Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2706 | 0.4411 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3232 | 0.5589 | 0.5589 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.2706 | 0.4411 | 0.2279 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5201 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5201 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.5201 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.5201 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5201 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.5201 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3232 | 0.5589 | 0.5589 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.5201 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.2706 | 0.4411 | 0.2279 |
Loa Loa (eye worm) | hypothetical protein | 0.5201 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.2706 | 0.4411 | 0.4411 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.5201 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.5201 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.2706 | 0.4411 | 0.2279 |
Trypanosoma brucei | AMP deaminase, putative | 0.2706 | 0.4411 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.2706 | 0.4411 | 0.2279 |
Echinococcus multilocularis | adenosine deaminase | 0.5201 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.5201 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1969 | 0.2762 | 0.2762 |
Trypanosoma brucei | AMP deaminase, putative | 0.2706 | 0.4411 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3232 | 0.5589 | 0.5589 |
Trypanosoma brucei | AMP deaminase, putative | 0.2706 | 0.4411 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.5201 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5201 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.2706 | 0.4411 | 0.2279 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2706 | 0.4411 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2706 | 0.4411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3232 | 0.5589 | 0.5589 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5201 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 390 nM | Displacement of [3H]WIN35,428 from Dopamine Transporter of guinea pig striatal membrane | ChEMBL. | 12213053 |
IC50 (binding) | = 390 nM | Displacement of [3H]WIN35,428 from Dopamine Transporter of guinea pig striatal membrane | ChEMBL. | 12213053 |
Ratio (functional) | = 0.1 | Ratio of the IC50 value of Mazindol to that of the compound. | ChEMBL. | 12213053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.