Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor M1 | Starlite/ChEMBL | References |
Rattus norvegicus | Muscarinic acetylcholine receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0682 | 0.9749 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9524 | 0.977 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0032 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0682 | 0.9749 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.5 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-oxotremorine-M binding on rat brain homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 4.5 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-oxotremorine-M binding on rat brain homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 44 nM | In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 44 nM | In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 100 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-quinuclidinyl benzilate binding on rat brain stem homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 100 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-quinuclidinyl benzilate binding on rat brain stem homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 230 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-Quinuclidinyl benzilate binding on rat brain homogenate | ChEMBL. | 7990109 |
Ki (binding) | = 230 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-Quinuclidinyl benzilate binding on rat brain homogenate | ChEMBL. | 7990109 |
Ratio (functional) | = 2.3 | Ratio of binding affinity at [3H]-Quinuclidinyl benzilate binding on rat brain stem homogenate to [3H]-Piperazine binding on rat brain homogenate | ChEMBL. | 7990109 |
Ratio (functional) | = 51 | Ratio of binding affinity at [3H]-Quinuclidinyl benzilate binding on rat brain homogenate to [3H]- Oxotremorine-M binding on rat brain homogenate | ChEMBL. | 7990109 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.