TDR Targets

Basic information

Technical information

TDR Targets ID: 228751
Name: (2E)-2-(4,6-difluoro-2,3-dihydroinden-1-ylide ne)-N-ethylacetamide
MW: 237.245 | Formula: C13H13F2NO
H donors: 1 H acceptors: 1 LogP: 2.11 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)/C=C/1\CCc2c1cc(F)cc2F
InChi: 1S/C13H13F2NO/c1-2-16-13(17)5-8-3-4-10-11(8)6-9(14)7-12(10)15/h5-7H,2-4H2,1H3,(H,16,17)/b8-5+
InChiKey: LTKGPLMKKNACRX-VMPITWQZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2E)-2-(4,6-difluoroindan-1-ylidene)-N-ethyl-acetamide
(2E)-2-(4,6-difluoro-1-indanylidene)-N-ethylacetamide
(2E)-2-(4,6-difluoro-2,3-dihydroinden-1-ylidene)-N-ethyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptides capa receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	neuropeptide Y receptor	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Onchocerca volvulus		0.0076	0.0854	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0154	0.2803	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	neuropeptide F receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	neuropeptide receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	fmrfamide receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	g protein coupled receptor	0.0076	0.0854	0.0854
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0154	0.2803	0.2803
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Plasmodium falciparum	glutathione reductase	0.0154	0.2803	0.2803
Echinococcus granulosus	neuropeptide receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0154	0.2803	0.2803
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0446	1	1
Schistosoma mansoni	biogenic amine receptor	0.0076	0.0854	0.0854
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0113	0.179	0.179
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Trypanosoma cruzi	trypanothione reductase, putative	0.0446	1	1
Schistosoma mansoni	amine GPCR	0.0076	0.0854	0.0854
Brugia malayi	Dopamine receptor protein 2	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus multilocularis	fmrfamide receptor	0.0076	0.0854	0.0854
Brugia malayi	putative neuropeptide receptor NPR1	0.0076	0.0854	0.0854
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0154	0.2803	0.2803
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0076	0.0854	0.0854
Echinococcus granulosus	tm gpcr rhodopsin	0.0076	0.0854	0.0854
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0154	0.2803	0.2803
Onchocerca volvulus		0.0076	0.0854	1
Echinococcus multilocularis	neuropeptide receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0154	0.2803	0.2803
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	biogenic amine 5HT receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0076	0.0854	0.0854
Toxoplasma gondii	NADPH-glutathione reductase	0.0154	0.2803	0.2803
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0154	0.2803	0.2803
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.0041	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0076	0.0854	0.0854
Brugia malayi	sulfakinin receptor protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	g protein coupled receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Leishmania major	trypanothione reductase	0.0446	1	1
Echinococcus granulosus	orexin receptor type 2	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0154	0.2803	0.2803
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0076	0.0854	0.0854
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Loa Loa (eye worm)	G-protein coupled receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus multilocularis	somatostatin receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	hypothetical protein	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0154	0.2803	0.2803
Onchocerca volvulus		0.0076	0.0854	1
Brugia malayi	neuropeptide F receptor	0.0076	0.0854	0.0854
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0154	0.2803	0.2803
Brugia malayi	RE15519p	0.0076	0.0854	0.0854
Schistosoma mansoni	opsin-like receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	allatostatin A receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0076	0.0854	0.0854
Echinococcus multilocularis	neuropeptides capa receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0076	0.0854	0.0854
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0041	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Echinococcus multilocularis	serotonin receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0076	0.0854	0.0854
Entamoeba histolytica	thioredoxin reductase, putative	0.0041	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	fmrfamide receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	neuropeptide receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	neuropeptides capa receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0076	0.0854	0.0854
Plasmodium vivax	glutathione reductase, putative	0.0446	1	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0154	0.2803	0.2803
Schistosoma mansoni	neuropeptide f receptor 76f	0.0076	0.0854	0.0854
Brugia malayi	neuropeptide F receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	thioredoxin reductase	0.0446	1	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0154	0.2803	0.2803
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0154	0.2803	0.2803
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0446	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0076	0.0854	0.0854
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0076	0.0854	0.0854
