TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 499.927 | Formula: C23H24ClN6O5-
H donors: 1 H acceptors: 5 LogP: 3.58 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(N)nc(nc2cc1OC)N1CCN(CC1)C(=O)/C=C\c1cccc(c1)[N+](=O)[O-].[Cl-]
InChi: 1S/C23H24N6O5.ClH/c1-33-19-13-17-18(14-20(19)34-2)25-23(26-22(17)24)28-10-8-27(9-11-28)21(30)7-6-15-4-3-5-16(12-15)29(31)32;/h3-7,12-14H,8-11H2,1-2H3,(H2,24,25,26);1H/p-1/b7-6+;
InChiKey: CHZNUBDZHIXKKU-UHDJGPCESA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus multilocularis	neuropeptide Y receptor	0.0173	0.0768	0.0946
Loa Loa (eye worm)	SPRY domain-containing protein	0.0043	0.0098	0.0075
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0173	0.0768	0.0747
Onchocerca volvulus		0.0173	0.0768	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0038	0.007	0.0047
Echinococcus multilocularis	fmrfamide receptor	0.0173	0.0768	0.0946
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0173	0.0768	0.0747
Schistosoma mansoni	site-1 peptidase (S08 family)	0.009	0.0339	0.0317
Brugia malayi	putative neuropeptide receptor NPR1	0.0173	0.0768	0.0767
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0173	0.0768	0.0747
Echinococcus multilocularis	neuropeptides capa receptor	0.0173	0.0768	0.0946
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0173	0.0768	0.0946
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0173	0.0768	0.0747
Onchocerca volvulus	Alhambra homolog	0.0029	0.0023	0.0298
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0173	0.0768	0.0946
Schistosoma mansoni	amine GPCR	0.0173	0.0768	0.0747
Echinococcus multilocularis	somatostatin receptor	0.0173	0.0768	0.0946
Loa Loa (eye worm)	hypothetical protein	0.004	0.0082	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.036	0.0428
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0015	0.0027
Echinococcus granulosus	serotonin receptor	0.0173	0.0768	0.0747
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0178	0.0156
Schistosoma mansoni	histamine h1 receptor	0.0173	0.0768	0.0747
Echinococcus multilocularis	fmrfamide receptor	0.0173	0.0768	0.0946
Brugia malayi	Furin-like cysteine rich region family protein	0.0127	0.0531	0.053
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Echinococcus granulosus	tm gpcr rhodopsin	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0073	0.005
Leishmania major	trypanothione reductase	0.0046	0.0115	0.2188
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.009	0.0339	0.5
Brugia malayi	AKH receptor	0.0173	0.0768	0.0767
Schistosoma mansoni	neuropeptide F-like receptor	0.0173	0.0768	0.0747
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.0423	0.8342
Schistosoma mansoni	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus granulosus	g protein coupled receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.009	0.0339	0.0338
Giardia lamblia	High cysteine membrane protein Group 2	0.0638	0.3176	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0115	0.2188
Loa Loa (eye worm)	TYRA-2 protein	0.0173	0.0768	0.0747
Brugia malayi	TAR-binding protein	0.0062	0.0197	0.0195
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0117	0.1526
Echinococcus multilocularis	sex peptide receptor	0.0173	0.0768	0.0946
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0173	0.0768	0.0747
Schistosoma mansoni	biogenic amine receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.009	0.0339	0.0317
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0115	0.0092
Schistosoma mansoni	trithorax protein ash2	0.0043	0.0098	0.0075
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0117	0.0095
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0053	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0073	0.0954
Loa Loa (eye worm)	hypothetical protein	0.0848	0.426	0.4246
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0129	0.0106
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.009	0.0339	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.026	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.0484	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0197	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.008	0.014
Echinococcus granulosus	allatostatin A receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Brugia malayi	Melatonin receptor type 1A	0.0173	0.0768	0.0767
Echinococcus multilocularis	peregrin	0.0031	0.0035	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0015	0.0027
Brugia malayi	Dopamine receptor	0.0173	0.0768	0.0767
Onchocerca volvulus		0.0173	0.0768	1
Brugia malayi	Hypothetical WD-repeat protein F21H12.1 in chromosome II	0.0075	0.026	0.0259
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.009	0.0339	1
Brugia malayi	neuroendocrine convertase 1 precursor	0.1496	0.7615	0.7615
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.0484	1
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	opsin-like receptor	0.0173	0.0768	0.0747
Toxoplasma gondii	SPRY domain-containing protein	0.004	0.008	0.147
Echinococcus multilocularis	set1:ash2 histone methyltransferase complex	0.0043	0.0098	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Loa Loa (eye worm)	melatonin receptor type 1A	0.0173	0.0768	0.0747
