TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.463 | Formula: C20H21N3O5S
H donors: 2 H acceptors: 4 LogP: 3.53 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)Nc1[nH]c2c(n1)cc(cc2)C(=O)c1scc(c1)CC(=O)OC(C)(C)C
InChi: 1S/C20H21N3O5S/c1-20(2,3)28-16(24)8-11-7-15(29-10-11)17(25)12-5-6-13-14(9-12)22-18(21-13)23-19(26)27-4/h5-7,9-10H,8H2,1-4H3,(H2,21,22,23,26)
InChiKey: XZBCJXRKHAFCOB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Tubulin alpha chain	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Cryptosporidium parvum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	peroxisome assembly protein 26	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin isotype 2	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium vivax	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Babesia bovis	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania braziliensis	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	alpha tubulin 1	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin subunit TubB	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	alpha tubulin 2	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin subunit TubB	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Entamoeba histolytica	tubulin alpha-1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma congolense	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania braziliensis	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium falciparum	alpha tubulin 2	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium falciparum	alpha tubulin 1	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei gambiense	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium knowlesi	alpha-tubulin II, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Candida albicans	cytoskeletal structural protein	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	tubulin alpha chain - mouse	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha-3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-2/alpha-4 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	alpha tubulin TUBA1	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Entamoeba histolytica	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	peroxisome assembly protein 26	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium yoelii	Tubulin/FtsZ family, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium knowlesi	alpha tubulin, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-1C chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Cryptosporidium hominis	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Theileria parva	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	alpha-tubulin I, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma cruzi	alpha tubulin, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium yoelii	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Neospora caninum	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania donovani	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Theileria parva	Tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium vivax	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Babesia bovis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium vivax	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	458 aa	26.2 %
Echinococcus granulosus	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	41.5 %
Leishmania major	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	27.5 %
Plasmodium knowlesi	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	454 aa	26.2 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	438 aa	84.7 %
Trypanosoma congolense	epsilon tubulin	Tubulin alpha chain	451 aa	472 aa	26.5 %
Onchocerca volvulus	Putative cytochrome c-type heme lyase	Tubulin alpha chain	451 aa	434 aa	39.2 %
Echinococcus multilocularis	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	41.5 %
Entamoeba histolytica	tubulin family protein	Tubulin alpha chain	451 aa	434 aa	40.1 %
Brugia malayi	Tubulin beta-1 chain	Tubulin alpha chain	451 aa	434 aa	39.6 %
Neospora caninum	Beta-tubulin, related	Tubulin alpha chain	451 aa	417 aa	31.4 %
Neospora caninum	tubulin alpha chain, putative	Tubulin alpha chain	451 aa	436 aa	37.4 %
Echinococcus granulosus	tubulin beta 4A class IVa	Tubulin alpha chain	451 aa	388 aa	38.9 %
Leishmania infantum	epsilon tubulin, putative	Tubulin alpha chain	451 aa	471 aa	27.0 %
Drosophila melanogaster	gamma-Tubulin at 23C	Tubulin alpha chain	451 aa	446 aa	32.3 %
Drosophila melanogaster	beta-Tubulin at 60D	Tubulin alpha chain	451 aa	439 aa	39.2 %
Schistosoma mansoni	tubulin subunit beta	Tubulin alpha chain	451 aa	434 aa	40.1 %
Babesia bovis	tubulin, putative	Tubulin alpha chain	451 aa	463 aa	20.7 %
Schistosoma mansoni	tubulin subunit epsilon	Tubulin alpha chain	451 aa	469 aa	27.9 %
Trichomonas vaginalis	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	422 aa	28.4 %
Cryptosporidium hominis	gamma-tubulin	Tubulin alpha chain	451 aa	443 aa	30.9 %
Trypanosoma cruzi	epsilon tubulin, putative	Tubulin alpha chain	451 aa	474 aa	27.4 %
Plasmodium yoelii	tubulin beta chain	Tubulin alpha chain	451 aa	455 aa	26.8 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	478 aa	25.7 %
