Detailed information for compound 22769

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 680.718 | Formula: C35H36O12S
  • H donors: 2 H acceptors: 3 LogP: 3.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCc1c(OC)cc(cc1OC)[C@@H]1[C@@H]2C(=O)OC[C@@H]2[C@H](c2c1cc1OCOc1c2)OC1OC2COC(OC2C(C1O)O)c1cccs1
  • InChi: 1S/C35H36O12S/c1-4-6-17-21(39-2)9-16(10-22(17)40-3)27-18-11-23-24(44-15-43-23)12-19(18)31(20-13-41-33(38)28(20)27)46-35-30(37)29(36)32-25(45-35)14-42-34(47-32)26-7-5-8-48-26/h4-5,7-12,20,25,27-32,34-37H,1,6,13-15H2,2-3H3/t20-,25?,27+,28-,29?,30?,31+,32?,34?,35?/m0/s1
  • InChiKey: VTGPKDNJPRKXST-PIPIBCBNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0389 0.57
Brugia malayi calpain family protein 1 0.0067 0.0099 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0033 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0506 0.1378 0.3019
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0059 0.0074 0.0162
Loa Loa (eye worm) hypothetical protein 0.1599 0.4566 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0251 0.0634 1
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.0274 0.4319
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0092 0.0171 0.0171
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0541 0.1482 0.1482
Schistosoma mansoni tyrosine kinase 0.0092 0.0171 0.0171
Brugia malayi Cathepsin L-like precursor 0.0033 0 0.0001
Echinococcus granulosus tyrosine protein kinase Lyn 0.0092 0.0173 0.0173
Brugia malayi hypothetical protein 0.0036 0.0008 0.0018
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0251 0.0634 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0136 0.1989
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0389 0.5701
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.001 0.001
Echinococcus multilocularis calpain A 0.0071 0.0109 0.0109
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0251 0.0634 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0017 0.0244
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0019 0.0042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0013 0.0549
Loa Loa (eye worm) latrophilin receptor protein 2 0.0506 0.1378 0.3019
Brugia malayi Protein kinase domain containing protein 0.0045 0.0033 0.0073
Echinococcus granulosus mixed lineage leukemia protein mll 0.0043 0.0028 0.0028
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0033 0.0518
Schistosoma mansoni tar DNA-binding protein 0.1034 0.292 0.292
Brugia malayi cell division control protein 2 homolog 0.0045 0.0033 0.0073
Echinococcus multilocularis tyrosine protein kinase Srms 0.0078 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0104 0.0205 0.2504
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0643 0.9437
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0541 0.1482 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0389 0.5701
Mycobacterium ulcerans putative regulatory protein 0.008 0.0136 0.0856
Schistosoma mansoni bromodomain containing protein 0.0778 0.2172 0.2172
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0076 0.0076
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.0205 0.8858
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0322 0.0843 0.0843
Entamoeba histolytica hypothetical protein 0.0044 0.003 0.1283
Schistosoma mansoni beta-mannosidase 0.0054 0.0061 0.0061
Schistosoma mansoni alpha-glucosidase 0.0146 0.033 0.033
Plasmodium vivax protein kinase Crk2 0.0045 0.0033 0.0222
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.0643 0.1409
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0033 0.0482
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0033 0.0033
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Brugia malayi protein-tyrosine kinase 0.0078 0.0131 0.0288
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0133 0.0291 0.0291
Echinococcus multilocularis calpain family protein 1, d 0.0047 0.0041 0.0041
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0033 0.0033
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0251 0.0634 0.9301
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0074 0.012 0.012
Echinococcus granulosus geminin 0.0866 0.2428 0.2428
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0231 0.1432
Echinococcus multilocularis expressed protein 0.0047 0.004 0.004
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0541 0.1482 0.1482
Trichomonas vaginalis helicase, putative 0.0039 0.0017 0.0244
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0043 0.0028 0.0028
Echinococcus multilocularis dnaJ subfamily B 0.2459 0.7073 0.7073
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Toxoplasma gondii hypothetical protein 0.008 0.0136 0.0915
Schistosoma mansoni zinc finger protein 0.0247 0.0625 0.0625
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.004 0.0266
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0047 0.0047
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0251 0.0634 0.0634
Schistosoma mansoni hypothetical protein 0.0506 0.1378 0.1378
Loa Loa (eye worm) hypothetical protein 0.008 0.0136 0.0298
Loa Loa (eye worm) glutaminase 2 0.0267 0.0682 0.1493
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0735 0.2045 0.2045
