TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.473 | Formula: C18H32N4O
H donors: 2 H acceptors: 3 LogP: 2.82 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CNCCNC1CCC2C3C1C(=O)C1CCCCC1C3NCN2
InChi: 1S/C18H16N4O/c1-19-8-9-20-14-7-6-13-15-16(14)18(23)12-5-3-2-4-11(12)17(15)22-10-21-13/h2-7,10,19-20H,8-9H2,1H3
InChiKey: SPGVCDNPEZGOIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus granulosus	AMP deaminase 2	0.2049	0.4751	0.4751
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0013	0.0013
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Onchocerca volvulus		0.0094	0.0174	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Trypanosoma cruzi	AMP deaminase, putative	0.2049	0.4751	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0107	0.0202	0.0202
Onchocerca volvulus		0.0094	0.0174	0.0161
Schistosoma mansoni	nAChR subunit	0.0081	0.0141	0.0141
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Brugia malayi	RNase H family protein	0.0401	0.0891	0.0891
Brugia malayi	neuropeptide F receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	neurotransmitter gated ion channel	0.0037	0.004	0.004
Echinococcus granulosus	neuropeptide FF receptor 2	0.0094	0.0174	0.0174
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0032	0.0032
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0081	0.0141	0.0141
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0094	0.0174	0.0174
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0094	0.0174	0.0174
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Giardia lamblia	Ribonuclease H	0.0401	0.0891	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Brugia malayi	hypothetical protein	0.0034	0.0032	0.0032
Echinococcus multilocularis	adenosine deaminase	0.429	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0081	0.0141	0.0141
Onchocerca volvulus		0.0094	0.0174	0.0161
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0019	0.0019
Trypanosoma brucei	AMP deaminase, putative	0.2049	0.4751	1
Echinococcus granulosus	G protein coupled receptor 139	0.0094	0.0174	0.0174
Echinococcus granulosus	tm gpcr rhodopsin	0.0094	0.0174	0.0174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0075	0.0075
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Echinococcus granulosus	survival motor neuron protein 1	0.0256	0.0552	0.0552
Treponema pallidum	adenosine deaminase	0.429	1	1
Onchocerca volvulus		0.0028	0.0019	0.0006
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0094	0.0174	0.0174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Trichomonas vaginalis	glucosylceramidase, putative	0.0272	0.059	0.059
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Schistosoma mansoni	amine GPCR	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0081	0.0141	0.0129
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0081	0.0141	0.0141
Onchocerca volvulus		0.0037	0.004	0.0027
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0013	0.0004
Schistosoma mansoni	phosphoglucomutase	0.0401	0.0891	0.0891
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0094	0.0174	0.0174
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	microtubule associated protein 2	0.0727	0.1655	0.1655
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0043	0.0054	0.0054
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0272	0.059	0.059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Echinococcus granulosus	Protein patched homolog 1	0.0046	0.006	0.006
Onchocerca volvulus		0.0043	0.0054	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0081	0.0141	0.0141
Echinococcus granulosus	neuropeptide receptor A26	0.0094	0.0174	0.0174
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0401	0.0891	0.5
Onchocerca volvulus		0.0094	0.0174	0.0161
Loa Loa (eye worm)	neuropeptide F receptor	0.0094	0.0174	0.0174
Leishmania major	ribonuclease H1, putative	0.0401	0.0891	0.0883
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0272	0.059	0.059
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0094	0.0174	0.0174
Trypanosoma cruzi	AMP deaminase, putative	0.2049	0.4751	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Schistosoma mansoni	microtubule-associated protein tau	0.0727	0.1655	0.1655
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0081	0.0141	0.0141
Brugia malayi	Cation transporter family protein	0.0081	0.0141	0.0141
Onchocerca volvulus		0.0094	0.0174	0.0161
Brugia malayi	reverse transcriptase	0.0034	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus granulosus	expressed protein	0.0393	0.0874	0.0874
Brugia malayi	putative neuropeptide receptor NPR1	0.0094	0.0174	0.0174
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0094	0.0174	0.0174
Schistosoma mansoni	adenoreceptor	0.0094	0.0174	0.0174
Brugia malayi	Zinc knuckle family protein	0.0034	0.0032	0.0032
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Echinococcus granulosus	serotonin receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0081	0.0141	0.0141
Brugia malayi	putative neuropeptide receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	neurotransmitter gated ion channel	0.0043	0.0054	0.0054
Onchocerca volvulus		0.0081	0.0141	0.0129