Echinococcus multilocularis	tubulin, beta 4A class IVa	Tubulin alpha chain	451 aa	388 aa	38.9 %
Entamoeba histolytica	tubulin family protein	Tubulin alpha chain	451 aa	434 aa	39.4 %
Echinococcus granulosus	tubulin gamma 1 chain	Tubulin alpha chain	451 aa	455 aa	31.4 %
Plasmodium vivax	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	429 aa	30.8 %
Echinococcus granulosus	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	40.3 %
Dictyostelium discoideum	beta tubulin	Tubulin alpha chain	451 aa	443 aa	40.4 %
Leishmania mexicana	beta tubulin	Tubulin alpha chain	451 aa	434 aa	42.4 %
Plasmodium yoelii	tubulin gamma chain	Tubulin alpha chain	451 aa	431 aa	31.3 %
Onchocerca volvulus	Regulatory-associated protein of mTOR homolog	Tubulin alpha chain	451 aa	439 aa	76.3 %
Loa Loa (eye worm)	BEN-1 protein	Tubulin alpha chain	451 aa	434 aa	41.5 %
Trypanosoma cruzi	epsilon tubulin, putative	Tubulin alpha chain	451 aa	474 aa	27.4 %
Plasmodium berghei	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	431 aa	31.1 %
Plasmodium falciparum	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	465 aa	25.8 %
Echinococcus multilocularis	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	40.6 %
Loa Loa (eye worm)	tubulin beta-1 chain	Tubulin alpha chain	451 aa	437 aa	39.4 %
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	Tubulin alpha chain	451 aa	436 aa	38.8 %
Plasmodium knowlesi	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	429 aa	30.8 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	441 aa	74.4 %
Theileria parva	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	462 aa	29.7 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	434 aa	41.5 %
Echinococcus multilocularis	tubulin gamma 1 chain	Tubulin alpha chain	451 aa	455 aa	31.4 %
Giardia lamblia	Epsilon tubulin	Tubulin alpha chain	451 aa	457 aa	29.3 %
Dictyostelium discoideum	gamma tubulin	Tubulin alpha chain	451 aa	436 aa	32.8 %
Giardia lamblia	Gamma tubulin	Tubulin alpha chain	451 aa	467 aa	29.6 %
Echinococcus multilocularis	tubulin delta chain	Tubulin alpha chain	451 aa	401 aa	22.9 %
Entamoeba histolytica	tubulin gamma chain	Tubulin alpha chain	451 aa	434 aa	30.9 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	479 aa	25.5 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	478 aa	25.7 %
Plasmodium berghei	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	455 aa	27.7 %
Schistosoma mansoni	tubulin subunit beta	Tubulin alpha chain	451 aa	435 aa	40.9 %
Cryptosporidium parvum	gamma tubulin	Tubulin alpha chain	451 aa	443 aa	30.9 %
Trypanosoma brucei gambiense	epsilon tubulin	Tubulin alpha chain	451 aa	479 aa	25.7 %
Echinococcus granulosus	tubulin alpha	Tubulin alpha chain	451 aa	433 aa	40.0 %
Schistosoma mansoni	tubulin subunit gamma	Tubulin alpha chain	451 aa	451 aa	31.5 %
Plasmodium falciparum	tubulin gamma chain	Tubulin alpha chain	451 aa	431 aa	31.8 %
Leishmania mexicana	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	27.7 %
Echinococcus multilocularis	tubulin alpha	Tubulin alpha chain	451 aa	436 aa	40.1 %
Leishmania donovani	epsilon tubulin, putative	Tubulin alpha chain	451 aa	471 aa	27.0 %
Schistosoma japonicum	ko:K10389 tubulin gamma, putative	Tubulin alpha chain	451 aa	434 aa	31.8 %
Onchocerca volvulus	Tyrosine kinase homolog	Tubulin alpha chain	451 aa	439 aa	87.7 %
Babesia bovis	tubulin gamma chain	Tubulin alpha chain	451 aa	429 aa	31.7 %
Leishmania braziliensis	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	29.4 %
Onchocerca volvulus	Putative methyltransferase KIAA1456	Tubulin alpha chain	451 aa	441 aa	31.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Leishmania major	hypothetical protein, conserved	0.0296	0.3651	0.3648
Echinococcus granulosus	tubulin alpha 3 chain	0.0022	0.0004	0.0004
Schistosoma mansoni	adenoreceptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Brugia malayi	neuropeptide F receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	dro:myosuppressin receptor	0.0058	0.0492	0.0492
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Echinococcus multilocularis	tubulin alpha 3 chain	0.0022	0.0004	0.0004
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0296	0.3651	0.3648
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0058	0.0492	0.0492
Plasmodium falciparum	nitric oxide synthase, putative	0.0774	1	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Loa Loa (eye worm)	diaphorase	0.0088	0.0887	0.0887
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0774	1	1
Trypanosoma cruzi	p450 reductase, putative	0.0774	1	1
Onchocerca volvulus		0.0058	0.0492	0.5545
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0774	1	1
Brugia malayi	flavodoxin family protein	0.0296	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Brugia malayi	G-protein coupled receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0058	0.0492	0.0492
Echinococcus granulosus	peroxisome assembly protein 26	0.0022	0.0004	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Onchocerca volvulus		0.0058	0.0492	0.5545
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0478	0.6067	0.6067
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Schistosoma mansoni	neuropeptide f receptor 76f	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	neuropeptide receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	neuropeptide F-like receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0058	0.0492	0.0492
