Detailed information for compound 228751

Basic information

Technical information
  • TDR Targets ID: 228751
  • Name: (2E)-2-(4,6-difluoro-2,3-dihydroinden-1-ylide ne)-N-ethylacetamide
  • MW: 237.245 | Formula: C13H13F2NO
  • H donors: 1 H acceptors: 1 LogP: 2.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)/C=C/1\CCc2c1cc(F)cc2F
  • InChi: 1S/C13H13F2NO/c1-2-16-13(17)5-8-3-4-10-11(8)6-9(14)7-12(10)15/h5-7H,2-4H2,1H3,(H,16,17)/b8-5+
  • InChiKey: LTKGPLMKKNACRX-VMPITWQZSA-N  

Network

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Synonyms

  • (2E)-2-(4,6-difluoroindan-1-ylidene)-N-ethyl-acetamide
  • (2E)-2-(4,6-difluoro-1-indanylidene)-N-ethylacetamide
  • (2E)-2-(4,6-difluoro-2,3-dihydroinden-1-ylidene)-N-ethyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0854 0.0854
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0854 0.0854
Echinococcus granulosus g protein coupled receptor 0.0076 0.0854 0.0854
Echinococcus granulosus thioredoxin glutathione reductase 0.0446 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0076 0.0854 0.0854
Trypanosoma cruzi trypanothione reductase, putative 0.0446 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Mycobacterium tuberculosis Probable oxidoreductase 0.0154 0.2803 0.2803
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Echinococcus granulosus serotonin receptor 0.0076 0.0854 0.0854
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Schistosoma mansoni neuropeptide receptor 0.0076 0.0854 0.0854
Echinococcus granulosus sex peptide receptor 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0076 0.0854 0.0854
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Schistosoma mansoni neuropeptide receptor 0.0076 0.0854 0.0854
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Echinococcus granulosus hypothetical protein 0.0076 0.0854 0.0854
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0154 0.2803 0.2803
Brugia malayi sulfakinin receptor protein 0.0076 0.0854 0.0854
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0076 0.0854 0.0854
Toxoplasma gondii thioredoxin reductase 0.0446 1 1
Echinococcus multilocularis serotonin receptor 0.0076 0.0854 0.0854
Brugia malayi putative neuropeptide receptor NPR1 0.0076 0.0854 0.0854
Echinococcus multilocularis G-protein coupled receptor, putative 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0076 0.0854 0.0854
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0076 0.0854 0.0854
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni hypothetical protein 0.0076 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni amine GPCR 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni myosin xvIII 0.0076 0.0854 0.0854
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0076 0.0854 0.0854
Schistosoma mansoni amine GPCR 0.0076 0.0854 0.0854
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0854 0.0854
Plasmodium falciparum thioredoxin reductase 0.0446 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.2803 0.2803
Brugia malayi neuropeptide F receptor 0.0076 0.0854 0.0854
Trichomonas vaginalis glutathione reductase, putative 0.0154 0.2803 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0154 0.2803 0.2803
Plasmodium falciparum glutathione reductase 0.0154 0.2803 0.2803
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Echinococcus multilocularis neuropeptide s receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Schistosoma mansoni biogenic amine receptor 0.0076 0.0854 0.0854
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0076 0.0854 0.0854
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0154 0.2803 0.2803
Echinococcus granulosus neuropeptide receptor 0.0076 0.0854 0.0854
Schistosoma mansoni biogenic amine receptor 0.0076 0.0854 0.0854
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0076 0.0854 0.0854
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.2803 0.2803
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus dro:myosuppressin receptor 0.0076 0.0854 0.0854
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.2803 0.2803
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0076 0.0854 0.0854
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0854 0.0854
Brugia malayi G protein-coupled receptor F59B2.13 0.0076 0.0854 0.0854
Schistosoma mansoni opsin-like receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis g-protein coupled receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) glutathione reductase 0.0446 1 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0113 0.179 0.179
Onchocerca volvulus 0.0076 0.0854 1
Brugia malayi Thioredoxin reductase 0.0446 1 1
Schistosoma mansoni histamine h1 receptor 0.0076 0.0854 0.0854
Treponema pallidum NADH oxidase 0.0154 0.2803 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Trypanosoma brucei trypanothione reductase 0.0446 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0154 0.2803 0.2803
Onchocerca volvulus 0.0076 0.0854 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0076 0.0854 0.0854
Echinococcus granulosus 7TM GPCR rhodopsin 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus g protein coupled receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0154 0.2803 0.2803
Onchocerca volvulus 0.0076 0.0854 1
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0854 0.0854
Echinococcus granulosus fmrfamide receptor 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0854 0.0854
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0854 0.0854
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0076 0.0854 0.0854
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0154 0.2803 1
Loa Loa (eye worm) TYRA-2 protein 0.0076 0.0854 0.0854