Echinococcus multilocularis geminin 0.0866 0.2428 0.2428
Onchocerca volvulus 0.0275 0.0706 0.8643
Brugia malayi PHD-finger family protein 0.0312 0.0814 0.1782
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0104 0.0205 0.0449
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.1254 0.1254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0092 0.0171 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0092 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0111 0.0226 0.0495
Brugia malayi Bromodomain containing protein 0.092 0.2587 0.5665
Loa Loa (eye worm) hypothetical protein 0.027 0.0691 0.1514
Onchocerca volvulus 0.0275 0.0706 0.8643
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.001 0.014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0355 0.0938 0.5959
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0284 0.073 0.073
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.011 0.0225 0.3449
Loa Loa (eye worm) hypothetical protein 0.0047 0.0041 0.009
Loa Loa (eye worm) histone methyltransferase 0.0053 0.0059 0.0129
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0231 0.1432
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Schistosoma mansoni cpg binding protein 0.0173 0.0406 0.0406
Brugia malayi jmjC domain containing protein 0.0057 0.0071 0.0155
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0544 0.7982
Brugia malayi TAR-binding protein 0.1034 0.292 0.6394
Loa Loa (eye worm) cysteine protease 0.0033 0 0.0001
Brugia malayi Cathepsin L-like precursor 0.0033 0 0.0001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.011 0.0225 0.3449
Echinococcus granulosus calpain A 0.0071 0.0109 0.0109
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.011 0.0225 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0415 0.6084
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0643 0.9437
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0211 0.0518 0.0518
Schistosoma mansoni cellular tumor antigen P53 0.0313 0.0817 0.0817
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.004 0.004
Trichomonas vaginalis glutaminase, putative 0.0267 0.0682 1
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0033 0.5
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.004 0.0266
Brugia malayi cytoplasmic intermediate filament protein 0.0148 0.0333 0.073
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.001 0.001
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.008 0.0136 0.0691
Echinococcus multilocularis tar DNA binding protein 0.1034 0.292 0.292
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0013 0.0013
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0033 0.0518
Schistosoma mansoni glutaminase 0.0267 0.0682 0.0682
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0013 0.0186
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0033 0.0518
Plasmodium falciparum thioredoxin reductase 0.0049 0.0047 0.0314
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0076 0.0449
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0071 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0544 0.7982
Echinococcus granulosus tar DNA binding protein 0.1034 0.292 0.292
Toxoplasma gondii hypothetical protein 0.0187 0.0447 0.3014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0231 0.1432
Schistosoma mansoni alpha-glucosidase 0.0146 0.033 0.033
Plasmodium vivax glutathione reductase, putative 0.0049 0.0047 0.0314
Plasmodium falciparum glutathione reductase 0.0049 0.0047 0.0314
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0019 0.0127
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0111 0.0226 0.0226
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0043 0.0028 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0017 0.0244
Entamoeba histolytica hypothetical protein 0.0112 0.0229 0.9899
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0506 0.1378 0.3019
Brugia malayi Isocitrate dehydrogenase 0.011 0.0225 0.0493
Schistosoma mansoni myst-related protein 0.0044 0.003 0.003
Echinococcus granulosus expressed protein 0.0047 0.004 0.004
Loa Loa (eye worm) PHD-finger family protein 0.025 0.0633 0.1387
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0033 0.0222
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0048 0.0044 0.0044
Brugia malayi SET domain containing protein 0.0037 0.001 0.0023
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0313 0.0817 0.1789
Brugia malayi latrophilin 2 splice variant baaae 0.1093 0.3091 0.6769
Brugia malayi glutaminase DH11.1 0.0267 0.0682 0.1493
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0076 0.051
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.004 0.0266
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0541 0.1482 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.011 0.0225 0.3548
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0 0.0001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0111 0.0226 0.0495
Schistosoma mansoni survival motor neuron protein 0.0101 0.0199 0.0199
Loa Loa (eye worm) TK protein kinase 0.0078 0.0131 0.0288
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0171 0.0401 0.5882
Schistosoma mansoni tar DNA-binding protein 0.1034 0.292 0.292
