Detailed information for compound 229222

Basic information

Technical information
  • TDR Targets ID: 229222
  • Name: 3-imidazol-1-yl-7-phenyl-2,3-dihydrochromen-4 -one
  • MW: 290.316 | Formula: C18H14N2O2
  • H donors: 0 H acceptors: 2 LogP: 3.02 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(COc2c1ccc(c2)c1ccccc1)n1cncc1
  • InChi: 1S/C18H14N2O2/c21-18-15-7-6-14(13-4-2-1-3-5-13)10-17(15)22-11-16(18)20-9-8-19-12-20/h1-10,12,16H,11H2
  • InChiKey: POAGOKHRBZRMEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-imidazol-1-yl-7-phenyl-chroman-4-one
  • 3-(1-imidazolyl)-7-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
  • 3-imidazol-1-yl-7-phenylchroman-4-one
  • 3-(1-imidazolyl)-7-phenyl-4-chromanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.219 0.2086
Schistosoma mansoni loxhd1 0.0019 0.2175 0.2175
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.9883 0.9881
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0055 1 1
Giardia lamblia Rrm3p helicase 0.0055 1 1
Schistosoma mansoni DNA helicase recq1 0.002 0.219 0.219
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.2175 0.2071
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0055 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0132 0.0132
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.219 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0229
Schistosoma mansoni thyroid hormone receptor 0.001 0.0132 0.0132
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.9883 0.9881
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0229
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0229
Schistosoma mansoni rab6-interacting 0.0019 0.2175 0.2175
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.219 0.2086
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.2175 0.2071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.219 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.2175 0.2071
Loa Loa (eye worm) hypothetical protein 0.0019 0.2175 0.9926
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0055 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.2175 0.9926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0132 0.0229
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0132 0.0132
Brugia malayi hypothetical protein 0.0019 0.2175 0.9925
Schistosoma mansoni thyroid hormone receptor 0.001 0.0132 0.0132
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.219 0.2086
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0055 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0132 0.0132
Entamoeba histolytica hypothetical protein, conserved 0.0055 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.2175 0.2071
Echinococcus multilocularis RUN 0.0019 0.2175 0.2071
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0229
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0132 0.0229
Schistosoma mansoni polycystin 1-related 0.0019 0.2175 0.2175
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0132 0.0229
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0083 0.0083
Schistosoma mansoni lipoxygenase 0.0055 0.9883 0.9883
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0132 0.0132
Loa Loa (eye worm) RecQ helicase 0.002 0.219 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0132 0.0229
Onchocerca volvulus 0.0019 0.2175 1
Schistosoma mansoni hypothetical protein 0.0019 0.2175 0.2175
Entamoeba histolytica recQ family helicase, putative 0.002 0.219 0.219
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.219 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0132 0.0229
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0132 0.0132
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0083 0.5
Onchocerca volvulus 0.0019 0.2175 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.219 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0083 0.0383
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0229
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.219 1
Echinococcus multilocularis bloom syndrome protein 0.002 0.219 0.2086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0132 0.0229
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.219 0.2086
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.2175 0.2071
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.2175 0.2071
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0132 0.0132
Brugia malayi hypothetical protein 0.0019 0.2175 0.9925
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.219 1
Echinococcus granulosus bloom syndrome protein 0.002 0.219 0.2086
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0083 0.0381
Schistosoma mansoni nuclear hormone receptor 0.001 0.0132 0.0132
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0055 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0132 0.0132
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.2175 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0229
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.219 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0055 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0132 0.0229
Loa Loa (eye worm) doublecortin family protein 0.0019 0.2175 0.9926
Echinococcus granulosus RUN 0.0019 0.2175 0.2071
Entamoeba histolytica DNA repair and recombination protein, putative 0.0055 1 1
Schistosoma mansoni rab6-interacting 0.0019 0.2175 0.2175
Brugia malayi Bloom's syndrome protein homolog 0.002 0.219 1
Schistosoma mansoni hypothetical protein 0.0055 1 1
Schistosoma mansoni coup transcription factor 0.001 0.0132 0.0132
Brugia malayi Doublecortin family protein 0.0019 0.2175 0.9925
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0132 0.0229
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.219 0.2125
Loa Loa (eye worm) hypothetical protein 0.002 0.219 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0055 1 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0055 1 1
Schistosoma mansoni lipoxygenase 0.0019 0.2175 0.2175
Loa Loa (eye worm) hypothetical protein 0.001 0.0083 0.00000000841
Schistosoma mansoni DNA helicase recq5 0.002 0.219 0.219
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0229
Entamoeba histolytica recQ family DNA helicase 0.001 0.0083 0.0083

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -48 % Percent change in total cholesterol concentration in serum from hypercholesterolemic rats at dose 50 mg/kg (po) ChEMBL. 3950919
Change (functional) = 22 % Percent increase in liver weight in rats when administered perorally ChEMBL. 3950919
Change (functional) = 118 % Percent change in high density lipoproteins cholesterol concentration in serum from hypercholesterolemic rats at dose 50 mg/kg (po) ChEMBL. 3950919

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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