Brugia malayi	RNA binding protein	0.0062	0.0197	0.0195
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0053	0.0935
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0173	0.0768	0.0946
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0173	0.0768	0.0747
Plasmodium falciparum	SPRY domain, putative	0.0043	0.0098	0.2376
Echinococcus multilocularis	protein will die slowly	0.0136	0.058	0.0707
Onchocerca volvulus		0.0173	0.0768	1
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.009	0.0339	0.5
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0188	0.085	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus granulosus	sex peptide receptor	0.0173	0.0768	0.0747
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.043	0.2101	0.3659
Echinococcus granulosus	furin	0.1957	1	1
Onchocerca volvulus		0.0173	0.0768	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0173	0.0768	0.0747
Brugia malayi	RE15519p	0.0173	0.0768	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1965	0.1947
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0406	0.1976	0.3441
Brugia malayi	G-protein coupled receptor	0.0173	0.0768	0.0767
Plasmodium falciparum	subtilisin-like protease 3	0.009	0.0339	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0173	0.0768	0.0747
Toxoplasma gondii	subtilisin SUB2	0.009	0.0339	0.8105
Schistosoma mansoni	amine GPCR	0.0173	0.0768	0.0747
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0127	0.0531	0.0509
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0117	0.0095
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0081	0.0074
Trypanosoma brucei	trypanothione reductase	0.0046	0.0115	0.2188
Echinococcus granulosus	fmrfamide receptor	0.0173	0.0768	0.0747
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0229	0.0399
Brugia malayi	Bromodomain containing protein	0.0031	0.0035	0.0034
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0117	0.0095
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.0423	0.8342
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0117	0.012
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0117	0.012
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0173	0.0768	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0173	0.0768	0.0747
Brugia malayi	mbt repeat family protein	0.0047	0.0117	0.0116
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Schistosoma mansoni	neuropeptide receptor	0.1254	0.6362	0.6353
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.0423	0.8342
Echinococcus granulosus	chromobox protein 1	0.0068	0.0229	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Brugia malayi	chromobox protein homolog 3	0.0038	0.0073	0.0072
Echinococcus multilocularis	neuropeptide receptor A26	0.0173	0.0768	0.0946
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0098	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0151	0.0128
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0173	0.0768	0.0946
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0173	0.0768	0.0767
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.009	0.0339	0.5
Schistosoma mansoni	opsin-like receptor	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Brugia malayi	larval opioid receptor	0.0173	0.0768	0.0767
Brugia malayi	Heterochromatin protein 1	0.0068	0.0229	0.0228
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0064	0.0041
Plasmodium falciparum	subtilisin-like protease 2	0.009	0.0339	1
Brugia malayi	PHD-finger family protein	0.0029	0.0023	0.0022
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0197	0.0174
Echinococcus multilocularis	neuroendocrine convertase 2	0.1343	0.6824	0.8635
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.036	0.0338
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0173	0.0768	0.0946
Plasmodium vivax	subtilisin-like protease 2, putative	0.009	0.0339	1
Loa Loa (eye worm)	subtilase	0.009	0.0339	0.0317
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Schistosoma mansoni	hypothetical protein	0.0167	0.0736	0.0715
Echinococcus multilocularis	g protein coupled receptor	0.0173	0.0768	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.009	0.0339	0.0401
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Onchocerca volvulus		0.0136	0.058	0.7551
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0058	0.0035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0117	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Onchocerca volvulus		0.0173	0.0768	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0173	0.0768	0.0747
Schistosoma mansoni	furin-1 (S08 family)	0.0913	0.4599	0.4586
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0151	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus multilocularis	neuropeptide s receptor	0.0173	0.0768	0.0946
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0197	0.0174
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0173	0.0768	0.0767
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	proprotein convertase 2	0.052	0.2565	0.2548
Schistosoma mansoni	neuropeptide receptor	0.0173	0.0768	0.0747
