Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | adenosine deaminase, putative | 0.3478 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.3478 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3478 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3478 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.3478 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3478 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.223 | 0.3502 | 0.3502 |
Echinococcus granulosus | adenosine deaminase | 0.3478 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3478 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1557 | 0 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3478 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1557 | 0 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.3478 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.3478 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.1557 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.3478 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3478 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1557 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.223 | 0.3502 | 0.3502 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1557 | 0 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3478 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.3478 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1557 | 0 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.3478 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1557 | 0 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.3478 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.223 | 0.3502 | 0.3502 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.3478 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.223 | 0.3502 | 0.3502 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1557 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1557 | 0 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.3478 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1557 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1557 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.22 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.22 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.25 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.25 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.25 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.25 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 3.9 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 3.9 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 4.4 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 4.4 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 5.6 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 5.6 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 8.8 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 8.8 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 25 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 25 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 50 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 50 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.