Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0164 | 0.1343 | 1 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0114 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0346 | 0.6119 | 0.8547 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0493 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0346 | 0.6119 | 0.8547 |
Brugia malayi | Dihydrofolate reductase | 0.0385 | 0.7159 | 1 |
Onchocerca volvulus | 0.0346 | 0.6119 | 1 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0385 | 0.7159 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0493 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0164 | 0.1343 | 0.1875 |
Echinococcus granulosus | dihydrofolate reductase | 0.0385 | 0.7159 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0385 | 0.7159 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0493 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0493 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0346 | 0.6119 | 0.8547 |
Mycobacterium ulcerans | thymidylate synthase | 0.0346 | 0.6119 | 0.8547 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0346 | 0.6119 | 0.8547 |
Loa Loa (eye worm) | thymidylate synthase | 0.0346 | 0.6119 | 0.8547 |
Brugia malayi | thymidylate synthase | 0.0346 | 0.6119 | 0.8547 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0385 | 0.7159 | 1 |
Brugia malayi | hypothetical protein | 0.0164 | 0.1343 | 0.1875 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0385 | 0.7159 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0385 | 0.7159 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0346 | 0.6119 | 0.8547 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0164 | 0.1343 | 0.1343 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0385 | 0.7159 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0493 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0385 | 0.7159 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0385 | 0.7159 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 710 nM | Ability to inhibit [3H]-Ro- 15-1788 binding to Gamma-aminobutyric-acid A receptor alpha in vitro in rat cortical membranes | ChEMBL. | 12213060 |
Ki (binding) | = 710 nM | Ability to inhibit [3H]-Ro- 15-1788 binding to Gamma-aminobutyric-acid A receptor alpha in vitro in rat cortical membranes | ChEMBL. | 12213060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.