Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 5 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 5 | 260 aa | 307 aa | 28.3 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0343 | 0.0521 | 0.0521 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0343 | 0.0521 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.0521 | 0.0521 |
Plasmodium vivax | protein kinase Crk2 | 0.0104 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2031 | 0.4199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4693 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0343 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.0521 | 0.0521 |
Echinococcus multilocularis | acetylcholinesterase | 0.2031 | 0.4199 | 1 |
Echinococcus multilocularis | neuroligin | 0.0343 | 0.0521 | 0.124 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0343 | 0.0521 | 0.124 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0104 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0104 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0343 | 0.0521 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0343 | 0.0521 | 0.124 |
Onchocerca volvulus | 0.0343 | 0.0521 | 0.5 | |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0104 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0343 | 0.0521 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0343 | 0.0521 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.0521 | 0.0521 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.4693 | 1 | 1 |
Onchocerca volvulus | 0.0343 | 0.0521 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0343 | 0.0521 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.0521 | 0.0521 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0343 | 0.0521 | 0.124 |
Onchocerca volvulus | 0.0343 | 0.0521 | 0.5 | |
Onchocerca volvulus | 0.0343 | 0.0521 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0343 | 0.0521 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.0521 | 0.0521 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2031 | 0.4199 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0343 | 0.0521 | 0.124 |
Echinococcus granulosus | acetylcholinesterase | 0.2031 | 0.4199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2031 | 0.4199 | 0.4199 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0343 | 0.0521 | 0.124 |
Leishmania major | C-8 sterol isomerase-like protein | 0.4693 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2031 | 0.4199 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0343 | 0.0521 | 0.124 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0343 | 0.0521 | 0.124 |
Brugia malayi | Carboxylesterase family protein | 0.0343 | 0.0521 | 0.0521 |
Brugia malayi | Carboxylesterase family protein | 0.0343 | 0.0521 | 0.0521 |
Echinococcus multilocularis | acetylcholinesterase | 0.2031 | 0.4199 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2031 | 0.4199 | 0.4199 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0343 | 0.0521 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.2399 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0343 | 0.0521 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.2031 | 0.4199 | 0.4199 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0343 | 0.0521 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2031 | 0.4199 | 0.4199 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0343 | 0.0521 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | carboxylesterase | 0.0343 | 0.0521 | 0.0521 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0343 | 0.0521 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0104 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0104 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0343 | 0.0521 | 0.0521 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0343 | 0.0521 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.0521 | 0.0521 |
Schistosoma mansoni | gliotactin | 0.0343 | 0.0521 | 0.124 |
Loa Loa (eye worm) | carboxylesterase | 0.2031 | 0.4199 | 0.4199 |
Echinococcus granulosus | acetylcholinesterase | 0.2031 | 0.4199 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0343 | 0.0521 | 0.0521 |
Giardia lamblia | Kinase, CMGC CDK | 0.0104 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0343 | 0.0521 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.2031 | 0.4199 | 0.4199 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.4693 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.3 uM | Inhibitory activity against Cyclin-dependent kinase 5 | ChEMBL. | 11063606 |
IC50 (binding) | = 2.3 uM | Inhibitory activity against Cyclin-dependent kinase 5 | ChEMBL. | 11063606 |
IC50 (binding) | = 2.5 uM | Inhibition of Cyclin-dependent kinase 1 (CDK1) | ChEMBL. | 11063606 |
IC50 (binding) | = 2.5 uM | Inhibition of Cyclin-dependent kinase 1 (CDK1) | ChEMBL. | 11063606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.