Echinococcus multilocularis	tubulin subunit TubB	0.0022	0.0004	0.0004
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0088	0.0887	0.0883
Echinococcus granulosus	G protein coupled receptor 139	0.0058	0.0492	0.0492
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0058	0.0492	0.0492
Plasmodium vivax	hypothetical protein, conserved	0.0296	0.3651	0.3648
Giardia lamblia	Hypothetical protein	0.0686	0.8831	1
Onchocerca volvulus		0.0058	0.0492	0.5545
Echinococcus multilocularis	g protein coupled receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0088	0.0887	0.0887
Brugia malayi	larval opioid receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	biogenic amine 5HT receptor	0.0058	0.0492	0.0492
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0088	0.0887	0.0883
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0058	0.0492	0.0492
Echinococcus multilocularis	neuropeptide s receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0058	0.0492	0.0492
Toxoplasma gondii	flavodoxin domain-containing protein	0.0384	0.482	1
Entamoeba histolytica	type A flavoprotein, putative	0.0296	0.3651	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0058	0.0492	0.0492
Brugia malayi	diaphorase	0.0088	0.0887	0.0887
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0004	0.0004
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0058	0.0492	0.0492
Brugia malayi	tubulin alpha chain - mouse	0.0022	0.0004	0.0004
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0058	0.0492	0.0492
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	G-protein coupled receptor	0.0058	0.0492	0.0492
Brugia malayi	Dopamine receptor protein 1	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0296	0.3651	0.3648
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus multilocularis	neuropeptide receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0058	0.0492	0.0492
Mycobacterium tuberculosis	Probable oxidoreductase	0.0088	0.0887	0.5
Brugia malayi	G protein-coupled receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	neuropeptide Y receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	TYRA-2 protein	0.0058	0.0492	0.0492
Echinococcus granulosus	neuropeptides capa receptor	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus granulosus	tm gpcr rhodopsin	0.0058	0.0492	0.0492
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus granulosus	neuropeptide receptor	0.0058	0.0492	0.0492
Brugia malayi	Serotonin receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	cytochrome b5 reductase 4	0.0088	0.0887	0.0887
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Echinococcus multilocularis	G protein coupled receptor 139	0.0058	0.0492	0.0492
Brugia malayi	sulfakinin receptor protein	0.0058	0.0492	0.0492
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0296	0.3651	0.3648
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0088	0.0887	0.0887
Brugia malayi	neuropeptide F receptor	0.0058	0.0492	0.0492
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus multilocularis	tubulin alpha 3 chain	0.0022	0.0004	0.0004
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0058	0.0492	0.0492
Trichomonas vaginalis	sulfite reductase, putative	0.0774	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0058	0.0492	0.0492
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0088	0.0887	0.0883
Trypanosoma cruzi	nitrate reductase, putative	0.0088	0.0887	0.0883
Onchocerca volvulus		0.0058	0.0492	0.5545
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0774	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0022	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	alpha tubulin	0.0022	0.0004	0.0004
Schistosoma mansoni	opsin-like receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0004	0.0004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0058	0.0492	0.0492
Brugia malayi	G-protein coupled receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	7TM GPCR rhodopsin	0.0058	0.0492	0.0492
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	tm gpcr rhodopsin	0.0058	0.0492	0.0492
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Echinococcus multilocularis	tubulin alpha 1C chain	0.0022	0.0004	0.0004
Giardia lamblia	Nitric oxide synthase, inducible	0.0686	0.8831	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0058	0.0492	0.0492
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0774	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Brugia malayi	ORL1-like opioid receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	serotonin receptor	0.0058	0.0492	0.0492
Leishmania major	cytochrome-b5 reductase, putative	0.0088	0.0887	0.0883
Echinococcus multilocularis	tubulin alpha 1C chain	0.0022	0.0004	0.0004
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0296	0.3651	0.3648
Schistosoma mansoni	cytochrome B5	0.0088	0.0887	0.0887
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0058	0.0492	0.0492
Echinococcus multilocularis	serotonin receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Onchocerca volvulus		0.0088	0.0887	1
