Detailed information for compound 228024

Basic information

Technical information
  • TDR Targets ID: 228024
  • Name: (2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amin o]-3-phenylpropanamide
  • MW: 251.282 | Formula: C12H17N3O3
  • H donors: 4 H acceptors: 3 LogP: -1.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)N
  • InChi: 1S/C12H17N3O3/c13-9(7-16)12(18)15-10(11(14)17)6-8-4-2-1-3-5-8/h1-5,9-10,16H,6-7,13H2,(H2,14,17)(H,15,18)/t9-,10-/m0/s1
  • InChiKey: UAUGDEYUYGSDKN-UWVGGRQHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[[(2S)-2-amino-3-hydroxy-propanoyl]amino]-3-phenyl-propanamide
  • (2S)-2-[[(2S)-2-amino-3-hydroxy-1-oxopropyl]amino]-3-phenylpropanamide
  • (2S)-2-[[(2S)-2-azanyl-3-hydroxy-propanoyl]amino]-3-phenyl-propanamide
  • (2S)-2-[[(2S)-2-amino-3-hydroxy-propanoyl]amino]-3-phenyl-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0062 0.0576 0.0576
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0572 0.0572
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1121 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0117 0.1415 0.1415
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0265 0.0265
Trypanosoma brucei NADH dehydrogenase 0.0062 0.0576 0.0576
Entamoeba histolytica thioredoxin reductase, putative 0.0062 0.0576 0.5138
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0062 0.0576 0.0576
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0062 0.0576 0.0576
Treponema pallidum NADH oxidase 0.0234 0.3218 1
Trypanosoma cruzi trypanothione reductase, putative 0.0234 0.3218 0.3218
Plasmodium falciparum thioredoxin reductase 0.0677 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0576 0.1789
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0234 0.3218 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0234 0.3218 0.3218
Echinococcus granulosus phd:f box containing protein 0.0031 0.01 0.01
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0234 0.3218 0.3218
Brugia malayi jmjC domain containing protein 0.0031 0.01 0.01
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0062 0.0576 0.5138
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.01 0.01
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0572 0.0572
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0301 0.0301
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0234 0.3218 0.3218
Echinococcus granulosus lysine specific demethylase 5A 0.0117 0.1415 0.1415
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0576 0.0576
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0576 0.1789
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0062 0.0576 0.0576
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.038 0.038
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.01 0.01
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0062 0.0576 0.0016
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0234 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0062 0.0576 0.0576
Schistosoma mansoni jumonji/arid domain-containing protein 0.0117 0.1415 0.1415
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0234 0.3218 1
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0062 0.0576 0.0016
Trichomonas vaginalis apoptosis inducing factor, putative 0.0062 0.0576 0.1789
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0062 0.0576 0.0576
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0062 0.0576 0.0576
Brugia malayi Fli-1 protein 0.0218 0.2969 0.2969
Toxoplasma gondii NADPH-glutathione reductase 0.0234 0.3218 0.3218
Schistosoma mansoni protein phosphatase 2C 0.0031 0.01 0.01
Trypanosoma cruzi NADH dehydrogenase, putative 0.0062 0.0576 0.0576
Schistosoma mansoni ets-related 0.0218 0.2969 0.2969
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.0576 0.1789
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0062 0.0576 0.1789
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0234 0.3218 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0172 0.2263 0.2263
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0062 0.0576 0.0576
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0301 0.0301
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0234 0.3218 0.2807
Loa Loa (eye worm) hypothetical protein 0.0034 0.014 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0576 0.0576
Plasmodium vivax thioredoxin reductase, putative 0.0677 1 1
Loa Loa (eye worm) programmed cell death 8 0.0062 0.0576 0.0576
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0234 0.3218 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0062 0.0576 0.0005
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.01 0.01
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0576 0.1789
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0062 0.0576 0.0576
Trypanosoma cruzi trypanothione reductase, putative 0.0677 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0234 0.3218 0.3218
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0234 0.3218 0.3218
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1121 0.1121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.038 0.038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.3218 0.3218
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0572 0.0572
Schistosoma mansoni jumonji/arid domain-containing protein 0.0117 0.1415 0.1415
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0062 0.0576 0.0576
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0301 0.0301
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0062 0.0576 0.0576
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0062 0.0576 0.0576
Schistosoma mansoni hypothetical protein 0.004 0.0241 0.0241
Schistosoma mansoni sulfide quinone reductase 0.0062 0.0576 0.0576
Mycobacterium ulcerans NADH dehydrogenase 0.0062 0.0576 0.0016
Brugia malayi Ets-domain containing protein 0.0072 0.0724 0.0724
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.01 0.01
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0062 0.0576 0.0576
Brugia malayi Thioredoxin reductase 0.0677 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0572 0.0572
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0234 0.3218 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0576 0.1789
Brugia malayi Ets-domain containing protein 0.0072 0.0724 0.0724
Mycobacterium ulcerans glutamate synthase subunit beta 0.0062 0.0576 0.0016
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0724 0.0724
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0062 0.0576 0.0576
