Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0039 | 0.0105 | 0.0105 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0054 | 0.0236 | 0.0236 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0458 | 0.3763 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0458 | 0.3763 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0104 | 0.0276 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0104 | 0.0104 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0104 | 0.0104 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.002 | 0.002 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0027 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0105 | 0.028 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.002 | 0.002 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0104 | 0.0104 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0105 | 0.028 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.0054 | 0.0236 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.3797 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0458 | 0.3763 | 0.9581 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0054 | 0.0236 | 0.0236 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0054 | 0.0236 | 0.0236 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0477 | 0.3928 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0029 | 0.002 | 0.002 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0104 | 0.0104 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1173 | 1 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0458 | 0.3763 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.064 | 0.064 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0105 | 0.0037 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0104 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.3459 | 0.9085 |
Toxoplasma gondii | GAF domain-containing protein | 0.0039 | 0.0105 | 0.0105 |
Giardia lamblia | Ribonuclease H | 0.0027 | 0 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0104 | 0.0104 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0104 | 0.0264 |
Mycobacterium ulcerans | putative regulatory protein | 0.0039 | 0.0105 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0105 | 0.028 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0236 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1173 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0105 | 0.028 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.002 | 0.002 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.002 | 0.002 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0458 | 0.3763 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1173 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1173 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1173 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1173 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1173 | 1 | 1 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Mycobacterium ulcerans | putative regulatory protein | 0.0039 | 0.0105 | 0.0002 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0458 | 0.3763 | 0.3763 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0242 | 0.1876 | 0.4799 |
Leishmania major | dihydroorotate dehydrogenase | 0.1173 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0458 | 0.3763 | 1 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0458 | 0.3763 | 0.9581 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.064 | 0.064 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0027 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0458 | 0.3763 | 1 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0236 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DosT | 0.0039 | 0.0105 | 0.0037 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0458 | 0.3763 | 1 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0054 | 0.0236 | 0.0236 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0104 | 0.0104 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0477 | 0.3928 | 1 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0039 | 0.0105 | 0.0002 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0458 | 0.3763 | 0.3763 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.0054 | 0.0236 | 0.0236 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0477 | 0.3928 | 0.3928 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1173 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0458 | 0.3763 | 0.9581 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1173 | 1 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1173 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0039 | 0.0105 | 0.0105 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1173 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0104 | 0.0104 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0458 | 0.3763 | 0.9581 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0039 | 0.0105 | 0.0037 |
Brugia malayi | follicle stimulating hormone receptor | 0.0242 | 0.1876 | 0.1876 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0104 | 0.0276 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0236 | 0.0358 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0236 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0104 | 0.0104 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1173 | 1 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.0054 | 0.0236 | 0.0601 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0104 | 0.0104 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Toxoplasma gondii | hypothetical protein | 0.0039 | 0.0105 | 0.0105 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1173 | 1 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0054 | 0.0236 | 0.0627 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0104 | 0.0276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 36.1 uM | Concentration required for cytotoxicity against mock infected CEM-SS cells | ChEMBL. | 11708913 |
CC50 (functional) | = 36.1 uM | Concentration required for cytotoxicity against mock infected CEM-SS cells | ChEMBL. | 11708913 |
EC50 (functional) | = 0.84 uM | Inhibitory concentration for cytopathicity of HIV-1RF in CEM-SS cells | ChEMBL. | 11708913 |
IC50 (binding) | > 100 uM | Inhibitory activity against HIV-1 Reverse Transcriptase with rCdG as the template primer | ChEMBL. | 11708913 |
IC50 (binding) | > 100 uM | Inhibitory activity against HIV-1 Reverse Transcriptase with rCdG as the template primer | ChEMBL. | 11708913 |
TI (ADMET) | = 42.9 | Ratio of CC50/EC50 was determined | ChEMBL. | 11708913 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.