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0774	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0058	0.0492	0.0492
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Onchocerca volvulus		0.0058	0.0492	0.5545
Schistosoma mansoni	histamine h1 receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	hypothetical protein	0.0022	0.0004	0.0004
Schistosoma mansoni	opsin-like receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	tubulin alpha 3 chain	0.0022	0.0004	0.0004
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0004	0.0004
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0296	0.3651	0.3648
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0296	0.3651	0.3648
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0058	0.0492	0.0492
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0004	0.0004
Schistosoma mansoni	alpha tubulin	0.0022	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	biogenic amine receptor	0.0058	0.0492	0.0492
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	amine GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	Tubulin alpha 1 chain	0.0022	0.0004	0.0004
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0004	0.0004
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0058	0.0492	0.0492
Leishmania major	cytochrome-b5 reductase, putative	0.0088	0.0887	0.0883
Echinococcus granulosus	neuropeptide receptor A26	0.0058	0.0492	0.0492
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0088	0.0887	0.0883
Echinococcus multilocularis	serotonin receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	g-protein coupled receptor	0.0058	0.0492	0.0492
Trypanosoma brucei	NADH-cytochrome b5 reductase-like protein	0.0088	0.0887	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Loa Loa (eye worm)	neuropeptide F receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	g-protein coupled receptor	0.0058	0.0492	0.0492
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus granulosus	tubulin alpha 1C chain	0.0022	0.0004	0.0004
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	neuropeptide receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	neuropeptide receptor	0.0058	0.0492	0.0492
Mycobacterium tuberculosis	Hypothetical oxidoreductase	0.0088	0.0887	0.5
Brugia malayi	FAD binding domain containing protein	0.0774	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	somatostatin receptor	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Brugia malayi	Melatonin receptor type 1A	0.0058	0.0492	0.0492
Schistosoma mansoni	tubulin subunit alpha	0.0022	0.0004	0.0004
Schistosoma mansoni	opsin-like receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	hypothetical protein	0.0058	0.0492	0.0492
Leishmania major	p450 reductase, putative	0.0774	1	1
Entamoeba histolytica	type A flavoprotein, putative	0.0296	0.3651	1
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0088	0.0887	0.0883
Giardia lamblia	Flavohemoprotein lateral transfer candidate	0.0088	0.0887	0.1
Chlamydia trachomatis	Na(+)-translocating NADH-quinone reductase subunit F	0.0088	0.0887	0.1462
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0058	0.0492	0.0492
Entamoeba histolytica	type A flavoprotein, putative	0.0296	0.3651	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Schistosoma mansoni	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus multilocularis	somatostatin receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	fmrfamide receptor	0.0058	0.0492	0.0492
Brugia malayi	Tubulin alpha-2 chain	0.0022	0.0004	0.0004
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0004	0.0004
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0088	0.0887	0.0883
Echinococcus multilocularis	orexin receptor type 2	0.0058	0.0492	0.0492
Mycobacterium tuberculosis	Probable monooxygenase	0.0088	0.0887	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0058	0.0492	0.0492
Schistosoma mansoni	amine GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	g protein coupled receptor	0.0058	0.0492	0.0492
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0774	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0058	0.0492	0.0492
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0058	0.0492	0.0492
Brugia malayi	Tubulin alpha chain	0.0022	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	amine GPCR	0.0058	0.0492	0.0492
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0088	0.0887	0.1833
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0058	0.0492	0.0492
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Leishmania major	oxidoreductase-like protein	0.0088	0.0887	0.0883
Echinococcus granulosus	allatostatin A receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0478	0.6067	0.6067
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	diflavin oxidoreductase	0.0384	0.482	0.482
Chlamydia trachomatis	sulfite reductase	0.0478	0.6067	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0088	0.0887	0.0883
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	Tubulin alpha 1 chain	0.0022	0.0004	0.0004
Echinococcus granulosus	neuropeptide receptor	0.0058	0.0492	0.0492
Leishmania major	nitrate reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	tm gpcr rhodopsin	0.0058	0.0492	0.0492
