Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0802 | 0.9518 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.2066 | 0.2171 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.2066 | 0.2171 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.047 | 0.5193 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0507 | 0.5675 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0802 | 0.9518 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9088 | 0.9548 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0507 | 0.5675 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 270 nM | Binding affinity against retinoic Acid gamma receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | = 270 nM | Binding affinity against retinoic Acid gamma receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | = 300 nM | Binding affinity against retinoic Acid X alpha receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | = 300 nM | Binding affinity against retinoic Acid X alpha receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | = 2700 nM | Binding affinity against retinoic Acid X gamma receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | = 2700 nM | Binding affinity against retinoic Acid X gamma receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | > 10000 nM | Binding affinity against retinoic Acid alpha receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | > 10000 nM | Binding affinity against retinoic Acid beta receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | > 10000 nM | Binding affinity against retinoic Acid X beta receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | > 10000 nM | Binding affinity against retinoic Acid alpha receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | > 10000 nM | Binding affinity against retinoic Acid beta receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
EC50 (binding) | > 10000 nM | Binding affinity against retinoic Acid X beta receptors cotransfected into CV-1 cells | ChEMBL. | 8308867 |
IC50 (binding) | = 10 nM | Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | = 10 nM | Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | = 50 nM | Binding affinity against retinoic Acid X beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | = 50 nM | Binding affinity against retinoic Acid X beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | = 150 nM | Binding affinity against retinoic Acid beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | = 150 nM | Binding affinity against retinoic Acid beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | = 320 nM | Binding affinity against retinoic Acid X alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | = 320 nM | Binding affinity against retinoic Acid X alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | > 1000 nM | Binding affinity against retinoic Acid alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | > 1000 nM | Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | > 1000 nM | Binding affinity against retinoic Acid alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
IC50 (binding) | > 1000 nM | Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | ChEMBL. | 8308867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.