Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 207 aa | 30.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0126 | 0.4176 | 0.3586 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.0126 | 0.4183 | 0.5 | |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2486 | 0.1724 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0816 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0126 | 0.4183 | 0.1261 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0105 | 0.2618 | 0.187 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0816 | 1 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0115 | 0.3344 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0126 | 0.4176 | 0.125 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0816 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0115 | 0.3344 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 1 | 1 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0115 | 0.3344 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0126 | 0.4183 | 0.1261 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0126 | 0.4176 | 0.125 |
Brugia malayi | Peptidase family M1 containing protein | 0.0126 | 0.4183 | 0.2267 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0816 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.011 uM | Median-effective concentration for inhibition of human HL-60 cell growth at 72 h | ChEMBL. | 3373490 |
ED50 (functional) | = 0.011 uM | Median-effective concentration for inhibition of human HL-60 cell growth at 72 h | ChEMBL. | 3373490 |
ED50 (functional) | = 2 uM | Median-effective concentration for inhibition of human HL-60 cell growth at 48 h | ChEMBL. | 3373490 |
ED50 (functional) | = 2 uM | Median-effective concentration for inhibition of human HL-60 cell growth at 48 h | ChEMBL. | 3373490 |
ED50 (functional) | = 123 uM | Inhibition of [6-3H]-dUrd incorporation into DNA in HL-60 cells | ChEMBL. | 3373490 |
ED50 (functional) | = 123 uM | Inhibition of [6-3H]-dUrd incorporation into DNA in HL-60 cells | ChEMBL. | 3373490 |
ED50 (functional) | = 144 uM | Median-effective concentration for inhibition of human HL-60 cell growth at 24 h | ChEMBL. | 3373490 |
ED50 (functional) | = 144 uM | Median-effective concentration for inhibition of human HL-60 cell growth at 24 h | ChEMBL. | 3373490 |
IC50 (functional) | = 0.08 uM | Inhibition of cell growth of murine L-1210 cells | ChEMBL. | 3373490 |
IC50 (functional) | = 0.08 uM | Inhibition of cell growth of murine L-1210 cells | ChEMBL. | 3373490 |
Inhibition (functional) | = 4.7 % | Compound was evaluated for inhibition of human HL-60 cell growth at 1 (microM) at 24 hr | ChEMBL. | 3373490 |
Inhibition (functional) | = 4.7 % | Compound was evaluated for inhibition of human HL-60 cell growth at 1 (microM) at 24 hr | ChEMBL. | 3373490 |
Inhibition (functional) | = 32.5 % | Compound was evaluated for inhibition of human HL-60 cell growth at 1 (microM) at 48 hr | ChEMBL. | 3373490 |
Inhibition (functional) | = 32.5 % | Compound was evaluated for inhibition of human HL-60 cell growth at 1 (microM) at 48 hr | ChEMBL. | 3373490 |
Inhibition (functional) | = 77.6 % | Compound was evaluated for inhibition of human HL-60 cell growth at 1 (microM) at 72 hr | ChEMBL. | 3373490 |
Inhibition (functional) | = 77.6 % | Compound was evaluated for inhibition of human HL-60 cell growth at 1 (microM) at 72 hr | ChEMBL. | 3373490 |
Ki (binding) | > 0.000004 uM | Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cells | ChEMBL. | 3373490 |
Ki (binding) | > 0.000004 uM | Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cells | ChEMBL. | 3373490 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 3373490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.