Loa Loa (eye worm)	melatonin receptor type 1A	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Mycobacterium tuberculosis	Possible oxygenase	0.0088	0.0887	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0058	0.0492	0.0492
Loa Loa (eye worm)	tubulin alpha chain	0.0022	0.0004	0.0004
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0774	1	1
Brugia malayi	AKH receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	g protein coupled receptor	0.0058	0.0492	0.0492
Brugia malayi	Tubulin alpha-2 chain	0.0022	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0774	1	1
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0088	0.0887	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Treponema pallidum	flavodoxin	0.0296	0.3651	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0058	0.0492	0.5545
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0686	0.8831	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0022	0.0004	0.0004
Echinococcus granulosus	alpha tubulin	0.0022	0.0004	0.0004
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Echinococcus granulosus	cytochrome b5 reductase 4	0.0088	0.0887	0.0887
Brugia malayi	FAD binding domain containing protein	0.0478	0.6067	0.6067
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0774	1	1
Echinococcus granulosus	orexin receptor type 2	0.0058	0.0492	0.0492
Echinococcus multilocularis	neuropeptides capa receptor	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0774	1	1
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	biogenic amine receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	tubulin subunit TubB	0.0022	0.0004	0.0004
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0774	1	1
Brugia malayi	GnHR receptor homolog	0.0058	0.0492	0.0492
Echinococcus multilocularis	neuropeptide Y receptor	0.0058	0.0492	0.0492
Brugia malayi	putative neuropeptide receptor NPR1	0.0058	0.0492	0.0492
Trypanosoma cruzi	p450 reductase, putative	0.0088	0.0887	0.0883
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Brugia malayi	follicle stimulating hormone receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	neuropeptide receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	neuropeptide s receptor	0.0058	0.0492	0.0492
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Trypanosoma cruzi	reductase, putative	0.0088	0.0887	0.0883
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Echinococcus multilocularis	methionine synthase reductase	0.0478	0.6067	0.6067
Brugia malayi	alpha-tubulin	0.0022	0.0004	0.0004
Loa Loa (eye worm)	alpha-tubulin	0.0022	0.0004	0.0004
Brugia malayi	RE15519p	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0774	1	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0088	0.0887	0.5
Echinococcus granulosus	tubulin alpha 1C chain	0.0022	0.0004	0.0004
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0088	0.0887	0.0887
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	myosin xvIII	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0058	0.0492	0.0492
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	NADPH flavin oxidoreductase	0.039	0.4898	0.4898
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Brugia malayi	Serotonin receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	growth hormone secretagogue receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	sex peptide receptor	0.0058	0.0492	0.0492
Plasmodium vivax	flavodoxin domain containing protein	0.0686	0.8831	0.8831
Echinococcus granulosus	Tubulin alpha 1 chain	0.0022	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0058	0.0492	0.0492
Echinococcus multilocularis	neuropeptides capa receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0004	0.0004
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0088	0.0887	0.1833
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0058	0.0492	0.0492
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.0004	0.0004
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0058	0.0492	0.0492
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0088	0.0887	0.0887
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0774	1	1
Leishmania major	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Echinococcus granulosus	neuropeptides capa receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0058	0.0492	0.0492
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	flavodoxin family protein	0.0296	0.3651	0.3651
Echinococcus multilocularis	fmrfamide receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	biogenic amine 5HT receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0058	0.0492	0.0492
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0088	0.0887	0.0887
Entamoeba histolytica	type A flavoprotein, putative	0.0296	0.3651	1
Onchocerca volvulus		0.0058	0.0492	0.5545
Echinococcus granulosus	fmrfamide receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	neuropeptide receptor	0.0058	0.0492	0.0492
Leishmania major	cytochrome P450 reductase, putative	0.0686	0.8831	0.8831
Echinococcus granulosus	neuropeptide Y receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	tubulin alpha chain	0.0022	0.0004	0.0004
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	alpha tubulin	0.0022	0.0004	0.0004
