Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0585 | 0.0832 | 0.5 |
Onchocerca volvulus | 0.0585 | 0.0832 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0585 | 0.0832 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.3463 | 0.5833 | 0.5821 |
Loa Loa (eye worm) | hypothetical protein | 0.2995 | 0.5021 | 0.5006 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0585 | 0.0832 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0585 | 0.0832 | 0.1382 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3463 | 0.5833 | 1 |
Onchocerca volvulus | 0.0585 | 0.0832 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0585 | 0.0832 | 0.1382 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0585 | 0.0832 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.0832 | 0.0805 |
Loa Loa (eye worm) | carboxylesterase | 0.0585 | 0.0832 | 0.0805 |
Brugia malayi | Carboxylesterase family protein | 0.0585 | 0.0832 | 0.0805 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.586 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.0832 | 0.0805 |
Brugia malayi | hypothetical protein | 0.0585 | 0.0832 | 0.0805 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.586 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3463 | 0.5833 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0585 | 0.0832 | 0.1382 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0585 | 0.0832 | 0.1382 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0585 | 0.0832 | 0.1382 |
Schistosoma mansoni | gliotactin | 0.0585 | 0.0832 | 0.1382 |
Echinococcus multilocularis | acetylcholinesterase | 0.3463 | 0.5833 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3463 | 0.5833 | 0.5821 |
Brugia malayi | Carboxylesterase family protein | 0.0585 | 0.0832 | 0.0805 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3463 | 0.5833 | 0.5821 |
Leishmania major | C-8 sterol isomerase-like protein | 0.586 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3463 | 0.5833 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0585 | 0.0832 | 0.1382 |
Loa Loa (eye worm) | carboxylesterase | 0.3463 | 0.5833 | 0.5821 |
Loa Loa (eye worm) | hypothetical protein | 0.586 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0585 | 0.0832 | 0.0805 |
Onchocerca volvulus | 0.0123 | 0.003 | 0.0356 | |
Brugia malayi | Carboxylesterase family protein | 0.0585 | 0.0832 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.0832 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.0832 | 0.0805 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0585 | 0.0832 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.0832 | 0.0805 |
Echinococcus multilocularis | acetylcholinesterase | 0.3463 | 0.5833 | 1 |
Onchocerca volvulus | 0.0585 | 0.0832 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.0832 | 0.0805 |
Onchocerca volvulus | 0.0585 | 0.0832 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.3463 | 0.5833 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3463 | 0.5833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.0832 | 0.0805 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0585 | 0.0832 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3463 | 0.5833 | 0.5821 |
Onchocerca volvulus | 0.0585 | 0.0832 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.3463 | 0.5833 | 0.5821 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0585 | 0.0832 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 uM | In vitro inhibition of coagulation factor Xa. | ChEMBL. | 11063603 |
IC50 (binding) | = 1.6 uM | In vitro inhibition of coagulation factor Xa. | ChEMBL. | 11063603 |
IC50 (binding) | = 1.9 uM | Inhibition of thrombin | ChEMBL. | 11063603 |
IC50 (binding) | = 1.9 uM | Inhibition of thrombin | ChEMBL. | 11063603 |
IC50 (binding) | = 2.2 uM | Compound was tested for in vitro inhibitory activity against plasmin | ChEMBL. | 11063603 |
IC50 (binding) | = 2.2 uM | Compound was tested for in vitro inhibitory activity against plasmin | ChEMBL. | 11063603 |
IC50 (binding) | = 2.5 uM | In vitro inhibitory activity against trypsin | ChEMBL. | 11063603 |
IC50 (binding) | = 2.5 uM | In vitro inhibitory activity against trypsin | ChEMBL. | 11063603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.