Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Platelet activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.2971 | 0.1977 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.5986 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.2971 | 0.1977 | 0.1977 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5986 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.5986 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5986 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5986 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3759 | 0.4073 | 0.4073 |
Plasmodium vivax | adenosine deaminase, putative | 0.5986 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2971 | 0.1977 | 0.5 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.2971 | 0.1977 | 0.1977 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2971 | 0.1977 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5986 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.5986 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2971 | 0.1977 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3759 | 0.4073 | 0.4073 |
Loa Loa (eye worm) | hypothetical protein | 0.3759 | 0.4073 | 0.4073 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5986 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2971 | 0.1977 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2971 | 0.1977 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.5986 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.5986 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5986 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2971 | 0.1977 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.2971 | 0.1977 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.3759 | 0.4073 | 0.4073 |
Loa Loa (eye worm) | AMP deaminase | 0.2971 | 0.1977 | 0.1977 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.2971 | 0.1977 | 0.1977 |
Echinococcus granulosus | adenosine deaminase | 0.5986 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.5986 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5986 | 1 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.2971 | 0.1977 | 0.1977 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.5986 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.5986 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2971 | 0.1977 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.5986 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2971 | 0.1977 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.5986 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2971 | 0.1977 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2971 | 0.1977 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0027 uM | Concentration of the compound tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%. | ChEMBL. | 1433215 |
IC50 (functional) | = 0.0027 uM | Concentration of the compound tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%. | ChEMBL. | 1433215 |
ID50 (functional) | = 0.061 mg kg-1 | Dose required to inhibit PAF-induced hypotension(PAF-Antagonistic activity) in normotensive rats by 50%. | ChEMBL. | 1433215 |
ID50 (functional) | = 0.061 mg kg-1 | Dose required to inhibit PAF-induced hypotension(PAF-Antagonistic activity) in normotensive rats by 50%. | ChEMBL. | 1433215 |
ID50 (functional) | = 7.7 mg kg-1 | Oral dose required to inhibit PAF-induced mortality(PAF-Antagonistic activity)in mice by 50%. | ChEMBL. | 1433215 |
ID50 (functional) | = 7.7 mg kg-1 | Oral dose required to inhibit PAF-induced mortality(PAF-Antagonistic activity)in mice by 50%. | ChEMBL. | 1433215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.