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0173	0.0768	0.0946
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0089	0.0154
Echinococcus granulosus	rhodopsin orphan GPCR	0.0173	0.0768	0.0747
Echinococcus multilocularis	neuropeptide Y receptor	0.0173	0.0768	0.0946
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0197	0.0174
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0173	0.0768	0.0747
Toxoplasma gondii	subtilisin SUB5	0.009	0.0339	0.8105
Onchocerca volvulus		0.0173	0.0768	1
Brugia malayi	putative neuropeptide receptor	0.0173	0.0768	0.0767
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Loa Loa (eye worm)	MBCTL1	0.0053	0.0151	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0339	0.0591
Schistosoma mansoni	hypothetical protein	0.0136	0.058	0.0558
Schistosoma mansoni	hypothetical protein	0.0406	0.1976	0.1957
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0151	0.0149
Echinococcus granulosus	peregrin	0.0031	0.0035	0.0012
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0173	0.0768	0.0946
Schistosoma mansoni	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0173	0.0768	0.0946
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0188	0.085	0.105
Schistosoma mansoni	amine GPCR	0.0173	0.0768	0.0747
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0117	0.0095
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.0484	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0404	0.1965	0.2466
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Plasmodium falciparum	subtilisin-like protease 1	0.009	0.0339	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Echinococcus granulosus	biogenic amine 5HT receptor	0.0173	0.0768	0.0747
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0115	0.2365
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0173	0.0768	0.0767
Schistosoma mansoni	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	opsin-like receptor	0.0173	0.0768	0.0747
Onchocerca volvulus		0.0173	0.0768	1
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Echinococcus granulosus	rhodopsin orphan GPCR	0.0173	0.0768	0.0747
Echinococcus granulosus	neuropeptide receptor	0.0173	0.0768	0.0747
Brugia malayi	Dopamine receptor protein 2	0.0173	0.0768	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus granulosus	7TM GPCR rhodopsin	0.0173	0.0768	0.0747
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0115	0.2918
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Schistosoma mansoni	hypothetical protein	0.0289	0.1368	0.1349
Leishmania major	subtilisin-like serine peptidase	0.009	0.0339	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0173	0.0768	0.0946
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0229	0.0262
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0114	0.0464	0.0442
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus multilocularis	g-protein coupled receptor	0.0173	0.0768	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Brugia malayi	mbt repeat family protein	0.0047	0.0117	0.0116
Toxoplasma gondii	subtilisin SUB4	0.009	0.0339	0.8105
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0173	0.0768	0.0747
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0197	0.0174
Schistosoma mansoni	chromobox protein	0.0068	0.0229	0.0206
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0115	0.2918
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0173	0.0768	0.0767
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.0261	0.0238
Toxoplasma gondii	subtilisin SUB1	0.009	0.0339	0.8105
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0173	0.0768	0.0747
Brugia malayi	Bromodomain containing protein	0.0038	0.007	0.0068
Echinococcus multilocularis	geminin	0.0167	0.0736	0.0906
Mycobacterium tuberculosis	Probable reductase	0.0106	0.0423	0.8342
Loa Loa (eye worm)	G-protein coupled receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.007	0.0234	0.0212
Schistosoma mansoni	myosin xvIII	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Brugia malayi	jmjC domain containing protein	0.0094	0.036	0.0359
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0173	0.0768	0.0946
Brugia malayi	neuropeptide F receptor	0.0173	0.0768	0.0767
Onchocerca volvulus		0.009	0.0339	0.4412
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	site-1 peptidase (S08 family)	0.009	0.0339	0.0317
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.052	0.2565	0.4468
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0229	0.0399
Brugia malayi	Thioredoxin reductase	0.0046	0.0115	0.0114
Echinococcus multilocularis	allatostatin A receptor	0.0173	0.0768	0.0946
Onchocerca volvulus		0.0173	0.0768	1
Brugia malayi	sulfakinin receptor protein	0.0173	0.0768	0.0767
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0173	0.0768	0.0946
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0197	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.052	0.2565	0.4468
Echinococcus granulosus	biogenic amine 5HT receptor	0.0173	0.0768	0.0747
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0173	0.0768	0.0946
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0173	0.0768	0.0946
