Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | AMP deaminase, putative | 0.4193 | 0.6056 | 0.5957 |
Entamoeba histolytica | adenosine deaminase, putative | 0.6823 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.4193 | 0.6056 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4193 | 0.6056 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.6823 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.6823 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.6823 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.6823 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.6823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.6823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4064 | 0.5862 | 0.5858 |
Echinococcus multilocularis | AMP deaminase 2 | 0.4193 | 0.6056 | 0.6051 |
Loa Loa (eye worm) | hypothetical protein | 0.4064 | 0.5862 | 0.5858 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4193 | 0.6056 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.6823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1435 | 0.1918 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.4064 | 0.5862 | 0.5858 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.6823 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4193 | 0.6056 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4193 | 0.6056 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.6823 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4193 | 0.6056 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.6823 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.4193 | 0.6056 | 0.5 |
Echinococcus granulosus | AMP deaminase 2 | 0.4193 | 0.6056 | 0.6051 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.4193 | 0.6056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2759 | 0.3904 | 0.3897 |
Echinococcus multilocularis | adenosine deaminase | 0.6823 | 1 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.4193 | 0.6056 | 0.353 |
Echinococcus granulosus | adenosine deaminase | 0.6823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4064 | 0.5862 | 0.5858 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.6823 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.4193 | 0.6056 | 0.353 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.6823 | 1 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.4193 | 0.6056 | 0.353 |
Mycobacterium ulcerans | adenosine deaminase | 0.6823 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.032 | 0.0245 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.4193 | 0.6056 | 0.6051 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.6823 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.4193 | 0.6056 | 0.353 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.4193 | 0.6056 | 0.353 |
Brugia malayi | adenosine monophosphate deaminase | 0.4193 | 0.6056 | 0.6051 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.6823 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.4193 | 0.6056 | 0.5 |
Entamoeba histolytica | AMP deaminase, putative | 0.4193 | 0.6056 | 0.5957 |
Trypanosoma brucei | AMP deaminase, putative | 0.4193 | 0.6056 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.6823 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.4193 | 0.6056 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.8 uM | Inhibition B16 melanoma cell monolayer proliferation | ChEMBL. | 2913301 |
IC50 (functional) | = 1.8 uM | Inhibition B16 melanoma cell monolayer proliferation | ChEMBL. | 2913301 |
IC50 (binding) | = 22 uM | Displacement of 5.8 uM [3H]-oncodazole from homogeneous tubulin. | ChEMBL. | 2913301 |
IC50 (binding) | = 22 uM | Displacement of 5.8 uM [3H]-oncodazole from homogeneous tubulin. | ChEMBL. | 2913301 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2913301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.