Brugia malayi jmjC domain containing protein 0.0031 0.01 0.01
Trichomonas vaginalis glutathione reductase, putative 0.0234 0.3218 1
Brugia malayi Muscleblind-like protein 0.0145 0.184 0.184
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0062 0.0576 0.0576
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0061 0.0564 0.0564
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1144 0.1144
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.01 0.01
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0062 0.0576 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.1415 0.1415
Mycobacterium ulcerans ferredoxin reductase 0.0062 0.0576 0.0016
Brugia malayi jmjC domain containing protein 0.0031 0.01 0.01
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0234 0.3218 0.3218
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0234 0.3218 0.3218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0301 0.0301
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0234 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0145 0.184 0.184
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.01 0.01
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0062 0.0576 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0301 0.0301
Brugia malayi CHE-14 protein 0.0042 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0098 0.1121 0.1121
Schistosoma mansoni phd/f-box containing protein 0.0031 0.01 0.01
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.01 0.01
Mycobacterium ulcerans hypothetical protein 0.0062 0.0576 0.0016
Toxoplasma gondii thioredoxin reductase 0.0677 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0265 0.0265
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0062 0.0576 0.5138
Onchocerca volvulus 0.0062 0.0576 0.5
Schistosoma mansoni gabp alpha 0.0072 0.0724 0.0724
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0062 0.0576 0.0016
Toxoplasma gondii selenide, water dikinase 0.0062 0.0576 0.0576
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0062 0.0576 0.0016
Echinococcus multilocularis lysine specific demethylase 5A 0.0117 0.1415 0.1415
Echinococcus multilocularis protein patched 0.0042 0.0265 0.0265
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0265 0.0265
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0062 0.0576 0.5138
Echinococcus granulosus thioredoxin glutathione reductase 0.0677 1 1
Giardia lamblia Glutamate synthase 0.0062 0.0576 0.1789
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0234 0.3218 0.3218
Leishmania major hypothetical protein, conserved 0.0062 0.0576 0.0576
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0234 0.3218 0.3218
Plasmodium vivax JmjC domain containing protein 0.0031 0.01 0.01
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0062 0.0576 0.1789
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0062 0.0576 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.01 0.01
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.0576 0.1789
Echinococcus granulosus geminin 0.0164 0.2139 0.2139
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0576 0.1789
Brugia malayi jmjC domain containing protein 0.0031 0.01 0.01
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0062 0.0576 0.0576
Brugia malayi glutamate synthase 0.0062 0.0576 0.0576
Trichomonas vaginalis glutamate synthase, putative 0.0062 0.0576 0.1789
Loa Loa (eye worm) fli-1 protein 0.0218 0.2969 0.2969
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0234 0.3218 0.3218
Schistosoma mansoni jumonji domain containing protein 0.0031 0.01 0.01
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1764 0.1764
Trichomonas vaginalis glutamate synthase, putative 0.0062 0.0576 0.1789
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1121 0.1121
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0062 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.01
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0301 0.0301
Echinococcus multilocularis protein dispatched 1 0.0048 0.0355 0.0355
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0062 0.0576 0.1789
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.01 0.01
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.01 0.01
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0062 0.0576 0.0576
Mycobacterium ulcerans dehydrogenase 0.0062 0.0576 0.0016
Schistosoma mansoni glutamate synthase 0.0062 0.0576 0.0576
Schistosoma mansoni jumonji domain containing protein 0.0117 0.1415 0.1415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0301 0.0301
Plasmodium falciparum ferrodoxin reductase-like protein 0.0062 0.0576 0.0576
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0062 0.0576 0.0576
Plasmodium vivax glutathione reductase, putative 0.0677 1 1
Brugia malayi jmjC domain containing protein 0.0117 0.1415 0.1415
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0572 0.0572
Mycobacterium tuberculosis Probable reductase 0.0062 0.0576 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.038 0.038
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0117 0.1415 0.1415
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0062 0.0576 0.0016
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0062 0.0576 0.0005
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1764 0.1764
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0576 0.1789
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0062 0.0576 0.0576
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.01 0.01
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0234 0.3218 0.3218
Leishmania major hypothetical protein, conserved 0.0062 0.0576 0.0576
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0062 0.0576 0.0576
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0234 0.3218 0.3218
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0576 0.0576
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0062 0.0576 0.0576
Schistosoma mansoni hypothetical protein 0.0034 0.014 0.014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.3218 0.3218
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0062 0.0576 0.0576
Echinococcus granulosus expressed conserved protein 0.0092 0.103 0.103
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0062 0.0576 0.0576
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0301 0.0301
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0234 0.3218 0.3218
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0062 0.0576 0.0005
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1121 0.1121