Echinococcus granulosus	wd40 repeat	0.0075	0.026	0.0238
Toxoplasma gondii	subtilisin SUB12	0.0104	0.0413	1
Schistosoma mansoni	chromobox protein	0.0068	0.0229	0.0206
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0229	0.0262
Echinococcus granulosus	neuropeptide receptor A26	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0339	0.0591
Echinococcus granulosus	epidermal growth factor receptor	0.0127	0.0531	0.0509
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.009	0.0339	0.606
Echinococcus granulosus	membrane bound transcription factor site 1	0.009	0.0339	0.0317
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Echinococcus multilocularis	orexin receptor type 2	0.0173	0.0768	0.0946
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Loa Loa (eye worm)	WD40 repeat protein	0.0136	0.058	0.0558
Brugia malayi	ORL1-like opioid receptor	0.0173	0.0768	0.0767
Onchocerca volvulus		0.0173	0.0768	1
Schistosoma mansoni	neuropeptide receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0115	0.0092
Echinococcus multilocularis	Furin 1	0.052	0.2565	0.3227
Trichomonas vaginalis	hypothetical protein	0.0406	0.1976	0.3441
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Trypanosoma brucei	subtilisin peptidase	0.009	0.0339	1
Loa Loa (eye worm)	endoprotease bli-4	0.1957	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0173	0.0768	0.0747
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0115	0.2918
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0339	0.0591
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.052	0.2565	0.2548
Trichomonas vaginalis	WD repeat domain, putative	0.0136	0.058	0.1011
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0073	0.0128
Brugia malayi	proprotein convertase 2	0.1343	0.6824	0.6824
Brugia malayi	Serotonin receptor	0.0173	0.0768	0.0767
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0173	0.0768	0.0747
Echinococcus granulosus	neuropeptide s receptor	0.0173	0.0768	0.0747
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0173	0.0768	0.0747
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0098	0.0171
Loa Loa (eye worm)	neuropeptide F receptor	0.0173	0.0768	0.0747
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0151	0.0162
Echinococcus multilocularis	serotonin receptor	0.0173	0.0768	0.0946
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0173	0.0768	0.0747
Schistosoma mansoni	hypothetical protein	0.0167	0.0736	0.0715
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0173	0.0768	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	biogenic amine receptor	0.0173	0.0768	0.0747
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0173	0.0768	0.0747
Echinococcus granulosus	neuropeptides capa receptor	0.0173	0.0768	0.0747
Entamoeba histolytica	transcription factor BTF3, putative	0.0034	0.0053	0.5
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	neuropeptide f receptor 76f	0.0173	0.0768	0.0747
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.009	0.0339	0.0317
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0117	0.0095
Echinococcus granulosus	hypothetical protein	0.0173	0.0768	0.0747
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0173	0.0768	0.0946
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.009	0.0339	0.606
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.0423	0.5793
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0173	0.0768	0.0946
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Brugia malayi	G-protein coupled receptor	0.0173	0.0768	0.0767
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0092	0.0069
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0173	0.0768	0.0767
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0173	0.0768	0.0747
Onchocerca volvulus		0.0173	0.0768	1
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0151	0.0128
Onchocerca volvulus		0.0173	0.0768	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1134	0.574	1
Echinococcus granulosus	neuroendocrine convertase 2	0.1343	0.6824	0.6817
Echinococcus granulosus	neuropeptide Y receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Toxoplasma gondii	subtilisin SUB11	0.009	0.0339	0.8105
Echinococcus multilocularis	neuropeptide receptor	0.1254	0.6362	0.8048
Brugia malayi	GnHR receptor homolog	0.0173	0.0768	0.0767
Schistosoma mansoni	retinoblastoma binding protein	0.0075	0.026	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0053	0.0092
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0173	0.0768	0.0747
Trichomonas vaginalis	retinoblastoma binding protein, putative	0.0075	0.026	0.0454
Toxoplasma gondii	subtilisin SUB10	0.009	0.0339	0.8105
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0404	0.1965	0.1964
Loa Loa (eye worm)	hypothetical protein	0.1957	1	1
Onchocerca volvulus		0.0173	0.0768	1
Brugia malayi	glutathione reductase	0.0046	0.0115	0.0114
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0229	0.0206
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Toxoplasma gondii	subtilisin SUB7	0.009	0.0339	0.8105
Toxoplasma gondii	subtilisin SUB6	0.009	0.0339	0.8105
