Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0032 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2539 | 1 | 1 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0025 | 0.0025 | 0.0025 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0971 | 0.3778 | 0.5 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.006 | 0.0163 | 0.0163 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0025 | 0.0026 | 0.0026 |
Onchocerca volvulus | 0.0025 | 0.0025 | 0.5 | |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0025 | 0.0026 | 0.0026 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0022 | 0.0011 | 0.0011 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0025 | 0.0025 | 0.0025 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0051 | 0.0127 | 0.0127 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2539 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0022 | 0.0011 | 0.0011 |
Brugia malayi | probable protein kinase | 0.0085 | 0.0263 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0025 | 0.0025 |
Schistosoma mansoni | jumonji domain containing protein | 0.004 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0031 | 0.0031 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0025 | 0.0025 | 0.0025 |
Echinococcus multilocularis | geminin | 0.009 | 0.0283 | 0.0283 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.0026 | 0.0026 |
Brugia malayi | Dihydrofolate reductase | 0.2539 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0032 | 0.0053 | 0.0053 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0025 | 0.0026 | 0.0026 |
Brugia malayi | Protein kinase domain containing protein | 0.0025 | 0.0026 | 0.0026 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0025 | 0.0025 | 0.0025 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0025 | 0.0025 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2539 | 1 | 0.5 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0025 | 0.0025 | 0.0025 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0025 | 0.0025 | 0.0025 |
Schistosoma mansoni | dihydrofolate reductase | 0.2539 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0971 | 0.3778 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0971 | 0.3778 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0051 | 0.0127 | 0.0127 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2539 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0085 | 0.0263 | 0.0263 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0025 | 0.0025 |
Echinococcus granulosus | protein kinase | 0.006 | 0.0163 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0261 | 0.0261 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0032 | 0.0054 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.009 | 0.0283 | 0.0283 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0971 | 0.3778 | 1 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0025 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0025 | 0.0025 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0051 | 0.0127 | 0.0127 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.0026 | 0.0026 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0025 | 0.0026 | 0.0026 |
Schistosoma mansoni | vam6/vps39 related | 0.0025 | 0.0025 | 0.0025 |
Schistosoma mansoni | protein kinase | 0.006 | 0.0163 | 0.0163 |
Echinococcus multilocularis | 0.006 | 0.0163 | 0.0163 | |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0025 | 0.0026 | 0.0026 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0032 | 0.0054 | 0.0054 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0971 | 0.3778 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2539 | 1 | 1 |
Echinococcus granulosus | geminin | 0.009 | 0.0283 | 0.0283 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0032 | 0.0054 | 0.0054 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2539 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2539 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0025 | 0.0026 | 0.0026 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0025 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0025 | 0.0026 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.009 | 0.0283 | 0.0283 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0971 | 0.3778 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0025 | 0.0025 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0085 | 0.0261 | 0.0261 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 60 uM | Cytostatic concentration required to inhibit CEM/0 cells proliferation by 50% | ChEMBL. | 10514282 |
EC50 (functional) | = 0.09 uM | Concentration required to protect CEM/TK cells against the cytopathicity of HIV-2 by 50% | ChEMBL. | 10514282 |
EC50 (functional) | = 0.13 uM | Concentration required to protect CEM/0 cells against the cytopathicity of HIV-2 by 50% | ChEMBL. | 10514282 |
EC50 (functional) | = 0.15 uM | Concentration required to protect CEM/0 cells against the cytopathicity of HIV-1 by 50% | ChEMBL. | 10514282 |
logD (ADMET) | = 0.91 | Partition coefficient (logD7.0) | ChEMBL. | 10514282 |
Selectivity index (functional) | = 400 | Ratio CC50/EC50 for HIV-1 in CEM/0 cells | ChEMBL. | 10514282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.