TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 527.533 | Formula: C25H32F3N3O6
H donors: 2 H acceptors: 5 LogP: 2.92 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)CCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)Cc1ccccc1)C(C)C
InChi: 1S/C25H32F3N3O6/c1-15(2)21(30-19(32)11-12-20(33)37-3)24(36)31-13-7-10-18(31)23(35)29-17(22(34)25(26,27)28)14-16-8-5-4-6-9-16/h4-6,8-9,15,17-18,21H,7,10-14H2,1-3H3,(H,29,35)(H,30,32)/t17-,18-,21-/m0/s1
InChiKey: RIOLEFSSMJYZOS-WFXMLNOXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin G	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	cercarial elastase (S01 family)	cathepsin G	255 aa	209 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0081	0.0081
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0024	0.0004	0.0005
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0029	0.0037
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0054	0.0064	0.0064
Trypanosoma cruzi	AMP deaminase, putative	0.3901	0.7683	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0029	0.0029
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0045	0.0046	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0044	0.0044
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0045	0.0046	0.0018
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.5071	1	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.004	0.0037	0.0037
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0068	0.0091	0.0091
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0044	0.0044
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0029	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0012	0.0012
Onchocerca volvulus		0.0054	0.0064	0.0061
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0044	0.0044
Brugia malayi	Importin beta-1 subunit	0.0028	0.0012	0.0012
Toxoplasma gondii	aminopeptidase N, putative	0.0024	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0054	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0297	0.0546	0.0546
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0044	0.0044
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0064	0.0064
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0024	0.0004	0.0004
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0054	0.0064	0.0064
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0044	0.0044
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0064	0.0064
Trypanosoma cruzi	aminopeptidase, putative	0.0068	0.0091	0.0119
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0068	0.0091	0.0119
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0054	0.0064	0.0064
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0054	0.0064	0.0064
Schistosoma mansoni	AMP deaminase	0.3901	0.7683	0.7683
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Trypanosoma brucei	AMP deaminase, putative	0.3901	0.7683	1
Trypanosoma cruzi	AMP deaminase, putative	0.3901	0.7683	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0054	0.0064	0.0064
Brugia malayi	neuropeptide F receptor	0.0054	0.0064	0.0064
Entamoeba histolytica	hypothetical protein, conserved	0.0178	0.031	0.031
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0054	0.0064	0.0064
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0041	0.0041
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0068	0.0091	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.0416	0.0389
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0054	0.0064	0.0061
Onchocerca volvulus		0.0054	0.0064	0.0061
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0054	0.0064	0.0064
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0045	0.0046	0.0046
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	opsin-like receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0054	0.0064	0.0064
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0045	0.0046	0.0042
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0045	0.0046	0.0046
Trypanosoma cruzi	AMP deaminase, putative	0.3901	0.7683	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	TYRA-2 protein	0.0054	0.0064	0.0064
Brugia malayi	Dopamine receptor protein 1	0.0054	0.0064	0.0064
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Echinococcus multilocularis	muscleblind protein	0.0145	0.0243	0.0243
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0064	0.0064
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0045	0.0046	0.0046
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0044	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0054	0.0064	0.0061
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0054	0.0064	0.0064
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0029	0.0029
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0044	0.0044
Onchocerca volvulus		0.0054	0.0064	0.0061
Echinococcus granulosus	somatostatin receptor	0.0054	0.0064	0.0064
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0012	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0012	0.0012
Brugia malayi	Bromodomain containing protein	0.0075	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0046	0.0046
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0027	0.0027
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0045	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	orexin receptor type 2	0.0054	0.0064	0.0064
Plasmodium falciparum	AMP deaminase, putative	0.3901	0.7683	0.7683
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Leishmania major	AMP deaminase, putative	0.3901	0.7683	0.7683
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0024	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus multilocularis	adenosine deaminase	0.5071	1	1
Brugia malayi	PHD-finger family protein	0.0025	0.0006	0.0006