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0076 0.0854 0.0854
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0076 0.0854 0.0854
Plasmodium vivax glutathione reductase, putative 0.0446 1 1
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni neuropeptide receptor 0.0076 0.0854 0.0854
Entamoeba histolytica disulphide oxidoreductase, putative 0.0041 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0854 0.0854
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0154 0.2803 0.2803
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi AKH receptor 0.0076 0.0854 0.0854
Schistosoma mansoni amine GPCR 0.0076 0.0854 0.0854
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0854 0.0854
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0854 0.0854
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0854 0.0854
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Echinococcus multilocularis serotonin receptor 0.0076 0.0854 0.0854
Schistosoma mansoni amine GPCR 0.0076 0.0854 0.0854
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0854 0.0854
Plasmodium falciparum glutathione reductase 0.0446 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0076 0.0854 0.0854
Echinococcus granulosus neuropeptide s receptor 0.0076 0.0854 0.0854
Toxoplasma gondii NADPH-glutathione reductase 0.0154 0.2803 0.2803
Loa Loa (eye worm) thioredoxin reductase 0.0446 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis sex peptide receptor 0.0076 0.0854 0.0854
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0154 0.2803 0.2803
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0154 0.2803 0.2803
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni biogenic amine receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Plasmodium vivax thioredoxin reductase, putative 0.0446 1 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0041 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0076 0.0854 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0154 0.2803 0.2803
Echinococcus multilocularis somatostatin receptor 0.0076 0.0854 0.0854
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0154 0.2803 0.2803
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0154 0.2803 1
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0854 0.0854
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0076 0.0854 0.0854
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0854 0.0854
Schistosoma mansoni alpha-1 adrenergic receptor 0.0076 0.0854 0.0854
Echinococcus granulosus orexin receptor type 2 0.0076 0.0854 0.0854
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0154 0.2803 1
Trypanosoma cruzi trypanothione reductase, putative 0.0154 0.2803 0.2803
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis thioredoxin glutathione reductase 0.0446 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0854 0.0854
Brugia malayi GnHR receptor homolog 0.0076 0.0854 0.0854
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0076 0.0854 0.0854
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0154 0.2803 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi follicle stimulating hormone receptor 0.0076 0.0854 0.0854
Brugia malayi Serotonin receptor 0.0076 0.0854 0.0854
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0076 0.0854 0.0854
Schistosoma mansoni growth hormone secretagogue receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Echinococcus granulosus g-protein coupled receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus somatostatin receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0854 0.0854
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0854 0.0854
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0854 0.0854
Trichomonas vaginalis mercuric reductase, putative 0.0154 0.2803 1
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0854 0.0854
Schistosoma mansoni opsin-like receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni opsin-like receptor 0.0076 0.0854 0.0854
Brugia malayi Serotonin receptor 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0076 0.0854 0.0854
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0041 0 0.5
Onchocerca volvulus 0.0076 0.0854 1
Brugia malayi G-protein coupled receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus allatostatin A receptor 0.0076 0.0854 0.0854
Brugia malayi ORL1-like opioid receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0154 0.2803 0.2803
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi neuropeptide F receptor 0.0076 0.0854 0.0854
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0854 0.0854
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0154 0.2803 1
Brugia malayi larval opioid receptor 0.0076 0.0854 0.0854
Echinococcus granulosus neuropeptide receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0076 0.0854 0.0854
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0854 0.0854
Schistosoma mansoni hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi putative neuropeptide receptor 0.0076 0.0854 0.0854
Schistosoma mansoni hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus G protein coupled receptor 139 0.0076 0.0854 0.0854
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0154 0.2803 0.2803
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0076 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Brugia malayi G protein-coupled receptor 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0154 0.2803 0.2803
Schistosoma mansoni neuropeptide f receptor 76f 0.0076 0.0854 0.0854
Echinococcus granulosus neuropeptide FF receptor 2 0.0076 0.0854 0.0854
Echinococcus multilocularis dro:myosuppressin receptor 0.0076 0.0854 0.0854
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.2803 0.2803