Echinococcus granulosus	thioredoxin glutathione reductase	0.0446	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	g protein coupled receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Echinococcus multilocularis	dro:myosuppressin receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	opsin-like receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	g-protein coupled receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0154	0.2803	0.2803
Schistosoma mansoni	histamine h1 receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Brugia malayi	follicle stimulating hormone receptor	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Trypanosoma cruzi	trypanothione reductase, putative	0.0154	0.2803	0.2803
Trichomonas vaginalis	glutathione reductase, putative	0.0154	0.2803	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0076	0.0854	0.0854
Echinococcus granulosus	neuropeptide receptor A26	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Schistosoma mansoni	amine GPCR	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	serotonin receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0076	0.0854	0.0854
Schistosoma mansoni	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0154	0.2803	0.2803
Echinococcus multilocularis	G protein coupled receptor 139	0.0076	0.0854	0.0854
Brugia malayi	putative neuropeptide receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	tm gpcr rhodopsin	0.0076	0.0854	0.0854
Echinococcus granulosus	7tm_1 domain containing protein	0.0076	0.0854	0.0854
Echinococcus granulosus	dro:myosuppressin receptor	0.0076	0.0854	0.0854
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0154	0.2803	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0076	0.0854	0.0854
Brugia malayi	G protein-coupled receptor	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	glutathione reductase	0.0446	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0076	0.0854	1
Brugia malayi	Dopamine receptor	0.0076	0.0854	0.0854
Entamoeba histolytica	disulphide oxidoreductase, putative	0.0041	0	0.5
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0154	0.2803	1
Onchocerca volvulus		0.0076	0.0854	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0076	0.0854	0.0854
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Brugia malayi	AKH receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	biogenic amine receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	neuropeptides capa receptor	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0154	0.2803	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Trichomonas vaginalis	mercuric reductase, putative	0.0154	0.2803	1
Schistosoma mansoni	opsin-like receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0076	0.0854	0.0854
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0154	0.2803	0.2803
Brugia malayi	Melatonin receptor type 1A	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0076	0.0854	0.0854
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0076	0.0854	0.0854
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0154	0.2803	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0154	0.2803	0.2803
Plasmodium vivax	thioredoxin reductase, putative	0.0446	1	1
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Schistosoma mansoni	neuropeptide receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	G-protein coupled receptor	0.0076	0.0854	0.0854
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0154	0.2803	0.2803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Schistosoma mansoni	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0154	0.2803	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0076	0.0854	0.0854
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0076	0.0854	0.0854
Plasmodium falciparum	glutathione reductase	0.0446	1	1
Onchocerca volvulus		0.0076	0.0854	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0076	0.0854	0.0854
Echinococcus granulosus	G protein coupled receptor 139	0.0076	0.0854	0.0854
Echinococcus granulosus	biogenic amine 5HT receptor	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	neuropeptide receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	neuropeptide F-like receptor	0.0076	0.0854	0.0854
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0154	0.2803	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0076	0.0854	0.0854
Schistosoma mansoni	adenoreceptor	0.0076	0.0854	0.0854
Echinococcus granulosus	neuropeptide s receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0076	0.0854	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0076	0.0854	0.0854
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Trypanosoma brucei	trypanothione reductase	0.0446	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Echinococcus granulosus	somatostatin receptor	0.0076	0.0854	0.0854
Toxoplasma gondii	thioredoxin reductase	0.0446	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0154	0.2803	0.2803
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0154	0.2803	0.2803
Loa Loa (eye worm)	neuropeptide F receptor	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0076	0.0854	0.0854
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0076	0.0854	0.0854
Mycobacterium tuberculosis	Probable oxidoreductase	0.0154	0.2803	0.2803
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0154	0.2803	1
Loa Loa (eye worm)	TYRA-2 protein	0.0076	0.0854	0.0854
Schistosoma mansoni	amine GPCR	0.0076	0.0854	0.0854
Echinococcus multilocularis	sex peptide receptor	0.0076	0.0854	0.0854