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.0484	1
Schistosoma mansoni	neuropeptide receptor	0.0173	0.0768	0.0747
Echinococcus granulosus	G protein coupled receptor 139	0.0173	0.0768	0.0747
Echinococcus multilocularis	g protein coupled receptor	0.0173	0.0768	0.0946
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0173	0.0768	0.0747
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0151	0.0162
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0064	0.0041
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1134	0.574	0.5731
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0115	0.0092
Echinococcus granulosus	rhodopsin orphan GPCR	0.0173	0.0768	0.0747
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1134	0.574	0.7259
Echinococcus granulosus	g protein coupled receptor	0.0173	0.0768	0.0747
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Brugia malayi	Subtilase family protein	0.009	0.0339	0.0338
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0339	0.0591
Plasmodium vivax	subtilisin-like serine protease, putative	0.009	0.0339	1
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0053	0.0758
Brugia malayi	G protein-coupled receptor	0.0173	0.0768	0.0767
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0053	0.0935
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Entamoeba histolytica	hypothetical protein	0.0034	0.0053	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0058	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Echinococcus granulosus	transcription factor btf3	0.0034	0.0053	0.003
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.009	0.0339	0.606
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.043	0.2101	0.3659
Brugia malayi	Bromodomain containing protein	0.0074	0.0256	0.0255
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0114	0.0464	0.0809
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Brugia malayi	Serotonin receptor	0.0173	0.0768	0.0767
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0098	0.2376
Echinococcus granulosus	set1:ash2 histone methyltransferase complex	0.0043	0.0098	0.0075
Echinococcus multilocularis	g protein coupled receptor	0.0173	0.0768	0.0946
Echinococcus granulosus	rhodopsin orphan GPCR	0.0173	0.0768	0.0747
Loa Loa (eye worm)	G-protein coupled receptor	0.0173	0.0768	0.0747
Echinococcus granulosus	rhodopsin orphan GPCR	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus granulosus	g protein coupled receptor	0.0173	0.0768	0.0747
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.0423	0.8342
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.009	0.0339	0.0338
Echinococcus granulosus	chromobox protein 1	0.0068	0.0229	0.0206
Giardia lamblia	Furin precursor putative serine protease	0.043	0.2101	0.659
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0197	0.0195
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0089	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0075	0.026	0.0238
Echinococcus multilocularis		0.1551	0.7899	1
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1957	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0181	0.0158
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0115	0.0117
Echinococcus multilocularis	dro:myosuppressin receptor	0.0173	0.0768	0.0946
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0053	0.0092
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0197	0.0221
Echinococcus granulosus	geminin	0.0167	0.0736	0.0715
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.009	0.0339	0.0317
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0151	0.0128
Onchocerca volvulus		0.0173	0.0768	1
Echinococcus granulosus	somatostatin receptor	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.052	0.2565	0.4468
Echinococcus granulosus	7tm_1 domain containing protein	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.052	0.2565	0.4468
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Toxoplasma gondii	subtilisin SUB8	0.009	0.0339	0.8105
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0089	0.115
Schistosoma mansoni	amine GPCR	0.0173	0.0768	0.0747
Echinococcus granulosus	neuropeptide Y receptor	0.0173	0.0768	0.0747
Echinococcus multilocularis	neuropeptide receptor	0.0173	0.0768	0.0946
Schistosoma mansoni	transcription factor btf3	0.0034	0.0053	0.003
Loa Loa (eye worm)	SPRY domain-containing protein	0.004	0.008	0.0057
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.009	0.0339	1
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.052	0.2565	0.4468
Brugia malayi	G protein-coupled receptor F59B2.13	0.0173	0.0768	0.0767
Echinococcus granulosus	g-protein coupled receptor	0.0173	0.0768	0.0747
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0081	0.0058
Brugia malayi	jmjC domain containing protein	0.0037	0.0064	0.0062
Onchocerca volvulus		0.0173	0.0768	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0031	0.0007
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1134	0.574	1
Echinococcus multilocularis	wd40 repeat	0.0075	0.026	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0117	0.0095
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0173	0.0768	0.0747
