Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0332 | 0.3653 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0191 | 0.0191 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0849 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0191 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0332 | 0.3653 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0023 | 0.0001 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0849 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0849 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0023 | 0.0023 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0849 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0849 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0849 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0023 | 0.0023 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0023 | 0.0023 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0023 | 0.1221 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0332 | 0.3653 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0023 | 0.0023 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0332 | 0.3653 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0849 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0332 | 0.3653 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0849 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0332 | 0.3653 | 0.3653 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.2377 | 0.2359 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0023 | 0.0023 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0849 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0023 | 0.5 | |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0332 | 0.3653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0023 | 0.1221 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0849 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0849 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0023 | 0.1221 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0023 | 0.0023 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0023 | 0.0001 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0332 | 0.3653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0023 | 0.1221 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0849 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0332 | 0.3653 | 1 |
Onchocerca volvulus | 0.0036 | 0.0023 | 0.5 | |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0023 | 0.1221 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0191 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0023 | 0.1221 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0023 | 0.1221 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0849 | 1 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0023 | 0.5 | |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0849 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0332 | 0.3653 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0023 | 0.1221 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0191 | 0.0191 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0332 | 0.3653 | 0.3638 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0332 | 0.3653 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0332 | 0.3653 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.9 mM | evaluated for the inhibition of Trypanosoma brucei Phosphoglycerate kinase (PGK) | ChEMBL. | 11063610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.