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0033 0.0073
Loa Loa (eye worm) hypothetical protein 0.0133 0.0291 0.0637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.0205 0.8858
Brugia malayi Tyrosine-protein kinase abl-1 0.0195 0.0471 0.1033
Echinococcus multilocularis tyrosine protein kinase HCK 0.0064 0.0091 0.0091
Echinococcus granulosus zinc finger protein 0.0247 0.0625 0.0625
Trypanosoma brucei glucosidase, putative 0.0038 0.0013 0.005
Schistosoma mansoni methyl-cpg binding protein mbd 0.0207 0.0507 0.0507
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0033 0.0482
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.0643 0.1409
Loa Loa (eye worm) hypothetical protein 0.0167 0.0391 0.0856
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0226 0.3308
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0033 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.009 0.0167 0.0167
Echinococcus multilocularis GPCR, family 2 0.0506 0.1378 0.1378
Trypanosoma brucei ISWI complex protein 0.0186 0.0445 0.6964
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.001 0.0064
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0033 0.0518
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0019 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0506 0.1378 0.1378
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0071 0.0071
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.001 0.014
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.008 0.0136 0.0691
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0643 0.9437
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.011 0.0225 0.0225
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0322 0.0843 0.1847
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0148 0.0333 0.073
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0071 0.0071
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0092 0.0171 0.0171
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0355 0.0938 0.6917
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0017 0.0244
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0092 0.0171 0.0171
Echinococcus multilocularis tumor protein p63 0.2141 0.6147 0.6147
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Brugia malayi HSF-type DNA-binding domain containing protein 0.0104 0.0205 0.0449
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0019 0.0127
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.011 0.0225 0.0225
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0033 0.1422
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0111 0.0226 0.0495
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0059 0.0074 0.0162
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0643 0.9437
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0322 0.0843 0.0843
Brugia malayi MH2 domain containing protein 0.0488 0.1325 0.2903
Schistosoma mansoni peptidase Clp (S14 family) 0.0541 0.1482 0.1482
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0415 0.6084
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0092 0.0171 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0389 0.5701
Brugia malayi CXXC zinc finger family protein 0.0173 0.0406 0.089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0274 0.4319
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0541 0.1482 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.001 0.015
Brugia malayi hypothetical protein 0.0036 0.0008 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0268 0.0982
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0013 0.0549
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0268 0.1716
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0506 0.1378 0.1378
Schistosoma mansoni tyrosine kinase 0.0092 0.0171 0.0171
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0229 0.0229
Schistosoma mansoni hypothetical protein 0.2459 0.7073 0.7073
Loa Loa (eye worm) bromodomain containing protein 0.0214 0.0528 0.1157
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0541 0.1482 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0043 0.0028 0.0028
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0226 0.3308
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0013 0.0186
Echinococcus granulosus tyrosine protein kinase Blk 0.0078 0.0131 0.0131
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0187 0.0447 0.3014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Schistosoma mansoni hypothetical protein 0.0506 0.1378 0.1378
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0033 0.0033
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0 0.0001
Echinococcus multilocularis lamin 0.0275 0.0706 0.0706
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0092 0.0171 0.0171
Onchocerca volvulus 0.0047 0.0041 0.0495
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Leishmania major cathepsin L-like protease 0.0127 0.0274 0.4319
Onchocerca volvulus Huntingtin homolog 0.0245 0.0618 0.7561
Loa Loa (eye worm) hypothetical protein 0.0245 0.0618 0.1353
Schistosoma mansoni hypothetical protein 0.0866 0.2428 0.2428
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0544 0.7982
