Detailed information for compound 229812

Basic information

Technical information
  • TDR Targets ID: 229812
  • Name: N-[(E,2S,3R)-1,3-dihydroxy-5-(4-pentylphenyl) pent-4-en-2-yl]hexanamide
  • MW: 361.518 | Formula: C22H35NO3
  • H donors: 3 H acceptors: 3 LogP: 4.74 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC(=O)N[C@H]([C@@H](/C=C/c1ccc(cc1)CCCCC)O)CO
  • InChi: 1S/C22H35NO3/c1-3-5-7-9-18-11-13-19(14-12-18)15-16-21(25)20(17-24)23-22(26)10-8-6-4-2/h11-16,20-21,24-25H,3-10,17H2,1-2H3,(H,23,26)/b16-15+/t20-,21+/m0/s1
  • InChiKey: IBQDUORNTQDWFN-RJCGUJTNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(E,1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(4-pentylphenyl)but-3-enyl]hexanamide
  • N-[(E,1S,2R)-4-(4-amylphenyl)-2-hydroxy-1-methylol-but-3-enyl]hexanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0258 0.0811 0.1628
Loa Loa (eye worm) hypothetical protein 0.0134 0.0371 0.0817
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0254 0.0798 0.1773
Brugia malayi nuclear receptor RXR 0.012 0.032 0.0703
Plasmodium falciparum phd finger protein, putative 0.0032 0.0006 0.5
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0163 0.0352
Onchocerca volvulus 0.0045 0.0053 0.0095
Echinococcus granulosus Nuclear hormone receptor HR96 0.012 0.032 0.0316
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0254 0.0798 0.0833
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0254 0.0798 0.0833
Schistosoma mansoni chromobox protein 0.0076 0.0163 0.0157
Schistosoma mansoni nuclear hormone receptor 0.012 0.032 0.0314
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0033 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1026 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 0.1026 1
Loa Loa (eye worm) hypothetical protein 0.0254 0.0798 0.1773
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0254 0.0798 0.0794
Loa Loa (eye worm) hypothetical protein 0.0071 0.0147 0.0317
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.0525 0.0545
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1419 0.4953 1
Brugia malayi Nuclear hormone receptor-like 1 0.0134 0.0371 0.0817
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0254 0.0798 0.0833
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Echinococcus multilocularis Nuclear hormone receptor HR96 0.012 0.032 0.033
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0033 0.0029
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.012 0.032 0.0316
Schistosoma mansoni retinoic acid receptor RXR 0.2834 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0134 0.0371 0.0365
Echinococcus granulosus peregrin 0.0032 0.0006 0.0002
Brugia malayi jmjC domain containing protein 0.0168 0.0491 0.1086
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0006 0.0002
Onchocerca volvulus 0.012 0.032 0.0635
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0168 0.0491 0.0487
Onchocerca volvulus 0.0102 0.0258 0.051
Echinococcus multilocularis nuclear receptor nhr 48 0.012 0.032 0.033
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0033 0.0321
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0086
Schistosoma mansoni alpha-glucosidase 0.0152 0.0437 0.0431
Schistosoma mansoni steroid hormone receptor ad4bp 0.0254 0.0798 0.0793
Brugia malayi Nuclear hormone receptor E75 0.012 0.032 0.0703
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0044 0.0078
Loa Loa (eye worm) steroid hormone receptor 0.0254 0.0798 0.1773
Echinococcus granulosus thyroid hormone receptor alpha 0.012 0.032 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0254 0.0798 0.1773
Brugia malayi nuclear hormone receptor family member nhr-6 0.012 0.032 0.0703
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0254 0.0798 0.1773
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.27 0.9522 1
Echinococcus granulosus chromobox protein 1 0.0076 0.0163 0.0159
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.0525 0.1161
Loa Loa (eye worm) hypothetical protein 0.0134 0.0371 0.0817
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0254 0.0798 0.0793
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0254 0.0798 0.0793
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0056 0.0101
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0056 0.0543
Loa Loa (eye worm) hypothetical protein 0.0134 0.0371 0.0817
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1026 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0254 0.0798 0.0794
Brugia malayi orphan nuclear receptor NR2E1 0.012 0.032 0.0703
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0215 0.0468
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.005 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0033 0.5
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0056 0.0543
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0033 0.5
Echinococcus granulosus nuclear receptor nhr 48 0.012 0.032 0.0316
Brugia malayi nuclear hormone receptor 0.0254 0.0798 0.1773
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0033 0.0321
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.012 0.032 0.0703
Brugia malayi chromobox protein homolog 3 0.0042 0.0044 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0254 0.0798 0.1773
Loa Loa (eye worm) hypothetical protein 0.009 0.0215 0.0468
Treponema pallidum fructose-bisphosphate aldolase 0.0318 0.1026 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1026 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0033 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0033 0.0321
