Detailed information for compound 229384

Basic information

Technical information
  • TDR Targets ID: 229384
  • Name: 2-pyridin-1-ium-1-ylethyl octadecanoate bromi de
  • MW: 470.526 | Formula: C25H44BrNO2
  • H donors: 0 H acceptors: 1 LogP: 10.19 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC[n+]1ccccc1.[Br-]
  • InChi: 1S/C25H44NO2.BrH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-20-25(27)28-24-23-26-21-18-16-19-22-26;/h16,18-19,21-22H,2-15,17,20,23-24H2,1H3;1H/q+1;/p-1
  • InChiKey: BYXLASNGNSAATO-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • octadecanoic acid 2-(1-pyridin-1-iumyl)ethyl ester bromide
  • stearic acid 2-pyridin-1-ium-1-ylethyl ester bromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0105 0.0103
Entamoeba histolytica protein kinase, putative 0.0055 0.0242 0.8373
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0041 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0141 0.0139
Onchocerca volvulus 0.0016 0.003 0.0066
Loa Loa (eye worm) inositol-1 0.0037 0.0143 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.028 0.0783
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0277 0.0275
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0143 0.0141
Leishmania major cathepsin L-like protease 0.0016 0.003 0.0027
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1848 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.0363 0.0363
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0704 0.197
Schistosoma mansoni rab6-interacting 0.0039 0.0151 0.0422
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0151 0.0151
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0164 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Mycobacterium ulcerans lipase LipD 0.0035 0.0135 0.8193
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0704 0.0703
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0164 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.0363 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0077 0.0363 0.0363
Onchocerca volvulus 0.0028 0.0096 0.0216
Schistosoma mansoni tyrosine kinase 0.0082 0.039 0.1089
Echinococcus multilocularis expressed protein 0.0017 0.0032 0.0031
Onchocerca volvulus Cathepsin L homolog 0.0016 0.003 0.0066
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0029
Schistosoma mansoni cpg binding protein 0.0028 0.0096 0.0267
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.003 0.0029
Echinococcus granulosus lamin 0.0027 0.0086 0.0086
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0158 0.0155
Loa Loa (eye worm) hypothetical protein 0.0077 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Echinococcus multilocularis activin receptor type 0.0011 0.0003 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0141 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0017 0.0036 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0214 0.0213
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0242 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0029 0.0026
Schistosoma mansoni hypothetical protein 0.0034 0.0128 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Brugia malayi nuclear hormone receptor 0.0077 0.0363 0.0363
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0164 0.0164
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0135 0.1011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0041 0.0038
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0141 0.014
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.003 0.0082
Schistosoma mansoni inositol monophosphatase 0.0037 0.0143 0.0399
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0041 0.0039
Schistosoma mansoni lipoxygenase 0.0161 0.0819 0.2292
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0289 0.0286
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0779 0.4179 0.4179
Loa Loa (eye worm) steroid hormone receptor 0.0077 0.0363 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0017
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0041 0.1587
Brugia malayi protein kinase C II. 0.0017 0.0036 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0187 0.0186
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0143 0.0141
Echinococcus multilocularis dna polymerase kappa 0.004 0.0158 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Loa Loa (eye worm) hypothetical protein 0.0039 0.0151 0.0151
Schistosoma mansoni ferritin 0.0017 0.0032 0.0087
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.2175 0.2174
Brugia malayi hypothetical protein 0.0041 0.0164 0.0164
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Echinococcus granulosus dna polymerase eta 0.0014 0.0018 0.0017
Schistosoma mansoni intermediate filament proteins 0.0027 0.0086 0.024
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0289 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0166 0.626
Onchocerca volvulus 0.0035 0.0135 0.0305
Brugia malayi tailless protein 0.0037 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.003 0.0117
Schistosoma mansoni nuclear receptor 0.0037 0.0141 0.0392
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0141 0.014
Brugia malayi hypothetical protein 0.0041 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0077 0.0363 0.0363
Brugia malayi nuclear receptor RXR 0.0037 0.0141 0.014
Brugia malayi nuclear receptor RXR 0.0041 0.0164 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.0363 0.0363
Brugia malayi photoreceptor-specific nuclear receptor 0.0077 0.0363 0.0363
