Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | Holo-[acyl-carrieir-protein] synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | Holo-[acyl-carrieir-protein] synthase | 121 aa | 106 aa | 25.5 % |
Loa Loa (eye worm) | reduced folate carrier family protein | Holo-[acyl-carrieir-protein] synthase | 121 aa | 97 aa | 24.7 % |
Trichomonas vaginalis | conserved hypothetical protein | Holo-[acyl-carrieir-protein] synthase | 121 aa | 117 aa | 24.8 % |
Plasmodium vivax | cloroquine resistance asscociatd protein Cg7, putative | Holo-[acyl-carrieir-protein] synthase | 121 aa | 101 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0143 | 0.8135 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0887 | 0.0887 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0111 | 0.5715 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.5649 | 0.657 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0111 | 0.5715 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0111 | 0.5715 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.005 | 0.0994 | 0.0994 |
Mycobacterium leprae | HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIE | 0.0115 | 0.597 | 0.3392 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0143 | 0.8135 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.5649 | 0.657 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.6595 | 0.7876 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0111 | 0.5715 | 0.5879 |
Brugia malayi | 6-phosphofructokinase | 0.0111 | 0.5715 | 0.5715 |
Brugia malayi | 6-phosphofructokinase | 0.0111 | 0.5715 | 0.5715 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0887 | 0.1552 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.5649 | 0.657 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0111 | 0.5715 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0111 | 0.5715 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0154 | 0.9006 | 0.8909 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0143 | 0.8135 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0111 | 0.5715 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0143 | 0.8135 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0143 | 0.8135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.6595 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0111 | 0.5715 | 0.5298 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0111 | 0.5715 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0111 | 0.5715 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.0887 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.5649 | 0.657 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0111 | 0.5715 | 0.5298 |
Brugia malayi | hypoxia-induced factor 1 | 0.0154 | 0.9006 | 0.9006 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0111 | 0.5715 | 0.0695 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0143 | 0.8135 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0111 | 0.5715 | 0.5 |
Brugia malayi | phosphofructokinase | 0.0111 | 0.5715 | 0.5715 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.6595 | 0.7876 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0111 | 0.5715 | 0.5879 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.6595 | 0.7876 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0111 | 0.5715 | 0.5 |
Loa Loa (eye worm) | phosphofructokinase | 0.0111 | 0.5715 | 0.5298 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0887 | 0.1552 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0111 | 0.5715 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0111 | 0.5715 | 0.7025 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0111 | 0.5715 | 0.6661 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0111 | 0.5715 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.5649 | 0.657 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0887 | 0.0887 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0143 | 0.8135 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.5649 | 0.657 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | In vitro inhibitory activity against Holo-[acyl-carrier-protein] synthase was determined using Bacillus subtilis GST-Acp-HTRFassay | ChEMBL. | 14684293 |
IC50 (binding) | = 2 uM | In vitro inhibitory activity against Holo-[acyl-carrier-protein] synthase was determined using Bacillus subtilis GST-Acp-HTRFassay | ChEMBL. | 14684293 |
MIC (functional) | = 50 uM | Minimum inhibitory concentration required against Escherichia faecalis VRE strain was determined | ChEMBL. | 14684293 |
MIC (functional) | = 100 uM | Minimum inhibitory concentration required against Escherichia faecalis ATCC strain was determined | ChEMBL. | 14684293 |
MIC (functional) | = 100 uM | Minimum inhibitory concentration required against Streptococcus pneumoniae | ChEMBL. | 14684293 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration required against Bacillus subtilis was determined | ChEMBL. | 14684293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.