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0024	0.0004	0.0004
Echinococcus granulosus	prolyl endopeptidase	0.0045	0.0046	0.0046
Trypanosoma cruzi	AMP deaminase, putative	0.3901	0.7683	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.2264	0.444	0.444
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0064	0.0064
Echinococcus granulosus	g-protein coupled receptor	0.0054	0.0064	0.0064
Onchocerca volvulus		0.2264	0.444	0.4438
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0054	0.0064	0.0064
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0024	0.0004	0.0005
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0024	0.0004	0.0004
Echinococcus granulosus	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0046	0.0046
Loa Loa (eye worm)	prolyl oligopeptidase	0.0571	0.1088	0.1088
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.5071	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0064	0.0064
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0029	0.0025
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0045	0.0046	0.006
Brugia malayi	sulfakinin receptor protein	0.0054	0.0064	0.0064
Echinococcus granulosus	tm gpcr rhodopsin	0.1666	0.3255	0.3255
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0029	0.0025
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0029	0.0029
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0012	0.0012
Toxoplasma gondii	aminopeptidase N protein	0.0024	0.0004	0.0004
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0064	0.0064
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.3901	0.7683	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0029	0.0029
Toxoplasma gondii	prolyl endopeptidase	0.0045	0.0046	0.0046
Onchocerca volvulus		0.0054	0.0064	0.0061
Brugia malayi	Peptidase family M1 containing protein	0.0024	0.0004	0.0004
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0024	0.0004	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0054	0.0064	0.0061
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0024	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0054	0.0064	0.0064
Trypanosoma brucei	Aminopeptidase M1, putative	0.0068	0.0091	0.0119
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.2807	0.5517	0.5517
Echinococcus multilocularis	allatostatin A receptor	0.0054	0.0064	0.0064
Entamoeba histolytica	aminopeptidase, putative	0.0068	0.0091	0.0091
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0045	0.0046	0.006
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Brugia malayi	G protein-coupled receptor F59B2.13	0.0054	0.0064	0.0064
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0118	0.0118
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0074	0.0074
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0045	0.0046	0.006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0054	0.0064	0.0064
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	amine GPCR	0.0054	0.0064	0.0064
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0571	0.1088	0.1088
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0068	0.0091	0.0091
Mycobacterium ulcerans	lipase LipD	0.0036	0.0029	0.0025
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0012	0.0015
Entamoeba histolytica	adenosine deaminase, putative	0.5071	1	1
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.3901	0.7683	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0064	0.0064
Brugia malayi	G-protein coupled receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.1637	0.3199	0.3199
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0064	0.0064
Brugia malayi	G-protein coupled receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0064	0.0064
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0024	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Loa Loa (eye worm)	TATA binding protein associated factor	0.0024	0.0004	0.0004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1666	0.3255	0.3255
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0064	0.0064
Toxoplasma gondii	AMP deaminase	0.3901	0.7683	0.7683
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0064	0.0064
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0045	0.0046	0.0046
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0064	0.0064
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0001	0.0001
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Echinococcus granulosus	G protein coupled receptor 139	0.0054	0.0064	0.0064
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.3901	0.7683	0.7683
Schistosoma mansoni	amine GPCR	0.0054	0.0064	0.0064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0029	0.0029
Onchocerca volvulus		0.0054	0.0064	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0045	0.0046	0.0046
Echinococcus granulosus	fmrfamide receptor	0.0054	0.0064	0.0064
Echinococcus granulosus	dro:myosuppressin receptor	0.0054	0.0064	0.0064
Brugia malayi	G protein-coupled receptor	0.0054	0.0064	0.0064
Brugia malayi	RNA, U transporter 1	0.0079	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0029	0.0029
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0024	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0004	0.0004
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0793	0.1527	0.1527
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0045	0.0046	0.0046
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0046	0.006
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0054	0.0064	0.0064
Entamoeba histolytica	AMP deaminase, putative	0.3901	0.7683	0.7683
Entamoeba histolytica	AMP deaminase, putative	0.3901	0.7683	0.7683
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0064	0.0064
Echinococcus granulosus	7TM GPCR rhodopsin	0.0054	0.0064	0.0064
