Detailed information for compound 230125

Basic information

Technical information
  • TDR Targets ID: 230125
  • Name: 2-(2,5-dioxo-3,6,7,7a-tetrahydropyrrolo[1,2-a ]imidazol-1-yl)acetamide
  • MW: 197.191 | Formula: C8H11N3O3
  • H donors: 1 H acceptors: 3 LogP: -1.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)CN1C(=O)CN2C1CCC2=O
  • InChi: 1S/C8H11N3O3/c9-5(12)3-10-6-1-2-7(13)11(6)4-8(10)14/h6H,1-4H2,(H2,9,12)
  • InChiKey: ZZMLXWDFRYZBQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,5-dioxo-3,6,7,7a-tetrahydropyrrolo[1,2-a]imidazol-1-yl)ethanamide
  • 2-(2,5-diketo-3,6,7,7a-tetrahydropyrrolo[1,2-a]imidazol-1-yl)acetamide
  • 2-(2,5-dioxo-3,6,7,7a-tetrahydropyrrolo[2,1-b]imidazol-1-yl)acetamide
  • 2-(2,5-diketo-3,6,7,7a-tetrahydropyrrolo[2,1-b]imidazol-1-yl)acetamide
  • 2-(2,5-dioxo-3,6,7,7a-tetrahydropyrrolo[2,1-b]imidazol-1-yl)ethanamide
  • 126101-04-0
  • 1H-Pyrrolo(1,2-a)imidazole-1-acetamide, hexahydro-2,5-dioxo-
  • 2,5-Dioxohexahydro-1H-pyrrolo(1,2-a)imidazole-1-acetamide
  • Hexahydro-2,5-dioxo-1H-pyrrolo(1,2-a)imidazole-1-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0303 0.2167 0.2481
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Onchocerca volvulus Ribonuclease H1 homolog 0.0276 0.1968 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0153 0.2335
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0153 0.0269
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0296 0.5709
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0015 0.0078
Schistosoma mansoni ap endonuclease 0.002 0.0069 0.0069
Echinococcus granulosus RNA directed DNA polymerase 0.0027 0.0118 0.0469
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0069 0.0101
Echinococcus granulosus lamin 0.0029 0.0134 0.0532
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0153 0.2596
Plasmodium vivax glutathione reductase, putative 0.0051 0.0296 0.5709
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0069 0.005
Trypanosoma brucei ingi protein (ORF1) 0.0303 0.2167 0.2481
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0069 0.0275
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Schistosoma mansoni hypothetical protein 0.1183 0.8701 0.8701
Toxoplasma gondii thioredoxin reductase 0.0051 0.0296 0.136
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.005 0.0046
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0276 0.1968 1
Brugia malayi hypothetical protein 0.0027 0.0118 0.0602
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Trichomonas vaginalis reverse transcriptases, putative 0.0027 0.0118 0.0278
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0089 0.0204
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.005 0.0088
Schistosoma mansoni phosphoglucomutase 0.0276 0.1968 0.1968
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0178
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0296 0.0736
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0027 0.0118 0.0469
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0296 0.2985
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.0779 0.8837
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0786 0.3835
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.005 0.0254
Plasmodium vivax thymidylate kinase, putative 0.0077 0.0493 1
Loa Loa (eye worm) RecQ helicase 0.0023 0.0089 0.0503
Plasmodium falciparum glutathione reductase 0.0051 0.0296 0.5558
Schistosoma mansoni ap endonuclease 0.002 0.0069 0.0069
Schistosoma mansoni phosphoglucomutase 0.0276 0.1968 0.1968
Trypanosoma brucei ribonuclease H1 0.0276 0.1968 0.2253
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0153 0.0622
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Treponema pallidum ribonuclease H (rnhA) 0.0276 0.1968 1
Trypanosoma brucei thymidylate kinase, putative 0.0077 0.0493 0.0555
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0786 0.3111
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.005 0.034
Trypanosoma brucei thymidylate kinase, putative 0.0077 0.0493 0.0555
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0035 0.0195
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0153 0.0622
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0118 0.0278
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Onchocerca volvulus 0.0027 0.0118 0.0602
Brugia malayi Zinc knuckle family protein 0.0027 0.0118 0.0602
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0153 0.2335
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Trichomonas vaginalis thymidine kinase, putative 0.0536 0.3897 1
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0178
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0786 0.0892
Echinococcus multilocularis RNA directed DNA polymerase 0.0027 0.0118 0.0469
Giardia lamblia CDC8 0.0077 0.0493 0.1151
Echinococcus multilocularis ribonuclease H1 0.0276 0.1968 0.7794
Trypanosoma cruzi thymidine kinase, putative 0.0536 0.3897 1
Trichomonas vaginalis reverse transcriptases, putative 0.0027 0.0118 0.0278
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0602
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.0779 0.8837
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0069 0.0425
Giardia lamblia Ribonuclease H 0.0276 0.1968 0.4986
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Brugia malayi 6-phosphofructokinase 0.0117 0.0786 0.3992
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Trypanosoma brucei thymidine kinase 0.0536 0.3897 0.4472
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0089 0.0354
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.0779 0.7488
Echinococcus multilocularis lamin dm0 0.0029 0.0134 0.0532
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Brugia malayi hypothetical protein 0.0027 0.0118 0.0602
Schistosoma mansoni hypothetical protein 0.0351 0.2525 0.2525
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0108
Treponema pallidum thymidylate kinase (tmk) 0.0077 0.0493 0.231
Brugia malayi thymidylate kinase 0.0077 0.0493 0.2505
