Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.7939 | 0.5611 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0115 | 0.6119 | 0.733 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.7939 | 0.7939 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0127 | 0.7241 | 0.8977 |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.7939 | 0.7939 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0134 | 0.7939 | 0.7939 |
Echinococcus granulosus | carboxylesterase 5A | 0.0134 | 0.7939 | 0.5611 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0144 | 0.8878 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.7939 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.7939 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.7939 | 0.7939 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0134 | 0.7939 | 0.5611 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.7939 | 0.5611 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0156 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.7939 | 0.5611 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0106 | 0.5304 | 0.5392 |
Loa Loa (eye worm) | glutamate receptor | 0.0127 | 0.7241 | 0.7241 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.7939 | 0.5611 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.7939 | 0.879 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 13 uM | Cytostatic concentration required to inhibit CEM/0 cells proliferation by 50% | ChEMBL. | 10514282 |
EC50 (functional) | = 0.01 uM | Concentration required to protect CEM/0 cells against the cytopathicity of HIV-1 by 50% | ChEMBL. | 10514282 |
EC50 (functional) | = 0.01 uM | Concentration required to protect CEM/0 cells against the cytopathicity of HIV-2 by 50% | ChEMBL. | 10514282 |
EC50 (functional) | = 0.018 uM | Concentration required to protect CEM/TK cells against the cytopathicity of HIV-2 by 50% | ChEMBL. | 10514282 |
logD (ADMET) | = 1.77 | Partition coefficient (logD7.0) | ChEMBL. | 10514282 |
Selectivity index (functional) | = 1300 | Ratio CC50/EC50 for HIV-1 in CEM/0 cells | ChEMBL. | 10514282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.