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Echinococcus multilocularis	fmrfamide receptor	0.0094	0.0174	0.0174
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0037	0.004	0.004
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0094	0.0174	0.0161
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0081	0.0141	0.0141
Trichomonas vaginalis	reverse transcriptases, putative	0.0034	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0878	0.2008	0.2008
Echinococcus multilocularis	neuropeptide Y receptor	0.0094	0.0174	0.0174
Trypanosoma brucei	ribonuclease H1	0.0401	0.0891	0.186
Echinococcus granulosus	ribonuclease H1	0.0401	0.0891	0.0891
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Brugia malayi	Cation transporter family protein	0.0081	0.0141	0.0141
Trichomonas vaginalis	glucosylceramidase, putative	0.0272	0.059	0.059
Onchocerca volvulus		0.0052	0.0075	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.006	0.006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0046	0.006	0.006
Trichomonas vaginalis	adenosine deaminase, putative	0.429	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0046	0.006	0.006
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.2715	0.6312	0.6312
Brugia malayi	TAR-binding protein	0.0069	0.0113	0.0113
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0094	0.0174	0.0174
Brugia malayi	RNase H family protein	0.0401	0.0891	0.0891
Plasmodium vivax	adenosine deaminase, putative	0.429	1	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0081	0.0141	0.0141
Leishmania major	adenine aminohydrolase	0.429	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Mycobacterium ulcerans	adenosine deaminase	0.429	1	1
Brugia malayi	RNase H family protein	0.0401	0.0891	0.0891
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.1575	0.3641	0.3641
Trichomonas vaginalis	glucosylceramidase, putative	0.0272	0.059	0.059
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0019	0.0019
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0141	0.0141
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0094	0.0174	0.0174
Schistosoma mansoni	nAChR subunit	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0202	0.0202
Onchocerca volvulus	Glucosylceramidase homolog	0.0179	0.0371	0.0358
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Entamoeba histolytica	AMP deaminase, putative	0.2049	0.4751	0.4751
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.0113	0.0113
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0081	0.0141	0.0141
Schistosoma mansoni	neuropeptide receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	lamin	0.0028	0.0019	0.0019
Echinococcus granulosus	lamin dm0	0.0028	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus granulosus	7TM GPCR rhodopsin	0.0094	0.0174	0.0174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Echinococcus multilocularis	g protein coupled receptor	0.0094	0.0174	0.0174
Brugia malayi	Serotonin receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	opsin-like receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	biogenic amine receptor	0.0094	0.0174	0.0174
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus multilocularis	Niemann Pick C1 protein	0.0107	0.0202	0.0202
Plasmodium falciparum	adenosine deaminase	0.429	1	1
Onchocerca volvulus		0.0094	0.0174	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Onchocerca volvulus		0.0034	0.0032	0.002
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	neuropeptide F-like receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Echinococcus multilocularis	somatostatin receptor	0.0094	0.0174	0.0174
Onchocerca volvulus	AMP deaminase 2 homolog	0.2049	0.4751	0.4744
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0108	0.0206	0.0206
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0013	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.2049	0.4751	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0081	0.0141	0.0141
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0371	0.0371
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0034	0.0032	0.0032
Brugia malayi	excitatory GABA receptor EXP-1A	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0013	0.0013
Echinococcus granulosus	fmrfamide receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Schistosoma mansoni	phosphoglucomutase	0.0401	0.0891	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Echinococcus granulosus	neuropeptide s receptor	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0037	0.004	0.0027
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	nAChR subunit	0.0037	0.004	0.004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0141	0.0141
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0034	0.0032	0.0032
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.2715	0.6312	0.6312
Echinococcus granulosus	expressed conserved protein	0.01	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Onchocerca volvulus		0.0094	0.0174	0.0161
Trypanosoma brucei	unspecified product	0.0435	0.0971	0.2029
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Schistosoma mansoni	amine GPCR	0.0094	0.0174	0.0174
