Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0551 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.1876 | 0.1876 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0028 | 0.05 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.2977 | 0.7531 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0551 | 0.0551 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0045 | 0.0771 | 0.195 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0028 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0028 | 0.0028 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0551 | 0.1394 |
Brugia malayi | RNA binding protein | 0.007 | 0.1876 | 0.4748 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit TIM10 | 0.0053 | 0.112 | 0.2834 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0254 | 0.9957 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.2977 | 0.2977 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0551 | 0.4791 |
Onchocerca volvulus | 0.004 | 0.0551 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0551 | 1 |
Echinococcus granulosus | expressed protein | 0.0053 | 0.112 | 0.112 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0551 | 0.1394 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0551 | 0.5 |
Leishmania major | basic transcription factor 3a, putative | 0.0039 | 0.0501 | 0.9084 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Toxoplasma gondii | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.112 | 1 |
Echinococcus granulosus | transcription factor btf3 | 0.0039 | 0.0501 | 0.0501 |
Schistosoma mansoni | transcription factor btf3 | 0.0039 | 0.0501 | 0.0501 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0551 | 0.0551 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 0.0501 | 0.9084 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.112 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.2086 | 0.2086 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0045 | 0.0771 | 0.195 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0551 | 1 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0045 | 0.0771 | 0.6801 |
Toxoplasma gondii | TIM10 family protein, putative | 0.0053 | 0.112 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0028 | 0.007 |
Brugia malayi | TAR-binding protein | 0.007 | 0.1876 | 0.4748 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0028 | 0.05 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0039 | 0.0501 | 0.4469 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0028 | 0.05 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0551 | 0.1394 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0551 | 1 |
Echinococcus multilocularis | expressed protein | 0.0053 | 0.112 | 0.112 |
Toxoplasma gondii | NAC domain-containing protein | 0.0039 | 0.0501 | 0.4469 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.1876 | 0.1876 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0028 | 0.0246 |
Brugia malayi | beta-NAC-like protein | 0.0039 | 0.0501 | 0.1266 |
Brugia malayi | hypothetical protein | 0.0075 | 0.2086 | 0.5278 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0551 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2086 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0551 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.1876 | 0.1876 |
Brugia malayi | beta-lactamase | 0.004 | 0.0551 | 0.1394 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0551 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0028 | 0.0246 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0551 | 0.0551 |
Echinococcus multilocularis | transcription factor btf3 | 0.0039 | 0.0501 | 0.0501 |
Echinococcus multilocularis | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0045 | 0.0771 | 0.0771 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2086 | 1 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0039 | 0.0501 | 0.4329 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0551 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0255 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.2977 | 0.2977 |
Toxoplasma gondii | mitochondrial inner membrane translocase subunit TIM17, putative | 0.0045 | 0.0771 | 0.6879 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0045 | 0.0771 | 0.6879 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.2977 | 0.2977 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0551 | 0.5 |
Brugia malayi | hypothetical protein | 0.004 | 0.058 | 0.1467 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0771 | 0.0771 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0551 | 0.4919 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Onchocerca volvulus | 0.004 | 0.0551 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.2086 | 0.2086 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2977 | 0.2977 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.1876 | 0.4748 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0551 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2977 | 0.2977 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2086 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 0.0501 | 0.9084 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0551 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0039 | 0.0501 | 0.9084 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0551 | 1 |
Onchocerca volvulus | 0.004 | 0.0551 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | transport to inner mitochondrial membrane family member | 0.0053 | 0.112 | 0.112 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0255 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.2977 | 0.2977 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0551 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0551 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | ICD-1 protein | 0.0039 | 0.0501 | 0.0501 |
Schistosoma mansoni | mitochondrial import inner membrane translocase subunit tim10 | 0.0053 | 0.112 | 0.112 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0551 | 0.0551 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.2086 | 0.2086 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2086 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.2977 | 0.2977 |
Brugia malayi | hypothetical protein | 0.004 | 0.058 | 0.1467 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0551 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0045 | 0.0771 | 0.195 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0771 | 0.0771 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0028 | 0.05 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.1876 | 0.1876 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2977 | 0.2977 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.112 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.2086 | 0.2086 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.1876 | 0.1876 |
Brugia malayi | hypothetical protein | 0.0117 | 0.3952 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0551 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | NA 0 mM | Inhibition of Trypanosoma brucei phosphoglycerate kinase (PGK); inactive at 4 mM | ChEMBL. | 11063610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.