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0123 0.012
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.003 0.0082
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0166 0.5787
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0682 0.0682
Onchocerca volvulus 0.0016 0.003 0.0066
Echinococcus granulosus RUN 0.0039 0.0151 0.0151
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.003 0.0029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0028 0.0027
Toxoplasma gondii cathepsin CPL 0.0016 0.003 0.1122
Loa Loa (eye worm) hypothetical protein 0.0059 0.0265 0.0264
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0141 0.014
Loa Loa (eye worm) raf kinase 0.0231 0.1198 0.1197
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0018 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0242 0.0972
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0242 0.0241
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.0003 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0151 0.0151
Onchocerca volvulus 0.0059 0.0265 0.06
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0041 0.1386
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0141 0.0392
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0041 0.0164 0.0164
Echinococcus granulosus GPCR family 2 0.0016 0.0028 0.0027
Leishmania major cathepsin L-like protease 0.0016 0.003 0.0027
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0141 0.0139
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0277 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0141 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0077 0.0363 0.0363
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0086 0.0086
Brugia malayi Pre-SET motif family protein 0.041 0.2175 0.2174
Echinococcus granulosus insulin receptor 0.0051 0.0217 0.0216
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0134
Schistosoma mansoni tyrosine kinase 0.0082 0.039 0.1089
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0019 0.0019
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0151 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0029 0.0026
Leishmania major cathepsin L-like protease 0.0016 0.003 0.0027
Onchocerca volvulus 0.0039 0.0151 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0289 0.0288
Schistosoma mansoni hypothetical protein 0.0016 0.0028 0.0076
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0017 0.0036 0.0035
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0151 0.0151
Echinococcus multilocularis ecdysone induced protein 78C 0.0077 0.0363 0.0362
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0164 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0135 0.0132
Entamoeba histolytica cysteine protease, putative 0.0016 0.003 0.101
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0143 0.0574
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0036 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0265 0.074
Brugia malayi Protein kinase domain containing protein 0.0051 0.0217 0.0217
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0012 0.0011
Brugia malayi Furin-like cysteine rich region family protein 0.0156 0.079 0.079
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1848 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.003 0.1134
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0084 0.04 0.112
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0041 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0147 0.6039
Echinococcus granulosus raf serine:threonine protein kinase 0.0233 0.1209 0.1208
Brugia malayi beta-lactamase 0.0035 0.0135 0.0134
Onchocerca volvulus 0.0035 0.0135 0.0305
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.003 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1848 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0018 0.0017
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.003 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0028 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0036 0.0098
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0158 0.0632
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0086 0.0086
Schistosoma mansoni nuclear hormone receptor 0.0077 0.0363 0.1016
Echinococcus granulosus protein kinase c epsilon type 0.0017 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Echinococcus granulosus cpg binding protein 0.003 0.0105 0.0104
Echinococcus granulosus arachidonate 5 lipoxygenase 0.023 0.1196 0.1195
Mycobacterium tuberculosis Conserved protein 0.0035 0.0135 0.1011
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0277 0.0275
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.079 0.079
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0242 0.8373
Echinococcus multilocularis protein kinase c epsilon type 0.0017 0.0036 0.0035
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0041 0.0038
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0158 0.0632
Mycobacterium tuberculosis Conserved protein 0.0035 0.0135 0.1011
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0017 0.0036 0.0035
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0265 0.0264
Trichomonas vaginalis ferritin, putative 0.0017 0.0032 0.0125
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0277 0.0275
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0242 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.003 0.1134
Leishmania major cysteine peptidase A (CPA) 0.0016 0.003 0.0027
Brugia malayi Pre-SET motif family protein 0.0059 0.0265 0.0264
