Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | adenosine deaminase-related growth factor | Adenosine deaminase | 363 aa | 299 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0288 | 0.0716 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0104 | 0.2528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2528 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0288 | 0.0215 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 0.2528 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0288 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0288 | 0.0706 |
Schistosoma mansoni | hypothetical protein | 0.0398 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0104 | 0.2528 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0034 | 0.0755 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0755 | 0.0768 | |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0288 | 0.0215 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1129 | 0.4197 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1672 | 0.6446 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0288 | 0.0288 |
Leishmania major | adenine aminohydrolase | 0.0104 | 0.2528 | 1 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0034 | 0.0755 | 0.0686 |
Plasmodium vivax | adenosine deaminase, putative | 0.0104 | 0.2528 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0.2528 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 0.2528 | 0.2528 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0104 | 0.2528 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.2528 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0648 | 0.0578 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1129 | 0.4204 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0288 | 0.0288 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.2528 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.074 | 0.074 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0608 | 0.0608 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1129 | 0.4204 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0648 | 0.0578 |
Echinococcus multilocularis | adenosine deaminase | 0.0104 | 0.2528 | 0.2472 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0648 | 0.0648 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Loa Loa (eye worm) | AMP deaminase | 0.0034 | 0.0755 | 0.2644 |
Schistosoma mansoni | AMP deaminase | 0.0034 | 0.0755 | 0.0755 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0288 | 0.0288 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0288 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1672 | 0.6446 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0104 | 0.2528 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0288 | 0.0215 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0648 | 0.0648 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.1403 | 0.1403 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0288 | 0.0215 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1129 | 0.4197 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.2528 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.0034 | 0.0755 | 0.0686 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1672 | 0.6446 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0.2528 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0288 | 0.0215 |
Brugia malayi | adenosine monophosphate deaminase | 0.0034 | 0.0755 | 0.2652 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0034 | 0.0755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0755 | 0.2644 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.074 | 0.259 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0398 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.074 | 0.2581 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0608 | 0.2032 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0288 | 0.0288 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Schistosoma mansoni | adenosine deaminase | 0.0104 | 0.2528 | 0.2528 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.2528 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0288 | 0.0706 |
Echinococcus granulosus | adenosine deaminase | 0.0104 | 0.2528 | 0.2472 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1672 | 0.6446 |
Treponema pallidum | adenosine deaminase | 0.0104 | 0.2528 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.1242 | 0.2746 |
Plasmodium falciparum | adenosine deaminase | 0.0104 | 0.2528 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0608 | 0.2041 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0034 | 0.0755 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0034 | 0.0755 | 0.0768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.