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	g protein coupled receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	G-protein coupled receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	7tm_1 domain containing protein	0.0058	0.0492	0.0492
Echinococcus multilocularis	g protein coupled receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Trypanosoma brucei	nitrate reductase, putative	0.0088	0.0887	0.0883
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0774	1	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus granulosus	neuropeptide FF receptor 2	0.0058	0.0492	0.0492
Onchocerca volvulus		0.0058	0.0492	0.5545
Entamoeba histolytica	type A flavoprotein, putative	0.0296	0.3651	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	neuropeptide F-like receptor	0.0058	0.0492	0.0492
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0296	0.3651	0.3648
Schistosoma mansoni	cytochrome P450 reductase	0.0774	1	1
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0774	1	1
Brugia malayi	tubulin alpha-2 chain	0.0022	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0004	0.0004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0058	0.0492	0.0492
Leishmania major	reductase, putative	0.0088	0.0887	0.0883
Trypanosoma brucei	oxidoreductase-protein, putative	0.0088	0.0887	0.0883
Onchocerca volvulus		0.0058	0.0492	0.5545
Schistosoma mansoni	tubulin subunit alpha	0.0022	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0296	0.3651	0.3648
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus granulosus	hypothetical protein	0.0058	0.0492	0.0492
Brugia malayi	putative neuropeptide receptor	0.0058	0.0492	0.0492
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Toxoplasma gondii	flavodoxin domain-containing protein	0.0384	0.482	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0004	0.0004
Schistosoma mansoni	biogenic amine receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.0004	0.0004
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0058	0.0492	0.0492
Brugia malayi	Dopamine receptor protein 2	0.0058	0.0492	0.0492
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0088	0.0887	0.0883
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0058	0.0492	0.5545
Echinococcus multilocularis	neuropeptide Y receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	g protein coupled receptor	0.0058	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.0492
Plasmodium falciparum	ferredoxin--NADP reductase	0.0088	0.0887	0.0883
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0058	0.0492	0.0492
Brugia malayi	hypothetical protein	0.0058	0.0492	0.0492
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0058	0.0492	0.0492
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0004	0.0004
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Echinococcus granulosus	methionine synthase reductase	0.0478	0.6067	0.6067
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0058	0.0492	0.0492
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.0004	0.0004
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0296	0.3651	0.3648
Brugia malayi	Dopamine receptor	0.0058	0.0492	0.0492
Schistosoma mansoni	tubulin subunit alpha	0.0022	0.0004	0.0004
Echinococcus multilocularis	peroxisome assembly protein 26	0.0022	0.0004	0.0004
Echinococcus multilocularis	allatostatin A receptor	0.0058	0.0492	0.0492
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0774	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0492	0.0492
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0058	0.0492	0.0492
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	amine GPCR	0.0058	0.0492	0.0492
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0058	0.0492	0.0492
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0088	0.0887	0.0883
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0058	0.0492	0.0492
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0296	0.3651	0.3648
Echinococcus granulosus	sex peptide receptor	0.0058	0.0492	0.0492
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0088	0.0887	0.0887

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.07 uM	Inhibition B16 melanoma cell monolayer proliferation	ChEMBL.	2913301
IC50 (functional)	= 0.07 uM	Inhibition B16 melanoma cell monolayer proliferation	ChEMBL.	2913301
IC50 (binding)	= 7.5 uM	Displacement of 5.8 uM [3H]-oncodazole from homogeneous tubulin.	ChEMBL.	2913301
IC50 (binding)	= 7.5 uM	Displacement of 5.8 uM [3H]-oncodazole from homogeneous tubulin.	ChEMBL.	2913301
ILS (functional)	= 105 %	In vivo percent increase in life span at Maximum tolerated dose in syngenic B6D2F1 female mice bearing ip implanted P388 leukemia.	ChEMBL.	2913301
ILS (functional)	= 105 %	In vivo percent increase in life span at Maximum tolerated dose in syngenic B6D2F1 female mice bearing ip implanted P388 leukemia.	ChEMBL.	2913301
MTD (functional)	= 160 mg kg-1	In vivo Maximum tolerated dose in syngenic B6D2F1 female mice bearing ip implanted P388 leukemia.	ChEMBL.	2913301
MTD (functional)	= 160 mg kg-1	In vivo Maximum tolerated dose in syngenic B6D2F1 female mice bearing ip implanted P388 leukemia.	ChEMBL.	2913301

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	2913301

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL133900

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 229918