Mycobacterium leprae Probable lipase LipE 0.0035 0.0135 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0018 0.0015
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0242 0.0239
Schistosoma mansoni DNA polymerase eta 0.0014 0.0018 0.0048
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0135 0.1011
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0158 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0143 0.0141
Leishmania major cathepsin L-like protease 0.0016 0.003 0.0027
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0135 0.1011
Brugia malayi protein kinase C3,putative 0.0017 0.0036 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0467 0.2483 1
Schistosoma mansoni protein kinase C mu 0.0017 0.0036 0.0098
Schistosoma mansoni ferritin 0.0017 0.0032 0.0087
Brugia malayi Protein kinase c protein 2 0.0017 0.0036 0.0035
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.003 0.0029
Schistosoma mansoni tyrosine kinase 0.0082 0.039 0.1089
Echinococcus multilocularis mitogen activated protein kinase 14 0.1848 1 1
Brugia malayi polk-prov protein 0.003 0.0105 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0077 0.0363 0.0363
Echinococcus granulosus protein kinase c iota type 0.0017 0.0036 0.0035
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0135 0.0134
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0158 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0135 0.0541
Schistosoma mansoni hypothetical protein 0.0016 0.0028 0.0076
Schistosoma mansoni tyrosine kinase 0.0084 0.04 0.112
Brugia malayi hypothetical protein 0.0037 0.0141 0.014
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0151 0.6217
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0265 1
Onchocerca volvulus 0.0016 0.003 0.0066
Onchocerca volvulus 0.0016 0.003 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0363 0.0363
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0141 0.014
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0028 0.0027
Schistosoma mansoni ferritin light chain 0.0017 0.0032 0.0087
Brugia malayi ecdysone receptor 0.0037 0.0141 0.014
Echinococcus multilocularis cysteine protease 0.0016 0.003 0.0029
Onchocerca volvulus 0.0055 0.0242 0.0548
Leishmania major DNA polymerase kappa, putative 0.002 0.0052 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0158 0.0155
Giardia lamblia DINP protein human, muc B family 0.002 0.0052 0.0591
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0055 0.0242 0.9133
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0041 0.004
Schistosoma mansoni ferritin light chain 0.0017 0.0032 0.0087
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0141 0.0318
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0012 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0499 0.2655 0.2655
Mycobacterium ulcerans beta-lactamase 0.0035 0.0135 0.8193
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.003 0.101
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0041 0.0792
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0036 0.0098
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0289 0.0286
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0041 0.004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.0363 0.1016
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0147 0.5292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0187 0.0186
Schistosoma mansoni retinoic acid receptor RXR 0.0499 0.2655 0.7436
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0217 0.0216
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0011
Brugia malayi Protein kinase domain containing protein 0.0017 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0027
Trypanosoma brucei unspecified product 0.0033 0.0123 0.012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0135 0.0376
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0052 0.005
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0289 0.0288
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0028 0.0027
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0017 0.0036 0.0035
Onchocerca volvulus 0.0016 0.003 0.0066
Echinococcus multilocularis RUN 0.0039 0.0151 0.015
Leishmania major cathepsin L-like protease 0.0062 0.0277 0.0275
Echinococcus multilocularis musashi 0.0027 0.0086 0.0085
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0141 0.014
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0041 0.0161
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0018 0.0048
Onchocerca volvulus 0.0037 0.0141 0.0318
Echinococcus granulosus FTZ F1 alpha 0.0077 0.0363 0.0363
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0077 0.0363 0.0363
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0214 0.0213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Loa Loa (eye worm) hypothetical protein 0.0041 0.0164 0.0164
Toxoplasma gondii ABC1 family protein 0.0035 0.0135 0.5092
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0141 0.014
Loa Loa (eye worm) cysteine protease 0.0016 0.003 0.0029
Brugia malayi Inositol-1 0.0037 0.0143 0.0143
Leishmania major DNA polymerase eta, putative 0.0014 0.0018 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0028 0.0027
Schistosoma mansoni hypothetical protein 0.0403 0.2136 0.5983
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0217 0.0216
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0135 0.1011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0096 0.0095
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0166 0.0665