Brugia malayi RNA binding protein 0.1034 0.292 0.6394
Trichomonas vaginalis beta-mannosidase, putative 0.0054 0.0061 0.0883
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0322 0.0843 0.1847
Echinococcus granulosus tyrosine protein kinase Fyn 0.0092 0.0171 0.0171
Schistosoma mansoni alpha glucosidase 0.0038 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0251 0.0634 0.9301
Echinococcus granulosus tyrosine protein kinase Src64B 0.0092 0.0171 0.0171
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0186
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0013 0.0085
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0187 0.0447 0.3014
Loa Loa (eye worm) hypothetical protein 0.0528 0.1441 0.3157
Loa Loa (eye worm) hypothetical protein 0.0541 0.1482 0.3245
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0171 0.0401 0.5882
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0076 0.0076
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0284 0.073 0.073
Echinococcus multilocularis lamin dm0 0.0275 0.0706 0.0706
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0171 0.0401 0.6325
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.011 0.0225 0.0225
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0251 0.0634 1
Loa Loa (eye worm) fibroinase 0.0033 0 0.0001
Brugia malayi Cathepsin L-like precursor 0.0033 0 0.0001
Leishmania major cathepsin L-like protease 0.0127 0.0274 0.4319
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0013 0.0029
Brugia malayi Cathepsin L-like precursor 0.0033 0 0.0001
Toxoplasma gondii isocitrate dehydrogenase 0.011 0.0225 0.1518
Echinococcus granulosus tyrosine protein kinase Fyn 0.0092 0.0171 0.0171
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.0399 0.0399
Plasmodium vivax hypothetical protein, conserved 0.008 0.0136 0.0915
Trichomonas vaginalis glycoside hydrolase, putative 0.0266 0.0679 0.9959
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0047 0.0103
Mycobacterium ulcerans glutaminase 0.0267 0.0682 0.4564
Brugia malayi isocitrate dehydrogenase 0.011 0.0225 0.0493
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0322 0.0843 0.0843
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.0399 0.0874
Mycobacterium tuberculosis Probable reductase 0.0113 0.0231 0.1432
Schistosoma mansoni hypothetical protein 0.0101 0.0199 0.0199
Echinococcus granulosus neuropeptide s receptor 0.0463 0.1254 0.1254
Onchocerca volvulus 0.0101 0.0199 0.2428
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.001 0.0413
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Brugia malayi F/Y-rich N-terminus family protein 0.0076 0.0124 0.0273
Schistosoma mansoni cpg binding protein 0.0206 0.0503 0.0503
Schistosoma mansoni hypothetical protein 0.025 0.0633 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0013 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0017 0.0244
Mycobacterium tuberculosis Possible exported protein 0.0491 0.1335 1
Onchocerca volvulus 0.0098 0.019 0.232
Loa Loa (eye worm) TAR-binding protein 0.1034 0.292 0.6394
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.001 0.014
Leishmania major hypothetical protein, conserved 0.0186 0.0445 0.701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Brugia malayi Intermediate filament tail domain containing protein 0.0275 0.0706 0.1547
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0541 0.1482 1
Echinococcus granulosus cpg binding protein 0.0206 0.0503 0.0503
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.004 0.0088
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0033 0.0518
Toxoplasma gondii GAF domain-containing protein 0.008 0.0136 0.0915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0322 0.0843 0.0843
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.004 0.0266
Schistosoma mansoni hypothetical protein 0.1093 0.3091 0.3091
Brugia malayi Tyrosine-protein kinase abl-1 0.0264 0.0672 0.1472
Echinococcus multilocularis cpg binding protein 0.0206 0.0503 0.0503
Toxoplasma gondii histone lysine methyltransferase SET1 0.0356 0.0941 0.6346
Loa Loa (eye worm) hypothetical protein 0.0062 0.0083 0.0182
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0274 0.4319
Brugia malayi Thioredoxin reductase 0.0049 0.0047 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0053 0.0059 0.0059
Echinococcus granulosus tumor protein p63 0.2141 0.6147 0.6147
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0207 0.0507 0.0507
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0541 0.1482 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0251 0.0634 0.0634
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0231 0.1432
Echinococcus multilocularis peptidase Clp (S14 family) 0.0355 0.0938 0.0938
Schistosoma mansoni hypothetical protein 0.0112 0.0229 0.0229
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0044 0.0032 0.007
Trypanosoma cruzi ISWI complex protein 0.0186 0.0445 0.701
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0076 0.0076
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Echinococcus granulosus tyrosine protein kinase ABL1 0.0445 0.1201 0.1201
Echinococcus granulosus histone lysine methyltransferase setb 0.0211 0.0518 0.0518