Schistosoma mansoni	nAChR subunit	0.0081	0.0141	0.0141
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0037	0.004	0.004
Trichomonas vaginalis	reverse transcriptases, putative	0.0034	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0037	0.004	0.004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0141	0.0141
Schistosoma mansoni	nAChR subunit	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.429	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0272	0.059	0.059
Onchocerca volvulus		0.0094	0.0174	0.0161
Loa Loa (eye worm)	RNA binding protein	0.0069	0.0113	0.0113
Loa Loa (eye worm)	AMP deaminase	0.2049	0.4751	0.4751
Loa Loa (eye worm)	hypothetical protein	0.0474	0.1063	0.1063
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0081	0.0141	0.0141
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0013	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Entamoeba histolytica	adenosine deaminase, putative	0.429	1	1
Echinococcus granulosus	neuropeptide receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0013	0.0013
Trichomonas vaginalis	ribonuclease H1, putative	0.0401	0.0891	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Echinococcus multilocularis	neuropeptide receptor	0.0094	0.0174	0.0174
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Trypanosoma brucei	SLACS retrotransposable element (part), putative	0.0034	0.0032	0.0049
Onchocerca volvulus		0.0094	0.0174	0.0161
Echinococcus multilocularis	Niemann Pick C1 protein	0.0152	0.0309	0.0309
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0081	0.0141	0.0141
Schistosoma mansoni	biogenic amine receptor	0.0094	0.0174	0.0174
Trypanosoma cruzi	ribonuclease H1, putative	0.0401	0.0891	0.186
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Schistosoma mansoni	phosphoglucomutase	0.0401	0.0891	0.0891
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0081	0.0141	0.0129
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0013	0.0004
Trypanosoma cruzi	AMP deaminase 2, putative	0.1575	0.3641	0.7658
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0094	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0037	0.004	0.004
Trypanosoma brucei	ingi protein (ORF1)	0.0435	0.0971	0.2029
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.429	1	1
Echinococcus multilocularis	lamin dm0	0.0028	0.0019	0.0019
Onchocerca volvulus		0.0094	0.0174	0.0161
Schistosoma mansoni	nAChR subunit	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0013	0.0013
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0081	0.0141	0.0141
Brugia malayi	ORL1-like opioid receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0094	0.0174	0.0174
Echinococcus multilocularis	g protein coupled receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.429	1	1
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.429	1	1
Onchocerca volvulus		0.0094	0.0174	0.0161
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0094	0.0174	0.0174
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0081	0.0141	0.0141
Schistosoma mansoni	nAChR subunit	0.0081	0.0141	0.0141
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0019	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Loa Loa (eye worm)	cytochrome P450 family protein	0.0035	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Trypanosoma cruzi	AMP deaminase, putative	0.2049	0.4751	1
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0019	0.0019
Entamoeba histolytica	adenosine deaminase, putative	0.429	1	1
Echinococcus granulosus	somatostatin receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0013	0.0013
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0371	0.0371
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0141	0.0141
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0034	0.0032	0.0032
Echinococcus granulosus	allatostatin A receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	RNA directed DNA polymerase	0.0034	0.0032	0.0032
Loa Loa (eye worm)	G-protein coupled receptor	0.0094	0.0174	0.0174
Trypanosoma brucei	hypothetical protein, conserved	0.0435	0.0971	0.2029
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	growth hormone secretagogue receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0009	0.0009
Brugia malayi	Dopamine receptor	0.0094	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0094	0.0174	0.0174
Onchocerca volvulus	Ribonuclease H1 homolog	0.0401	0.0891	0.088
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0081	0.0141	0.0141
Schistosoma mansoni	lamin	0.0028	0.0019	0.0019
Brugia malayi	intermediate filament protein	0.0028	0.0019	0.0019
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Echinococcus granulosus	sex peptide receptor	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0037	0.004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Trypanosoma brucei	Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative	0.0034	0.0032	0.0049
Trypanosoma brucei	AMP deaminase, putative	0.2049	0.4751	1
Echinococcus multilocularis	sex peptide receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Brugia malayi	CHE-14 protein	0.0046	0.006	0.006
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0113	0.0113
