Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0047 | 0.0216 | 0.0509 |
Onchocerca volvulus | 0.0115 | 0.0826 | 1 | |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0025 | 0.0015 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0216 | 0.262 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0047 | 0.0216 | 0.262 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0194 | 0.1533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0015 | 0.0179 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0047 | 0.0216 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0015 | 0.0179 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0047 | 0.0216 | 0.021 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0047 | 0.0216 | 0.021 |
Schistosoma mansoni | coup transcription factor | 0.0047 | 0.0216 | 0.021 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.006 | 0.033 | 0.0641 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0047 | 0.0216 | 0.1377 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.006 | 0.033 | 0.0453 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0047 | 0.0216 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0061 | 0.0736 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0047 | 0.0216 | 0.0509 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.004 | 0.0153 | 0.0219 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0116 | 0.0831 | 0.54 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.004 | 0.0153 | 0.0023 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0047 | 0.0216 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0015 | 0.0179 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0078 | 0.0491 | 0.3175 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0047 | 0.0216 | 0.0509 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0047 | 0.0216 | 0.0509 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0194 | 0.1533 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0047 | 0.0216 | 0.0509 |
Leishmania major | dihydroorotate dehydrogenase | 0.0496 | 0.4255 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0047 | 0.0216 | 0.021 |
Brugia malayi | MH2 domain containing protein | 0.0092 | 0.0615 | 0.1445 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0194 | 0.1533 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0047 | 0.0216 | 0.1377 |
Brugia malayi | steroid hormone receptor | 0.0047 | 0.0216 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0476 | 0.5761 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0047 | 0.0216 | 0.0509 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0025 | 0.0015 | 0.0056 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0047 | 0.0216 | 0.0509 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0047 | 0.0216 | 0.021 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0024 | 0.0006 | 0.0077 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0153 | 0.0219 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0496 | 0.4255 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0076 | 0.0476 | 0.1119 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0062 | 0.0346 | 0.2224 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0047 | 0.0216 | 0.1377 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0496 | 0.4255 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0047 | 0.0216 | 0.262 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0047 | 0.0216 | 0.021 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0194 | 0.1533 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0194 | 0.1533 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0153 | 0.185 |
Toxoplasma gondii | MAPEG family protein | 0.0116 | 0.0831 | 0.1276 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0496 | 0.4255 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0047 | 0.0216 | 0.0509 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.004 | 0.0153 | 0.0023 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0047 | 0.0216 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0006 | 0.0077 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0153 | 0.0219 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0039 | 0.0144 | 0.0232 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0116 | 0.0831 | 0.0825 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0216 | 0.262 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0216 | 0.262 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0047 | 0.0216 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0061 | 0.0736 |
Brugia malayi | Probable ClpP-like protease | 0.006 | 0.033 | 0.0775 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0047 | 0.0216 | 0.0945 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0047 | 0.0216 | 0.0945 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0047 | 0.0216 | 0.1377 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.006 | 0.033 | 0.2119 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0047 | 0.0216 | 0.1377 |
Schistosoma mansoni | thyroid hormone receptor | 0.0047 | 0.0216 | 0.021 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.004 | 0.0153 | 0.0254 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0047 | 0.0216 | 0.0509 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0116 | 0.0831 | 0.0825 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0047 | 0.0216 | 0.0509 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0092 | 0.0615 | 0.744 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0194 | 0.1533 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0496 | 0.4255 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0078 | 0.0491 | 0.5942 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0496 | 0.4255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0826 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0047 | 0.0216 | 0.1377 |
Brugia malayi | AMP-binding enzyme family protein | 0.004 | 0.0153 | 0.0359 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0047 | 0.0216 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0216 | 0.262 |
Brugia malayi | nuclear hormone receptor | 0.0047 | 0.0216 | 0.0509 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.006 | 0.033 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0052 | 0.0259 | 0.0608 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0496 | 0.4255 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0015 | 0.0035 |
