0.0249 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0726 | 0.0726 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.01 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.3099 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.199 | 0.6374 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0113 | 0.0176 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.061 | 0.1077 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0209 | 0.2469 | 0.4359 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.3099 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.01 | 0.0205 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0545 | 0.112 |
Echinococcus multilocularis | zinc finger protein | 0.0025 | 0.0181 | 0.0181 |
Echinococcus granulosus | cpg binding protein | 0.0065 | 0.0678 | 0.1197 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0521 | 0.0521 |
Schistosoma mansoni | zinc finger protein | 0.0025 | 0.0181 | 0.0373 |
Onchocerca volvulus | Huntingtin homolog | 0.0528 | 0.6434 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0426 | 0.0663 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0028 | 0.0222 | 0.0456 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.01 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0115 | 0.1302 | 1 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0755 | 0.1173 |
Onchocerca volvulus | 0.0059 | 0.061 | 0.0949 | |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0059 | 0.061 | 0.0949 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.01 | 0.0205 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.3099 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0361 | 0.0638 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.1365 | 0.2121 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.1365 | 0.2121 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0254 | 0.0394 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.0755 | 0.1333 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.199 | 0.6374 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0833 | 0.1295 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0105 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0494 | 0.0768 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.026 | 0.3099 | 0.4816 |
Schistosoma mansoni | hypothetical protein | 0.032 | 0.3853 | 0.7922 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0521 | 0.0521 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0018 | 0.0102 | 0.018 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.0105 | 0.0186 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.01 | 0.0176 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0755 | 0.1552 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.01 | 0.0155 |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.0933 | 0.145 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.01 | 0.0155 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.2104 | 0.6746 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0081 | 0.0167 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.017 | 0.199 | 0.3093 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.01 | 0.01 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.0081 | 0.0167 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.3099 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.199 | 0.6374 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0466 | 0.5666 | 0.5666 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.002 | 0.0121 | 0.0214 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.01 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0755 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0025 | 0.0181 | 0.032 |
Loa Loa (eye worm) | histone methyltransferase | 0.0018 | 0.0102 | 0.0158 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.002 | 0.0121 | 0.0121 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0521 | 0.081 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.01 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.2104 | 0.6746 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0521 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0394 | 0.0613 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0095 | 0.1055 | 0.164 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.01 | 0.0193 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0755 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0065 | 0.0678 | 0.0678 |
Brugia malayi | hypothetical protein | 0.0297 | 0.3561 | 0.5534 |
Brugia malayi | CXXC zinc finger family protein | 0.0059 | 0.061 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.3561 | 0.5534 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.061 | 0.1077 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.01 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0545 | 0.0847 |
Brugia malayi | hypothetical protein | 0.0528 | 0.6434 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0095 | 0.1055 | 0.2169 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.01 | 0.0193 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0057 | 0.0057 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.199 | 0.6374 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.01 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0028 | 0.0222 | 0.0222 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0393 | 0.0611 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0028 | 0.0222 | 0.0391 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.002 | 0.0125 | 0.0194 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0521 | 0.1071 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0521 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0121 | 0.0188 |
Onchocerca volvulus | 0.0052 | 0.0521 | 0.081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.25 mM | evaluated for the inhibition of Trypanosoma brucei Phosphoglycerate kinase (PGK) | ChEMBL. | 11063610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.