Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thioredoxin reductase | 0.0224 | 0.9894 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0224 | 0.9894 | 1 |
Treponema pallidum | NADH oxidase | 0.0061 | 0.1221 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0224 | 0.9894 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0061 | 0.1221 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0061 | 0.1221 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0224 | 0.9894 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0061 | 0.1221 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0224 | 0.9894 | 1 |
Leishmania major | trypanothione reductase | 0.0224 | 0.9894 | 1 |
Brugia malayi | glutathione reductase | 0.0224 | 0.9894 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0224 | 0.9894 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0224 | 0.9894 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0224 | 0.9894 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0061 | 0.1221 | 0.1234 |
Toxoplasma gondii | thioredoxin reductase | 0.0224 | 0.9894 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0061 | 0.1221 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0224 | 0.9894 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0061 | 0.1221 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0061 | 0.1221 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0061 | 0.1221 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0224 | 0.9894 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0061 | 0.1221 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0061 | 0.1221 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0061 | 0.1221 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.063 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against S. pyogenes 4 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 0.125 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Micrococcus luteus ATCC 9341 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 0.125 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against S. pneumoniae 6301 strain | ChEMBL. | 8308866 |
MIC (functional) | = 0.5 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Staphylococcus aureus smith strain. | ChEMBL. | 8308866 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Escherichia coli 257 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Escherichia coli ATCC 25922 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Klebsiella pneumoniae A strain. | ChEMBL. | 8308866 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against P. mirabilis 90 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Escherichia coli 257 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Escherichia coli ATCC 25922 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Escherichia coli TEM-1 (Beta lactamase producer) strain. | ChEMBL. | 8308866 |
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Escherichia coli TEM-1 (Beta lactamase producer) strain. | ChEMBL. | 8308866 |
MIC (functional) | = 16 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Enterobacter cloacae 5699 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 16 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Enterococcus faecalis ATCC 29212 strain. | ChEMBL. | 8308866 |
MIC (functional) | = 64 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against S. aureus 67-0 (Methicillin resistant) strain. | ChEMBL. | 8308866 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Citrobacter freundii BS-16 (beta lactamase producer) strain. | ChEMBL. | 8308866 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Enterobacter cloacae p99 (beta lactamase producer)strain. | ChEMBL. | 8308866 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Serratia marcescens 1071(beta lactamase producer) strain. | ChEMBL. | 8308866 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Proteus vulgaris 1028BC (beta lactamase producer) strain. | ChEMBL. | 8308866 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against Pseudomonas aeruginosa 8780 strain. | ChEMBL. | 8308866 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against P. aeruginosa 18S/H strain. | ChEMBL. | 8308866 |
MIC (functional) | = 128 ug ml-1 | In vitro minimum inhibitory concentration of the compound was measured against S. aureus 753 (Methicillin resistant) strain. | ChEMBL. | 8308866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.