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0296 0.1173
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0134 0.0683
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Schistosoma mansoni thymidylate kinase 0.0077 0.0493 0.0493
Echinococcus multilocularis musashi 0.0029 0.0134 0.0532
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0786 0.1995
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Onchocerca volvulus 0.0027 0.0118 0.0602
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Brugia malayi RNase H family protein 0.0276 0.1968 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0089 0.0204
Trypanosoma cruzi thymidylate kinase, putative 0.0077 0.0493 0.1242
Brugia malayi follicle stimulating hormone receptor 0.025 0.1778 0.9033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Echinococcus granulosus lamin dm0 0.0029 0.0134 0.0532
Brugia malayi hypothetical protein 0.0027 0.0118 0.0602
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Loa Loa (eye worm) glutathione reductase 0.0051 0.0296 0.1667
Trichomonas vaginalis thymidylate kinase, putative 0.0077 0.0493 0.1242
Schistosoma mansoni lamin 0.0029 0.0134 0.0134
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0875 1
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0786 0.1995
Trypanosoma cruzi thymidylate kinase, putative 0.0077 0.0493 0.1242
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.005 0.0088
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.005 0.0102
Schistosoma mansoni thymidylate kinase 0.0077 0.0493 0.0493
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0069 0.039
Chlamydia trachomatis thymidylate kinase 0.0077 0.0493 1
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0602
Trichomonas vaginalis thymidine kinase, putative 0.0536 0.3897 1
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0786 0.3111
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0108
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Trypanosoma cruzi ribonuclease H1, putative 0.0276 0.1968 0.5037
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.005 0.005
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0054 0.0054
Brugia malayi RNase H family protein 0.0276 0.1968 1
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0027 0.0118 0.0278
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0027 0.0118 0.0124
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.005 0.0046
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0786 0.4419
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0786 0.4419
Schistosoma mansoni protein kinase 0.0027 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0028 0.013 0.0734
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.005 0.0102
Trichomonas vaginalis thymidylate kinase, putative 0.0077 0.0493 0.1242
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.0779 0.8837
Trichomonas vaginalis thymidine kinase, putative 0.0536 0.3897 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0469
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0786 0.7663
Trypanosoma cruzi ribonuclease H1, putative 0.0276 0.1968 0.5037
Leishmania major thymidine kinase, putative 0.0536 0.3897 1
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0786 0.1995
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.005 0.0198
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0178
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0786 0.1995
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0134 0.0756
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0027 0.0118 0.0124
Leishmania major hypothetical protein, conserved 0.003 0.0145 0.0345
Schistosoma mansoni hypothetical protein 0.0077 0.0493 0.0493
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Echinococcus multilocularis geminin 0.0351 0.2525 1
Toxoplasma gondii exonuclease III APE 0.002 0.0069 0.0187
Onchocerca volvulus 0.0029 0.0134 0.0683
Echinococcus multilocularis thymidylate kinase 0.0077 0.0493 0.1953
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0469
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0027 0.0118 0.0278
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.1778 1
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0178
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0069 0.0436
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.005 0.0102
Trypanosoma brucei trypanothione reductase 0.0051 0.0296 0.0329
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0153 0.0539
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0786 0.0786
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0069 0.0152
Schistosoma mansoni phosphoglucomutase 0.0276 0.1968 0.1968
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0069 0.0262
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0153 0.2335
Loa Loa (eye worm) thymidylate kinase 0.0077 0.0493 0.2773
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0069 0.0101
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.0779 0.8837
Plasmodium falciparum thymidylate kinase 0.0077 0.0493 1
Brugia malayi Thioredoxin reductase 0.0051 0.0296 0.1505
Schistosoma mansoni lamin 0.0029 0.0134 0.0134
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0069 0.0068
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0786 0.0786
Echinococcus granulosus KRAB A domain containing protein 0.0027 0.0118 0.0469
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.003 0.0145 0.0345
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0069 0.0152
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Entamoeba histolytica thymidine kinase, putative 0.0536 0.3897 1
Trypanosoma brucei unspecified product 0.0303 0.2167 0.2481
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0875 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Echinococcus granulosus geminin 0.0351 0.2525 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0153 0.0622
Onchocerca volvulus 0.0029 0.0134 0.0683
Brugia malayi 6-phosphofructokinase 0.0117 0.0786 0.3992