Onchocerca volvulus Bile acid receptor homolog 0.0254 0.0798 0.1602
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0254 0.0798 0.0793
Brugia malayi Heterochromatin protein 1 0.0076 0.0163 0.0352
Brugia malayi nuclear receptor NHR-88 0.012 0.032 0.0703
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.012 0.032 0.0635
Schistosoma mansoni nuclear hormone receptor 0.0254 0.0798 0.0793
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.0525 0.1161
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0134 0.0371 0.0384
Onchocerca volvulus 0.0254 0.0798 0.1602
Brugia malayi hypothetical protein 0.0134 0.0371 0.0817
Brugia malayi Nuclear hormone receptor-like 1 0.0254 0.0798 0.1773
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0254 0.0798 0.1773
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0134 0.0371 0.0817
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0009 0.0003
Echinococcus multilocularis chromobox protein 1 0.0076 0.0163 0.0165
Schistosoma mansoni thyroid hormone receptor 0.0254 0.0798 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0254 0.0798 0.1773
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 0.1026 1
Schistosoma mansoni nuclear hormone receptor 0.012 0.032 0.0314
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.0258 0.0252
Brugia malayi tailless protein 0.012 0.032 0.0703
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0126 0.0269
Onchocerca volvulus 0.0033 0.0011 0.0011
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0168 0.0491 0.051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0254 0.0798 0.1773
Brugia malayi ecdysone receptor 0.012 0.032 0.0703
Echinococcus granulosus lysine specific demethylase 5A 0.0102 0.0258 0.0253
Loa Loa (eye worm) hypothetical protein 0.0254 0.0798 0.1773
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0254 0.0798 0.0833
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0009 0.0003
Loa Loa (eye worm) nuclear receptor NHR-67 0.012 0.032 0.0703
Brugia malayi steroid hormone receptor 0.0254 0.0798 0.1773
Onchocerca volvulus 0.012 0.032 0.0635
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Loa Loa (eye worm) jmjC domain-containing protein 0.0102 0.0258 0.0564
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0033 0.0321
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0356 0.0783
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0254 0.0798 0.0793
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0134 0.0371 0.0367
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0033 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1026 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0033 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0254 0.0798 0.1773
Loa Loa (eye worm) hypothetical protein 0.0254 0.0798 0.1773
Brugia malayi hypothetical protein 0.0134 0.0371 0.0817
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Loa Loa (eye worm) hypothetical protein 0.0033 0.0011 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0053 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0009 0.0003
Loa Loa (eye worm) nuclear receptor nhr-7B 0.1285 0.4474 1
Brugia malayi hypothetical protein 0.012 0.032 0.0703
Echinococcus granulosus jumonji domain containing protein 0.0044 0.005 0.0046
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.0525 0.0545
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0033 0.0029
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0033 0.0061
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0215 0.022
Echinococcus granulosus Nuclear hormone receptor HR96 0.012 0.032 0.0316
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0356 0.0783
Echinococcus granulosus FTZ F1 alpha 0.0254 0.0798 0.0794
Plasmodium vivax SET domain protein, putative 0.0032 0.0009 1
Schistosoma mansoni coup transcription factor 0.0254 0.0798 0.0793
Schistosoma mansoni nuclear receptor nhr-48 0.012 0.032 0.0314
Loa Loa (eye worm) hypothetical protein 0.0134 0.0371 0.0817
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.0525 0.052
Brugia malayi hypothetical protein 0.012 0.032 0.0703
Loa Loa (eye worm) hypothetical protein 0.0134 0.0371 0.0817
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0254 0.0798 0.0794
Schistosoma mansoni nuclear receptor 0.012 0.032 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0254 0.0798 0.1773
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0009 0.0997
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0044 0.0431
Brugia malayi conserved hypotetical protein 0.012 0.032 0.0703
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0033 0.0321
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0033 0.0321
Loa Loa (eye worm) hypothetical protein 0.1165 0.4047 0.9044
Brugia malayi photoreceptor-specific nuclear receptor 0.0254 0.0798 0.1773
Brugia malayi nuclear receptor RXR 0.0134 0.0371 0.0817
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0254 0.0798 0.1773
Schistosoma mansoni RAR-like nuclear receptor 0.0254 0.0798 0.0793
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.07 0.1553
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0254 0.0798 0.0794
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1026 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0254 0.0798 0.1773
Brugia malayi MH2 domain containing protein 0.013 0.0356 0.0783
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0254 0.0798 0.1773