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0106	0.0166	0.0166
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0192	0.0337	0.0337
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0054	0.0064	0.0064
Brugia malayi	neuropeptide F receptor	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0054	0.0064	0.0061
Brugia malayi	prolyl oligopeptidase family protein	0.0045	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	growth hormone secretagogue receptor	0.0054	0.0064	0.0064
Echinococcus granulosus	muscleblind protein	0.0145	0.0243	0.0243
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0024	0.0004	0.0005
Treponema pallidum	adenosine deaminase	0.5071	1	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0054	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0029	0.0029
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0024	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Brugia malayi	larval opioid receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	AMP deaminase	0.3901	0.7683	0.7683
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0029	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Brugia malayi	AKH receptor	0.0054	0.0064	0.0064
Onchocerca volvulus	AMP deaminase 2 homolog	0.3901	0.7683	0.7682
Brugia malayi	beta-lactamase	0.0036	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0068	0.0091	0.0091
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0029	0.0029
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0044	0.0044
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.5071	1	1
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0045	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0571	0.1088	0.1084
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0064	0.0064
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0029	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0054	0.0064	0.0061
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus multilocularis	neuropeptide s receptor	0.0054	0.0064	0.0064
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0045	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0054	0.0064	0.0064
Trypanosoma cruzi	AMP deaminase, putative	0.3901	0.7683	1
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0045	0.0046	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0029	0.0037
Onchocerca volvulus		0.0068	0.0091	0.0087
Brugia malayi	Peptidase family M1 containing protein	0.0068	0.0091	0.0091
Brugia malayi	ORL1-like opioid receptor	0.0054	0.0064	0.0064
Trypanosoma brucei	prolyl endopeptidase	0.0045	0.0046	0.006
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0001	0.0001
Brugia malayi	putative neuropeptide receptor NPR1	0.0054	0.0064	0.0064
Echinococcus multilocularis	sex peptide receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0064	0.0064
Entamoeba histolytica	adenosine deaminase, putative	0.5071	1	1
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0068	0.0091	0.0119
Brugia malayi	Dopamine receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0064	0.0064
Brugia malayi	follicle stimulating hormone receptor	0.0054	0.0064	0.0064
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0054	0.0064	0.0064
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0054	0.0064	0.0061
Schistosoma mansoni	amine GPCR	0.0054	0.0064	0.0064
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0054	0.0064	0.0061
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0001	0.0001
Mycobacterium ulcerans	aminopeptidase N PepN	0.0068	0.0091	0.0087
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0029	0.0037
Echinococcus multilocularis	AMP deaminase 2	0.3901	0.7683	0.7683
Echinococcus granulosus	neuropeptide FF receptor 2	0.0054	0.0064	0.0064
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0064	0.0064
Trichomonas vaginalis	esterase, putative	0.0036	0.0029	0.0029
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0029	0.0029
Brugia malayi	adenosine monophosphate deaminase	0.3901	0.7683	0.7683
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0054	0.0064	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0045	0.0046	0.006
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0192	0.0337	0.0337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0044	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0571	0.1088	0.1088
Mycobacterium leprae	conserved hypothetical protein	0.0178	0.031	0.0282
Mycobacterium ulcerans	hypothetical protein	0.0178	0.031	0.0306
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0068	0.0091	0.0119
Echinococcus multilocularis	somatostatin receptor	0.0054	0.0064	0.0064
Toxoplasma gondii	hypothetical protein	0.0045	0.0046	0.0046
Entamoeba histolytica	hypothetical protein	0.0023	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0243	0.0243
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0045	0.0046	0.0042
Toxoplasma gondii	ABC1 family protein	0.0036	0.0029	0.0029
Brugia malayi	Serotonin receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.5071	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0036	0.0029	0.0025
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0064	0.0064
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0029	0.0025
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0046	0.0046
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus granulosus	allatostatin A receptor	0.0054	0.0064	0.0064
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0024	0.0004	0.0004
Onchocerca volvulus		0.0054	0.0064	0.0061
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.5071	1	1
Trypanosoma cruzi	AMP deaminase 2, putative	0.2264	0.444	0.5779
Onchocerca volvulus	Adenosine deaminase homolog	0.5071	1	1