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0131 0.0131
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0186
Loa Loa (eye worm) MH2 domain-containing protein 0.0488 0.1325 0.2903
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0268 0.1716
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.011 0.0225 0.1518
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0506 0.1378 0.1378
Plasmodium falciparum zinc finger protein, putative 0.0044 0.003 0.02
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.011 0.0225 0.1384
Brugia malayi jmjC domain containing protein 0.009 0.0167 0.0366
Echinococcus multilocularis musashi 0.0275 0.0706 0.0706
Echinococcus granulosus tyrosine protein kinase HCK 0.0064 0.0091 0.0091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.011 0.0225 0.0225
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0019 0.0019
Loa Loa (eye worm) glutathione reductase 0.0049 0.0047 0.0103
Loa Loa (eye worm) ctsf protein 0.0033 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0128 0.0276 0.0604
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0274 0.4319
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0445 0.1201 0.1201
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0355 0.0938 0.6917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Brugia malayi Probable ClpP-like protease 0.0541 0.1482 0.3245
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.008 0.0136 0.0856
Echinococcus granulosus GPCR family 2 0.0506 0.1378 0.1378
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0076 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0076 0.0449
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0187 0.0447 0.2311
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.0399 0.0874
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.011 0.0225 0.0225
Schistosoma mansoni tyrosine kinase 0.0431 0.116 0.116
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0231 0.1432
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0071 0.0109 0.0109
Brugia malayi calpain family protein 1 0.0067 0.0099 0.0217
Echinococcus granulosus peptidase Clp S14 family 0.0355 0.0938 0.0938
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0033 0.0073
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0033 0.5
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.011 0.0225 0.3548
Plasmodium falciparum protein kinase 5 0.0045 0.0033 0.0222
Echinococcus granulosus dnaJ subfamily B 0.2459 0.7073 0.7073
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0251 0.0634 0.9301
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0186
Schistosoma mansoni hypothetical protein 0.0186 0.0445 0.0445
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0076 0.0449
Brugia malayi intermediate filament protein 0.0275 0.0706 0.1547
Schistosoma mansoni hypothetical protein 0.0506 0.1378 0.1378
Leishmania major cathepsin L-like protease 0.0127 0.0274 0.4319
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.1254 0.1254
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.1254 0.1254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0322 0.0843 0.0843
Brugia malayi Beta-glucuronidase precursor 0.0054 0.0061 0.0133
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0047 0.0735
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0033 0.0033
Schistosoma mansoni tar DNA-binding protein 0.1034 0.292 0.292
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0033 0.0033
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0251 0.0634 1
Loa Loa (eye worm) transcription factor SMAD2 0.0488 0.1325 0.2903
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0047 0.0314
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1599 0.4566 1
Loa Loa (eye worm) hypothetical protein 0.1093 0.3091 0.6769
Loa Loa (eye worm) hypothetical protein 0.0245 0.0618 0.1353
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2401 0.6903 0.6903
Loa Loa (eye worm) hypothetical protein 0.0495 0.1345 0.2946
Brugia malayi hypothetical protein 0.0245 0.0618 0.1353
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0541 0.1482 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.011 0.0225 0.1518
Echinococcus multilocularis zinc finger protein 0.0247 0.0625 0.0625
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0231 0.0709
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0643 0.9437
Entamoeba histolytica hypothetical protein 0.0112 0.0229 0.9899
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0389 0.5701
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0013 0.0013
Loa Loa (eye worm) isocitrate dehydrogenase 0.011 0.0225 0.0493
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0389 0.5701
Schistosoma mansoni microtubule-associated protein tau 0.3462 1 1
Schistosoma mansoni lamin 0.0275 0.0706 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0211 0.0518 0.0518
Entamoeba histolytica protein kinase, putative 0.0064 0.0091 0.3904
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.001 0.015
Toxoplasma gondii isocitrate dehydrogenase 0.011 0.0225 0.1518
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0389 0.5701
Schistosoma mansoni intermediate filament proteins 0.0275 0.0706 0.0706
