Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0177 | 0.0418 | 0.1345 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0177 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0418 | 0.1345 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0177 | 0.0418 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | nuclear hormone receptor | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | nuclear hormone receptor | 0.0714 | 0.3111 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0177 | 0.0418 | 0.0418 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0177 | 0.0418 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0177 | 0.0418 | 0.1345 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0177 | 0.0418 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0177 | 0.0418 | 0.1345 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0177 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0177 | 0.0418 | 0.1345 |
Echinococcus granulosus | FTZ F1 alpha | 0.0177 | 0.0418 | 0.0418 |
Brugia malayi | nuclear receptor NHR-88 | 0.0177 | 0.0418 | 0.1345 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0177 | 0.0418 | 0.0418 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0177 | 0.0418 | 0.0418 |
Schistosoma mansoni | coup transcription factor | 0.0177 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0177 | 0.0418 | 0.1345 |
Schistosoma mansoni | nuclear hormone receptor | 0.0177 | 0.0418 | 0.0418 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0177 | 0.0418 | 0.1345 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0177 | 0.0418 | 0.0418 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0177 | 0.0418 | 0.1345 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0177 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0714 | 0.3111 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0177 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0418 | 0.1345 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0177 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0418 | 0.1345 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0177 | 0.0418 | 0.0439 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0177 | 0.0418 | 0.0439 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0177 | 0.0418 | 0.0439 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1995 | 0.9531 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0177 | 0.0418 | 0.1345 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0177 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | steroid hormone receptor | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0177 | 0.0418 | 0.1345 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0177 | 0.0418 | 0.0439 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0177 | 0.0418 | 0.1345 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0177 | 0.0418 | 0.0418 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0177 | 0.0418 | 0.0418 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0177 | 0.0418 | 0.0418 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0177 | 0.0418 | 0.1345 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0177 | 0.0418 | 0.0418 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0177 | 0.0418 | 0.0439 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0177 | 0.0418 | 0.0439 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0177 | 0.0418 | 0.1345 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0177 | 0.0418 | 0.0418 |
Schistosoma mansoni | thyroid hormone receptor | 0.0177 | 0.0418 | 0.0418 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0177 | 0.0418 | 0.0418 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0177 | 0.0418 | 0.1345 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0177 | 0.0418 | 0.1345 |
Loa Loa (eye worm) | hypothetical protein | 0.0631 | 0.2692 | 0.8655 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.2088 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0177 | 0.0418 | 0.1345 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0807 | 0.358 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 nM | In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement. | ChEMBL. | 12565939 |
Ki (binding) | = 1 nM | In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement. | ChEMBL. | 12565939 |
Ki (binding) | = 100 nM | In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]-Spiperone displacement. | ChEMBL. | 12565939 |
Ki (binding) | = 100 nM | In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]-Spiperone displacement. | ChEMBL. | 12565939 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.