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0192	0.0337	0.0337
Onchocerca volvulus		0.0054	0.0064	0.0061
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0029	0.0029
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.3901	0.7683	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0027	0.0027
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0044	0.0044	0.0057
Schistosoma mansoni	adenosine deaminase-related	0.5071	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0054	0.0064	0.0064
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0192	0.0337	0.0439
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0206	0.0206
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0045	0.0046	0.0046
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0054	0.0064	0.0064
Plasmodium falciparum	importin beta, putative	0.0028	0.0012	0.0012
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0571	0.1088	0.1088
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0192	0.0337	0.0439
Schistosoma mansoni	histamine h1 receptor	0.0054	0.0064	0.0064
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0001	0.0001
Brugia malayi	Peptidase family M1 containing protein	0.015	0.0253	0.0253
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0012	0.0012
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0054	0.0064	0.0064
Trypanosoma cruzi	prolyl endopeptidase	0.0045	0.0046	0.006
Onchocerca volvulus		0.0036	0.0029	0.0025
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0243	0.0243
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0046	0.006
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0045	0.0046	0.0046
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0147	0.0247	0.0247
Brugia malayi	putative neuropeptide receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Mycobacterium ulcerans	hypothetical protein	0.0178	0.031	0.0306
Echinococcus granulosus	AMP deaminase 2	0.3901	0.7683	0.7683
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0297	0.0546	0.0546
Brugia malayi	Muscleblind-like protein	0.0145	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0045	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0024	0.0004	0.0004
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Echinococcus granulosus	neuropeptide s receptor	0.0054	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Brugia malayi	GnHR receptor homolog	0.0054	0.0064	0.0064
Trypanosoma brucei	oligopeptidase b	0.0045	0.0046	0.006
Echinococcus multilocularis	dro:myosuppressin receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0054	0.0064	0.0064
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0029	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.2807	0.5517	0.5517
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Schistosoma mansoni	hypothetical protein	0.0054	0.0064	0.0064
Plasmodium vivax	adenosine/AMP deaminase, putative	0.3901	0.7683	0.7683
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	adenoreceptor	0.0054	0.0064	0.0064
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0024	0.0004	0.0004
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0192	0.0337	0.0439
Onchocerca volvulus		0.0054	0.0064	0.0061
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0001	0.0002
Schistosoma mansoni	neuropeptide f receptor 76f	0.0054	0.0064	0.0064
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0178	0.031	0.0282
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0054	0.0064	0.0061
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.2807	0.5517	0.5517
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Echinococcus multilocularis	g-protein coupled receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	adenosine deaminase	0.5071	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0045	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0046	0.0046
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0046	0.0046
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0064	0.0064
Echinococcus granulosus	orexin receptor type 2	0.0054	0.0064	0.0064
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0029	0.0029
Onchocerca volvulus		0.0054	0.0064	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0029	0.0029
Plasmodium falciparum	adenosine deaminase	0.5071	1	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0083	0.0121	0.0121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0029	0.0029
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0029	0.0029
Echinococcus granulosus	neuropeptide receptor A26	0.0054	0.0064	0.0064
Trypanosoma brucei	AMP deaminase, putative	0.3901	0.7683	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0064	0.0064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Trypanosoma brucei	AMP deaminase, putative	0.3901	0.7683	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0029	0.0029
Brugia malayi	Dopamine receptor protein 2	0.0054	0.0064	0.0064
Echinococcus granulosus	7tm_1 domain containing protein	0.0054	0.0064	0.0064
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0064	0.0064
Schistosoma mansoni	myosin xvIII	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0029	0.0029
Echinococcus granulosus	sex peptide receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	opsin-like receptor	0.0054	0.0064	0.0064
Trypanosoma brucei	aminopeptidase, putative	0.0024	0.0004	0.0005
Brugia malayi	prolyl oligopeptidase family protein	0.0192	0.0337	0.0337
Echinococcus multilocularis	aminopeptidase N	0.015	0.0253	0.0253
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	importin beta-1	0.0028	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0032	0.0032
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0001	0.0001