Onchocerca volvulus 0.0313 0.0817 1
Schistosoma mansoni hypothetical protein 0.0866 0.2428 0.2428
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0033 0.0373
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0053 0.0059 0.0059
Brugia malayi hypothetical protein 0.0112 0.0229 0.0501
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0389 0.4756
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0195 0.3066
Echinococcus granulosus fetal alzheimer antigen falz 0.0284 0.073 0.073
Brugia malayi Cathepsin L-like precursor 0.0033 0 0.0001
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0047 0.0047
Loa Loa (eye worm) glutaminase 0.0267 0.0682 0.1493
Toxoplasma gondii hypothetical protein 0.008 0.0136 0.0915
Echinococcus granulosus tyrosine protein kinase Src42A 0.0074 0.012 0.012
Echinococcus granulosus survival motor neuron protein 1 0.0497 0.1353 0.1353
Trypanosoma cruzi ISWI complex protein 0.0186 0.0445 0.701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0033 0.0373
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0128 0.0276 0.0604
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1034 0.292 0.6394
Echinococcus granulosus tyrosine kinase 0.0078 0.0131 0.0131
Echinococcus granulosus lamin dm0 0.0275 0.0706 0.0706
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0013 0.0186
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0033 0.0518
Loa Loa (eye worm) hypothetical protein 0.0859 0.2407 0.5271
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0251 0.0634 0.9301
Schistosoma mansoni tar DNA-binding protein 0.1034 0.292 0.292
Loa Loa (eye worm) intermediate filament protein 0.0275 0.0706 0.1547
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0211 0.0518 0.0518
Brugia malayi hypothetical protein 0.0497 0.1353 0.2962
Entamoeba histolytica hypothetical protein 0.0112 0.0229 0.9899
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0076 0.1193
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0013 0.0029
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0092 0.0171 0.0171
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0109 0.0109
Schistosoma mansoni inositol monophosphatase 0.0037 0.001 0.001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0017 0.0244
Loa Loa (eye worm) TK protein kinase 0.0064 0.0091 0.0198
Onchocerca volvulus 0.0173 0.0406 0.4972
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0017 0.0244
Loa Loa (eye worm) calpain family protein 1 0.0067 0.0099 0.0217
Brugia malayi Papain family cysteine protease containing protein 0.0033 0 0.0001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0111 0.0226 0.3308
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0541 0.1482 1
Plasmodium falciparum GAF domain-related protein, putative 0.008 0.0136 0.0915
Schistosoma mansoni hypothetical protein 0.0506 0.1378 0.1378
Onchocerca volvulus 0.0037 0.001 0.0121
Schistosoma mansoni tar DNA-binding protein 0.1034 0.292 0.292
Echinococcus granulosus lysine specific demethylase 5A 0.009 0.0167 0.0167
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0092 0.0171 0.0171
Brugia malayi Bromodomain containing protein 0.0465 0.1259 0.2757
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.004 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.009 0.0167 0.0366
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0017 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0244
Loa Loa (eye worm) hypothetical protein 0.0067 0.0099 0.0217
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0071 0.0071
Loa Loa (eye worm) beta-glucuronidase 0.0054 0.0061 0.0133
Echinococcus multilocularis microtubule associated protein 2 0.3462 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0366 0.0971 0.0971
Schistosoma mansoni methyl-cpg binding protein mbd 0.0207 0.0507 0.0507
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0033 0.0482
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0019 0.0127
Loa Loa (eye worm) hypothetical protein 0.0275 0.0706 0.1547
Loa Loa (eye worm) hypothetical protein 0.0466 0.1261 0.2762
Entamoeba histolytica beta-galactosidase, putative 0.0113 0.0231 1
Schistosoma mansoni hypothetical protein 0.004 0.0019 0.0019
Brugia malayi glutathione reductase 0.0049 0.0047 0.0103
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0541 0.1482 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0275 0.0706 0.1547
Echinococcus multilocularis tyrosine protein kinase Abl 0.0195 0.0471 0.0471
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.001 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0322 0.0843 0.0843
Brugia malayi Cathepsin L-like precursor 0.0033 0 0.0001
Schistosoma mansoni zinc finger protein 0.0186 0.0445 0.0445
Echinococcus granulosus intermediate filament protein 0.0275 0.0706 0.0706
Brugia malayi manba-prov protein 0.0054 0.0061 0.0133
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0268 0.1716
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0436 0.1175 0.1175
Loa Loa (eye worm) hypothetical protein 0.0211 0.0518 0.1134
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0048 0.0044 0.0044
Trypanosoma brucei trypanothione reductase 0.0049 0.0047 0.0593
Entamoeba histolytica hypothetical protein 0.0112 0.0229 0.9899