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.004	0.004
Echinococcus granulosus	Niemann Pick C1 protein	0.0107	0.0202	0.0202
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0081	0.0141	0.0141
Schistosoma mansoni	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0094	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0044	0.0056	0.0056
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.2049	0.4751	0.4746
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0435	0.0971	0.2029
Echinococcus multilocularis	expressed protein	0.0393	0.0874	0.0874
Loa Loa (eye worm)	GABA receptor subunit	0.0043	0.0054	0.0054
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0094	0.0174	0.0174
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0081	0.0141	0.0141
Echinococcus granulosus	g protein coupled receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	nAChR subunit	0.0043	0.0054	0.0054
Echinococcus multilocularis	orexin receptor type 2	0.0094	0.0174	0.0174
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0107	0.0202	0.0202
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0094	0.0174	0.0174
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0081	0.0141	0.0141
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0081	0.0141	0.0141
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Onchocerca volvulus		0.0094	0.0174	0.0161
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0013	0.0013
Echinococcus multilocularis	serotonin receptor	0.0881	0.2016	0.2016
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0037	0.004	0.004
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0043	0.0054	0.0054
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0043	0.0054	0.0054
Echinococcus granulosus	dro:myosuppressin receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Brugia malayi	GnHR receptor homolog	0.0094	0.0174	0.0174
Onchocerca volvulus		0.1575	0.3641	0.3632
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0034	0.0032	0.0032
Brugia malayi	larval opioid receptor	0.0094	0.0174	0.0174
Mycobacterium tuberculosis	Possible maturase	0.0034	0.0032	0.002
Echinococcus granulosus	g-protein coupled receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Schistosoma mansoni	patched 1	0.0046	0.006	0.006
Echinococcus granulosus	biogenic amine 5HT receptor	0.0881	0.2016	0.2016
Echinococcus granulosus	glycine receptor subunit beta	0.0081	0.0141	0.0141
Onchocerca volvulus	Adenosine deaminase homolog	0.429	1	1
Echinococcus multilocularis	protein dispatched 1	0.0052	0.0075	0.0075
Schistosoma mansoni	hypothetical protein	0.1503	0.3473	0.3473
Brugia malayi	hypothetical protein	0.0037	0.004	0.004
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0113	0.0113
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0043	0.0054	0.0054
Brugia malayi	Serotonin receptor	0.3066	0.7134	0.7134
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus granulosus	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0081	0.0141	0.0141
Schistosoma mansoni	protein kinase	0.0034	0.0032	0.0032
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0094	0.0174	0.0174
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0013	0.0004
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0032	0.0049
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0081	0.0141	0.0141
Echinococcus granulosus	neuropeptide Y receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Echinococcus multilocularis	neuropeptides capa receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	g protein coupled receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0044	0.0056	0.0056
Echinococcus multilocularis	lamin	0.0028	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Brugia malayi	RNA binding protein	0.0069	0.0113	0.0113
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0009	0.0009
Echinococcus granulosus	orexin receptor type 2	0.0094	0.0174	0.0174
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0013	0.0013
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Echinococcus granulosus	tar DNA binding protein	0.0069	0.0113	0.0113
Echinococcus multilocularis	neuropeptide receptor	0.0094	0.0174	0.0174
Trypanosoma brucei	AMP deaminase, putative	0.2049	0.4751	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Echinococcus granulosus	neuropeptides capa receptor	0.0094	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Leishmania major	AMP deaminase, putative	0.2049	0.4751	0.4746
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0081	0.0141	0.0141
Schistosoma mansoni	neuropeptide receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0044	0.0056	0.0056
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0013	0.0013
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0393	0.0393
Onchocerca volvulus		0.0081	0.0141	0.0129
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0094	0.0174	0.0174
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Schistosoma mansoni	hypothetical protein	0.0034	0.0032	0.0032
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Trichomonas vaginalis	adenosine deaminase, putative	0.429	1	1
Brugia malayi	hypothetical protein	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0081	0.0141	0.0141