Brugia malayi	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0076	0.0854	0.0854
Echinococcus multilocularis	neuropeptide Y receptor	0.0076	0.0854	0.0854
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0041	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Brugia malayi	G protein-coupled receptor F59B2.13	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Schistosoma mansoni	growth hormone secretagogue receptor	0.0076	0.0854	0.0854
Treponema pallidum	NADH oxidase	0.0154	0.2803	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0076	0.0854	0.0854
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0076	0.0854	0.0854
Echinococcus granulosus	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Echinococcus multilocularis	neuropeptide Y receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	myosin xvIII	0.0076	0.0854	0.0854
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0154	0.2803	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Brugia malayi	larval opioid receptor	0.0076	0.0854	0.0854
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0154	0.2803	0.2803
Schistosoma mansoni	amine GPCR	0.0076	0.0854	0.0854
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Plasmodium falciparum	thioredoxin reductase	0.0154	0.2803	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0076	0.0854	0.0854
Brugia malayi	GnHR receptor homolog	0.0076	0.0854	0.0854
Schistosoma mansoni	neuropeptide receptor	0.0076	0.0854	0.0854
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0154	0.2803	0.2803
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0154	0.2803	0.2803
Echinococcus multilocularis	g protein coupled receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	g protein coupled receptor	0.0076	0.0854	0.0854
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0113	0.179	0.179
Echinococcus granulosus	neuropeptide Y receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Schistosoma mansoni	biogenic amine receptor	0.0076	0.0854	0.0854
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0154	0.2803	1
Brugia malayi	Thioredoxin reductase	0.0446	1	1
Plasmodium falciparum	thioredoxin reductase	0.0446	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0076	0.0854	0.0854
Brugia malayi	Serotonin receptor	0.0076	0.0854	0.0854
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0154	0.2803	0.2803
Brugia malayi	Serotonin receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	rhodopsin orphan GPCR	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Brugia malayi	Dopamine receptor protein 1	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0076	0.0854	0.0854
Brugia malayi	G-protein coupled receptor	0.0076	0.0854	0.0854
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0041	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Onchocerca volvulus		0.0076	0.0854	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0076	0.0854	0.0854
Schistosoma mansoni	amine GPCR	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Loa Loa (eye worm)	melatonin receptor type 1A	0.0076	0.0854	0.0854
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0076	0.0854	0.0854
Echinococcus granulosus	7TM GPCR rhodopsin	0.0076	0.0854	0.0854
Echinococcus multilocularis	orexin receptor type 2	0.0076	0.0854	0.0854
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0154	0.2803	0.2803
Brugia malayi	ORL1-like opioid receptor	0.0076	0.0854	0.0854
Echinococcus multilocularis	neuropeptide receptor	0.0076	0.0854	0.0854
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0154	0.2803	0.2803
Brugia malayi	G-protein coupled receptor	0.0076	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0854	0.0854
Echinococcus granulosus	sex peptide receptor	0.0076	0.0854	0.0854
Echinococcus granulosus	neuropeptide FF receptor 2	0.0076	0.0854	0.0854
Echinococcus multilocularis	serotonin receptor	0.0076	0.0854	0.0854
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0154	0.2803	0.2803
Echinococcus multilocularis	g protein coupled receptor	0.0076	0.0854	0.0854
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0076	0.0854	0.0854
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0041	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 63 %	Percent inhibition for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats.	ChEMBL.	12540239
Inhibition (functional)	= 67 %	Percent effect profile muscle relaxation at 100 mg/kg by intraperitoneal administration in mouse using Straub-tail (ST) assay	ChEMBL.	12540239
Inhibition (functional)	= 67 %	Percent effect profile muscle relaxation at 100 mg/kg by intraperitoneal administration in mouse using Straub-tail (ST) assay	ChEMBL.	12540239
ND (functional)	0	Effective dose required for muscle relaxation by oral administration in mouse using Straub-tail (ST) assay.	ChEMBL.	12540239
ND (functional)	0	Sedation by oral administration was estimated using rotorod (RR) assay.	ChEMBL.	12540239
ND (functional)	0	Ratio of rotorod to straub tail activity, which indicates the dose exhibiting muscle relaxant activity versus that producing sedation.	ChEMBL.	12540239
ND (functional)	0	Antiinflammatory activity in cells by Carragenaan pleurisy assay by oral administration.	ChEMBL.	12540239
ND (functional)	0	Antiinflammatory activity in edema by Carragenaan pleurisy assay by oral administration.	ChEMBL.	12540239
ND (functional)	0	Effective dose required for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats.	ChEMBL.	12540239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL133632
PubChem: 11020910

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 228751