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0289 0.0286
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0135 0.1011
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0242 0.0972
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0077 0.0363 0.0363
Brugia malayi intermediate filament protein 0.0027 0.0086 0.0086
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0041 0.0197
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0242 0.0241
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0265 0.0264
Trypanosoma brucei protein kinase, putative 0.0055 0.0242 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0077 0.0363 0.0363
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0289 0.0288
Echinococcus multilocularis raf serine:threonine protein kinase 0.0233 0.1209 0.1208
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0143 0.4947
Schistosoma mansoni zinc finger protein 0.0037 0.0141 0.0392
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0151 0.015
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0141 0.0139
Brugia malayi hypothetical protein 0.0039 0.0151 0.0151
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0141 0.0392
Brugia malayi Steroid receptor seven-up type 2 0.0077 0.0363 0.0363
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0363 0.0363
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.0363 0.0363
Schistosoma mansoni lipoxygenase 0.023 0.1196 0.3349
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1176 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0147 0.5084
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0242 0.0241
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0143 1
Onchocerca volvulus 0.0027 0.0086 0.0195
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0041 0.0161
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0214 0.0213
Echinococcus multilocularis mitogen activated protein kinase 11 0.1848 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.0034 0.0128 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0135 0.0132
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0135 0.8193
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0077 0.0363 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Echinococcus granulosus protein kinase shaggy 0.0055 0.0242 0.0241
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.04 0.0399
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0086 0.0086
Brugia malayi nuclear receptor NHR-67 0.0037 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.0077 0.0363 0.0363
Onchocerca volvulus Cathepsin F homolog 0.0016 0.003 0.0066
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0289 0.0807
Onchocerca volvulus 0.0016 0.003 0.0066
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0077 0.0363 0.1016
Schistosoma mansoni lamin 0.0027 0.0086 0.024
Onchocerca volvulus 0.0039 0.0151 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0041 0.0164 0.0164
Loa Loa (eye worm) fibroinase 0.0016 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0077 0.0363 0.0363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0522
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0018 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0077 0.0363 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0077 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0135 0.0541
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.357 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.003 0.0117
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0077 0.0363 0.0362
Mycobacterium ulcerans hypothetical protein 0.0035 0.0135 0.8193
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0704 0.0703
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0017 0.0036 0.0035
Schistosoma mansoni coup transcription factor 0.0077 0.0363 0.1016
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0205 0.0203
Echinococcus granulosus mitogen activated protein kinase 14 0.1848 1 1
Schistosoma mansoni lamin 0.0027 0.0086 0.024
Brugia malayi CXXC zinc finger family protein 0.0028 0.0096 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0028 0.0027
Leishmania major cathepsin L-like protease 0.0016 0.003 0.0027
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0135 0.0134
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0134
Toxoplasma gondii exonuclease III APE 0.0018 0.0041 0.1532
Brugia malayi conserved hypotetical protein 0.0037 0.0141 0.014
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0122 0.8759
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.0363 0.0363
Echinococcus multilocularis insulin receptor 0.0051 0.0217 0.0216
Onchocerca volvulus 0.0016 0.003 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.0363 0.0362
Onchocerca volvulus 0.0467 0.2483 0.564
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0143 0.0574
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0135 0.0541
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.003 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0164 0.0459
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0135 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.003 0.1134
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0135 0.4471
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0143 0.5406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0077 0.0363 0.0363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0522
Schistosoma mansoni ap endonuclease 0.0018 0.0041 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Echinococcus multilocularis thyroid hormone receptor alpha 0.0077 0.0363 0.0362