Entamoeba histolytica	AMP deaminase, putative	0.2049	0.4751	0.4751
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0081	0.0141	0.0141
Leishmania major	hypothetical protein, conserved	0.1575	0.3641	0.3635
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0013	0.0004
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.2049	0.4751	1
Toxoplasma gondii	AMP deaminase	0.2049	0.4751	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0371	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	AKH receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	ribonuclease H1	0.0401	0.0891	0.0891
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.0174	0.0174
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	neuropeptides capa receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	adenosine monophosphate deaminase	0.2049	0.4751	0.4751
Echinococcus granulosus	tm gpcr rhodopsin	0.0094	0.0174	0.0174
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Echinococcus multilocularis	expressed conserved protein	0.01	0.0187	0.0187
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0013	0.0004
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0094	0.0174	0.0174
Echinococcus granulosus	biogenic amine 5HT receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	g-protein coupled receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0081	0.0141	0.0141
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0081	0.0141	0.0141
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0094	0.0174	0.0174
Trypanosoma brucei	ingi protein (ORF1)	0.0435	0.0971	0.2029
Brugia malayi	G-protein coupled receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	g protein coupled receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0081	0.0141	0.0141
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0081	0.0141	0.0141
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	AMP deaminase 2	0.2049	0.4751	0.4751
Echinococcus granulosus	KRAB A domain containing protein	0.0034	0.0032	0.0032
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Brugia malayi	G protein-coupled receptor F59B2.13	0.0094	0.0174	0.0174
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.0034	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Brugia malayi	RE15519p	0.0094	0.0174	0.0174
Loa Loa (eye worm)	neuropeptide F receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0094	0.0174	0.0161
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0371	0.0371
Trichomonas vaginalis	glucosylceramidase, putative	0.0272	0.059	0.059
Schistosoma mansoni	biogenic amine receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	LGC-31 protein	0.0081	0.0141	0.0141
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0094	0.0174	0.0174
Echinococcus granulosus	glycine receptor subunit beta	0.0081	0.0141	0.0141
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	G-protein coupled receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Echinococcus multilocularis	sterol regulatory element binding protein	0.0046	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0081	0.0141	0.0141
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0081	0.0141	0.0141
Loa Loa (eye worm)	ACC-1 protein	0.0081	0.0141	0.0141
Brugia malayi	reverse transcriptase	0.0034	0.0032	0.0032
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0113	0.0113
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0009	0.0009
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0034	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.3376	0.7859	0.7859
Echinococcus multilocularis	neuropeptide s receptor	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0094	0.0174	0.0161
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0371	0.0371
Schistosoma mansoni	nAChR subunit	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0052	0.0075	0.0075
Loa Loa (eye worm)	ACC-1 protein	0.0081	0.0141	0.0141
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0094	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0037	0.004	0.004
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0081	0.0141	0.0141
Schistosoma mansoni	adenosine deaminase	0.429	1	1
Brugia malayi	hypothetical protein	0.0034	0.0032	0.0032
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0043	0.0054	0.0042
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0081	0.0141	0.0141
Echinococcus multilocularis	neuropeptides capa receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	fmrfamide receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0081	0.0141	0.0141
Onchocerca volvulus		0.0081	0.0141	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0043	0.0054	0.0054
Brugia malayi	follicle stimulating hormone receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	nAChR subunit	0.0043	0.0054	0.0054
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0037	0.004	0.004
Brugia malayi	G-protein coupled receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	microtubule associated protein 2	0.0727	0.1655	0.1655
Loa Loa (eye worm)	CYP4Cod1	0.0024	0.0009	0.0009
Brugia malayi	Melatonin receptor type 1A	0.0094	0.0174	0.0174