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.005 0.0102
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0303 0.2167 0.2481
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0027 0.0118 0.0602
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0035 0.0176
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0247 0.1752 0.1752
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0786 0.1995
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0469
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0069 0.0352
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0296 0.1173
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0786 0.1995
Brugia malayi glutathione reductase 0.0051 0.0296 0.1505
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0069 0.0152
Brugia malayi RNase H family protein 0.0276 0.1968 1
Brugia malayi Zinc knuckle family protein 0.0027 0.0118 0.0602
Mycobacterium tuberculosis Possible maturase 0.0027 0.0118 0.0829
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0786 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.005 0.0102
Entamoeba histolytica Thymidylate kinase, putative 0.0077 0.0493 0.1242
Brugia malayi intermediate filament protein 0.0029 0.0134 0.0683
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.031
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.005 0.0198
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0027 0.0118 0.0124
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.005 0.0102
Toxoplasma gondii ribonuclease HI protein 0.0276 0.1968 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0027 0.0118 0.0118
Onchocerca volvulus Putative thymidylate kinase 0.0077 0.0493 0.2505
Echinococcus granulosus bloom syndrome protein 0.0023 0.0089 0.0354
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.003 0.0145 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0118 0.0118
Plasmodium falciparum thioredoxin reductase 0.0051 0.0296 0.5558
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0153 0.0368
Mycobacterium ulcerans thymidylate kinase 0.0077 0.0493 0.6022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.005 0.0046
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0296 0.1667
Toxoplasma gondii thymidylate kinase 0.0077 0.0493 0.2377
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0153 0.2335
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0786 0.1995
Giardia lamblia Reverse transcriptase/endonuclease 0.0027 0.0118 0.0178
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0786 0.1995
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0069 0.0152
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0069 0.0152
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0875 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0069 0.0152
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0786 0.8918
Leishmania major thymidylate kinase-like protein 0.0077 0.0493 0.1242
Mycobacterium tuberculosis Probable reductase 0.0116 0.0779 0.8837
Giardia lamblia Thymidine kinase 0.0536 0.3897 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0875 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.005 0.0046
Brugia malayi hypothetical protein 0.0027 0.0118 0.0602
Schistosoma mansoni intermediate filament proteins 0.0029 0.0134 0.0134
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0134 0.0756
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0077 0.0493 0.231
Trypanosoma cruzi thymidine kinase, putative 0.0536 0.3897 1
Echinococcus multilocularis lamin 0.0029 0.0134 0.0532
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0602
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0015 0.0078
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Leishmania major ribonuclease H1, putative 0.0276 0.1968 0.5037
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0069 0.0275
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0469
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.005 0.034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0756
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.005 0.0102
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0069 0.0234
Schistosoma mansoni hypothetical protein 0.0351 0.2525 0.2525
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0153 0.2596
Leishmania major trypanothione reductase 0.0051 0.0296 0.0736
Echinococcus granulosus ribonuclease H1 0.0276 0.1968 0.7794
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0153 0.0368
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.0779 0.8837
Trichomonas vaginalis ribonuclease H1, putative 0.0276 0.1968 0.5037
Echinococcus granulosus thymidylate kinase 0.0077 0.0493 0.1953
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0469
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0089 0.0455
Trypanosoma brucei RNA helicase, putative 0.1183 0.8701 1
Brugia malayi phosphofructokinase 0.0117 0.0786 0.3992
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0602
Echinococcus granulosus intermediate filament protein 0.0029 0.0134 0.0532
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0786 0.4419
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0786 0.1995
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0077 0.0493 0.5371
Trypanosoma brucei ingi protein (ORF1) 0.0303 0.2167 0.2481
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0069 0.0761

Activities

Activity type Activity value Assay description Source Reference
Reversal (functional) = 0 % Percent reversal of scopalamine-induced amnesia rat at 1.0 mg/kg po ChEMBL. 8277504
Reversal (functional) = 9 % Percent reversal of scopalamine-induced amnesia rat at 10 mg/kg po ChEMBL. 8277504
Reversal (functional) = 49 % Percent reversal of scopalamine-induced amnesia rat following 1.0 mg/kg i.p. ChEMBL. 8277504
Reversal (functional) = 62 % Percent reversal of scopalamine-induced amnesia rat following 10 mg/kg i.p. ChEMBL. 8277504

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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