Schistosoma mansoni tyrosine kinase 0.0051 0.0217 0.0606
Onchocerca volvulus Cathepsin L homolog 0.0016 0.003 0.0066
Brugia malayi hypothetical protein 0.0037 0.0141 0.014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0041 0.0038
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0141 0.014
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0017 0.0036 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0077 0.0363 0.1016
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.0363 0.0362
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0141 0.0392
Brugia malayi Raf kinase 0.0225 0.1165 0.1164
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0143 0.0143
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0032 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0135 0.0541
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0141 0.014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0135 0.1011
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0141 0.0392
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0077 0.0363 0.0362
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.003 0.0029
Schistosoma mansoni apoferritin-2 0.0017 0.0032 0.0087
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0018 0.0017
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0032 0.0121
Onchocerca volvulus 0.0037 0.0141 0.0318
Schistosoma mansoni tyrosine kinase 0.0156 0.079 0.2212
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0055 0.0242 0.0239
Schistosoma mansoni hypothetical protein 0.0016 0.0028 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0164 0.0164
Echinococcus multilocularis GPCR, family 2 0.0016 0.0028 0.0027
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0141 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0029 0.0026
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0151 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0158 0.0155
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0011 0.0003 0.0098
Echinococcus granulosus ecdysone induced protein 78C 0.0077 0.0363 0.0363
Brugia malayi beta-lactamase family protein 0.0035 0.0135 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Brugia malayi nuclear receptor NHR-88 0.0037 0.0141 0.014
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0143 0.8853
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0141 0.014
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0166 0.626
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0077 0.0363 0.1016
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0019 0.0019
Plasmodium vivax SET domain protein, putative 0.0059 0.0265 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0028 0.0027
Schistosoma mansoni cpg binding protein 0.003 0.0105 0.0291
Schistosoma mansoni steroid hormone receptor ad4bp 0.0077 0.0363 0.1016
Schistosoma mansoni apoferritin-2 0.0017 0.0032 0.0087
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.025 0.0249
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.357 0.3569
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0011 0.0003 0.0001
Loa Loa (eye worm) TK/EGFR protein kinase 0.0156 0.079 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0135 0.1011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.005
Echinococcus multilocularis lamin dm0 0.0027 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Echinococcus multilocularis 0.0048 0.0202 0.0201
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0819 0.4402 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0029
Echinococcus granulosus microtubule associated protein 2 0.0667 0.357 0.357
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0151 0.5174
Onchocerca volvulus 0.0027 0.0086 0.0195
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0134
Echinococcus multilocularis FTZ F1 alpha 0.0077 0.0363 0.0362
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0018 0.0596
Echinococcus multilocularis dna polymerase eta 0.0014 0.0018 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0135 0.0134
Loa Loa (eye worm) DR-78 0.0037 0.0141 0.014
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0077 0.0363 0.1016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0141 0.014
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0041 0.0164 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0187 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0105 0.0103
Schistosoma mansoni cpg binding protein 0.003 0.0105 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0077 0.0363 0.0363
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.079 0.0789
Loa Loa (eye worm) beta-lactamase 0.0035 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0039 0.0151 0.0151
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0077 0.0363 0.1016
Loa Loa (eye worm) hypothetical protein 0.0077 0.0363 0.0363
Brugia malayi hypothetical protein 0.0039 0.0151 0.0151
Schistosoma mansoni tyrosine kinase 0.0051 0.0217 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0077 0.0363 0.0363
Leishmania major cathepsin L-like protease 0.0062 0.0277 0.0275
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0164 0.0459
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0122 0.09
Schistosoma mansoni ferritin 0.0017 0.0032 0.0087
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0143 0.0142
Schistosoma mansoni thyroid hormone receptor 0.0077 0.0363 0.1016
Echinococcus granulosus expressed protein 0.0017 0.0032 0.0031