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0173	0.0768	0.0946
Brugia malayi	SPRY domain containing protein	0.0043	0.0098	0.0097
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0173	0.0768	0.0747
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.0423	0.8342
Onchocerca volvulus		0.0173	0.0768	1
Brugia malayi	neuropeptide F receptor	0.0173	0.0768	0.0767
Plasmodium falciparum	glutathione reductase	0.0046	0.0115	0.2918
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0197	0.0174
Schistosoma mansoni	biogenic amine receptor	0.0173	0.0768	0.0747
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.052	0.2565	0.4468
Echinococcus granulosus	neuropeptide FF receptor 2	0.0404	0.1965	0.1947
Trypanosoma cruzi	subtilisin peptidase	0.009	0.0339	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0173	0.0768	0.0747
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0173	0.0768	0.0946
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0197	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus multilocularis	neuropeptides capa receptor	0.0173	0.0768	0.0946
Schistosoma mansoni	growth hormone secretagogue receptor	0.0173	0.0768	0.0747
Brugia malayi	follicle stimulating hormone receptor	0.0173	0.0768	0.0767
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0173	0.0768	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0173	0.0768	0.0946
Echinococcus multilocularis	membrane bound transcription factor site 1	0.009	0.0339	0.0401
Echinococcus multilocularis	epidermal growth factor receptor	0.0127	0.0531	0.0645
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.1976	0.3441
Echinococcus granulosus	orexin receptor type 2	0.0173	0.0768	0.0747
Echinococcus granulosus	tm gpcr rhodopsin	0.0173	0.0768	0.0747
Echinococcus granulosus	Furin 1	0.052	0.2565	0.2548
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Schistosoma mansoni	adenoreceptor	0.0173	0.0768	0.0747
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.009	0.0339	1
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Plasmodium vivax	subtilisin-like protease 1	0.009	0.0339	1
Echinococcus granulosus	neuropeptide receptor	0.1254	0.6362	0.6353
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0173	0.0768	0.0946
Echinococcus granulosus	neuropeptides capa receptor	0.0173	0.0768	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0173	0.0768	0.0747
Echinococcus granulosus	tm gpcr rhodopsin	0.0173	0.0768	0.0747
Schistosoma mansoni	tyrosine kinase	0.0127	0.0531	0.0509
Onchocerca volvulus		0.0173	0.0768	1
Brugia malayi	Will die slowly protein	0.0136	0.058	0.0579
Onchocerca volvulus		0.003	0.0031	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0173	0.0768	0.0747
Schistosoma mansoni	amine GPCR	0.0173	0.0768	0.0747
Onchocerca volvulus		0.0173	0.0768	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0173	0.0768	0.0946
Brugia malayi	hypothetical protein	0.0173	0.0768	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0173	0.0768	0.0946
Echinococcus multilocularis	G protein coupled receptor 139	0.1254	0.6362	0.8048
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0073	0.0128
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0053	0.003
Onchocerca volvulus		0.0047	0.0117	0.1526
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0054	0.004
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0197	0.0174
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0173	0.0768	0.0747
Brugia malayi	celfurPC protein	0.1551	0.7899	0.7899
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0173	0.0768	0.0747
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0339	0.0591
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0197	0.0174
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Brugia malayi	Dopamine receptor protein 1	0.0173	0.0768	0.0767
Brugia malayi	beta-NAC-like protein	0.0034	0.0053	0.0051
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0064	0.0041
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.009	0.0339	0.606
Loa Loa (eye worm)	neuropeptide F receptor	0.0173	0.0768	0.0747
Toxoplasma gondii	subtilisin SUB9	0.009	0.0339	0.8105
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.009	0.0339	0.0591
Echinococcus granulosus	protein will die slowly	0.0136	0.058	0.0558
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0064	0.0041
Echinococcus multilocularis	serotonin receptor	0.0173	0.0768	0.0946
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0173	0.0768	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0791	0.077
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0178	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0053	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0768	0.0747

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0	Antihypertensive activity rating in conscious SHR after 3 h post dose at 10 mg/kg (po)	ChEMBL.	6131135
Activity (functional)	= 0	Antihypertensive activity rating in conscious SHR after 6 h post dose at 10 mg/kg (po)	ChEMBL.	6131135

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 320517

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 229479