Brugia malayi	prolyl oligopeptidase family protein	0.0571	0.1088	0.1088
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0054	0.0064	0.0064
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0024	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0068	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0064	0.0064
Echinococcus multilocularis	neuropeptide receptor A26	0.0054	0.0064	0.0064
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0044	0.0044
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0054	0.0064	0.0064
Leishmania major	adenine aminohydrolase	0.5071	1	1
Brugia malayi	TATA binding protein associated factor	0.0024	0.0004	0.0004
Plasmodium vivax	adenosine deaminase, putative	0.5071	1	1
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0045	0.0046	1
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0068	0.0091	0.0091
Brugia malayi	prolyl oligopeptidase family protein	0.0045	0.0046	0.0046
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0012	0.0012
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0192	0.0337	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.3901	0.7683	0.7683
Plasmodium falciparum	peptidase, putative	0.0045	0.0046	0.0046
Echinococcus granulosus	adenosine deaminase	0.5071	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Brugia malayi	Serotonin receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0045	0.0046	0.006
Onchocerca volvulus		0.015	0.0253	0.0249
Echinococcus multilocularis	serotonin receptor	0.0054	0.0064	0.0064
Brugia malayi	Melatonin receptor type 1A	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0004	0.0004
Echinococcus granulosus	serotonin receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	aminopeptidase N	0.0068	0.0091	0.0091
Echinococcus granulosus	aminopeptidase N	0.015	0.0253	0.0253
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0064	0.0064
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0045	0.0046	0.0046
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.007	0.0096	0.0096
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0068	0.0091	0.0091
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0064	0.0064
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0064	0.0064
Leishmania major	hypothetical protein, conserved	0.2264	0.444	0.444
Brugia malayi	RE15519p	0.0054	0.0064	0.0064
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0192	0.0337	0.0439
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0024	0.0004	0.0005
Echinococcus multilocularis	prolyl endopeptidase	0.0045	0.0046	0.0046
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0024	0.0004	0.0004
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0091	0.0091
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0045	0.0046	0.0046
Trichomonas vaginalis	adenosine deaminase, putative	0.5071	1	1
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0001	0.0001
Echinococcus granulosus	snurportin 1	0.0297	0.0546	0.0546
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0054	0.0064	0.0064
Leishmania major	oligopeptidase b	0.0045	0.0046	0.0046
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0054	0.0064	0.0064
Onchocerca volvulus		0.0054	0.0064	0.0061
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0024	0.0004	0.0004
Brugia malayi	prolyl oligopeptidase family protein	0.0045	0.0046	0.0046
Loa Loa (eye worm)	prolyl oligopeptidase	0.0045	0.0046	0.0046
Echinococcus multilocularis	serotonin receptor	0.0054	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0054	0.0064	0.0064
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0001	0.0001
Echinococcus granulosus	acylamino acid releasing enzyme	0.0045	0.0046	0.0046
Trypanosoma cruzi	aminopeptidase, putative	0.0024	0.0004	0.0005
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0054	0.0064	0.0064
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0192	0.0337	0.0337
Trypanosoma cruzi	oligopeptidase b	0.0045	0.0046	0.006
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0004	0.0004
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.3901	0.7683	0.7683
Trypanosoma brucei	Aminopeptidase M1, putative	0.0068	0.0091	0.0119
Echinococcus multilocularis	G protein coupled receptor 139	0.0054	0.0064	0.0064
Trichomonas vaginalis	adenosine deaminase, putative	0.5071	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0247	0.0247
Onchocerca volvulus		0.0036	0.0029	0.0025
Mycobacterium tuberculosis	Probable peptidase	0.0045	0.0046	0.0018
Toxoplasma gondii	aminopeptidase n, putative	0.0024	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0054	0.0064	0.0064
Brugia malayi	Bromodomain containing protein	0.0038	0.0032	0.0032
Brugia malayi	hypothetical protein	0.0024	0.0004	0.0004
Trypanosoma cruzi	oligopeptidase b	0.0045	0.0046	0.006
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0045	0.0046	0.0046
Mycobacterium ulcerans	adenosine deaminase	0.5071	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0064	0.0064
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0064	0.0064
Mycobacterium tuberculosis	Conserved protein	0.0178	0.031	0.0282
Loa Loa (eye worm)	hypothetical protein	0.2807	0.5517	0.5517
Echinococcus multilocularis	snurportin 1	0.0297	0.0546	0.0546
Schistosoma mansoni	opsin-like receptor	0.0054	0.0064	0.0064

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.2 uM	Binding affinity against rat Cathepsin G	ChEMBL.	2296031
Ki (binding)	= 0.2 uM	Binding affinity against rat Cathepsin G	ChEMBL.	2296031
Ki (binding)	= 3 uM	Binding affinity against human Cathepsin G	ChEMBL.	2296031
Ki (binding)	= 3 uM	Binding affinity against human Cathepsin G	ChEMBL.	2296031

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL130190

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 228148