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0018 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0036 0.0098
Loa Loa (eye worm) hypothetical protein 0.0077 0.0363 0.0363
Schistosoma mansoni inositol monophosphatase 0.0037 0.0143 0.0399
Schistosoma mansoni loxhd1 0.0039 0.0151 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0077 0.0363 0.0363
Trichomonas vaginalis esterase, putative 0.0035 0.0135 0.0541
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Schistosoma mansoni polycystin 1-related 0.0039 0.0151 0.0422
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0086
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0128 0.0127
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0077 0.0363 0.0363
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0187 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Schistosoma mansoni protein kinase 0.0011 0.0003 0.0006
Schistosoma mansoni protein kinase 0.0011 0.0003 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0742 0.398 0.398
Loa Loa (eye worm) hypothetical protein 0.0077 0.0363 0.0363
Onchocerca volvulus 0.0035 0.0135 0.0305
Schistosoma mansoni atypical protein kinase C 0.0017 0.0036 0.0098
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0143 0.0142
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0264 0.9969
Leishmania major cathepsin L-like protease 0.0062 0.0277 0.0275
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0132 0.0662 0.0661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0522
Echinococcus granulosus mitogen activated protein kinase 11 0.1848 1 1
Echinococcus granulosus lamin dm0 0.0027 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0151 0.015
Echinococcus multilocularis cysteine protease 0.0016 0.003 0.0029
Brugia malayi steroid hormone receptor 0.0077 0.0363 0.0363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 0.0117
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0242 0.0676
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0187 0.0187
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0135 0.0376
Loa Loa (eye worm) ctsf protein 0.0016 0.003 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0265 0.074
Echinococcus granulosus cathepsin l1 0.0016 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0011 0.0003 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0077 0.0363 0.0363
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0041 0.0701
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0187 0.0186
Loa Loa (eye worm) acetyltransferase 0.014 0.0704 0.0703
Onchocerca volvulus 0.0077 0.0363 0.0824
Schistosoma mansoni hypothetical protein 0.0039 0.0151 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0166 0.0165
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.2136 0.2135
Schistosoma mansoni nuclear receptor 0.0037 0.0141 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0077 0.0363 0.0363
Mycobacterium tuberculosis Conserved protein 0.0035 0.0135 0.1011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0135 0.8193
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0289 0.0288
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0083
Schistosoma mansoni hypothetical protein 0.0016 0.0028 0.0076
Schistosoma mansoni RAR-like nuclear receptor 0.0077 0.0363 0.1016
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0242 0.9024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0041 0.0461
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.023 0.1196 0.1195
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.003 0.0029
Onchocerca volvulus Bile acid receptor homolog 0.0077 0.0363 0.0824
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Echinococcus granulosus dnaJ subfamily B 0.0403 0.2136 0.2136
Brugia malayi beta-lactamase family protein 0.0035 0.0135 0.0134
Echinococcus multilocularis ferritin 0.0017 0.0032 0.0031
Brugia malayi C1-like domain containing protein 0.0017 0.0036 0.0035
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0242 0.8373
Brugia malayi Doublecortin family protein 0.0039 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0041 0.0164 0.0164
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0143 0.0574
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0158 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117
Leishmania major hypothetical protein, conserved 0.0035 0.0135 0.0132
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1848 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0214 0.0213
Onchocerca volvulus Protein ultraspiracle homolog 0.0077 0.0363 0.0824
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0143 0.0141
Echinococcus granulosus dna polymerase kappa 0.004 0.0158 0.0157
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.003 0.101
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0158 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0141 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0277 0.0275
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0141 0.014
Brugia malayi intracellular kinase 0.0055 0.0242 0.0241
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0141 0.014
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0158 0.0155
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0001
Schistosoma mansoni protein kinase 0.0011 0.0003 0.0006
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0143 0.0141
Echinococcus granulosus intermediate filament protein 0.0027 0.0086 0.0086
