Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosine deaminase | 0.7026 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.7026 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.7026 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.7026 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.7026 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.7026 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.7026 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.4531 | 0.1393 | 0.1393 |
Echinococcus multilocularis | adenosine deaminase | 0.7026 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.7026 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.7026 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.7026 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.7026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.7026 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.7026 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.7026 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.7026 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.4531 | 0.1393 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.7026 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.7026 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.7026 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.4531 | 0.1393 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibitory activity against Cyclin-dependent kinase 5 | ChEMBL. | 11063606 |
IC50 (binding) | > 100 uM | Inhibitory activity against Cyclin-dependent kinase 5 | ChEMBL. | 11063606 |
IC50 (binding) | = 150 uM | Inhibition of Cyclin-dependent kinase 1 (CDK1) | ChEMBL. | 11063606 |
IC50 (binding) | = 150 uM | Inhibition of Cyclin-dependent kinase 1 (CDK1) | ChEMBL. | 11063606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.