Leishmania major hypothetical protein, conserved 0.0062 0.0576 0.0576
Plasmodium falciparum glutathione reductase 0.0677 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0234 0.3218 1
Leishmania major hypothetical protein, conserved 0.0031 0.01 0.01
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0062 0.0576 0.0576
Giardia lamblia NADH oxidase lateral transfer candidate 0.0234 0.3218 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0172 0.2263 0.2263
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0062 0.0576 0.0576
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0062 0.0576 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.01
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0062 0.0576 0.0576
Schistosoma mansoni hypothetical protein 0.004 0.0241 0.0241
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0062 0.0576 0.0576
Schistosoma mansoni hypothetical protein 0.0164 0.2139 0.2139
Echinococcus multilocularis phd:f box containing protein 0.0031 0.01 0.01
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0234 0.3218 0.3218
Schistosoma mansoni hypothetical protein 0.004 0.0241 0.0241
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.01 0.01
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0062 0.0576 0.0576
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0234 0.3218 0.3218
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0265 0.0265
Schistosoma mansoni sulfide quinone reductase 0.0062 0.0576 0.0576
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0062 0.0576 0.0016
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0062 0.0576 0.5138
Leishmania major NADH dehydrogenase, putative 0.0062 0.0576 0.0576
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0234 0.3218 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0062 0.0576 0.0005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0062 0.0576 0.0005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0234 0.3218 0.2807
Mycobacterium tuberculosis Probable oxidoreductase 0.0234 0.3218 0.2807
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.3218 0.3218
Brugia malayi jmjC domain containing protein 0.0117 0.1415 0.1415
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0265 0.0265
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.01 0.01
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0234 0.3218 0.3218
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.01 0.01
Echinococcus multilocularis glutamate synthase 0.0062 0.0576 0.0576
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0062 0.0576 0.0576
Trypanosoma cruzi NADH dehydrogenase, putative 0.0062 0.0576 0.0576
Leishmania major trypanothione reductase 0.0677 1 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0062 0.0576 0.5138
Echinococcus multilocularis muscleblind protein 1 0.0145 0.184 0.184
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.014 0.014
Echinococcus multilocularis geminin 0.0164 0.2139 0.2139
Schistosoma mansoni patched 1 0.0042 0.0265 0.0265
Trichomonas vaginalis mercuric reductase, putative 0.0234 0.3218 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0062 0.0576 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0572 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0265 0.0822
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0301 0.0301
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0062 0.0576 0.0576
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.3218 0.3218
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0062 0.0576 0.0576
Entamoeba histolytica disulphide oxidoreductase, putative 0.0062 0.0576 0.5138
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0062 0.0576 0.0576
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0062 0.0576 0.0016
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.01 0.01
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0724 0.0724
Plasmodium vivax ferrodoxin reductase, putative 0.0062 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.01
Plasmodium falciparum glutathione reductase 0.0234 0.3218 0.3218
Echinococcus multilocularis expressed conserved protein 0.0092 0.103 0.103
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0062 0.0576 0.0005
Schistosoma mansoni disulfide oxidoreductase 0.0062 0.0576 0.0576
Echinococcus granulosus muscleblind protein 0.0145 0.184 0.184
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0062 0.0576 0.0576
Echinococcus multilocularis thioredoxin glutathione reductase 0.0677 1 1
Schistosoma mansoni glutamate synthase 0.0062 0.0576 0.0576
Echinococcus granulosus glutamate synthase 0.0062 0.0576 0.0576
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.3218 0.3218
Plasmodium falciparum thioredoxin reductase 0.0234 0.3218 0.3218
Loa Loa (eye worm) thioredoxin reductase 0.0677 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0409 0.0409
Loa Loa (eye worm) glutathione reductase 0.0677 1 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0062 0.0576 0.0576
Mycobacterium ulcerans monoxygenase 0.0062 0.0576 0.0016
Schistosoma mansoni hypothetical protein 0.004 0.0241 0.0241
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.01 0.01
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0724 0.0724
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0234 0.3218 0.2807
Trypanosoma brucei trypanothione reductase 0.0677 1 1
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0062 0.0576 0.0576
Schistosoma mansoni hypothetical protein 0.0164 0.2139 0.2139
Schistosoma mansoni glutamate synthase 0.0062 0.0576 0.0576
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0677 1 1
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0062 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0145 0.184 0.184
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0062 0.0576 0.0576
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0234 0.3218 0.3218
Giardia lamblia Thioredoxin reductase 0.0062 0.0576 0.1789
Loa Loa (eye worm) hypothetical protein 0.0049 0.038 0.038
Echinococcus multilocularis muscleblind protein 0.0145 0.184 0.184
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.01 0.01

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 800 uM Evaluated for the activation of human thrombin receptor measured by platelet aggregation ChEMBL. 7562949
EC50 (functional) > 800 uM Evaluated for the activation of human thrombin receptor measured by platelet aggregation ChEMBL. 7562949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.