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Echinococcus granulosus alpha 1A adrenergic receptor 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0076 0.0854 0.0854
Brugia malayi RE15519p 0.0076 0.0854 0.0854
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Schistosoma mansoni adenoreceptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0154 0.2803 0.2803
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0854 0.0854
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0076 0.0854 0.0854
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0154 0.2803 0.2803
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0041 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0854 0.0854
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Brugia malayi Dopamine receptor 0.0076 0.0854 0.0854
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.2803 0.2803
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus multilocularis G protein coupled receptor 139 0.0076 0.0854 0.0854
Echinococcus multilocularis allatostatin A receptor 0.0076 0.0854 0.0854
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0446 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0854 0.0854
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0154 0.2803 1
Brugia malayi Dopamine receptor protein 2 0.0076 0.0854 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0076 0.0854 0.0854
Brugia malayi Melatonin receptor type 1A 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus neuropeptide receptor A26 0.0076 0.0854 0.0854
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0041 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0854 0.0854
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0154 0.2803 0.2803
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Entamoeba histolytica thioredoxin reductase, putative 0.0041 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0076 0.0854 0.0854
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0154 0.2803 0.2803
Schistosoma mansoni hypothetical protein 0.0076 0.0854 0.0854
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0041 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0854 0.0854
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0154 0.2803 0.2803
Giardia lamblia NADH oxidase lateral transfer candidate 0.0154 0.2803 1
Brugia malayi Dopamine receptor protein 1 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0076 0.0854 0.0854
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0154 0.2803 0.2803
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus g protein coupled receptor 0.0076 0.0854 0.0854
Leishmania major trypanothione reductase 0.0446 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0113 0.179 0.179
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0854 0.0854
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0854 0.0854
Echinococcus multilocularis neuropeptide FF receptor 2 0.0076 0.0854 0.0854
Brugia malayi Tachykinin-like peptides receptor 99D 0.0076 0.0854 0.0854
Schistosoma mansoni amine GPCR 0.0076 0.0854 0.0854
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0154 0.2803 0.2803
Onchocerca volvulus 0.0076 0.0854 1
Brugia malayi G-protein coupled receptor 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0076 0.0854 0.0854
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0854 0.0854
Brugia malayi hypothetical protein 0.0076 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Echinococcus granulosus tachykinin peptides receptor 99D 0.0076 0.0854 0.0854
Onchocerca volvulus 0.0076 0.0854 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0076 0.0854 0.0854
Echinococcus granulosus 7tm_1 domain containing protein 0.0076 0.0854 0.0854
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0154 0.2803 0.2803
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0854 0.0854
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0076 0.0854 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0154 0.2803 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0854 0.0854
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0154 0.2803 0.2803
Plasmodium falciparum thioredoxin reductase 0.0154 0.2803 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.2803 0.2803
Echinococcus multilocularis orexin receptor type 2 0.0076 0.0854 0.0854

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 63 % Percent inhibition for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats. ChEMBL. 12540239
Inhibition (functional) = 67 % Percent effect profile muscle relaxation at 100 mg/kg by intraperitoneal administration in mouse using Straub-tail (ST) assay ChEMBL. 12540239
Inhibition (functional) = 67 % Percent effect profile muscle relaxation at 100 mg/kg by intraperitoneal administration in mouse using Straub-tail (ST) assay ChEMBL. 12540239
ND (functional) 0 Effective dose required for muscle relaxation by oral administration in mouse using Straub-tail (ST) assay. ChEMBL. 12540239
ND (functional) 0 Sedation by oral administration was estimated using rotorod (RR) assay. ChEMBL. 12540239
ND (functional) 0 Ratio of rotorod to straub tail activity, which indicates the dose exhibiting muscle relaxant activity versus that producing sedation. ChEMBL. 12540239
ND (functional) 0 Antiinflammatory activity in cells by Carragenaan pleurisy assay by oral administration. ChEMBL. 12540239
ND (functional) 0 Antiinflammatory activity in edema by Carragenaan pleurisy assay by oral administration. ChEMBL. 12540239
ND (functional) 0 Effective dose required for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats. ChEMBL. 12540239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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