Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0059 | 0.6556 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0059 | 0.6556 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0073 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0059 | 0.6556 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0059 | 0.6556 | 0.6556 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.6556 | 0.6556 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.6556 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1866 | 0.1866 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.6249 | 0.6249 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0059 | 0.6556 | 0.6556 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0059 | 0.6556 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0059 | 0.6556 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0059 | 0.6556 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0059 | 0.6556 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.6249 | 0.6249 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0059 | 0.6556 | 0.6556 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1866 | 0.1866 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0059 | 0.6556 | 0.6556 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.6249 | 0.6249 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1866 | 0.1866 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0059 | 0.6556 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0059 | 0.6556 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0059 | 0.6556 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.6556 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0059 | 0.6556 | 0.6556 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.6556 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.6249 | 0.6249 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0059 | 0.6556 | 0.6556 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.6556 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.9 | In vitro inhibitory activity against Prostaglandin G/H synthase 2 from mouse peritoneal macrophages | ChEMBL. | 15225716 |
IC50 (binding) | = 0.05 ug ml-1 | In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages | ChEMBL. | 12565941 |
IC50 (binding) | = 0.05 ug ml-1 | In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages | ChEMBL. | 12565941 |
Inhibition (binding) | = 67 % | In vitro percentage inhibition against prostaglandin G/H synthase 1 using freshly harvested mouse peritoneal macrophages at 10 microg/mL concentration | ChEMBL. | 12565941 |
Inhibition (binding) | = 67 % | In vitro percentage inhibition against prostaglandin G/H synthase 1 using freshly harvested mouse peritoneal macrophages at 10 microg/mL concentration | ChEMBL. | 12565941 |
Log IC50 (binding) | = 3.9 | In vitro inhibitory activity against Prostaglandin G/H synthase 2 from mouse peritoneal macrophages | ChEMBL. | 15225716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.