Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.7 nM | Agonistic activity against human progesterone receptor in CV-1 cells | ChEMBL. | 12954062 |
EC50 (functional) | = 2.7 nM | Agonistic activity against human progesterone receptor in CV-1 cells | ChEMBL. | 12954062 |
EC50 (functional) | = 26 nM | Agonistic activity against human progesterone receptor in T47D breast cancer cells | ChEMBL. | 12954062 |
EC50 (functional) | = 26 nM | Agonistic activity against human progesterone receptor in T47D breast cancer cells | ChEMBL. | 12954062 |
Efficacy (functional) | % | Antagonistic efficacy human estrogen receptor; No data | ChEMBL. | 12954062 |
Efficacy (functional) | 0 % | Agonistic efficacy against human Mineralocorticoid receptor; No data | ChEMBL. | 12954062 |
Efficacy (functional) | 0 % | Antagonistic efficacy human estrogen receptor; No data | ChEMBL. | 12954062 |
Efficacy (functional) | = 59 % | Percent agonistic effect towards human progesterone receptor in T47D breast cancer cells | ChEMBL. | 12954062 |
Efficacy (functional) | = 59 % | Percent agonistic effect towards human progesterone receptor in T47D breast cancer cells | ChEMBL. | 12954062 |
Efficacy (functional) | = 60 % | Antagonistic efficacy for human androgen receptor | ChEMBL. | 12954062 |
Efficacy (functional) | = 60 % | Antagonistic efficacy for human androgen receptor | ChEMBL. | 12954062 |
Efficacy (functional) | = 88 % | Antagonistic efficacy for human glucocorticoid receptor | ChEMBL. | 12954062 |
Efficacy (functional) | = 88 % | Antagonistic efficacy for human glucocorticoid receptor | ChEMBL. | 12954062 |
Efficacy (functional) | = 172 % | Percent agonistic effect towards human progesterone receptor in CV-1 cells | ChEMBL. | 12954062 |
Efficacy (functional) | = 172 % | Percent agonistic effect towards human progesterone receptor in CV-1 cells | ChEMBL. | 12954062 |
IC50 (binding) | = 320 nM | Inhibition of human glucocorticoid receptor at 10e-12 to 10e-5 M | ChEMBL. | 12954062 |
IC50 (binding) | = 320 nM | Inhibition of human glucocorticoid receptor at 10e-12 to 10e-5 M | ChEMBL. | 12954062 |
IC50 (binding) | = 1500 nM | Inihibition of human androgen receptor at 10e-12 to 10e-5 M | ChEMBL. | 12954062 |
IC50 (binding) | = 1500 nM | Inihibition of human androgen receptor at 10e-12 to 10e-5 M | ChEMBL. | 12954062 |
IC50 (binding) | uM | Inhibition of binding to human estrogen receptor; No data | ChEMBL. | 12954062 |
IC50 (binding) | uM | Inhibitory activity against human Mineralocorticoid receptor; No data | ChEMBL. | 12954062 |
IC50 (binding) | 0 uM | Inhibitory activity against human Mineralocorticoid receptor; No data | ChEMBL. | 12954062 |
IC50 (binding) | 0 uM | Inhibition of binding to human estrogen receptor; No data | ChEMBL. | 12954062 |
Ki (binding) | = 1.2 nM | Binding affinity towards human progesterone receptor A isoform using progesterone as radioligand | ChEMBL. | 12954062 |
Ki (binding) | = 1.2 nM | Binding affinity towards human progesterone receptor A isoform using progesterone as radioligand | ChEMBL. | 12954062 |
Ki (binding) | = 493 nM | Inhibition of Dexamethasone binding to human glucocorticoid receptor expressed in baculovirus SF-12 cells | ChEMBL. | 12954062 |
Ki (binding) | = 493 nM | Inhibition of Dexamethasone binding to human glucocorticoid receptor expressed in baculovirus SF-12 cells | ChEMBL. | 12954062 |
Ki (binding) | = 819 nM | Inhibition of DHT binding to human androgen receptor expressed in baculovirus SF-12 cells | ChEMBL. | 12954062 |
Ki (binding) | = 819 nM | Inhibition of DHT binding to human androgen receptor expressed in baculovirus SF-12 cells | ChEMBL. | 12954062 |
Ratio (binding) | = 119 | Relative potency for human glucocorticoid and progesterone receptors | ChEMBL. | 12954062 |
Ratio (binding) | = 556 | Relative potency for human androgen and progesterone receptors | ChEMBL. | 12954062 |
Ratio (binding) | > 1000 | Relative potency for human mineralocorticoid and progesterone receptors | ChEMBL. | 12954062 |
Ratio (binding) | > 1000 | Relative potency for human estrogen and progesterone receptors | ChEMBL. | 12954062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.