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0017 0.0036 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.1209 0.3384
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0003 0.0069
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0077 0.0363 0.1016
Brugia malayi ecdysteroid receptor 0.0077 0.0363 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0265 0.074
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0052 0.03
Echinococcus multilocularis lamin 0.0027 0.0086 0.0085
Echinococcus granulosus activin receptor type 0.0011 0.0003 0.0002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0077 0.0363 0.0363
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.04 0.04
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0217 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.0363 0.0363
Echinococcus multilocularis mitogen activated protein kinase 11 0.1848 1 1
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0242 0.0241
Brugia malayi nuclear hormone receptor 0.0779 0.4179 0.4179
Echinococcus multilocularis mitogen activated protein kinase 14 0.1848 1 1
Schistosoma mansoni ap endonuclease 0.0018 0.0041 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.0363 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0265 0.074
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0036 0.0098
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0265 0.0264
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0458 0.2432 0.2431
Echinococcus granulosus ferritin 0.0017 0.0032 0.0031
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1848 1 1
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0242 1
Echinococcus multilocularis protein kinase c iota type 0.0017 0.0036 0.0035
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0141 0.0392
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0248 0.0245
Echinococcus granulosus Protein kinase C brain isozyme 0.0017 0.0036 0.0035
Schistosoma mansoni ferritin 0.0017 0.0032 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0077 0.0363 0.0363
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0135 0.0541
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0018 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0135 0.0132
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.003 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0141 0.014
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0242 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0077 0.0363 0.0363
Brugia malayi nuclear receptor NHR-88 0.0077 0.0363 0.0363
Schistosoma mansoni rab6-interacting 0.0039 0.0151 0.0422
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0077 0.0363 0.0362
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0289 0.0286
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0029
Echinococcus multilocularis cpg binding protein 0.003 0.0105 0.0103
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0166 0.0665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 0.0117

Activities

Activity type Activity value Assay description Source Reference
cLogP = 4.92 Calculation partition coefficient (CLogP) ChEMBL. 12954069
Log (functional) = 0 1/MIC Tested for antibacterial activity against Staphylococcus aureus ChEMBL. 12954069
Log t1/2 (ADMET) = 0.9 Half life (t1/2) of the compound was determined ChEMBL. 12954069
Log TCID50 (functional) = 1.3 Tested for antiviral activity of the compound against HSV-1 at a concentration of 100 microg/mL after 2 hr of treatment at 37 degrees C ChEMBL. 12954069
Log TCID50 (functional) = 1.63 Tested for antiviral activity of the compound against HSV-1 at a concentration of 50 microg/mL after 2 hr of treatment at 37 degrees C ChEMBL. 12954069
Log TCID50 (functional) = 2.9 Tested for antiviral activity of the compound against HSV-1 at a concentration of 25 microg/mL after 2 hr of treatment at 37 degrees C ChEMBL. 12954069
Log TCID50 (functional) = 6.1 Tested for antiviral activity of the compound against HSV-1 at a concentration of 12.5 microg/mL after 2 hr of treatment at 37 degrees C ChEMBL. 12954069
Log TCID50 (functional) = 6.9 Tested for antiviral activity of the compound against HSV-1 at a concentration of 6.25 microg/mL after 2 hr of treatment at 37 degrees C ChEMBL. 12954069
MIC (functional) = 1 ug ml-1 Minimum concentration required to inhibit Staphylococcus aureus ATCC25923 ChEMBL. 12954069
MIC (functional) = 8 ug ml-1 Minimum concentration required to inhibit Enterococcus faecalis ATCC29212 ChEMBL. 12954069
MIC (functional) = 250 ug ml-1 Minimum concentration required to inhibit Pseudomonas aeruginosa ATCC27853 ChEMBL. 12954069
MIC (functional) = 500 ug ml-1 Minimum concentration required to inhibit Escherichia coli ATCC25922 ChEMBL. 12954069
MIC (functional) = 500 ug ml-1 Minimum concentration required to inhibit Escherichia coli ATCC25922 ChEMBL. 12954069
MLC (functional) = 2 ug ml-1 Minimum concentration required to inhibit Staphylococcus aureus ATCC25923 ChEMBL. 12954069
MLC (functional) = 8 ug ml-1 Minimum concentration required to inhibit Enterococcus faecalis ATCC29212 ChEMBL. 12954069
MLC (functional) = 250 ug ml-1 Minimum concentration required to inhibit Pseudomonas aeruginosa ATCC27853 ChEMBL. 12954069
MLC (functional) = 500 ug ml-1 Minimum concentration required to inhibit Escherichia coli ATCC25922 ChEMBL. 12954069
MLC (functional) = 500 ug ml-1 Minimum concentration required to inhibit Escherichia coli ATCC25922 ChEMBL. 12954069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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