Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosylhomocysteinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0233 | 0.3739 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0233 | 0.3739 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0233 | 0.3739 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0233 | 0.3739 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0233 | 0.3739 | 0.3739 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0233 | 0.3739 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0233 | 0.3739 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0233 | 0.3739 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.1745 | 0.4667 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0089 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.01 | 0.0279 | 0.0279 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0201 | 0.2908 | 0.7777 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0156 | 0.1745 | 0.4667 |
Schistosoma mansoni | immunophilin | 0.0233 | 0.3739 | 0.3739 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0156 | 0.1745 | 1 |
Schistosoma mansoni | immunophilin | 0.0233 | 0.3739 | 0.3739 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0156 | 0.1745 | 0.4667 |
Trypanosoma brucei | ingi protein (ORF1) | 0.01 | 0.0279 | 0.0279 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0233 | 0.3739 | 0.3739 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.1745 | 0.4667 |
Trypanosoma brucei | unspecified product | 0.01 | 0.0279 | 0.0279 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0233 | 0.3739 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0233 | 0.3739 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0233 | 0.3739 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0233 | 0.3739 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0156 | 0.1745 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0233 | 0.3739 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.01 | 0.0279 | 0.0279 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.0203 | 0.0203 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.1745 | 0.4667 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0089 | 0 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0233 | 0.3739 | 1 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0156 | 0.1745 | 0.5 |
Brugia malayi | Adenosylhomocysteinase | 0.0156 | 0.1745 | 0.4667 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0233 | 0.3739 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0233 | 0.3739 | 1 |
Schistosoma mansoni | immunophilin | 0.0201 | 0.2908 | 0.2908 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0233 | 0.3739 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0233 | 0.3739 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.1745 | 0.1745 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0233 | 0.3739 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.0203 | 0.0203 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0233 | 0.3739 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.01 | 0.0279 | 0.0279 |
Leishmania major | fk506-binding protein 1-like protein | 0.0233 | 0.3739 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0201 | 0.2908 | 0.7777 |
Echinococcus multilocularis | fk506 binding protein | 0.0233 | 0.3739 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0233 | 0.3739 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.0203 | 0.0203 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0233 | 0.3739 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0233 | 0.3739 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0156 | 0.1745 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0475 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0233 | 0.3739 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.0203 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2908 | 0.5831 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0233 | 0.3739 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0156 | 0.1745 | 0.4667 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0233 | 0.3739 | 0.3739 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.1745 | 0.4667 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0156 | 0.1745 | 0.1745 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.018 uM | Tested for inhibitory concentration of the compound against S-adenosylhomocysteine hydrolase | ChEMBL. | No reference |
MIC (functional) | = 0.3 ug ml-1 | Evaluation for antiviral activity against vaccinia virus in primary rabbit kidney cell culture | ChEMBL. | 3027326 |
MIC (functional) | = 20 ug ml-1 | Evaluation for antiviral activity against vesion stomatitis virus in primary rabbit kidney cell culture | ChEMBL. | 3027326 |
MIC (functional) | = 200 ug ml-1 | Evaluation for antiviral activity against herpes simplex virus type 1 (strain KOS) in primary rabbit kidney cell culture | ChEMBL. | 3027326 |
MIC (functional) | >= 400 ug ml-1 | Evaluation for antiviral activity against herpes simplex virus type 2 (strain G) in primary rabbit kidney cell culture | ChEMBL. | 3027326 |
Min cytotoxic concentration (functional) | > 400 ug ml-1 | Evaluation for antiviral activity in primary rabbit kidney cell culture | ChEMBL. | 3027326 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.