Echinococcus granulosus | FTZ F1 alpha | 0.0047 | 0.0216 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0153 | 0.185 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0259 | 0.0252 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0025 | 0.0015 | 0.0056 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.003 | 0.0061 | 0.0035 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0078 | 0.0491 | 0.0485 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0024 | 0.0006 | 0.0015 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0194 | 0.1533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0061 | 0.0736 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0025 | 0.0015 | 0.0008 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0025 | 0.0015 | 0.0179 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0039 | 0.0144 | 0.0232 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0047 | 0.0216 | 0.262 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0496 | 0.4255 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0496 | 0.4255 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0078 | 0.0491 | 0.0485 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.006 | 0.033 | 0.0641 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0078 | 0.0491 | 0.3175 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0047 | 0.0216 | 0.262 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0216 | 0.262 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0047 | 0.0216 | 0.1377 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0078 | 0.0491 | 0.0485 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.006 | 0.033 | 0.2119 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0216 | 0.262 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0015 | 0.0035 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.004 | 0.0153 | 0.0219 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0024 | 0.0006 | 0.0015 |
Brugia malayi | AMP-binding enzyme family protein | 0.004 | 0.0153 | 0.0359 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.004 | 0.0153 | 0.0254 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0047 | 0.0216 | 0.021 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0116 | 0.0831 | 0.54 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0047 | 0.0216 | 0.262 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0496 | 0.4255 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0076 | 0.0476 | 0.5761 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0039 | 0.0144 | 0.0899 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0047 | 0.0216 | 0.0509 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0047 | 0.0216 | 0.262 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0039 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.033 | 0.3992 |
Brugia malayi | nuclear receptor NHR-88 | 0.0047 | 0.0216 | 0.0509 |
Brugia malayi | ecdysteroid receptor | 0.0047 | 0.0216 | 0.0509 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0025 | 0.0015 | 0.0035 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0047 | 0.0216 | 0.1377 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0047 | 0.0216 | 0.1377 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.004 | 0.0153 | 0.0219 |
Schistosoma mansoni | thyroid hormone receptor | 0.0047 | 0.0216 | 0.021 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0047 | 0.0216 | 0.1377 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0047 | 0.0216 | 0.0509 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.004 | 0.0153 | 0.0219 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.006 | 0.033 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0015 | 0.0179 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0062 | 0.0346 | 0.2224 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0047 | 0.0216 | 0.1377 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0078 | 0.0491 | 0.1154 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0047 | 0.0216 | 0.1377 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0047 | 0.0216 | 0.021 |
Brugia malayi | hypothetical protein | 0.0115 | 0.0826 | 0.1942 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0047 | 0.0216 | 0.262 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0496 | 0.4255 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.006 | 0.033 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0039 | 0.0144 | 0.0899 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0216 | 0.262 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0076 | 0.0476 | 0.1119 |
Brugia malayi | AMP-binding enzyme family protein | 0.004 | 0.0153 | 0.0359 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.006 | 0.033 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0194 | 0.1533 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0496 | 0.4255 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0194 | 0.1533 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0061 | 0.0736 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0047 | 0.0216 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0216 | 0.262 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0025 | 0.0015 | 0.0035 |
Schistosoma mansoni | lipoxygenase | 0.0043 | 0.0178 | 0.0172 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0078 | 0.0491 | 0.3175 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.006 | 0.033 | 0.0641 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0153 | 0.0219 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0047 | 0.0216 | 0.021 |
Brugia malayi | nuclear receptor RXR | 0.0025 | 0.0015 | 0.0035 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0047 | 0.0216 | 0.262 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0496 | 0.4255 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0153 | 0.0219 |
Schistosoma mansoni | lipoxygenase | 0.0062 | 0.0346 | 0.034 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0078 | 0.0491 | 0.3175 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0047 | 0.0216 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0061 | 0.0736 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0194 | 0.1533 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0194 | 0.1533 | 0.3602 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0259 | 0.313 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0092 | 0.0615 | 0.744 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.006 | 0.033 | 0.0641 |
Onchocerca volvulus | 0.0047 | 0.0216 | 0.0945 | |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0496 | 0.4255 | 0.4252 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0015 | 0.0179 |
Schistosoma mansoni | nuclear hormone receptor | 0.0047 | 0.0216 | 0.021 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0194 | 0.1533 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0047 | 0.0216 | 0.0509 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0047 | 0.0216 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0153 | 0.185 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0496 | 0.4255 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0047 | 0.0216 | 0.0509 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = 2 % | Percent increase in liver weight in rats when administered perorally | ChEMBL. | 3950919 |
Change (functional) | = 5 % | Percent change in high density lipoproteins cholesterol concentration in serum from hypercholesterolemic rats at dose 50 mg/kg (po) | ChEMBL. | 3950919 |
Change (functional) | = 11 % | Percent change in total cholesterol concentration in serum from hypercholesterolemic rats at dose 50 mg/kg (po) | ChEMBL. | 3950919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.