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0141	0.0141
Loa Loa (eye worm)	TYRA-2 protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.2715	0.6312	0.6312
Schistosoma mansoni	hypothetical protein	0.0044	0.0056	0.0056
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	amine GPCR	0.0094	0.0174	0.0174
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0094	0.0174	0.0174
Brugia malayi	G protein-coupled receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	neuropeptide receptor A26	0.0094	0.0174	0.0174
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0113	0.0113
Echinococcus multilocularis	nAChR subunit	0.0081	0.0141	0.0141
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Schistosoma mansoni	nAChR subunit	0.0037	0.004	0.004
Schistosoma mansoni	amine GPCR	0.0094	0.0174	0.0174
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0371	0.0371
Schistosoma mansoni	adenosine deaminase-related	0.429	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0094	0.0174	0.0174
Onchocerca volvulus	Putative nachr subunit	0.0081	0.0141	0.0129
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0013	0.0004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0141	0.0141
Trypanosoma cruzi	AMP deaminase, putative	0.2049	0.4751	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0013	0.0013
Brugia malayi	sulfakinin receptor protein	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0034	0.0032	0.002
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	glycine receptor subunit beta	0.0081	0.0141	0.0141
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	dro:myosuppressin receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0881	0.2016	0.2016
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Loa Loa (eye worm)	acetylcholine receptor protein	0.0037	0.004	0.004
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0094	0.0174	0.0174
Echinococcus multilocularis	protein patched	0.0046	0.006	0.006
Echinococcus granulosus	tm gpcr rhodopsin	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0094	0.0174	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	neuropeptide f receptor 76f	0.0094	0.0174	0.0174
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0037	0.004	0.004
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0081	0.0141	0.0141
Onchocerca volvulus		0.0028	0.0019	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	neuropeptide F-like receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0552	0.0552
Echinococcus multilocularis	allatostatin A receptor	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0081	0.0141	0.0129
Schistosoma mansoni	hypothetical protein	0.0034	0.0032	0.0032
Schistosoma mansoni	opsin-like receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.0113	0.0113
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0043	0.0054	0.0054
Echinococcus multilocularis	serotonin receptor	0.0881	0.2016	0.2016
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0081	0.0141	0.0141
Echinococcus multilocularis	survival motor neuron protein 1	0.0256	0.0552	0.0552
Trypanosoma cruzi	ribonuclease H1, putative	0.0401	0.0891	0.186
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.2049	0.4751	0.4746
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0013	0.0004
Trypanosoma cruzi	AMP deaminase, putative	0.2049	0.4751	1
Schistosoma mansoni	lamin	0.0028	0.0019	0.0019
Trichomonas vaginalis	glucosylceramidase, putative	0.0272	0.059	0.059
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.429	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0094	0.0174	0.0174
Schistosoma mansoni	neurotransmitter gated ion channel	0.0037	0.004	0.004
Echinococcus granulosus	neuropeptide Y receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	neuropeptide receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0094	0.0174	0.0174
Entamoeba histolytica	hypothetical protein	0.0043	0.0054	0.0054
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0094	0.0174	0.0174
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.0113	0.0113
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0094	0.0174	0.0174
Schistosoma mansoni	amine GPCR	0.0094	0.0174	0.0174
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0081	0.0141	0.0141
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0094	0.0174	0.0174
Echinococcus granulosus	adenosine deaminase	0.429	1	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	Pao retrotransposon peptidase family protein	0.0034	0.0032	0.0032
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.2049	0.4751	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0094	0.0174	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0054	0.0054
Schistosoma mansoni	myosin xvIII	0.0094	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0037	0.004	0.004
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0081	0.0141	0.0141
Onchocerca volvulus		0.0094	0.0174	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0881	0.2016	0.2016
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0094	0.0174	0.0174
Echinococcus granulosus	sterol regulatory element binding protein	0.0046	0.006	0.006
Brugia malayi	Zinc knuckle family protein	0.0034	0.0032	0.0032
