Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | serine/threonine kinase 12 | 0.0175 | 0.2303 | 0.2303 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0305 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0294 | 0.9347 | 0.9347 |
Trypanosoma brucei | aurora B kinase | 0.0175 | 0.2303 | 0.5 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Echinococcus multilocularis | nAChR subunit | 0.0159 | 0.1344 | 0.1344 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0159 | 0.1344 | 0.1344 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0294 | 0.9347 | 0.9347 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0305 | 1 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0294 | 0.9347 | 0.9347 |
Entamoeba histolytica | protein kinase, putative | 0.0175 | 0.2303 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0305 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0175 | 0.2303 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0294 | 0.9347 | 0.9347 |
Trichomonas vaginalis | AGC family protein kinase | 0.0175 | 0.2303 | 0.5 |
Echinococcus granulosus | nAChR subunit | 0.0159 | 0.1344 | 0.1344 |
Echinococcus granulosus | aurora kinase A | 0.0175 | 0.2303 | 0.2303 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0294 | 0.9347 | 0.9347 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | dihydrofolate reductase | 0.0305 | 1 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0175 | 0.2303 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Toxoplasma gondii | aurora kinase | 0.0175 | 0.2303 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0159 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | AUR protein kinase | 0.0175 | 0.2303 | 0.2303 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0305 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0175 | 0.2303 | 1 |
Onchocerca volvulus | 0.0294 | 0.9347 | 1 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0175 | 0.2303 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Onchocerca volvulus | 0.0159 | 0.1344 | 0.1438 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Schistosoma mansoni | protein kinase | 0.0175 | 0.2303 | 0.2303 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0175 | 0.2303 | 0.2303 |
Schistosoma mansoni | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0175 | 0.2303 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0294 | 0.9347 | 0.9347 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0175 | 0.2303 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0294 | 0.9347 | 0.9347 |
Onchocerca volvulus | 0.0294 | 0.9347 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0175 | 0.2303 | 0.2303 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | ACC-1 protein | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Onchocerca volvulus | 0.0294 | 0.9347 | 1 | |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0159 | 0.1344 | 0.1344 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0175 | 0.2303 | 0.2303 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0294 | 0.9347 | 0.9347 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | AUR protein kinase | 0.0175 | 0.2303 | 0.2303 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0305 | 1 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Cation transporter family protein | 0.0294 | 0.9347 | 0.9347 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0175 | 0.2303 | 0.5 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | LGC-31 protein | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | AUR protein kinase | 0.0175 | 0.2303 | 0.2303 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0159 | 0.1344 | 0.1344 |
Brugia malayi | Dihydrofolate reductase | 0.0305 | 1 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0294 | 0.9347 | 0.9347 |
Leishmania major | protein kinase, putative | 0.0175 | 0.2303 | 0.5 |
Entamoeba histolytica | protein kinase , putative | 0.0175 | 0.2303 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0175 | 0.2303 | 0.2303 |
Onchocerca volvulus | 0.0294 | 0.9347 | 1 | |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0294 | 0.9347 | 0.9347 |
Onchocerca volvulus | 0.0159 | 0.1344 | 0.1438 | |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0294 | 0.9347 | 0.9347 |
Giardia lamblia | Aurora kinase | 0.0175 | 0.2303 | 0.5 |
Echinococcus multilocularis | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Onchocerca volvulus | Putative nachr subunit | 0.0294 | 0.9347 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0175 | 0.2303 | 0.5 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0159 | 0.1344 | 0.1344 |
Schistosoma mansoni | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Cation transporter family protein | 0.0294 | 0.9347 | 0.9347 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0175 | 0.2303 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0294 | 0.9347 | 0.9347 |
Trichomonas vaginalis | AGC family protein kinase | 0.0175 | 0.2303 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Onchocerca volvulus | 0.0294 | 0.9347 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0159 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Echinococcus multilocularis | aurora kinase A | 0.0175 | 0.2303 | 0.2303 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0159 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0305 | 1 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | dihydrofolate reductase | 0.0305 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0294 | 0.9347 | 0.9347 |
Trichomonas vaginalis | AGC family protein kinase | 0.0175 | 0.2303 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | ACC-1 protein | 0.0294 | 0.9347 | 0.9347 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0294 | 0.9347 | 0.9347 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.9347 | 0.9347 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1344 | 0.1344 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0294 | 0.9347 | 0.9347 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0159 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0294 | 0.9347 | 0.9347 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0175 | 0.2303 | 0.2303 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0294 | 0.9347 | 0.9347 |
Onchocerca volvulus | 0.0294 | 0.9347 | 1 | |
Brugia malayi | Cation transporter family protein | 0.0294 | 0.9347 | 0.9347 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0294 | 0.9347 | 0.9347 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 83 mg kg-1 | Percent inhibition of muscle relaxant profile evaluated by straub tail assay when administered intraperitoneally at 100 mg/kg in mouse | ChEMBL. | 12540240 |
ED50 (functional) | = 83 mg kg-1 | Percent inhibition of muscle relaxant profile evaluated by straub tail assay when administered intraperitoneally at 100 mg/kg in mouse | ChEMBL. | 12540240 |
ED50 (functional) | > 100 mg kg-1 | Effective dose required for muscle relaxant profile evaluated by straub tail assay when administered perorally in mouse | ChEMBL. | 12540240 |
ED50 (functional) | > 100 mg kg-1 | Effective dose required for muscle relaxant profile evaluated by straub tail assay when administered perorally in mouse | ChEMBL. | 12540240 |
Inhibition (functional) | = 9 % | Antiinflammatory activity against 3h carragenaan pleurisy (cells) in rat at 20 mg/kg peroral administration | ChEMBL. | 12540240 |
Inhibition (functional) | = 12 % | Percent inhibition of analgesia activity when administered perorally at 20 mg/kg in rat | ChEMBL. | 12540240 |
Inhibition (functional) | = 34 % | Antiinflammatory activity against 3h carragenaan pleurisy (edma) in rat at 20 mg/kg peroral administration | ChEMBL. | 12540240 |
ND (functional) | 0 | Effective dose required for muscle relaxant profile in mouse by rotorod assay, when compound administered perorally ; ND is activity not determined. | ChEMBL. | 12540240 |
ND (functional) | 0 | Ratio of rotorod to that of staub tail; ND is activity not determined. | ChEMBL. | 12540240 |
ND (functional) | 0 | Inhibition of trypsin hyperalgesia when administered perorally in rat; ND is activity not determined. | ChEMBL. | 12540240 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.