Onchocerca volvulus Huntingtin homolog 0.0245 0.0618 0.7561
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.0242 0.3811
Schistosoma mansoni inositol monophosphatase 0.0037 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0506 0.1378 0.3019
Schistosoma mansoni jumonji/arid domain-containing protein 0.009 0.0167 0.0167
Echinococcus multilocularis tyrosine protein kinase Blk 0.0078 0.0131 0.0131
Schistosoma mansoni bromodomain containing protein 0.0062 0.0083 0.0083
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1599 0.4566 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0013 0.02
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0099 0.0099
Loa Loa (eye worm) inositol-1 0.0037 0.001 0.0022
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0541 0.1482 0.5
Brugia malayi RNA recognition motif domain containing protein 0.1034 0.292 0.6394
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Schistosoma mansoni myst-related protein 0.0044 0.003 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0322 0.0843 0.0843
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0076 0.0076
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0251 0.0634 1
Trichomonas vaginalis beta-galactosidase, putative 0.0167 0.0389 0.57
Echinococcus multilocularis survival motor neuron protein 1 0.0497 0.1353 0.1353
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0013 0.02
Loa Loa (eye worm) RNA binding protein 0.1034 0.292 0.6394
Brugia malayi Calcitonin receptor-like protein seb-1 0.1599 0.4566 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0207 0.0507 0.0507
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0092 0.0171 0.0171
Leishmania major trypanothione reductase 0.0049 0.0047 0.0735
Toxoplasma gondii thioredoxin reductase 0.0049 0.0047 0.0314
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0643 0.9437
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0133 0.0291 0.0291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0274 0.4233
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0186
Schistosoma mansoni SET domain protein 0.0037 0.001 0.001
Brugia malayi SRC-1 0.0092 0.0171 0.0375
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0017 0.0244
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0399 0.0399
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.011 0.0225 0.3548
Echinococcus granulosus tyrosine protein kinase Src42A 0.0092 0.0171 0.0171
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0111 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0067 0.0099 0.0217
Schistosoma mansoni hypothetical protein 0.0158 0.0364 0.0364
Loa Loa (eye worm) TK/ABL protein kinase 0.0445 0.1201 0.2629
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0186
Schistosoma mansoni lamin 0.0275 0.0706 0.0706
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.0205 0.8858
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0078 0.0131 0.0131
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0111 0.0226 0.0226
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0092 0.0171 0.0171
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0033 0.0073
Echinococcus granulosus tyrosine protein kinase Fyn 0.0092 0.0171 0.0171
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0735 0.2045 0.2045
Loa Loa (eye worm) CXXC zinc finger family protein 0.0173 0.0406 0.089
Loa Loa (eye worm) hypothetical protein 0.0033 0 0.0001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0541 0.1482 1
Echinococcus multilocularis isocitrate dehydrogenase 0.011 0.0225 0.0225
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0033 0.0033
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0033 0.1422
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0019 0.0042
Toxoplasma gondii hypothetical protein 0.022 0.0544 0.3671
Echinococcus granulosus lamin 0.0275 0.0706 0.0706
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0251 0.0634 0.9301
Mycobacterium ulcerans putative regulatory protein 0.008 0.0136 0.0856
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0389 0.5701
Loa Loa (eye worm) calpain family protein 1 0.0047 0.0041 0.009
Brugia malayi Inositol-1 0.0037 0.001 0.0022
Schistosoma mansoni cpg binding protein 0.0206 0.0503 0.0503
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0506 0.1378 0.1378
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0013 0.0186
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0199 0.0435
Loa Loa (eye worm) hypothetical protein 0.0497 0.1353 0.2962
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0436 0.1175 0.1175
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0028 0.0028
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0229 0.0229
Loa Loa (eye worm) SRC-1 0.0092 0.0171 0.0375
Loa Loa (eye worm) hypothetical protein 0.0047 0.0041 0.009

Activities

Activity type Activity value Assay description Source Reference
DSB (binding) = 42 Double strand DNA breakage reflecting stabilization of DNA topoisomerase II intermediate by the compound expressed in terms of ng of DNA/unit of enzyme/mM of drug ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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