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Brugia malayi	Cytochrome P450 family protein	0.0035	0.0035	0.0035
Trypanosoma brucei	SLACS reverse transcriptase, putative	0.0034	0.0032	0.0049
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0037	0.004	0.004
Schistosoma mansoni	neuropeptide receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0037	0.004	0.004
Brugia malayi	hypothetical protein	0.0034	0.0032	0.0032
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0094	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0881	0.2016	0.2016
Schistosoma mansoni	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0019	0.0019
Echinococcus multilocularis	neuropeptide Y receptor	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.2715	0.6312	0.6312
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0081	0.0141	0.0141
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0371	0.0371
Brugia malayi	Dopamine receptor protein 1	0.0094	0.0174	0.0174
Schistosoma mansoni	acetylcholine receptor-related	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0013	0.0004
Echinococcus granulosus	7tm_1 domain containing protein	0.0094	0.0174	0.0174
Onchocerca volvulus		0.0094	0.0174	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0037	0.004	0.004
Trypanosoma brucei	RNA helicase, putative	0.1503	0.3473	0.7305
Schistosoma mansoni	histamine h1 receptor	0.0094	0.0174	0.0174
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Brugia malayi	Cation transporter family protein	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus multilocularis	G protein coupled receptor 139	0.0094	0.0174	0.0174
Echinococcus granulosus	intermediate filament protein	0.0028	0.0019	0.0019
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.0174	0.0174
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.0034	0.0032	0.0032
Schistosoma mansoni	AMP deaminase	0.2049	0.4751	0.4751
Brugia malayi	neuropeptide F receptor	0.0094	0.0174	0.0174
Brugia malayi	reverse transcriptase	0.0034	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0034	0.0032	0.002
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0034	0.0032	0.0032
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0094	0.0174	0.0174
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.004	0.004
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.2049	0.4751	0.4746
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0034	0.0032	0.0032
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0081	0.0141	0.0141
Echinococcus granulosus	Niemann Pick C1 protein	0.0152	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Schistosoma mansoni	neuropeptide receptor	0.0094	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0256	0.0552	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0094	0.0174	0.0174
Echinococcus multilocularis	musashi	0.0028	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus granulosus	RNA directed DNA polymerase	0.0034	0.0032	0.0032
Schistosoma mansoni	opsin-like receptor	0.0094	0.0174	0.0174
Brugia malayi	Dopamine receptor protein 2	0.0094	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0013	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0174	0.0174
Echinococcus granulosus	nAChR subunit	0.0081	0.0141	0.0141
Loa Loa (eye worm)	melatonin receptor type 1A	0.0094	0.0174	0.0174
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0034	0.0032	0.0032

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0.75 ml	Activity of NADH dehydrogenase was determined	ChEMBL.	8421288
Activity (functional)	= 0.75 ml	Activity of NADH dehydrogenase was determined	ChEMBL.	8421288
Activity (functional)	= 7.6 uM min-1	NADH oxidation by the compound was determined	ChEMBL.	8421288
EC50 (functional)	= 268 nM	Concentration of compound required to inhibit the cellular protein biosynthesis by 50%	ChEMBL.	8421288
EC50 (functional)	= 268 nM	Concentration of compound required to inhibit the cellular protein biosynthesis by 50%	ChEMBL.	8421288
IC10 (functional)	> 300 uM	Concentration of substrate at which the amount of total cytochrome c reduction is decreased by 10%	ChEMBL.	8421288
T/C (functional)	= 146 %	Ratio of medium survival time of the treated to the control mice at the dose of 50 (mg/kg)	ChEMBL.	8421288
T/C (functional)	= 146 %	Ratio of medium survival time of the treated to the control mice at the dose of 50 (mg/kg)	ChEMBL.	8421288
T/C (functional)	= 164 %	Ratio of medium survival time of the treated to the control mice at the dose of 100 (mg/kg)	ChEMBL.	8421288
T/C (functional)	= 164 %	Ratio of medium survival time of the treated to the control mice at the dose of 100 (mg/kg)	ChEMBL.	8421288
ToxD/Surv (ADMET)	= 6	Ratio of toxic deaths/survivors 7 days after the day 5 injection as a measure of drug toxicity at the dose of 50 (mg/kg)	ChEMBL.	8421288
ToxD/Surv (ADMET)	= 6	Ratio of toxic deaths/survivors 7 days after the day 5 injection as a measure of drug toxicity at the dose of 100 (mg/kg)	ChEMBL.	8421288

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	8421288

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL424265

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 228937