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0044 0.0431
Loa Loa (eye worm) hypothetical protein 0.0254 0.0798 0.1773
Brugia malayi Nuclear hormone receptor-like 1 0.0134 0.0371 0.0817
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1026 1
Schistosoma mansoni zinc finger protein 0.012 0.032 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0254 0.0798 0.1773
Brugia malayi nuclear receptor NHR-67 0.012 0.032 0.0703
Schistosoma mansoni chromobox protein 0.0076 0.0163 0.0157
Schistosoma mansoni nuclear receptor 0.012 0.032 0.0314
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0254 0.0798 0.1773
Echinococcus multilocularis lysine specific demethylase 5A 0.0102 0.0258 0.0265
Echinococcus multilocularis ecdysone induced protein 78C 0.0254 0.0798 0.0833
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0254 0.0798 0.1773
Trichomonas vaginalis set domain proteins, putative 0.0258 0.0811 0.7907
Schistosoma mansoni alpha-glucosidase 0.0152 0.0437 0.0431
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0009 0.0004
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0163 0.1588
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.012 0.032 0.0635
Onchocerca volvulus Protein ultraspiracle homolog 0.0254 0.0798 0.1602
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0254 0.0798 0.0793
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0009 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0254 0.0798 0.0793
Loa Loa (eye worm) DR-78 0.012 0.032 0.0703
Schistosoma mansoni alpha glucosidase 0.0039 0.0033 0.0027
Brugia malayi nuclear receptor NHR-88 0.0254 0.0798 0.1773
Echinococcus multilocularis thyroid hormone receptor alpha 0.0254 0.0798 0.0833
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.0446 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.012 0.032 0.033
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.012 0.032 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0254 0.0798 0.1773
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1026 1
Echinococcus multilocularis chromobox protein 1 0.0076 0.0163 0.0165
Echinococcus multilocularis FTZ F1 alpha 0.0254 0.0798 0.0833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0254 0.0798 0.1773
Echinococcus granulosus nuclear receptor 2DBD gamma 0.012 0.032 0.0316
Loa Loa (eye worm) hypothetical protein 0.0254 0.0798 0.1773
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Echinococcus granulosus ecdysone induced protein 78C 0.0254 0.0798 0.0794
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0254 0.0798 0.0833
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0215 0.0211
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0215 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1026 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.0258 0.0252
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0033 0.0321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.012 0.032 0.033
Echinococcus granulosus chromobox protein 1 0.0076 0.0163 0.0159
Brugia malayi nuclear hormone receptor 0.1285 0.4474 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0254 0.0798 0.0833
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0254 0.0798 0.1773
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.012 0.032 0.0314
Brugia malayi Pre-SET motif family protein 0.0032 0.0009 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.0318 0.1026 1
Brugia malayi nuclear hormone receptor family member odr-7 0.012 0.032 0.0703
Trypanosoma brucei glucosidase, putative 0.0039 0.0033 0.5
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0163 0.1588
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0134 0.0371 0.0365
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0254 0.0798 0.0793
Brugia malayi Nuclear hormone receptor E75 0.012 0.032 0.0703
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0254 0.0798 0.0794
Brugia malayi jmjC domain containing protein 0.0102 0.0258 0.0564
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.0446 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0254 0.0798 0.1773
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.0446 0.5
Loa Loa (eye worm) hypothetical protein 0.0254 0.0798 0.1773
Onchocerca volvulus 0.009 0.0215 0.0423
Brugia malayi Pre-SET motif family protein 0.0226 0.07 0.1553
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Brugia malayi Steroid receptor seven-up type 2 0.0254 0.0798 0.1773
Schistosoma mansoni jumonji domain containing protein 0.0146 0.0415 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0254 0.0798 0.1773
Brugia malayi ecdysteroid receptor 0.0254 0.0798 0.1773
Loa Loa (eye worm) hypothetical protein 0.012 0.032 0.0703
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0254 0.0798 0.1773
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0033 0.0321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0254 0.0798 0.0794
Loa Loa (eye worm) nuclear hormone receptor 0.012 0.032 0.0703
Loa Loa (eye worm) hypothetical protein 0.0254 0.0798 0.1773
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.012 0.032 0.033

Activities

Activity type Activity value Assay description Source Reference
No. of axonal points (functional) < 1.54 Evaluation for reversing the inhibitory effects of Fumonisin B1(FB1) on accelerated axonal growth of hippocampal neurons ChEMBL. 11063615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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