Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Oxytocin receptor | Starlite/ChEMBL | No references |
Rattus norvegicus | Vasopressin V2 receptor | Starlite/ChEMBL | No references |
Rattus norvegicus | Vasopressin V1a receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | orexin receptor type 2 | Oxytocin receptor | 388 aa | 332 aa | 23.2 % |
Loa Loa (eye worm) | hypothetical protein | Vasopressin V1a receptor | 424 aa | 382 aa | 22.8 % |
Onchocerca volvulus | Oxytocin receptor | 388 aa | 327 aa | 23.9 % | |
Echinococcus granulosus | allatostatin A receptor | Oxytocin receptor | 388 aa | 313 aa | 23.6 % |
Onchocerca volvulus | Phospholipase d-related homolog | Oxytocin receptor | 388 aa | 330 aa | 20.0 % |
Echinococcus multilocularis | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.6 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Vasopressin V2 receptor | 371 aa | 310 aa | 20.3 % |
Schistosoma mansoni | adenoreceptor | Vasopressin V2 receptor | 371 aa | 317 aa | 26.2 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 327 aa | 19.3 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 323 aa | 21.7 % |
Brugia malayi | GnHR receptor homolog | Vasopressin V2 receptor | 371 aa | 304 aa | 22.4 % |
Onchocerca volvulus | Vasopressin V1a receptor | 424 aa | 378 aa | 21.4 % | |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Vasopressin V1a receptor | 424 aa | 400 aa | 21.8 % |
Onchocerca volvulus | Vasopressin V2 receptor | 371 aa | 315 aa | 22.5 % | |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Oxytocin receptor | 388 aa | 346 aa | 24.0 % |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Vasopressin V2 receptor | 371 aa | 382 aa | 22.5 % |
Echinococcus multilocularis | neuropeptides capa receptor | Vasopressin V1a receptor | 424 aa | 462 aa | 19.5 % |
Echinococcus multilocularis | rhodopsin orphan GPCR | Vasopressin V1a receptor | 424 aa | 370 aa | 21.9 % |
Echinococcus granulosus | orexin receptor type 2 | Oxytocin receptor | 388 aa | 338 aa | 24.3 % |
Echinococcus granulosus | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.9 % |
Onchocerca volvulus | Vasopressin V2 receptor | 371 aa | 331 aa | 21.4 % | |
Schistosoma mansoni | biogenic amine (5HT) receptor | Vasopressin V2 receptor | 371 aa | 357 aa | 21.6 % |
Onchocerca volvulus | Vasopressin V1a receptor | 424 aa | 347 aa | 21.9 % | |
Echinococcus multilocularis | allatostatin A receptor | Oxytocin receptor | 388 aa | 311 aa | 21.9 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Oxytocin receptor | 388 aa | 349 aa | 22.9 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Vasopressin V2 receptor | 371 aa | 314 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.761 | 0.9014 | 0.9509 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.5802 | 0.6637 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.5405 | 0.6116 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.7964 | 0.9479 | 1 |
Brugia malayi | nuclear hormone receptor | 0.7964 | 0.9479 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.5802 | 0.6637 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 44 nM | Inhibition of binding of [3H]-oxytocin to rat uterine oxytocin receptor | ChEMBL. | No reference |
IC50 (binding) | = 44 nM | Inhibition of binding of [3H]-oxytocin to rat uterine oxytocin receptor | ChEMBL. | No reference |
IC50 (binding) | = 4100 nM | Inhibition of binding of [3H]-vasopressin to rat liver vasopressin V1a receptor | ChEMBL. | No reference |
IC50 (binding) | = 4100 nM | Inhibition of binding of [3H]-vasopressin to rat liver vasopressin V1a receptor | ChEMBL. | No reference |
IC50 (binding) | = 7200 nM | Inhibition of binding of [3H]-vasopressin to rat kidney vasopressin V2 receptor | ChEMBL. | No reference |
IC50 (binding) | = 7200 nM | Inhibition of binding of [3H]-vasopressin to rat kidney vasopressin V2 receptor | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.